The Fountain of Youth - An Introduction to Epitalon

[emeraldglass]

yeah the more you normalize it the worse it becomes, when i first joined i was only reading threads on BOTB and the looksmax section and i was actually implementing them, now i just rot and kill my time..

Need to go back to that mindset

 

[Deleted member 131140]

keinen badge für dein gesicht bro
@Volksstaffel @Jonasㅤㅤ⠀ why is ts so easy

Nazi language detected. Straight to Nuremberg incel

 

[Zagro]

Geen badge voor je gezicht bro.

Kijk deze flikker menas pest mij nu omdat ik geen badge heb, brutaal

 

[Menas]

Need to go back to that mindset

indeed, i'm planning to self ban /delete and make a new account and focus on that, so basically a clear page.
and also i'm planning on actually implementing some looksmaxxes i've learned over a year.

 

[Deleted member 131140]

indeed, i'm planning to self ban /delete and make a new account and focus on that, so basically a clear page.
and also i'm planning on actually implementing some looksmaxxes i've learned over a year.

You had that opportunity once, yet you chose addiction. Now there is no escape unless you nuke this site off your devices

 

[Deleted member 110192]

indeed, i'm planning to self ban /delete and make a new account and focus on that, so basically a clear page.
and also i'm planning on actually implementing some looksmaxxes i've learned over a year.

Why make a new acc specifically for that reason tho? Why not do it in your acc rn haha

 

[imontheloose]

These colour gradients are pretty cool.

 

[Menas]

Kijk deze flikker menas pest mij nu omdat ik geen badge heb, brutaal

ich bin kein flikker du fucking nigger.

Why make a new acc specifically for that reason tho? Why not do it in your acc rn haha

because of the shit i've posted on here, i'm also planning on posting myself and more..
and when you have that much connections on here its even harder not to rot.

 

[Deleted member 110192]

ich bin kein flikker du fucking nigger.

because of the shit i've posted on here, i'm also planning on posting myself and more..
and when you have that much connections on here its even harder not to rot.

Make sense

 

[Zagro]

ich bin kein flikker du fucking nigger.

because of the shit i've posted on here, i'm also planning on posting myself and more..
and when you have that much connections on here its even harder not to rot.

How did you translate “flikker” i choose it specifically so that you cant, probeer dit dan zemmer.

 

[emeraldglass]

Kijk deze flikker menas pest mij nu omdat ik geen badge heb, brutaal

Vergeet nooit voor wat je bent gejoined, bro.

 

[White_Bwoi]

I always knew Claudia Shiffer enjoyer's are high IQ

 

[Lightskin Ethnic]

Dnr but agreed

 

[kazama]

Look at this
@Seishin
Always stay young nigga

 

[kazama]

Bump

 

[5aesar]

Interesting

 

[kief]

Spoiler: DISCLAIMER

By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others.

---

Table of Contents


Introduction
Mechanism of Action
Benefits, Risks & Safety Information
Cycling, Administration & Costs
Conclusion
References


​

---

Introduction

View attachment 3743166

What if I told you that there was a magical compound that not only could quite literally extend your life by a significant amount, but also come with a ton of other benefits desired by all people trying to defy the agepill and embrace youthfulness as much as humanly possible?

Well, there was only one lie in the above sentence - the fact that I called it magical. In reality, it is no magic at all! It is but a simple, yet heavily overlooked peptide that can be easily sourced - and just as easily used.


​

---

Mechanism of Action

Epitalon enhances telomerase activity, which protects telomeres from shortening during cell division(1). What are telomeres? Best said by @AstroSky, they are like those plastic shoelace tips that keep those shoelaces (in this case, your chromosome endings), from dilapidating.
Additionally, it stimulates neurogenic gene expression(2),
reduces intracellular reactive oxygen species and enhances mitochondrial function(3), promotes continued cell division(4)(1), stimulates melatonin synthesis and modulates STAT1 phosphorylation(1).


​

---

Benefits

If you could not tell by the previous section - this compound does a lot. In simple terms, it delays cellular aging by up to 25%(1); promotes neuronal differentiation up to 2.1x(1); In clinical trials with mice, it increased maximum lifespan by 12.3%+(5); provides antioxidant and mitochondrial protection, studies showed 86% and 1.5x improvements respectively(6)(3); delays age-related dysfunction (restored IDE/NEP mRNA synthesis under hypoxia to 100%)(4)(1).

