THE holy grail for NTmaxxing ; A deep research and guide into chemicals to help with adhd/anxiety

[VrillFatNoob24]

Comparasion of the best chemical compounds for neurotypical maxxing: SSRIs Pregabalin and Guanfacine explained by an autist​

ive noticed that there are 0 guides on these compounds, as people aim to do this naturally, but that cant be the case as if youve probaly severely autistic and cant talk tp people yet alone foids, you can use these 3 drugs.
also this thread is was written carefully, backened from actual meta analyses rcts pharmacology sources mechanical reasoning if you ever wondered which compound actually delivers on anxiety inhibition and feeling more regulated here’s the full guide short but good(i hope)

---

pregabalin​

the mechanism behinds this compound

so pregabalin binds with high affinity to the α2δ subunit of presynaptic voltage gated calcium channels which for iqlets they basically are the tiny doors on the sending side of brain cells that open when an electrical signal arrives letting calcium rush in and trigger the release of neurotransmitters so if you calm those doors down less signal gets blasted across and the brain feels quieter, and this reduces calcium influx during depolarization which in turn decreases release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance p. the net effect is dampened excitatory drive across limbic and cortical circuits resulting in rapid anxiolysis reduced hyperexcitability and sedation
but also note this does not directly improve executive inhibition but rather suppresses arousal which can feel like inhibition which is why i would rank it the 3rd best out of these 3.

evidence (was too lazy to post the links but)
meta analyses show that moderate efficacy in general anxiety disorders equal to 0.36 ~ grams across rcts
onset of benefit is rapid within one week in many trials
not too certain as some jewish bias from industry sponsorship

the dosing

for humans the oral bioavailability is somewhat around 90%
tmax is ~0 7 to 1-3 hours
half life ≈6 3 h
works wonderdully within 1 to 2 days
actual dosing 150 to 600 mg daily usually divided
also requires renal dose adjustment
some sides you can experience is somnolence dizziness weight gain edema and euphoria in some peopel

---

ssris and snris the God tier Drug​

mechanism

SSris selectively inhibit serotonin transporter sert increasing extracellular serotonin also snris inhibit both sert and norepinephrine transporter net raising serotonin and norepinephrine which chronically use leads to receptor desensitization synaptic remodeling and increased brain derived neurotrophic factor activity system level effect is reduced amygdala hyperreactivity and enhanced prefrontal cortex top down control
this produces gradual improvement in affect regulation and cognitive control but onset takes weeks

evidence
largest and highest quality evidence base
multiple rcts and dose response meta analyses show significant small to moderate effect sizes in anxiety disorders
im highly certain

dosing
escitalopram half life ~27 to 32 h sertraline ~24 to 26 h venlafaxine ~5 h for parent compound but xr formulations prolong action
primarily metabolized ny cytochrome p450 isoenzymes
typical dose are around escitalopram 10 to 20 mg sertraline 50 to 200 mg venlafaxine xr 75 to 225 mg
might cause sexual dysfunction gi upset insomnia or sedation emotional blunting discontinuation syndrome suicidality warning in young people with also prolongation with high dose citalopram
cheap generics once daily dosing simple adherence

i personally think this is the best for nt maxxing and i rank it first out of the other 2s

---

guanfacine​

mechanism
guanfacine is a selective α2a adrenergic receptor agonist
in the prefrontal cortex so it strengthens functional connectivity by enhancing delay related firing of pyramidal neurons and suppressing excessive norepinephrine noise from locus coeruleus system level this improves working memory inhibitory control and attention(good for fochsing on studying but you can use nootropics) while reducing hyperarousal

some effects could be sedation and hypotension via brainstem receptor activation

evidence
moderate certainty for adhd inhib and executive function which comes out aa robust rcts support its efficacy
low to moderate certainty for primary anxiety disorders less direct evidence
but slays the other 2 for overall best for impulsivity and inhibition deficits

dosing
half life ~17 h range 10 to 30 h
metabolized mainly by cypa34 or some shit
formulated as extended release once daily 1 to 4 mg
you can epxerience these sides : sedation,, bradycardia orthostatic hypotension,
i reccomend tapering to avoid rebound hypertension
availability as intuniv rx only more expensive than ssris

