The effect of IGF-1 and growth hormone injections on Height growth, a detailed analysis.

[JOTAROSON]

Распространяется ли это также на препарат Increlex IGF-1, используемый для лечения идиопатической низкорослости, или только на модифицированные версии IGF-1, такие как DES и LR3?

Yes, this drug was originally intended for children with deficiency. You won't grow taller than your genetic height.

 

[tomacōck]

Growth hormone is not effective after age 14 unless you have a deficiency.

Based on?

 

[JOTAROSON]

На чём основано?

Studies, almost all of them were done in children with Laron syndrome. After 14, unless you have a deficiency, you will not grow with local growth hormone.

 

[tomacōck]

Studies, almost all of them were done in children with Laron syndrome. After 14, unless you have a deficiency, you will not grow with local growth hormone.

Link then

 

[Zagro]

Replies on his threads arent doing too much either because it’s all just circlejerk slop like “uhh wow so cool youre doing tren and hgh at 15 so cool, mirin brahh”
Easy to understand why he’s so deadlocked on this mindset / belief because if it’s wrong all that money and hard work would have been for nothing (it already is).

As you can see he’s just 15 and still developing his frontal lobe so he probably cant properly understand the
consequences of his actionsView attachment 5208976

Ego / pride is truly the downfall of so many people @Zagro

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

 

[JOTAROSON]

Затем перейдите по ссылке.

Insulin-like growth factor 1 (IGF-1): a growth hormone - PMC

Aim—To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on the growth process. Methods—To describe growth in human and animal models of isolated IGF-1 deficiency (IGHD), such as in ...

pmc.ncbi.nlm.nih.gov

 

[JOTAROSON]

«Поймите последствия его действий».

> не знает, что я начал принимать стероиды, чтобы покончить с собой

How old are you bro?

 

[Noriju]

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

Proving my point

 

[Zagro]

Proving my point

Yes bro im an egoist all my hard work and money is gone but you don’t realise that i don’t care about any of those, better to spend that shit rather than keep it with me to the grave

 

[JOTAROSON]

Да, брат, я эгоист, все мои усилия и деньги пропали, но ты не понимаешь, что мне наплевать на всё это. Лучше потратить эти деньги, чем хранить их до самой могилы.

 

[JOTAROSON]

Да, брат, я эгоист, все мои усилия и деньги пропали, но ты не понимаешь, что мне наплевать на всё это. Лучше потратить эти деньги, чем хранить их до самой могилы.

Сколько тебе лет, братан?

?

 

[JOTAROSON]

Доказательство моей точки зрения

By the way, what did Zagro do to you? Why don't you like him?

 

[Paul.jnxy]

LMFAO all this nigga does is say “ermm ahcktualley” and never elaborates.
Obstinate arguer Final boss
View attachment 5208956

The thread is shit but you are right

 

[JOTAROSON]

Тема обсуждения — отстой, но ты прав.

Arguments

 

[Paul.jnxy]

Yeah, yeah, nigga, and the gpt also gave me photos of the research. Dumb nigga.

Yes. It’s actually what the new 5.0 model van do

 

[Noriju]

The thread is shit but you are right

Why

 

[JOTAROSON]

Да. Именно так работает новая модель фургона 5.0.:вынужденнаяулыбка:

I don’t know what this is, I don’t understand the GPT.

 

[JOTAROSON]

Да. Именно так работает новая модель фургона 5.0.:вынужденнаяулыбка:

Apparently you often use it for your themes, my theme is written by hand, I searched for these studies on the Internet

 

[Paul.jnxy]

Arguments

When combined with an AI it showed massive results for Kids with ISS. It worked for me aswell

 

[Paul.jnxy]

Apparently you often use it for your themes, my theme is written by hand, I searched for these studies on the Internet

Nigha wtf you mean my themes. I don’t use any LLMs except grok for school

 

[Paul.jnxy]

Why

Becouse Zargo is a attention seeking fag. Also explain why rHGH would be the gold standard for kids with genetic short stature?

 

[JOTAROSON]

Потому что Зарго — это жаждущий внимания гомосексуалист. А ещё объясните, почему рекомбинантный гормон роста (rHGH) считается золотым стандартом для детей с генетически обусловленной низкорослостью?