View attachment 3743368


​

---

Risks & Safety Information

​

Injection site reactions(3) are pretty much the only adverse side effects, but that is the same with anything you inject. No chronic toxicity has been found in long-term administration in mice (6.5 months), with no mortality or weight changes(5)(6).

I’ve heard some people ask about epitalon’s potential cancer risks, so here is my answer:
Paradoxically, while epitalon enhances telomerase activity, peer-reviewed studies demonstrate reduced tumor incidence. No evidence of carcinogenic promotion exists to this day(5)(6). But this still goes without saying - do not take it if you have any malignant tumors, however that applies to like any compound you will find info about on this forum, or anywhere else.


​

---

Cycling

Unlike many other compounds, epitalon only has to be administered in relatively short cycles, and only two times per year.
The most optimal dosing is 10mg/day for a 10-day cycle every 6 months.
Simple as that. From all the studies I’ve read, this will yield the most optimal results.


​

---

Administration & Storage

Just like with any other peptides, you will need Bacteriostatic water & 1cc Insulin syringes. It’s very simple: assuming the vials are 10mg each, reconstitute the powder with 1ml BAC water for 10mg/ml concentration. Draw 1ml of the solution & inject subcutaneously into any of the following areas:

View attachment 3743238


​

---

Costs

View attachment 3743337
Online, most epitalon sources I’ve found dose it at 10mg/vial. The costs per vial of epitalon range from $15 to $25, setting you back $150-$250 per cycle. Of course, Chinese sources are cheaper, and EU/elsewhere usually charge more. However, some sources sell it in kits (essentially in bulk), cutting some costs by a decent margin.


View attachment 3743346
BAC water is usually dosed at 10ml/vial minimum, so you can buy one vial and be good to go for the entire cycle. Most expensive BAC water at 10ml/vial I’ve found costs just over $10.


View attachment 3743339
Insulin pins are pretty cheap too ($10-$20), and come in packs of 100 (water, but has to be said).


Total cost range per cycle: $170 to $280 on the absolute highest end,
but I doubt you will even come across any sources charging that much.


​

---

Conclusion


Everyone should be on epitalon past the age of 20. The absurd amount of benefits outweigh the (barely-existent) side effects to the slums of New Delhi. It is criminally overlooked, even on this forum, surprisingly, and is a great addition to anyone’s ant-aging protocols.

However, there are a number of other peptides, that can also be implemented into your longevity/anti-agepill stack, which I may talk about later on!


​

---

References

Spoiler

Anisimov, V.N. et al. (2003) Biogerontology, 4(4), pp. 193–202. Available at: https://doi.org/10.1023/a:1025114230714.

Araj, S.K. et al. (2025) ‘Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties’, International Journal of Molecular Sciences, 26(6), p. 2691. Available at: https://doi.org/10.3390/ijms26062691.

Khavinson, V. et al. (2020) ‘AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism’, Molecules, 25(3), p. 609. Available at: https://doi.org/10.3390/molecules25030609.

Kossoy, G. et al. (no date) Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice. Available at: https://iv.iiarjournals.org/content/invivo/20/2/253.full.pdf (Accessed: 17 May 2025).

Lee, E. (no date) THE FOUNTAIN OF YOUTH PEPTIDE EPITALON. Available at: https://agemed.org/wp-content/uploads/LEE-Epitalon.pdf.

Yue, X. et al. (2022) ‘Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro’, Aging, 14(7), pp. 3191–3202. Available at: https://doi.org/10.18632/aging.204007.

​

---

@menas
​

---

extendyourlife.org

 

[Daddy's Home]

i'm planning on actually implementing some looksmaxxes i've learned over a year.

Looksmax without having a social life, friends, relationships, stuff going on in life in general is temporary..

But rooting on a forum with your crew, having all the badges / colored names / frame / all the special and shiny things etc. is permanent (at least until you all get banned)

Also massive aura loss without Rias pfp.. Now you look like a avg greycel carried only by badge and the random name color..