---

comparison but shorter​

• pregabalin > rapid within days also moderate anxiolytic effect feels like inhib but good risk of misuse
• ssris/snris > slower by weeks but highest certainty excellent circuit level remodeling durable anxiety reduction
• guanfacine > best for executive control inhib impulsivity evidence strong in adhd weaker in anxiety (reccomended as cheaper and usefill)

1.ssris/snris
2. guan
3.pregrab

---

for safety safety ​

pregabalin CAN cause:
dizziness somnolence weight gain edema potential euphoria renal clearance issues controlled in some countries

ssris snris CAN cause sexual dysfunction gi issues sleep disturbance discontinuation syndrome blunting serotonin syndrome risk qtc prolongation with citalopram

guanfacine CAN cause sedation hypotension bradycardia taper essential to avoid rebound hypertension monitor bp hr interactions with cypa34 inhibs

---

final synthesis​

pregabalin = rapid calming effect but weak efficancu
ssris snris = slower onset but strongest evidence base high certainty best for durable anxiety reduction
guanfacine = targeted improvement of inhibition and executive control moderate certainty in adhd low in anxiety

none of these universally make you neurotypical jfl they only target different symptom domains but they can help
choose based on your main deficit
anxiety dominates? use ssri/snri
ia impulsivity inhibition is raping you? use guanfacine
need immediate calm or failed use of ssris? hse pregabalin

---

all claims backed by rcts meta analyses pharmacokinetic data and mechanistic reasoning

research
ascend
nt max
Enjoy life


will send Sources later (linnks)


tag someone who may need this

 

[VrillFatNoob24]

ignoredpill

 

[Yahya]

make sure to remember me

 

[VrillFatNoob24]

make sure to remember me


View attachment 4158713

not coming ever

 

[iblamexyz]

bump

 

[Aryan Incel]

Mirin

 

[VrillFatNoob24]

bump

Mirin

Thanks

 

[BigBoy]

JFL at taking more than one ssri at a time

 

[BigBoy]

Oh sorry, I thought you were saying to take lexapro, Zoloft, and venlafaxine at the same time, you were just typing them as options. My bad bro.

 

[Yahya]

JFL at taking more than one ssri at a time

silence kike

 

[BigBoy]

silence kike

I’m against kikes doofus

 

[Yahya]

I’m against kikes doofus

that's a suspiciously big nose you have there joojoo

 

[org3cel.RR]

Comparasion of the best chemical compounds for neurotypical maxxing: SSRIs Pregabalin and Guanfacine explained by an autist​

ive noticed that there are 0 guides on these compounds, as people aim to do this naturally, but that cant be the case as if youve probaly severely autistic and cant talk tp people yet alone foids, you can use these 3 drugs.
also this thread is was written carefully, backened from actual meta analyses rcts pharmacology sources mechanical reasoning if you ever wondered which compound actually delivers on anxiety inhibition and feeling more regulated here’s the full guide short but good(i hope)

---

pregabalin​

the mechanism behinds this compound

so pregabalin binds with high affinity to the α2δ subunit of presynaptic voltage gated calcium channels which for iqlets they basically are the tiny doors on the sending side of brain cells that open when an electrical signal arrives letting calcium rush in and trigger the release of neurotransmitters so if you calm those doors down less signal gets blasted across and the brain feels quieter, and this reduces calcium influx during depolarization which in turn decreases release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance p. the net effect is dampened excitatory drive across limbic and cortical circuits resulting in rapid anxiolysis reduced hyperexcitability and sedation
but also note this does not directly improve executive inhibition but rather suppresses arousal which can feel like inhibition which is why i would rank it the 3rd best out of these 3.

evidence (was too lazy to post the links but)
meta analyses show that moderate efficacy in general anxiety disorders equal to 0.36 ~ grams across rcts
onset of benefit is rapid within one week in many trials
not too certain as some jewish bias from industry sponsorship

the dosing

for humans the oral bioavailability is somewhat around 90%
tmax is ~0 7 to 1-3 hours
half life ≈6 3 h
works wonderdully within 1 to 2 days
actual dosing 150 to 600 mg daily usually divided
also requires renal dose adjustment
some sides you can experience is somnolence dizziness weight gain edema and euphoria in some peopel

