anthrocellogy
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In this guide ill be talking about what sublingual minoxidil is,
why its the best, how to avoid bloating and how to make it at home.
Section 1
What is sublingual minoxidil
Sublingual minoxidil mechanism
Why sublingual is superior
Why sublingual causes minimal bloating
When to take sublingual minoxidil
Sublingual minoxidil tldr
Section 2
How to get sublingual minoxidil
Compounds for DIY sublingual minoxidil
Resources for DIY sublingual minoxidil
Formula for DIY sublingual minoxidil
Video's of DIY sublingual minoxidil
these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.
Tips and tricks
why its the best, how to avoid bloating and how to make it at home.
Section 1
What is sublingual minoxidil
Sublingual minoxidil is the most recent form of minoxidil and is absorped by placing a tablet or liquid drop under the tongue.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
this absorption method is the best since it goes directly through the mucous membrane into the bloodstream, this method bypasses the digestive system and the liver completely making this safer and more optimal then oral and topical minoxidil.
Sublingual minoxidil mechanism
1. drug diffuses through the mucosal membrane into the sublingual veins
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth
2. enters the heart without going through the digestive system or liver
3. reaches the systemic arteries
4. gets converted to minoxidil sulfate by platelet and tissue enzymes
5. opens the K_ATP channels
6. vasodilation + prolonged anagen phase
7. hair growth
Why sublingual is superior
1. Sublingual vs oral
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth
2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply
Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/
the plasma concentration of sublingual minoxidil is way lower than oral
resulting in no/minimal palpitations, peripheral oederma and hypertension
making sublingual superior for having extremely lower cardiovascular side effects
whilst still getting the same amount of hair regrowth
2. Sublingual vs topical
the absorption from topical minoxidil isnt great for everyone.
Infact ~50% of people have to little SULTA1A1 resulting in little to no hair growth
even if you do get hair growth you'll encounter shedding and annoying application processes
making sublingual superior due to everyone being able to respond and easy to apply
Citations:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12207719/
https://pubmed.ncbi.nlm.nih.gov/39688293/
https://pubmed.ncbi.nlm.nih.gov/37638619/
Why sublingual causes minimal bloating
As we all know oral minoxidil causes bloating due to its sodium retaining properties and its vasodilatory effects.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:
1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.
So the reason that sublingual has a lower downtime and less of it is due to this mechanism:
1. lower plasma concentration
2. weaker vasodilation
3. causing less sodium retention
4. less fluid accumulation.
When to take sublingual minoxidil
since we know that the half life of minoxidil is 4,5 hours we are able to make an approximate timeline of the plasma levels.
for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.
for reference the baseline of plasma levels is 0, with topical minoxidil you get up to 1.6ng/ml and with 5mg oral you get all the way up to 37ng/ml.
when taking a 2.5mg sublingual dose (comparable to 3.75-5mg oral) you'd have a peak plasma of 9ng/ml at 30 minutes in
and it would basicly be gone withing 8 hours in comparison 5mg oral would still have plasma levels of 6ng/ml so 6x more.
meaning that its best to take before going to sleep, so adjust it based on your needs.
Sublingual minoxidil tldr
Sublingual minoxidil has the same efficacy for hair growth as oral minoxidil whilst having less side effects.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.
sublingual minoxidil is also 1.5-2x stronger than oral meaning that 1mg sublinguel = 1.5-2mg oral.
For taking sublingual minoxidil i would recommend taking 2.5mg before bed.
Section 2
How to get sublingual minoxidil
1. Live in autralia and get a prescribtion or know someone that has one.
2. Buy raw minoxidil powder and DIY
Those are the only ways for now since it hasnt passed FDA and is still in phase III
2. Buy raw minoxidil powder and DIY
Those are the only ways for now since it hasnt passed FDA and is still in phase III
Compounds for DIY sublingual minoxidil
raw minoxidil powder
propylene glycol
ethanol 95% food grade
water
Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)
propylene glycol
ethanol 95% food grade
water
Optional:
sucralose (sweetener)
peppermint/mint flavor food grade
citric acid (pH regulator)
Resources for DIY sublingual minoxidil
0.001g precision scale
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles
optional:
pH strips
funnel + filter paper
pipettes/syringes
glass beakers 50ml and 100ml
stirrer (magnetic stirrer or glass rod)
amber glass dropper bottles
optional:
pH strips
funnel + filter paper
pipettes/syringes
Formula for DIY sublingual minoxidil
1. 0.3ml/ml 95% ethanol food grade
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol
optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade
This is in order of how you should brew
100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring
Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil
2. 2.5mg/ml minoxidil powder
3. 0.5ml/ml propylene glycol
optional:
4. 0.2-0.3mg/ml sucralose
5. 0.5-1mg citric acid adjust to pH 4.5-5.5
6. 0.001-0.002ml peppermint/mint flavor food grade
This is in order of how you should brew
100ml example:
1. 30ml ethanol
2. 250mg minoxidil powder
3. 50ml propylene glycol
4. 20-30mg sucralose
5. 50-100mg citric acid (adjust based on pH
6. 0.1-0.2ml peppermint/mint flavoring
Following these instructions you should get 2.5mg/ml meaning that 1ml is 2.5mg worth of sublingual minoxidil
Video's of DIY sublingual minoxidil
these should give you an idea how it should look.
DO NOT follow these exactly since they are for topical solutions.
Tips and tricks
warm the ethanol slightly (30-40°C) before adding powder for faster dissolvement
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral
make sure that the powder doesnt have any clumps, if so break them apart till fine.
DONT shake instead stir
store away from light and heat
keep in fridge (2–8°C)
shelf life of ~1 year
start low with 0.5ml daily and titrate up to 1ml daily if you respond fine
keep in mind: sublingual is 1.5-2x stronger then oral
Im not a doctor nor pharmacist, do your own research and be extremely carefull.
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