 

[Menas]

Also massive aura loss without Rias pfp.. Now you look like a avg greycel carried only by badge and the random name color..

i had to change it, i still have the rias avi deep down in my hearth..

 

[Deleted member 110192]

i had to change it, i still have the rias avi deep down in my hearth..

Mog the fuck out of the other pfp

 

[curryascenderr]

Mirin, high iq thread

 

[Deleted member 134523]

Spoiler: DISCLAIMER

By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others.

---

Table of Contents


Introduction
Mechanism of Action
Benefits, Risks & Safety Information
Cycling, Administration & Costs
Conclusion
References


​

---

Introduction

View attachment 3743166

What if I told you that there was a magical compound that not only could quite literally extend your life by a significant amount, but also come with a ton of other benefits desired by all people trying to defy the agepill and embrace youthfulness as much as humanly possible?

Well, there was only one lie in the above sentence - the fact that I called it magical. In reality, it is no magic at all! It is but a simple, yet heavily overlooked peptide that can be easily sourced - and just as easily used.


​

---

Mechanism of Action

Epitalon enhances telomerase activity, which protects telomeres from shortening during cell division(1). What are telomeres? Best said by @AstroSky, they are like those plastic shoelace tips that keep those shoelaces (in this case, your chromosome endings), from dilapidating.
Additionally, it stimulates neurogenic gene expression(2),
reduces intracellular reactive oxygen species and enhances mitochondrial function(3), promotes continued cell division(4)(1), stimulates melatonin synthesis and modulates STAT1 phosphorylation(1).


​

---

Benefits

If you could not tell by the previous section - this compound does a lot. In simple terms, it delays cellular aging by up to 25%(1); promotes neuronal differentiation up to 2.1x(1); In clinical trials with mice, it increased maximum lifespan by 12.3%+(5); provides antioxidant and mitochondrial protection, studies showed 86% and 1.5x improvements respectively(6)(3); delays age-related dysfunction (restored IDE/NEP mRNA synthesis under hypoxia to 100%)(4)(1).

View attachment 3743368


​

---

Risks & Safety Information

​

Injection site reactions(3) are pretty much the only adverse side effects, but that is the same with anything you inject. No chronic toxicity has been found in long-term administration in mice (6.5 months), with no mortality or weight changes(5)(6).

I’ve heard some people ask about epitalon’s potential cancer risks, so here is my answer:
Paradoxically, while epitalon enhances telomerase activity, peer-reviewed studies demonstrate reduced tumor incidence. No evidence of carcinogenic promotion exists to this day(5)(6). But this still goes without saying - do not take it if you have any malignant tumors, however that applies to like any compound you will find info about on this forum, or anywhere else.


​

---

Cycling

Unlike many other compounds, epitalon only has to be administered in relatively short cycles, and only two times per year.
The most optimal dosing is 10mg/day for a 10-day cycle every 6 months.
Simple as that. From all the studies I’ve read, this will yield the most optimal results.


​

---

Administration & Storage

Just like with any other peptides, you will need Bacteriostatic water & 1cc Insulin syringes. It’s very simple: assuming the vials are 10mg each, reconstitute the powder with 1ml BAC water for 10mg/ml concentration. Draw 1ml of the solution & inject subcutaneously into any of the following areas:

View attachment 3743238


​

---

Costs

View attachment 3743337
Online, most epitalon sources I’ve found dose it at 10mg/vial. The costs per vial of epitalon range from $15 to $25, setting you back $150-$250 per cycle. Of course, Chinese sources are cheaper, and EU/elsewhere usually charge more. However, some sources sell it in kits (essentially in bulk), cutting some costs by a decent margin.


View attachment 3743346
BAC water is usually dosed at 10ml/vial minimum, so you can buy one vial and be good to go for the entire cycle. Most expensive BAC water at 10ml/vial I’ve found costs just over $10.


View attachment 3743339
Insulin pins are pretty cheap too ($10-$20), and come in packs of 100 (water, but has to be said).


Total cost range per cycle: $170 to $280 on the absolute highest end,
but I doubt you will even come across any sources charging that much.


​

---

Conclusion


Everyone should be on epitalon past the age of 20. The absurd amount of benefits outweigh the (barely-existent) side effects to the slums of New Delhi. It is criminally overlooked, even on this forum, surprisingly, and is a great addition to anyone’s ant-aging protocols.