---

ssris and snris the God tier Drug​

mechanism

SSris selectively inhibit serotonin transporter sert increasing extracellular serotonin also snris inhibit both sert and norepinephrine transporter net raising serotonin and norepinephrine which chronically use leads to receptor desensitization synaptic remodeling and increased brain derived neurotrophic factor activity system level effect is reduced amygdala hyperreactivity and enhanced prefrontal cortex top down control
this produces gradual improvement in affect regulation and cognitive control but onset takes weeks

evidence
largest and highest quality evidence base
multiple rcts and dose response meta analyses show significant small to moderate effect sizes in anxiety disorders
im highly certain

dosing
escitalopram half life ~27 to 32 h sertraline ~24 to 26 h venlafaxine ~5 h for parent compound but xr formulations prolong action
primarily metabolized ny cytochrome p450 isoenzymes
typical dose are around escitalopram 10 to 20 mg sertraline 50 to 200 mg venlafaxine xr 75 to 225 mg
might cause sexual dysfunction gi upset insomnia or sedation emotional blunting discontinuation syndrome suicidality warning in young people with also prolongation with high dose citalopram
cheap generics once daily dosing simple adherence

i personally think this is the best for nt maxxing and i rank it first out of the other 2s

---

guanfacine​

mechanism
guanfacine is a selective α2a adrenergic receptor agonist
in the prefrontal cortex so it strengthens functional connectivity by enhancing delay related firing of pyramidal neurons and suppressing excessive norepinephrine noise from locus coeruleus system level this improves working memory inhibitory control and attention(good for fochsing on studying but you can use nootropics) while reducing hyperarousal

some effects could be sedation and hypotension via brainstem receptor activation

evidence
moderate certainty for adhd inhib and executive function which comes out aa robust rcts support its efficacy
low to moderate certainty for primary anxiety disorders less direct evidence
but slays the other 2 for overall best for impulsivity and inhibition deficits

dosing
half life ~17 h range 10 to 30 h
metabolized mainly by cypa34 or some shit
formulated as extended release once daily 1 to 4 mg
you can epxerience these sides : sedation,, bradycardia orthostatic hypotension,
i reccomend tapering to avoid rebound hypertension
availability as intuniv rx only more expensive than ssris

---

comparison but shorter​

• pregabalin > rapid within days also moderate anxiolytic effect feels like inhib but good risk of misuse
• ssris/snris > slower by weeks but highest certainty excellent circuit level remodeling durable anxiety reduction
• guanfacine > best for executive control inhib impulsivity evidence strong in adhd weaker in anxiety (reccomended as cheaper and usefill)

1.ssris/snris
2. guan
3.pregrab

---

for safety safety ​

pregabalin CAN cause:
dizziness somnolence weight gain edema potential euphoria renal clearance issues controlled in some countries

ssris snris CAN cause sexual dysfunction gi issues sleep disturbance discontinuation syndrome blunting serotonin syndrome risk qtc prolongation with citalopram

guanfacine CAN cause sedation hypotension bradycardia taper essential to avoid rebound hypertension monitor bp hr interactions with cypa34 inhibs

---

final synthesis​

pregabalin = rapid calming effect but weak efficancu
ssris snris = slower onset but strongest evidence base high certainty best for durable anxiety reduction
guanfacine = targeted improvement of inhibition and executive control moderate certainty in adhd low in anxiety

none of these universally make you neurotypical jfl they only target different symptom domains but they can help
choose based on your main deficit
anxiety dominates? use ssri/snri
ia impulsivity inhibition is raping you? use guanfacine
need immediate calm or failed use of ssris? hse pregabalin

---

all claims backed by rcts meta analyses pharmacokinetic data and mechanistic reasoning

research
ascend
nt max
Enjoy life


will send Sources later (linnks)


tag someone who may need this

Dont need it but bump for effort

 

[BigBoy]

that's a suspiciously big nose you have there joojoo

Caught me bro

 

[Gaygymmaxx]

