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Kortajarena lurking
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Alright. We want bone growth. Ideally in the maxilla forwards, and in the mandible downwards. There are some ideas which can cause cancer like reactive oxygen species to indice chromocyte hypertrophy so I wont go down that path. I triy to condense thousands of studies here and I dont think more than 3 people will actually read it all but its time for a higher effort post so:
I know people cope with saying its all genes, but the genes only make you produce hormones. We can do that artificially. A few things which should be obvious, since there has been research on them for some time:
1. High t to e ratio makes maxilla and especially mandible grow in adolescents ( all of this for adolescents, but mandible could grow pretty late so even if youre over 25 keep reading)
2. High growth hormones give you a bigger mandible but have little effect on maxilla
3. Some people say we need E to stop bone resorption.
Lets start with point three: we do need to stop osteoclast activity to an extent (osteoclasts resorb bone). It is common knowledge that E stops osteoclasts and acts as a shield for the bone. But also, a high t to e ratio is good for masculine bone growth, so we want lower e. Well, i found out there are some other ways to inhibit osteoclast activity, one of them being bisphosphonates. Bisphosphonates have side effects including bone muscle and joint pain. Crazy thing is after three years they are kind of in your system so your osteoclasts get blocked and you can stop taking them. That increases bone mass by inhibiting osteoclast activity, so we dont need to be high E.
Another thing that stops bone growth is sclerostin, which is secreted more if you, for example, lie on a hospital bed all day. It breaks down bone and decreases density significantly. There are new methods to inhibit this, one of them being Evenity. Evenity has a moderate amount of side effects, and is generally safe. It has been shown to increase bone mass!
Now, we need to increase osteoblast activity to build new bones. Osteoblasts are made from preosteoblasts, which are made from mesenchymal stem cells. They dont always convert to osteoblasts tho, sometimes they convert to adiposicytes, a form of fat cells. Recent research suggests that if the mesenchymal stem cells, short MSC convert into adiposicytes more often than into osteoblasts this can cause bone loss and osteoporosis. So what is the trigger that makes them turn into osteoblasts which then create osteoids aka new bone? One idea here might be Forteo, which has been shown to build new bone but it has sever side effects. The main factors tho for differentiating MSC to osteoblasts are runx2 and osterix. Runx2 can be increased via some complicated shit which I might target in the future or simply bough. Its pretty expensive tho at 300 bucks for 100 mykrogramm. Osterix is even harder to produce, which is why I looked deeper. Basically, osterix helps with bone growth via the protein NELL-1. I looked deeper into NELL and it stimulates a protein called GLI1 which than increases both osterix and runx2. Bingo! Still, even NELL is pretty expensive and well have to wait till its easily and cheaply consumable. other transcription factors (TAZ, forkhead box C2 (Foxc2), and the proteins Twist-1 and Twist-2) also regulate osteogenic differentiation of MSCs, most of those can cause cancer so not so bingo. Other ways might be BMP2 (very expensive) β-catenin (can lead to cancer) and WNT10B, which at first seems like a dream. It does everything to convert MSCs into osteoblasts and it can be increased via the iPTH, a form of the parathyroid hormone. To my great surprise and happiness, this also leeds to cancer, death and cardiovascular disease. Yay. I literally went through hundreds of factors to find more ways to increase bone mass via MSCs but most led to cancer or death, until I found a side note in a study talking about vibration. Basically vibration can increase osteoblasts from MSCs, maybe thats how bonesmashing works. So if you have a vibrator or something stronger lol hold it to your cheekbones every once in a while. Or maybe try some light bonesmashing. after I looked into what makes MSCs become adipocytes instead, and here the main factor is PPARγ. By inhibiting it, we might be able to induce bone growth, common inhibitors are clofibrate (too little research) gemfibrozil (impotence as common side effect) and bezafibrate, the best options. At a dollar fifty per portion its relativepy cheap and has proven to help grow bones.
As for t, e and growth factors I recommend a mild aromasin with the perfect dosage of clomid and you are at high t low e. As for the growth hornones, maybe some mk677 and a sauna can get them uo by a little, for drastic measures tRy IGF-1-L3 as a microdose.
I won't write a tldr, all those people who read it will hopefully be rewarded with the information. It was pretty straight forward so tldr wont be pssbl sry boys. Only high IQ responses @Nosecel and we can get the ideal bone growth boys. Got some favorites out of the list which I might try, especially the osteoclast inhibitors.