However, there are a number of other peptides, that can also be implemented into your longevity/anti-agepill stack, which I may talk about later on!


​

---

References

Spoiler

Anisimov, V.N. et al. (2003) Biogerontology, 4(4), pp. 193–202. Available at: https://doi.org/10.1023/a:1025114230714.

Araj, S.K. et al. (2025) ‘Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties’, International Journal of Molecular Sciences, 26(6), p. 2691. Available at: https://doi.org/10.3390/ijms26062691.

Khavinson, V. et al. (2020) ‘AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism’, Molecules, 25(3), p. 609. Available at: https://doi.org/10.3390/molecules25030609.

Kossoy, G. et al. (no date) Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice. Available at: https://iv.iiarjournals.org/content/invivo/20/2/253.full.pdf (Accessed: 17 May 2025).

Lee, E. (no date) THE FOUNTAIN OF YOUTH PEPTIDE EPITALON. Available at: https://agemed.org/wp-content/uploads/LEE-Epitalon.pdf.

Yue, X. et al. (2022) ‘Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro’, Aging, 14(7), pp. 3191–3202. Available at: https://doi.org/10.18632/aging.204007.

​

---

@menas
​

---

Nice thread bro

 

[Deleted member 134523]

I was wondering why ChatGPT was so laggy, I guess the bandwidth should be back to normal since this thread is finished.

No wonder why people dont like you

 

[Daddy's Home]

i had to change it, i still have the rias avi deep down in my hearth..

Change it for something cooler, like some ex pfp of mine..

100% return of the normal aura, and even more of it..

 

[Sadist]

I always knew Claudia Shiffer enjoyer's are high IQ

u know it bhai

 

[Menas]

Vergeet nooit voor wat je bent gejoined, bro.

bumping because this thread mogs.
@Gengar @Orc

 

[Sadist]

Nice thread bro

thank you bhai

 

[champagnepapi]

really promising peptide, great thread

 

[Deleted member 113294]

How is a 6.5 months study an even remotely long enough period of time to test for any long term health effects?

 

[Orc]

bumping because this thread mogs.
@Gengar @Orc

it's not very good and reads like gpt generated slop.

 

[Menas]

it's not very good and reads like gpt generated slop.

in my opinion it is good, since i watched him while he made the thread i can guarantee he didn't use any type of ai but idk, still i think it deserves to be stickied when you compare it to other shit.. and he literally included literal papers and studies i still don't understand why people are assuming he used ai.

@xnj brutal..

 

[Sadist]

in my opinion it is good, since i watched him while he made the thread i can guarantee he didn't use any type of ai but idk, still i think it deserves to be stickied when you compare it to other shit.. and he literally included literal papers and studies i still don't understand why people are assuming he used ai.

@xnj brutal..

the more info you add - the worse the thread is, dummy! cmon, didnt you know how org works? you need to pull shit out of your ass for the thread to be credible - once you add any quotes from papers, your thread becomes gpt

 

[Sadist]

How is a 6.5 months study an even remotely long enough period of time to test for any long term health effects?

its been studied since the 1980s jfl

 

[garoupilled_]

Good thread, love to see it. Been using epitalon for 3+ years alongside other peptides to reach longevity escape velocity. Telomeres are super interesting - research TA65 and TAM 818 if you want to look further. Great stuff

 

[AstroSky]

Damn you remember me saying that? Lol thanks

Spoiler: DISCLAIMER

By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others.

---

Table of Contents


Introduction
Mechanism of Action
Benefits, Risks & Safety Information
Cycling, Administration & Costs
Conclusion
References


​

---

Introduction

View attachment 3743166

What if I told you that there was a magical compound that not only could quite literally extend your life by a significant amount, but also come with a ton of other benefits desired by all people trying to defy the agepill and embrace youthfulness as much as humanly possible?

Well, there was only one lie in the above sentence - the fact that I called it magical. In reality, it is no magic at all! It is but a simple, yet heavily overlooked peptide that can be easily sourced - and just as easily used.