Comparasion of the best chemical compounds for neurotypical maxxing: SSRIs Pregabalin and Guanfacine explained by an autist​

ive noticed that there are 0 guides on these compounds, as people aim to do this naturally, but that cant be the case as if youve probaly severely autistic and cant talk tp people yet alone foids, you can use these 3 drugs.
also this thread is was written carefully, backened from actual meta analyses rcts pharmacology sources mechanical reasoning if you ever wondered which compound actually delivers on anxiety inhibition and feeling more regulated here’s the full guide short but good(i hope)

---

pregabalin​

the mechanism behinds this compound

so pregabalin binds with high affinity to the α2δ subunit of presynaptic voltage gated calcium channels which for iqlets they basically are the tiny doors on the sending side of brain cells that open when an electrical signal arrives letting calcium rush in and trigger the release of neurotransmitters so if you calm those doors down less signal gets blasted across and the brain feels quieter, and this reduces calcium influx during depolarization which in turn decreases release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance p. the net effect is dampened excitatory drive across limbic and cortical circuits resulting in rapid anxiolysis reduced hyperexcitability and sedation
but also note this does not directly improve executive inhibition but rather suppresses arousal which can feel like inhibition which is why i would rank it the 3rd best out of these 3.

evidence (was too lazy to post the links but)
meta analyses show that moderate efficacy in general anxiety disorders equal to 0.36 ~ grams across rcts
onset of benefit is rapid within one week in many trials
not too certain as some jewish bias from industry sponsorship

the dosing

for humans the oral bioavailability is somewhat around 90%
tmax is ~0 7 to 1-3 hours
half life ≈6 3 h
works wonderdully within 1 to 2 days
actual dosing 150 to 600 mg daily usually divided
also requires renal dose adjustment
some sides you can experience is somnolence dizziness weight gain edema and euphoria in some peopel

---

ssris and snris the God tier Drug​

mechanism

SSris selectively inhibit serotonin transporter sert increasing extracellular serotonin also snris inhibit both sert and norepinephrine transporter net raising serotonin and norepinephrine which chronically use leads to receptor desensitization synaptic remodeling and increased brain derived neurotrophic factor activity system level effect is reduced amygdala hyperreactivity and enhanced prefrontal cortex top down control
this produces gradual improvement in affect regulation and cognitive control but onset takes weeks

evidence
largest and highest quality evidence base
multiple rcts and dose response meta analyses show significant small to moderate effect sizes in anxiety disorders
im highly certain

dosing
escitalopram half life ~27 to 32 h sertraline ~24 to 26 h venlafaxine ~5 h for parent compound but xr formulations prolong action
primarily metabolized ny cytochrome p450 isoenzymes
typical dose are around escitalopram 10 to 20 mg sertraline 50 to 200 mg venlafaxine xr 75 to 225 mg
might cause sexual dysfunction gi upset insomnia or sedation emotional blunting discontinuation syndrome suicidality warning in young people with also prolongation with high dose citalopram
cheap generics once daily dosing simple adherence

i personally think this is the best for nt maxxing and i rank it first out of the other 2s

---

guanfacine​

mechanism
guanfacine is a selective α2a adrenergic receptor agonist
in the prefrontal cortex so it strengthens functional connectivity by enhancing delay related firing of pyramidal neurons and suppressing excessive norepinephrine noise from locus coeruleus system level this improves working memory inhibitory control and attention(good for fochsing on studying but you can use nootropics) while reducing hyperarousal

some effects could be sedation and hypotension via brainstem receptor activation

evidence
moderate certainty for adhd inhib and executive function which comes out aa robust rcts support its efficacy
low to moderate certainty for primary anxiety disorders less direct evidence
but slays the other 2 for overall best for impulsivity and inhibition deficits

dosing
half life ~17 h range 10 to 30 h
metabolized mainly by cypa34 or some shit
formulated as extended release once daily 1 to 4 mg
you can epxerience these sides : sedation,, bradycardia orthostatic hypotension,
i reccomend tapering to avoid rebound hypertension
availability as intuniv rx only more expensive than ssris

---

comparison but shorter​

• pregabalin > rapid within days also moderate anxiolytic effect feels like inhib but good risk of misuse
• ssris/snris > slower by weeks but highest certainty excellent circuit level remodeling durable anxiety reduction
• guanfacine > best for executive control inhib impulsivity evidence strong in adhd weaker in anxiety (reccomended as cheaper and usefill)

