THE MOST UP TO DATE HEIGHTMAXXING STACK

[futureashtray]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

 

[thereallegend]

I have something similar to vosoritide. Also KY19382 is expensive af

 

[Osie]

I have something similar to vosoritide. Also KY19382 is expensive af

I have pretty cheap (as in comparison to the 12-14,000$ sources) pharma vosoritide links.

 

[futureashtray]

I have something similar to vosoritide. Also KY19382 is expensive af

meclezine isnt that good, also. ky109382isnt that expensive

 

[futureashtray]

I have pretty cheap (as in comparison to the 12-14,000$ sources) pharma vosoritide links.

tryna help a brotha out? im 5"8 15yo

 

[Osie]

W

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

The only experimental drug worthwhile there is KY19382 since it works on a height growth pathway not commonly explored by other compounds on the market. IGF-1 LR3 hasn't really shown much benefit over HGH and isn't as well researched and backed up as HGH to increase longitudinal bone growth in healthy short males. The effects of IGF-1 LR3 on longitudinal bone growth isn't even completely understood yet in a practical sense.

The problem with vosoritide is that it targets a genetic mutation in dwarves that might not be applicable to normal people. For example, it hasn't been explored if normal humans have a natural regulation system where our FGFR3 can't get to a certain point without being forced back to its normal state. It possibly means that normal people would have to inject much higher doses in dwarves for the similar results.

 

[Deleted member 31022]

are you guys okay to not keep gate this?
I mean information like this might be spread on more public space like tiktok

 

[futureashtray]

are you guys okay to not keep gate this?
I mean information like this might be spread on more public space like tiktok

no tiktokers are this downbad to research the deepest of the deep catacombs of the web to find this info

 

[Gaygymmaxx]

no tiktokers are this downbad to research the deepest of the deep catacombs of the web to find this info

are you guys okay to not keep gate this?
I mean information like this might be spread on more public space like tiktok

They aren't low inhib enough to Inject experimental shit

 

[futureashtray]

The problem with vosoritide is that it targets a genetic mutation in dwarves that might not be applicable to normal people. For example, it hasn't been explored if normal humans have a natural regulation system where our FGFR3 can't get to a certain point without being forced back to its normal state. It possibly means that normal people would have to inject much higher doses in dwarves for the similar results.

true, also that drug costs alot of money anyways (not for me im not poorcel).

i guss just taking igf1 lr3 with hexarelin and aromasin works too.

 

[futureashtray]

They aren't low inhib enough to Inject experimental shit

more like they are mind controlled by the dopamine overload since they see and hear their favorite songs, content, etc.

 

[Deleted member 31022]

no tiktokers are this downbad to research the deepest of the deep catacombs of the web to find this info

They aren't low inhib enough to Inject experimental shit

understandable, I think if this got on tiktok everyone will just cancel it

 

[IMOGYOU]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

have anyone actually tried it
also if you want to apply it on humans you should only care about vivo results

In Vivo

Vosoritide (subcutaneous injection; 800 μg/kg; once daily; 20 d) treatment leads to improvement in skeletal parameters in Fgfr3 gain-of-function mutation mouse[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Fgfr3Y367C/+ mice[3] Dosage: 800 μg/kg Administration: Subcutaneous injection; 800 μg/kg; once daily; 20 days Result: Observed phenotypic changes including flattening of the skull, elongation of the snout, improvement of the anterior crossbite, larger paws and digits, and longer and straightened tibias and femurs.

Dosage is 800 μg/kg which is 0.06g for someone who weights 75Kg also it is was taken everyday for 20 days as a subcutaneous injection

For KY19382:

In Vivo

KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice[1]. KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice[1]. KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ng•h/ml[1]. KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects[2]. A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice[2]. A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 male mice (7-weeks-old or 3-weeks-old)[1] Dosage: 0.1 mg/kg Administration: I.p. once daily for 2 weeks Result: Increased nuclear β-catenin in the growth plate chondrocytes dramatically. Elevated the height of each growth plate zone and BrdU-positive cells. Did not affect the cartilage resorption of rapidly growing young mice.

the dosage is 0.1 mg/kg which will be 7.5mg for someone who weights 75kg taken once daily for 2 weeks
The problem is there is no enough results for human use and the instructions is not very clear
price is not really a problem since the results would be life changing if this actually applicable

 

[thereallegend]

best ky19382 sources? @Osie

 

[Osie]

best ky19382 sources? @Osie

Nope, but I’ll answer ya pm

 

[IMOGYOU]

Nope, but I’ll answer ya pm

Can you pm it to me too
Also is it trusted?