​

---

Mechanism of Action

Epitalon enhances telomerase activity, which protects telomeres from shortening during cell division(1). What are telomeres? Best said by @AstroSky, they are like those plastic shoelace tips that keep those shoelaces (in this case, your chromosome endings), from dilapidating.
Additionally, it stimulates neurogenic gene expression(2),
reduces intracellular reactive oxygen species and enhances mitochondrial function(3), promotes continued cell division(4)(1), stimulates melatonin synthesis and modulates STAT1 phosphorylation(1).


​

---

Benefits

If you could not tell by the previous section - this compound does a lot. In simple terms, it delays cellular aging by up to 25%(1); promotes neuronal differentiation up to 2.1x(1); In clinical trials with mice, it increased maximum lifespan by 12.3%+(5); provides antioxidant and mitochondrial protection, studies showed 86% and 1.5x improvements respectively(6)(3); delays age-related dysfunction (restored IDE/NEP mRNA synthesis under hypoxia to 100%)(4)(1).

View attachment 3743368


​

---

Risks & Safety Information


Injection site reactions(3) are pretty much the only adverse side effects, but that is the same with anything you inject. No chronic toxicity has been found in long-term administration in mice (6.5 months), with no mortality or weight changes(5)(6).
I’ve heard some people ask about epitalon’s potential cancer risks, so here is my answer:
Paradoxically, while epitalon enhances telomerase activity, peer-reviewed studies demonstrate reduced tumor incidence. No evidence of carcinogenic promotion exists to this day(5)(6). But this still goes without saying - do not take it if you have any malignant tumors, however that applies to like any compound you will find info about on this forum, or anywhere else.


​

---

Cycling

Unlike many other compounds, epitalon only has to be administered in relatively short cycles, and only two times per year.
The most optimal dosing is 10mg/day for a 10-day cycle every 6 months.
Simple as that. From all the studies I’ve read, this will yield the most optimal results.


​

---

Administration & Storage

Just like with any other peptides, you will need Bacteriostatic water & 1cc Insulin syringes. It’s very simple: assuming the vials are 10mg each, reconstitute the powder with 1ml BAC water for 10mg/ml concentration. Draw 1ml of the solution & inject subcutaneously into any of the following areas:


View attachment 3743238

In powder form, just like any other peptide, epitalon can be stored in dry, cool conditions for a long period of time. After reconstituting, must be stored in the fridge.

​

---

Costs

View attachment 3743337
Online, most epitalon sources I’ve found dose it at 10mg/vial. The costs per vial of epitalon range from $15 to $25, setting you back $150-$250 per cycle. Of course, Chinese sources are cheaper, and EU/elsewhere usually charge more. However, some sources sell it in kits (essentially in bulk), cutting some costs by a decent margin.


View attachment 3743346
BAC water is usually dosed at 10ml/vial minimum, so you can buy one vial and be good to go for the entire cycle. Most expensive BAC water at 10ml/vial I’ve found costs just over $10.


View attachment 3743339
Insulin pins are pretty cheap too ($10-$20), and come in packs of 100 (water, but has to be said).


Total cost range per cycle: $170 to $280 on the absolute highest end,
but I doubt you will even come across any sources charging that much.


​

---

Conclusion


Everyone should be on epitalon past the age of 20. The absurd amount of benefits outweigh the (barely-existent) side effects to the slums of New Delhi. It is criminally overlooked, even on this forum, surprisingly, and is a great addition to anyone’s ant-aging protocols.

However, there are a number of other peptides, that can also be implemented into your longevity/anti-agepill stack, which I may talk about later on!


​

---

References

Spoiler

Anisimov, V.N. et al. (2003) Biogerontology, 4(4), pp. 193–202. Available at: https://doi.org/10.1023/a:1025114230714.

Araj, S.K. et al. (2025) ‘Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties’, International Journal of Molecular Sciences, 26(6), p. 2691. Available at: https://doi.org/10.3390/ijms26062691.

Khavinson, V. et al. (2020) ‘AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism’, Molecules, 25(3), p. 609. Available at: https://doi.org/10.3390/molecules25030609.

Kossoy, G. et al. (no date) Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice. Available at: https://iv.iiarjournals.org/content/invivo/20/2/253.full.pdf (Accessed: 17 May 2025).

Lee, E. (no date) THE FOUNTAIN OF YOUTH PEPTIDE EPITALON. Available at: https://agemed.org/wp-content/uploads/LEE-Epitalon.pdf.