1.ssris/snris
2. guan
3.pregrab

---

for safety safety ​

pregabalin CAN cause:
dizziness somnolence weight gain edema potential euphoria renal clearance issues controlled in some countries

ssris snris CAN cause sexual dysfunction gi issues sleep disturbance discontinuation syndrome blunting serotonin syndrome risk qtc prolongation with citalopram

guanfacine CAN cause sedation hypotension bradycardia taper essential to avoid rebound hypertension monitor bp hr interactions with cypa34 inhibs

---

final synthesis​

pregabalin = rapid calming effect but weak efficancu
ssris snris = slower onset but strongest evidence base high certainty best for durable anxiety reduction
guanfacine = targeted improvement of inhibition and executive control moderate certainty in adhd low in anxiety

none of these universally make you neurotypical jfl they only target different symptom domains but they can help
choose based on your main deficit
anxiety dominates? use ssri/snri
ia impulsivity inhibition is raping you? use guanfacine
need immediate calm or failed use of ssris? hse pregabalin

---

all claims backed by rcts meta analyses pharmacokinetic data and mechanistic reasoning

research
ascend
nt max
Enjoy life


will send Sources later (linnks)


tag someone who may need this

Good thread

@Gengar tldr this

 

[Gaygymmaxx]

Oh sorry, I thought you were saying to take lexapro, Zoloft, and venlafaxine at the same time, you were just typing them as options. My bad bro.

Oh all of these are ssri's?

I'm a bit suspicious of them as jewish chemicals hopefully people use these as temporary means to alter disposition then taper off

 

[Tigermoggerlol]

Comparasion of the best chemical compounds for neurotypical maxxing: SSRIs Pregabalin and Guanfacine explained by an autist​

ive noticed that there are 0 guides on these compounds, as people aim to do this naturally, but that cant be the case as if youve probaly severely autistic and cant talk tp people yet alone foids, you can use these 3 drugs.
also this thread is was written carefully, backened from actual meta analyses rcts pharmacology sources mechanical reasoning if you ever wondered which compound actually delivers on anxiety inhibition and feeling more regulated here’s the full guide short but good(i hope)

---

pregabalin​

the mechanism behinds this compound

so pregabalin binds with high affinity to the α2δ subunit of presynaptic voltage gated calcium channels which for iqlets they basically are the tiny doors on the sending side of brain cells that open when an electrical signal arrives letting calcium rush in and trigger the release of neurotransmitters so if you calm those doors down less signal gets blasted across and the brain feels quieter, and this reduces calcium influx during depolarization which in turn decreases release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance p. the net effect is dampened excitatory drive across limbic and cortical circuits resulting in rapid anxiolysis reduced hyperexcitability and sedation
but also note this does not directly improve executive inhibition but rather suppresses arousal which can feel like inhibition which is why i would rank it the 3rd best out of these 3.

evidence (was too lazy to post the links but)
meta analyses show that moderate efficacy in general anxiety disorders equal to 0.36 ~ grams across rcts
onset of benefit is rapid within one week in many trials
not too certain as some jewish bias from industry sponsorship

the dosing

for humans the oral bioavailability is somewhat around 90%
tmax is ~0 7 to 1-3 hours
half life ≈6 3 h
works wonderdully within 1 to 2 days
actual dosing 150 to 600 mg daily usually divided
also requires renal dose adjustment
some sides you can experience is somnolence dizziness weight gain edema and euphoria in some peopel

---

ssris and snris the God tier Drug​

mechanism

SSris selectively inhibit serotonin transporter sert increasing extracellular serotonin also snris inhibit both sert and norepinephrine transporter net raising serotonin and norepinephrine which chronically use leads to receptor desensitization synaptic remodeling and increased brain derived neurotrophic factor activity system level effect is reduced amygdala hyperreactivity and enhanced prefrontal cortex top down control
this produces gradual improvement in affect regulation and cognitive control but onset takes weeks

evidence
largest and highest quality evidence base
multiple rcts and dose response meta analyses show significant small to moderate effect sizes in anxiety disorders
im highly certain

dosing
escitalopram half life ~27 to 32 h sertraline ~24 to 26 h venlafaxine ~5 h for parent compound but xr formulations prolong action
primarily metabolized ny cytochrome p450 isoenzymes
typical dose are around escitalopram 10 to 20 mg sertraline 50 to 200 mg venlafaxine xr 75 to 225 mg
might cause sexual dysfunction gi upset insomnia or sedation emotional blunting discontinuation syndrome suicidality warning in young people with also prolongation with high dose citalopram
cheap generics once daily dosing simple adherence

i personally think this is the best for nt maxxing and i rank it first out of the other 2s