 

[Usernameofthisuser]

Hey osie does your source have the ability to synth proteins?

 

[Osie]

Hey osie does your source have the ability to synth proteins?

Hit PM's and wdym?

 

[Osie]

Can you pm it to me too
Also is it trusted?

Alright, PM me first

 

[enchanted_elixir]

no tiktokers are this downbad to research the deepest of the deep catacombs of the web to find this info

23,000+ men were down bad so much, they came to this site.
JFL if you don't think that there's like 600x the amount of men who want this kind of info but can't find it.

 

[enchanted_elixir]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

Make a guide on KY19382 and I might move it to BOTB if you're willing.

 

[enchanted_elixir]

Thanks for sharing this information, I deeply appreciate it.

 

[Deleted member 31155]

Thanks for sharing this information, I deeply appreciate it.

hey ur back have u ascended yet

 

[enchanted_elixir]

hey ur back have u ascended yet

Knowledge-wise, yes (in other domains).
Looks-wise, no.

I am likely to start this winter.

 

[Deleted member 31155]

Knowledge-wise, yes (in other domains).
Looks-wise, no.

I am likely to start this winter.

good luck

 

[Deleted member 31022]

23,000+ men were down bad so much, they came to this site.
JFL if you don't think that there's like 600x the amount of men who want this kind of info but can't find it.

yea someone like aestheticprimal or a guy who selling height growth course will make this more easier to understand and bring it on tiktok for promoting their products

 

[Deleted member 29747]

KY19382, from my understanding this will keep your plates open but will stop bone remolding correct me if i am wrong also what are the side effects it seems good and all but i feel like it will have very bad sides.

 

[Deleted member 30323]

Finally my boy ky getting some recognition.

But do be aware, it can also turn of tumkur supression genes, causing ultra cancer

 

[JCaesar]

Finally my boy ky getting some recognition.

But do be aware, it can also turn of tumkur supression genes, causing ultra cancer

What's the chances of that? Or is there a dose that can be avoided completely?

 

[Deleted member 30323]

What's the chances of that? Or is there a dose that can be avoided completely?

Nigger if you are talking about suddenly proliferation of cells, you are also taking about cancer. That's how biology works

 

[futureashtray]

Knowledge-wise, yes (in other domains).
Looks-wise, no.

I am likely to start this winter.

What do you mean “(in other domains)”

 

[futureashtray]

Nigger if you are talking about suddenly proliferation of cells, you are also taking about cancer. That's how biology works

nigger?

Also that can also happen if you take hgh/igf1 etc. using any hormones or etc to proliferate any cells will always have an increased risk for cancer

 

[7zyzz7]

kill a tall nigger and eat his thyroid gland primal style and you will grow taller #science

 

[enchanted_elixir]

What do you mean “(in other domains)”

I gained knowledge in areas outside of looksmaxing.
I should have made that statement clearer.

 

[enchanted_elixir]

Nigger if you are talking about suddenly proliferation of cells, you are also taking about cancer. That's how biology works

But, you'd have to be kind of unhealthy for that to be likely enough to stay away from.
If your DNA repair abilities and your immune system is in top shape, you don't have to be worried since the chance is so low.

 

[BloodClot]

Dnrd height is all genetics

 

[BloodClot]

23,000+ men were down bad so much, they came to this site.
JFL if you don't think that there's like 600x the amount of men who want this kind of info but can't find it.

Can you make a thread on the analytics of looksmax?

 

[enchanted_elixir]

Can you make a thread on the analytics of looksmax?

What would I write in the thread?

 

[vulcan_]

What do I run as a 15 yrs old?

 

[the_nextDavidLaid]

Tag nigger in upcoming threads

 

[Osie]

What do I run as a 15 yrs old?

Hit Pm's

 

[futureashtray]

Hit Pm's

ay bruh could u help me out too? im also 15

 

[Osie]

ay bruh could u help me out too? im also 15

Yup

 

[Ultravisionary Bism]

Join: https://incels.in/index.php and what animals is Alexs Jones talking about in this video? Answer: Frog

 

[Randolf]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

BMN-111 seems quite promising.

 

[Randolf]

This is Best of the Best. Please update.

 

[Deleted member 32440]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

Tldr; doesn't work on closedplatecels

 

[Randolf]

BMN-111 (?)
KY19382 (?)
Relaxin-2 (?)
BPC-157 (?)

Meclizine (?)

 

[futureashtray]

BMN-111 (?)
KY19382 (?)
Relaxin-2 (?)
BPC-157 (?)

Meclizine (?)

Talk about them bro

 

[Randolf]

Talk about them bro

I know nothing about them. Are they any good?