Hope it was worth writing all that while I should be studying for medicine exam but this could help bone growth which is my holy grail
Take care boys
I know people cope with saying its all genes, but the genes only make you produce hormones. We can do that artificially. A few things which should be obvious, since there has been research on them for some time:
1. High t to e ratio makes maxilla and especially mandible grow in adolescents ( all of this for adolescents, but mandible could grow pretty late so even if youre over 25 keep reading)
2. High growth hormones give you a bigger mandible but have little effect on maxilla
3. Some people say we need E to stop bone resorption.
Lets start with point three: we do need to stop osteoclast activity to an extent (osteoclasts resorb bone). It is common knowledge that E stops osteoclasts and acts as a shield for the bone. But also, a high t to e ratio is good for masculine bone growth, so we want lower e. Well, i found out there are some other ways to inhibit osteoclast activity, one of them being bisphosphonates. Bisphosphonates have side effects including bone muscle and joint pain. Crazy thing is after three years they are kind of in your system so your osteoclasts get blocked and you can stop taking them. That increases bone mass by inhibiting osteoclast activity, so we dont need to be high E.
Another thing that stops bone growth is sclerostin, which is secreted more if you, for example, lie on a hospital bed all day. It breaks down bone and decreases density significantly. There are new methods to inhibit this, one of them being Evenity. Evenity has a moderate amount of side effects, and is generally safe. It has been shown to increase bone mass!
Now, we need to increase osteoblast activity to build new bones. Osteoblasts are made from preosteoblasts, which are made from mesenchymal stem cells. They dont always convert to osteoblasts tho, sometimes they convert to adiposicytes, a form of fat cells. Recent research suggests that if the mesenchymal stem cells, short MSC convert into adiposicytes more often than into osteoblasts this can cause bone loss and osteoporosis. So what is the trigger that makes them turn into osteoblasts which then create osteoids aka new bone? One idea here might be Forteo, which has been shown to build new bone but it has sever side effects. The main factors tho for differentiating MSC to osteoblasts are runx2 and osterix. Runx2 can be increased via some complicated shit which I might target in the future or simply bough. Its pretty expensive tho at 300 bucks for 100 mykrogramm. Osterix is even harder to produce, which is why I looked deeper. Basically, osterix helps with bone growth via the protein NELL-1. I looked deeper into NELL and it stimulates a protein called GLI1 which than increases both osterix and runx2. Bingo! Still, even NELL is pretty expensive and well have to wait till its easily and cheaply consumable. other transcription factors (TAZ, forkhead box C2 (Foxc2), and the proteins Twist-1 and Twist-2) also regulate osteogenic differentiation of MSCs, most of those can cause cancer so not so bingo. Other ways might be BMP2 (very expensive) β-catenin (can lead to cancer) and WNT10B, which at first seems like a dream. It does everything to convert MSCs into osteoblasts and it can be increased via the iPTH, a form of the parathyroid hormone. To my great surprise and happiness, this also leeds to cancer, death and cardiovascular disease. Yay. I literally went through hundreds of factors to find more ways to increase bone mass via MSCs but most led to cancer or death, until I found a side note in a study talking about vibration. Basically vibration can increase osteoblasts from MSCs, maybe thats how bonesmashing works. So if you have a vibrator or something stronger lol hold it to your cheekbones every once in a while. Or maybe try some light bonesmashing. after I looked into what makes MSCs become adipocytes instead, and here the main factor is PPARγ. By inhibiting it, we might be able to induce bone growth, common inhibitors are clofibrate (too little research) gemfibrozil (impotence as common side effect) and bezafibrate, the best options. At a dollar fifty per portion its relativepy cheap and has proven to help grow bones.
As for t, e and growth factors I recommend a mild aromasin with the perfect dosage of clomid and you are at high t low e. As for the growth hornones, maybe some mk677 and a sauna can get them uo by a little, for drastic measures tRy IGF-1-L3 as a microdose.
I won't write a tldr, all those people who read it will hopefully be rewarded with the information. It was pretty straight forward so tldr wont be pssbl sry boys. Only high IQ responses @Nosecel and we can get the ideal bone growth boys. Got some favorites out of the list which I might try, especially the osteoclast inhibitors.
Hope it was worth writing all that while I should be studying for medicine exam but this could help bone growth which is my holy grail
Take care boys
Last edited:
but yeah it will help a lot