---

guanfacine​

mechanism
guanfacine is a selective α2a adrenergic receptor agonist
in the prefrontal cortex so it strengthens functional connectivity by enhancing delay related firing of pyramidal neurons and suppressing excessive norepinephrine noise from locus coeruleus system level this improves working memory inhibitory control and attention(good for fochsing on studying but you can use nootropics) while reducing hyperarousal

some effects could be sedation and hypotension via brainstem receptor activation

evidence
moderate certainty for adhd inhib and executive function which comes out aa robust rcts support its efficacy
low to moderate certainty for primary anxiety disorders less direct evidence
but slays the other 2 for overall best for impulsivity and inhibition deficits

dosing
half life ~17 h range 10 to 30 h
metabolized mainly by cypa34 or some shit
formulated as extended release once daily 1 to 4 mg
you can epxerience these sides : sedation,, bradycardia orthostatic hypotension,
i reccomend tapering to avoid rebound hypertension
availability as intuniv rx only more expensive than ssris

---

comparison but shorter​

• pregabalin > rapid within days also moderate anxiolytic effect feels like inhib but good risk of misuse
• ssris/snris > slower by weeks but highest certainty excellent circuit level remodeling durable anxiety reduction
• guanfacine > best for executive control inhib impulsivity evidence strong in adhd weaker in anxiety (reccomended as cheaper and usefill)

1.ssris/snris
2. guan
3.pregrab

---

for safety safety ​

pregabalin CAN cause:
dizziness somnolence weight gain edema potential euphoria renal clearance issues controlled in some countries

ssris snris CAN cause sexual dysfunction gi issues sleep disturbance discontinuation syndrome blunting serotonin syndrome risk qtc prolongation with citalopram

guanfacine CAN cause sedation hypotension bradycardia taper essential to avoid rebound hypertension monitor bp hr interactions with cypa34 inhibs

---

final synthesis​

pregabalin = rapid calming effect but weak efficancu
ssris snris = slower onset but strongest evidence base high certainty best for durable anxiety reduction
guanfacine = targeted improvement of inhibition and executive control moderate certainty in adhd low in anxiety

none of these universally make you neurotypical jfl they only target different symptom domains but they can help
choose based on your main deficit
anxiety dominates? use ssri/snri
ia impulsivity inhibition is raping you? use guanfacine
need immediate calm or failed use of ssris? hse pregabalin

---

all claims backed by rcts meta analyses pharmacokinetic data and mechanistic reasoning

research
ascend
nt max
Enjoy life


will send Sources later (linnks)


tag someone who may need this

I book marked this

 

[BigBoy]

Oh all of these are ssri's?

I'm a bit suspicious of them as jewish chemicals hopefully people use these as temporary means to alter disposition then taper off

The first two are ssris, the third is an snri. They aren’t bad and typically well tolerated. From what I understand they’re used to help you get to a better place where you don’t need them anymore and you can get off them.

 

[VrillFatNoob24]

bump

 

[FiendFiend]

The first two are ssris, the third is an snri. They aren’t bad and typically well tolerated. From what I understand they’re used to help you get to a better place where you don’t need them anymore and you can get off them.

i used to shit on ssri's but im on benzos and feel decent all be it im on a small dose and a light as fuck one

 

[BigBoy]

i used to shit on ssri's but im on benzos and feel decent all be it im on a small dose and a light as fuck one

I wouldn’t use benzodiazepines tbh, the risk of teoleranxe and addiction is too great.

 

[VrillFatNoob24]

nigjtly and last bump + tag @chadisbeingmade

 

[thonstuff]

Nice I don’t like sainis tho

 

[Yahya]

Good thread

@Gengar tldr this

he is NOT your animal you FAGGOT. Respect MY PAKI