Yue, X. et al. (2022) ‘Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro’, Aging, 14(7), pp. 3191–3202. Available at: https://doi.org/10.18632/aging.204007.

​

---

@menas
​

 

[Sadist]

Good thread, love to see it. Been using epitalon for 3+ years alongside other peptides to reach longevity escape velocity. Telomeres are super interesting - research TA65 and TAM 818 if you want to look further. Great stuff

thanks a lot man
i was going to look into a few, including those, so yeah
shit gonna be crazy

 

[Deleted member 152711]

i found epithalon in nasal spray format, does that work as well as injecting it?

 

[Deleted member 110192]

Spoiler: DISCLAIMER

By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others.

---

Table of Contents


Introduction
Mechanism of Action
Benefits, Risks & Safety Information
Cycling, Administration & Costs
Conclusion
References


​

---

Introduction

View attachment 3743166

What if I told you that there was a magical compound that not only could quite literally extend your life by a significant amount, but also come with a ton of other benefits desired by all people trying to defy the agepill and embrace youthfulness as much as humanly possible?

Well, there was only one lie in the above sentence - the fact that I called it magical. In reality, it is no magic at all! It is but a simple, yet heavily overlooked peptide that can be easily sourced - and just as easily used.


​

---

Mechanism of Action

Epitalon enhances telomerase activity, which protects telomeres from shortening during cell division(1). What are telomeres? Best said by @AstroSky, they are like those plastic shoelace tips that keep those shoelaces (in this case, your chromosome endings), from dilapidating.
Additionally, it stimulates neurogenic gene expression(2),
reduces intracellular reactive oxygen species and enhances mitochondrial function(3), promotes continued cell division(4)(1), stimulates melatonin synthesis and modulates STAT1 phosphorylation(1).


​

---

Benefits

If you could not tell by the previous section - this compound does a lot. In simple terms, it delays cellular aging by up to 25%(1); promotes neuronal differentiation up to 2.1x(1); In clinical trials with mice, it increased maximum lifespan by 12.3%+(5); provides antioxidant and mitochondrial protection, studies showed 86% and 1.5x improvements respectively(6)(3); delays age-related dysfunction (restored IDE/NEP mRNA synthesis under hypoxia to 100%)(4)(1).

View attachment 3743368


​

---

Risks & Safety Information


Injection site reactions(3) are pretty much the only adverse side effects, but that is the same with anything you inject. No chronic toxicity has been found in long-term administration in mice (6.5 months), with no mortality or weight changes(5)(6).
I’ve heard some people ask about epitalon’s potential cancer risks, so here is my answer:
Paradoxically, while epitalon enhances telomerase activity, peer-reviewed studies demonstrate reduced tumor incidence. No evidence of carcinogenic promotion exists to this day(5)(6). But this still goes without saying - do not take it if you have any malignant tumors, however that applies to like any compound you will find info about on this forum, or anywhere else.


​

---

Cycling

Unlike many other compounds, epitalon only has to be administered in relatively short cycles, and only two times per year.
The most optimal dosing is 10mg/day for a 10-day cycle every 6 months.
Simple as that. From all the studies I’ve read, this will yield the most optimal results.


​

---

Administration & Storage

Just like with any other peptides, you will need Bacteriostatic water & 1cc Insulin syringes. It’s very simple: assuming the vials are 10mg each, reconstitute the powder with 1ml BAC water for 10mg/ml concentration. Draw 1ml of the solution & inject subcutaneously into any of the following areas:


View attachment 3743238

In powder form, just like any other peptide, epitalon can be stored in dry, cool conditions for a long period of time. After reconstituting, must be stored in the fridge.

​

---

Costs

View attachment 3743337
Online, most epitalon sources I’ve found dose it at 10mg/vial. The costs per vial of epitalon range from $15 to $25, setting you back $150-$250 per cycle. Of course, Chinese sources are cheaper, and EU/elsewhere usually charge more. However, some sources sell it in kits (essentially in bulk), cutting some costs by a decent margin.


View attachment 3743346
BAC water is usually dosed at 10ml/vial minimum, so you can buy one vial and be good to go for the entire cycle. Most expensive BAC water at 10ml/vial I’ve found costs just over $10.


