The effect of IGF-1 and growth hormone injections on Height growth, a detailed analysis.

[JOTAROSON]

«Поймите последствия его действий».

> не знает, что я начал принимать стероиды, чтобы покончить с собой

How old are you bro?

 

[Fuldblod]

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

Proving my point

 

[Zagro]

Proving my point

Yes bro im an egoist all my hard work and money is gone but you don’t realise that i don’t care about any of those, better to spend that shit rather than keep it with me to the grave

 

[JOTAROSON]

Да, брат, я эгоист, все мои усилия и деньги пропали, но ты не понимаешь, что мне наплевать на всё это. Лучше потратить эти деньги, чем хранить их до самой могилы.

 

[JOTAROSON]

Да, брат, я эгоист, все мои усилия и деньги пропали, но ты не понимаешь, что мне наплевать на всё это. Лучше потратить эти деньги, чем хранить их до самой могилы.

Сколько тебе лет, братан?

?

 

[JOTAROSON]

Доказательство моей точки зрения

By the way, what did Zagro do to you? Why don't you like him?

 

[Paul.jnxy]

LMFAO all this nigga does is say “ermm ahcktualley” and never elaborates.
Obstinate arguer Final boss
View attachment 5208956

The thread is shit but you are right

 

[JOTAROSON]

Тема обсуждения — отстой, но ты прав.

Arguments

 

[Paul.jnxy]

Yeah, yeah, nigga, and the gpt also gave me photos of the research. Dumb nigga.

Yes. It’s actually what the new 5.0 model van do

 

[Fuldblod]

The thread is shit but you are right

Why

 

[JOTAROSON]

Да. Именно так работает новая модель фургона 5.0.:вынужденнаяулыбка:

I don’t know what this is, I don’t understand the GPT.

 

[JOTAROSON]

Да. Именно так работает новая модель фургона 5.0.:вынужденнаяулыбка:

Apparently you often use it for your themes, my theme is written by hand, I searched for these studies on the Internet

 

[Paul.jnxy]

Arguments

When combined with an AI it showed massive results for Kids with ISS. It worked for me aswell

 

[Paul.jnxy]

Apparently you often use it for your themes, my theme is written by hand, I searched for these studies on the Internet

Nigha wtf you mean my themes. I don’t use any LLMs except grok for school

 

[Paul.jnxy]

Why

Becouse Zargo is a attention seeking fag. Also explain why rHGH would be the gold standard for kids with genetic short stature?

 

[JOTAROSON]

Потому что Зарго — это жаждущий внимания гомосексуалист. А ещё объясните, почему рекомбинантный гормон роста (rHGH) считается золотым стандартом для детей с генетически обусловленной низкорослостью?

You just answered your own question, "for children with conditioned short stature," that is, for children with Laron syndrome, who have an IGF-1 deficiency, stop coping

 

[JOTAROSON]

You just answered your own question, "for children with conditioned short stature," that is, for children with Laron syndrome, who have an IGF-1 deficiency, stop coping

@Paul.jnxy

 

[Paul.jnxy]

@Paul.jnxy

Worked for me buddy 12 ius ed

 

[lmnopq]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

androgen mediated, localized igf1 production is the main effect hgh has and is why NAAAS are so effective for height

 

[AtrophicPyra]

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

Why do u want to kill yourself zagro

 

[AtrophicPyra]

androgen mediated, localized igf1 production is the main effect hgh has and is why NAAAS are so effective for height

They all sensitize the igf1r they dont increase production anywhere

 

[AtrophicPyra]

It’s because hes on a huge cycle rn and needs to cope because of sunk cost fallacy and he’ll have to realize that he fucked up his life for no gains
“HGH 8iu ED
Anavar 25mg ED
Testosterone Enanthate 300mg E3D
Trenbolone Enanthate 200mg E3D
Retatrutide 5mg Weekly
Gluthathione 300mg EOD
BPC-157 500mcg ED
GHK-Cu 2.5mg ED

Aromasin 15mg ED
Isotretinoin 30mg ED
Tadalafil 10mg ED
Caber 0.25mg EOD
T4 20mcg ED
+ More ancillaries and other shit (sartans, statins, supplements and other substances)”

Is his cycle
JFL

@Zagro is this fr ur cycle bro?

 

[occipital]

mirin

 

[Zagro]

@Zagro is this fr ur cycle bro?

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

 

[Fuldblod]

Becouse Zargo is a attention seeking fag. Also explain why rHGH would be the gold standard for kids with genetic short stature?

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

Shi mb

 

[JOTAROSON]

У меня сработало, приятель, 12 ius ed

You haven't grown beyond your genetic height. I used growth hormone too and I know what I'm talking about.

 

[JOTAROSON]

Основной эффект гормона роста (HGH) заключается в локализованном производстве IGF1, опосредованном андрогенами, и именно поэтому анаболические стероиды (NAAAS) так эффективны для увеличения роста.

У You will increase in height, but not above your genetic level.

 

[AtrophicPyra]

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

whats ur current cycle

 

[JOTAROSON]

Какой у вас сейчас цикл?

Do you know how old he is?

 

[AtrophicPyra]

Do you know how old he is?

no how is that relevant

 

[JOTAROSON]

no how is that relevant

Just curious

 

[Paul.jnxy]

No fucking shit. Would not have grown to it without it tho

You haven't grown beyond your genetic height. I used growth hormone too and I know what I'm talking about.