You just answered your own question, "for children with conditioned short stature," that is, for children with Laron syndrome, who have an IGF-1 deficiency, stop coping

 

[JOTAROSON]

You just answered your own question, "for children with conditioned short stature," that is, for children with Laron syndrome, who have an IGF-1 deficiency, stop coping

@Paul.jnxy

 

[Paul.jnxy]

@Paul.jnxy

Worked for me buddy 12 ius ed

 

[lmnopq]

Can IGF-1-LR3 be used to influence growth?

View attachment 5206959

Short answer: No, you can’t. Because the growth zone is a strictly locally regulated environment.
View attachment 5206970

This means that autocrine and paracrine mechanisms play a more significant role than systemic factors (in our case, high IGF-1)
View attachment 5206975

This is precisely why growth hormone injections do not increase an adult’s final height

View attachment 5206986

Furthermore, chondrocytes themselves produce IGF-1, which can undergo alternative splicing to form different isoforms, such as E, B, I and C.

View attachment 5206996
View attachment 5206997

Alternative splicing is important because the growth zone requires different types of IGF-1 signalling at different times and in different regions. It is through this mechanism that the system achieves such precise regulation; alternative splicing determines the stability of the transcript, its localisation and its link to chondrocyte proliferation and hypertrophy.

View attachment 5207001

View attachment 5207002

Therefore, IGF-1 cannot bind to the cellular proteins that are critical for vertical growth.


Conclusion: It is not possible to exceed one’s final height through IGF-1 or growth hormone injections without having a deficiency.

androgen mediated, localized igf1 production is the main effect hgh has and is why NAAAS are so effective for height

 

[AtrophicPyra]

“Understand the consequences of his actions”

> doesn’t know i started roiding to kill myself

Why do u want to kill yourself zagro

 

[AtrophicPyra]

androgen mediated, localized igf1 production is the main effect hgh has and is why NAAAS are so effective for height

They all sensitize the igf1r they dont increase production anywhere

 

[AtrophicPyra]

It’s because hes on a huge cycle rn and needs to cope because of sunk cost fallacy and he’ll have to realize that he fucked up his life for no gains
“HGH 8iu ED
Anavar 25mg ED
Testosterone Enanthate 300mg E3D
Trenbolone Enanthate 200mg E3D
Retatrutide 5mg Weekly
Gluthathione 300mg EOD
BPC-157 500mcg ED
GHK-Cu 2.5mg ED

Aromasin 15mg ED
Isotretinoin 30mg ED
Tadalafil 10mg ED
Caber 0.25mg EOD
T4 20mcg ED
+ More ancillaries and other shit (sartans, statins, supplements and other substances)”

Is his cycle
JFL

@Zagro is this fr ur cycle bro?

 

[Foidobliterator67]

mirin

 

[Zagro]

@Zagro is this fr ur cycle bro?

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

 

[Noriju]

Becouse Zargo is a attention seeking fag. Also explain why rHGH would be the gold standard for kids with genetic short stature?

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

Shi mb

 

[JOTAROSON]

У меня сработало, приятель, 12 ius ed

You haven't grown beyond your genetic height. I used growth hormone too and I know what I'm talking about.

 

[JOTAROSON]

Основной эффект гормона роста (HGH) заключается в локализованном производстве IGF1, опосредованном андрогенами, и именно поэтому анаболические стероиды (NAAAS) так эффективны для увеличения роста.

У You will increase in height, but not above your genetic level.

 

[AtrophicPyra]

No dumbass nigger holy shit man it’s a random cycle i designed a year ago which is publicly posted on the site

whats ur current cycle

 

[JOTAROSON]

Какой у вас сейчас цикл?

Do you know how old he is?

 

[AtrophicPyra]

Do you know how old he is?

no how is that relevant

 

[JOTAROSON]

no how is that relevant

Just curious

 

[Paul.jnxy]

No fucking shit. Would not have grown to it without it tho

You haven't grown beyond your genetic height. I used growth hormone too and I know what I'm talking about.