View attachment 3743339
Insulin pins are pretty cheap too ($10-$20), and come in packs of 100 (water, but has to be said).


Total cost range per cycle: $170 to $280 on the absolute highest end,
but I doubt you will even come across any sources charging that much.


​

---

Conclusion


Everyone should be on epitalon past the age of 20. The absurd amount of benefits outweigh the (barely-existent) side effects to the slums of New Delhi. It is criminally overlooked, even on this forum, surprisingly, and is a great addition to anyone’s ant-aging protocols.

However, there are a number of other peptides, that can also be implemented into your longevity/anti-agepill stack, which I may talk about later on!


​

---

References

Spoiler

Anisimov, V.N. et al. (2003) Biogerontology, 4(4), pp. 193–202. Available at: https://doi.org/10.1023/a:1025114230714.

Araj, S.K. et al. (2025) ‘Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties’, International Journal of Molecular Sciences, 26(6), p. 2691. Available at: https://doi.org/10.3390/ijms26062691.

Khavinson, V. et al. (2020) ‘AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism’, Molecules, 25(3), p. 609. Available at: https://doi.org/10.3390/molecules25030609.

Kossoy, G. et al. (no date) Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice. Available at: https://iv.iiarjournals.org/content/invivo/20/2/253.full.pdf (Accessed: 17 May 2025).

Lee, E. (no date) THE FOUNTAIN OF YOUTH PEPTIDE EPITALON. Available at: https://agemed.org/wp-content/uploads/LEE-Epitalon.pdf.

Yue, X. et al. (2022) ‘Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro’, Aging, 14(7), pp. 3191–3202. Available at: https://doi.org/10.18632/aging.204007.

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@menas
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@org3cel.RR read this

 

[Org3cel]

@org3cel.RR read this

@highinhibcel here bro

 

[willbetruechang2299]

Spoiler: DISCLAIMER

By no means is this medical advice. Even though the risks are low, everyone is different and some people may respond to this differently to others.

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Table of Contents


Introduction
Mechanism of Action
Benefits, Risks & Safety Information
Cycling, Administration & Costs
Conclusion
References


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Introduction

View attachment 3743166

What if I told you that there was a magical compound that not only could quite literally extend your life by a significant amount, but also come with a ton of other benefits desired by all people trying to defy the agepill and embrace youthfulness as much as humanly possible?

Well, there was only one lie in the above sentence - the fact that I called it magical. In reality, it is no magic at all! It is but a simple, yet heavily overlooked peptide that can be easily sourced - and just as easily used.


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Mechanism of Action

Epitalon enhances telomerase activity, which protects telomeres from shortening during cell division(1). What are telomeres? Best said by @AstroSky, they are like those plastic shoelace tips that keep those shoelaces (in this case, your chromosome endings), from dilapidating.
Additionally, it stimulates neurogenic gene expression(2),
reduces intracellular reactive oxygen species and enhances mitochondrial function(3), promotes continued cell division(4)(1), stimulates melatonin synthesis and modulates STAT1 phosphorylation(1).


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Benefits

If you could not tell by the previous section - this compound does a lot. In simple terms, it delays cellular aging by up to 25%(1); promotes neuronal differentiation up to 2.1x(1); In clinical trials with mice, it increased maximum lifespan by 12.3%+(5); provides antioxidant and mitochondrial protection, studies showed 86% and 1.5x improvements respectively(6)(3); delays age-related dysfunction (restored IDE/NEP mRNA synthesis under hypoxia to 100%)(4)(1).

View attachment 3743368


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Risks & Safety Information


Injection site reactions(3) are pretty much the only adverse side effects, but that is the same with anything you inject. No chronic toxicity has been found in long-term administration in mice (6.5 months), with no mortality or weight changes(5)(6).
I’ve heard some people ask about epitalon’s potential cancer risks, so here is my answer:
Paradoxically, while epitalon enhances telomerase activity, peer-reviewed studies demonstrate reduced tumor incidence. No evidence of carcinogenic promotion exists to this day(5)(6). But this still goes without saying - do not take it if you have any malignant tumors, however that applies to like any compound you will find info about on this forum, or anywhere else.