 

[JOTAROSON]

Да уж, блин. Без этого я бы до этого не дошёл.

So why don't you like my topic, nigga?

 

[JOTAROSON]

.

 

[Peco]

LMFAO all this nigga does is say “ermm ahcktualley” and never elaborates.
Obstinate arguer Final boss
View attachment 5208956

True. Tried having a conversation with him and he tried egoing me and straight up avoided the criticism.

 

[JOTAROSON]

Верно. Я пытался поговорить с ним, а он пытался меня задеть, всячески избегая критики.

How do you know about zagro?

 

[Peco]

How do you know about zagro?

I read a thread he made in response to another guy talking about HgH. I read the post and commented and he just avoided the question by calling me a retard. It seems that's something he does quite a lot, avoiding criticism

 

[JOTAROSON]

@drowining.in.sins

 

[asgard]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

in the study you showed where GH injections did not increase FAH, that could possibly be due to the fact that they were giving clinical dosages only to reach target height and not to increase FAH as much as the people on this forum actually mean. secondly, even though chondrocytes express IGF-1, most IGF-1 still depends on HGH-mediated IGF-1 production in the liver. also IGF-1 after reaching the systemic arterial circulation, leaves the capillaries, travels through interstitial fluid and binds onto the IGF-1 receptors on the chondrocytes, which my point in explaining this is that just because its systemic doesn't mean it can't reach the growth plates (which presumably, you claim due to the growth plates being highly avascular). its simple, GH is injected, through the systemic circulation it reaches the liver, diffuses into the sinusoids, binds onto the GHRs on the hepatocytes, then through the protein STAT5b binding via SH2 onto the GHR, it enters the nucleus, and transcribes IGF-1, IGF-1 then exits the sinusoids, enters the hepatic veins, then the inferior vena cava, then the systemic arterial circulation, and then it leaves the capillaries, travels/diffuses thru interstitial fluid and then finally binds onto the chondrocytes activating PI3K-mTORC1/C2 and MAPK pathways. although i do agree that IGF-1 LR3 is inefficient for height enhancement. but the claim that GH can't increase FAH when taken at higher doses then that which is taken clinically to correct deficiencies due to the strict regulation and avascularity of the plates is simply incorrect.

 

[JOTAROSON]

В показанном вами исследовании, где инъекции гормона роста не увеличивали рост в области таза, это, возможно, связано с тем, что использовались только клинические дозы для достижения целевого роста, а не для увеличения роста в области таза в той степени, в какой это подразумевается на этом форуме. Во-вторых, хотя хондроциты экспрессируют ИФР-1, большая часть ИФР-1 все еще зависит от опосредованной гормоном роста продукции ИФР-1 в печени. Кроме того, после попадания в системный артериальный кровоток ИФР-1 покидает капилляры, перемещается через интерстициальную жидкость и связывается с рецепторами ИФР-1 на хондроцитах. Моя мысль в объяснении этого заключается в том, что тот факт, что он попадает в системный кровоток, не означает, что он не может достичь зон роста (что, как вы, вероятно, утверждаете, связано с высокой степенью аваскуляризации зон роста). Всё просто: гормон роста (ГР) вводится инъекционно, через системный кровоток достигает печени, диффундирует в синусоиды, связывается с рецепторами ГР на гепатоцитах, затем через белок STAT5b, связывающийся через SH2 с рецептором ГР, проникает в ядро и транскрибирует IGF-1, затем IGF-1 выходит из синусоидов, попадает в печеночные вены, затем в нижнюю полую вену, затем в системный артериальный кровоток, затем покидает капилляры, перемещается/диффундирует через интерстициальную жидкость и, наконец, связывается с хондроцитами, активируя пути PI3K-mTORC1/C2 и MAPK. Хотя я согласен, что IGF-1 LR3 неэффективен для увеличения роста. Но утверждение о том, что ГР не может увеличить рост печени при приеме в более высоких дозах, чем те, которые клинически используются для коррекции дефицита из-за строгой регуляции и аваскулярности пластинок, просто неверно.

I said there's no point in taking it unless you have a deficiency. Basically, you'll just accelerate your puberty. You won't increase your genetic growth, you'll just speed it up. Yes, you'll grow. From the growth hormone, but just as much as if you hadn't injected it

 

[asgard]

I said there's no point in taking it unless you have a deficiency. Basically, you'll just accelerate your puberty. You won't increase your genetic growth, you'll just speed it up. Yes, you'll grow. From the growth hormone, but just as much as if you hadn't injected it

No it could in theory still increase your FAH even if you weren't deficient, but it is true that it does accelerate if you're taking it too early and there are some nuances

 

[80llo]

t

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

here are 20 thousand cases of successful hgh use on people with ideopatic short stature

 

[JOTAROSON]

Нет, теоретически это может повысить уровень ФАГ, даже если у вас нет дефицита, но правда и то, что процесс ускоряется, если принимать препарат слишком рано, и здесь есть некоторые нюансы.

I literally wrote that it makes sense to take it until 12-14 years old.

 

[JOTAROSON]

т

Существует 20 тысяч случаев успешного применения гормона роста у людей с идиопатической низкорослостью.

Stadises Stadises

 

[Taylorhillenjoyer]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

What about kids who are still growing and whose growth plates are still open

 

[JOTAROSON]

А что насчет детей, которые еще растут и у которых зоны роста костей еще не открыты?

Did you mean to say not closed yet?