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Cycling

Unlike many other compounds, epitalon only has to be administered in relatively short cycles, and only two times per year.
The most optimal dosing is 10mg/day for a 10-day cycle every 6 months.
Simple as that. From all the studies I’ve read, this will yield the most optimal results.


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Administration & Storage

Just like with any other peptides, you will need Bacteriostatic water & 1cc Insulin syringes. It’s very simple: assuming the vials are 10mg each, reconstitute the powder with 1ml BAC water for 10mg/ml concentration. Draw 1ml of the solution & inject subcutaneously into any of the following areas:


View attachment 3743238

In powder form, just like any other peptide, epitalon can be stored in dry, cool conditions for a long period of time. After reconstituting, must be stored in the fridge.

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Costs

View attachment 3743337
Online, most epitalon sources I’ve found dose it at 10mg/vial. The costs per vial of epitalon range from $15 to $25, setting you back $150-$250 per cycle. Of course, Chinese sources are cheaper, and EU/elsewhere usually charge more. However, some sources sell it in kits (essentially in bulk), cutting some costs by a decent margin.


View attachment 3743346
BAC water is usually dosed at 10ml/vial minimum, so you can buy one vial and be good to go for the entire cycle. Most expensive BAC water at 10ml/vial I’ve found costs just over $10.


View attachment 3743339
Insulin pins are pretty cheap too ($10-$20), and come in packs of 100 (water, but has to be said).


Total cost range per cycle: $170 to $280 on the absolute highest end,
but I doubt you will even come across any sources charging that much.


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Conclusion


Everyone should be on epitalon past the age of 20. The absurd amount of benefits outweigh the (barely-existent) side effects to the slums of New Delhi. It is criminally overlooked, even on this forum, surprisingly, and is a great addition to anyone’s ant-aging protocols.

However, there are a number of other peptides, that can also be implemented into your longevity/anti-agepill stack, which I may talk about later on!


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References

Spoiler

Anisimov, V.N. et al. (2003) Biogerontology, 4(4), pp. 193–202. Available at: https://doi.org/10.1023/a:1025114230714.

Araj, S.K. et al. (2025) ‘Overview of Epitalon—Highly Bioactive Pineal Tetrapeptide with Promising Properties’, International Journal of Molecular Sciences, 26(6), p. 2691. Available at: https://doi.org/10.3390/ijms26062691.

Khavinson, V. et al. (2020) ‘AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism’, Molecules, 25(3), p. 609. Available at: https://doi.org/10.3390/molecules25030609.

Kossoy, G. et al. (no date) Effect of the Synthetic Pineal Peptide Epitalon on Spontaneous Carcinogenesis in Female C3H/He Mice. Available at: https://iv.iiarjournals.org/content/invivo/20/2/253.full.pdf (Accessed: 17 May 2025).

Lee, E. (no date) THE FOUNTAIN OF YOUTH PEPTIDE EPITALON. Available at: https://agemed.org/wp-content/uploads/LEE-Epitalon.pdf.

Yue, X. et al. (2022) ‘Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro’, Aging, 14(7), pp. 3191–3202. Available at: https://doi.org/10.18632/aging.204007.

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@menas
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Another botb thread

 

[Sadist]

@Alexanderr @NumbThePain @Clavicular @Orc @emeraldglass put ts in botb rn..
View attachment 3743756

 

[jeoyw9192]

Good thread, love to see it. Been using epitalon for 3+ years alongside other peptides to reach longevity escape velocity. Telomeres are super interesting - research TA65 and TAM 818 if you want to look further. Great stuff

What were the results/benefits for you

 

[FutureExoticChad]

Excellent thread

Mirin the formating / text colors aswell

 

[Sadist]

i found epithalon in nasal spray format, does that work as well as injecting it?

if the molecule is small enough then yes

i assume if it is sold in sprays already - it should work

 

[jeoyw9192]

thanks a lot man
i was going to look into a few, including those, so yeah
shit gonna be crazy

What'd u find related to those (Telomeres)

 

[LTNUser]

Looksmax without having a carried only by badge and the random name color..

What's that pink verification tick mark for?

 

[Sadist]

What'd u find related to those (Telomeres)

just epitalon

 

[diddly]

bump for effort