THE MOST UP TO DATE HEIGHTMAXXING STACK

[barnmatrix]

I have something similar to vosoritide. Also KY19382 is expensive af

what is it

 

[thereallegend]

what is it

meclizine

 

[barnmatrix]

meclizine

wheres the sources for meclizine improving height

 

[Xyjarz]

meclizine

Is it working? What dosage do you use?

 

[gooner888]

"heightmaxxing"

 

[tempelcat4]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

theory no one will do that irl

 

[Corpuscula]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

bro vosoritide on a 62kg guy is like 0.9mcg which is almost 1mg; meaning you would only get 10 days before it runs out even though its fricking 600$

 

[flippasav]

Nice, hope it makes a difference

 

[20/04/2008]

Take igf1-lr3 and aromasin (this is self explanatory)

and lastly add ky19382 and vosoritide

ky19382 inhibits the cxxc5 gene that regulates the wnt signaling pathway.

chatgpt summary of what the wnt signaling pathway does:

Wnt signaling pathway plays a significant role in the regulation of growth plates and ultimately influences a person's height. Here's how it works:

1. Chondrocyte Proliferation: Growth plates, also known as epiphyseal plates, are found at the ends of long bones in the body and are responsible for longitudinal bone growth. Within these plates, specialized cells called chondrocytes are responsible for producing new cartilage, which then turns into bone. The Wnt signaling pathway is involved in regulating the proliferation (multiplication) of these chondrocytes. Activation of Wnt signaling can promote chondrocyte proliferation, leading to bone growth.
2. Chondrocyte Differentiation: In addition to promoting cell proliferation, the Wnt pathway also influences the differentiation (maturation) of chondrocytes. Proper chondrocyte differentiation is essential for the orderly transition of cartilage to bone in the growth plates. Dysregulation of the Wnt pathway can disrupt this process and potentially impact bone growth.
3. Bone Remodeling: The Wnt signaling pathway also plays a role in the process of bone remodeling, which continues throughout life. This pathway helps maintain the balance between bone formation and bone resorption. Imbalances can affect overall bone density and potentially impact height.

Overall, the Wnt signaling pathway is crucial for the regulation of growth plates and, consequently, for determining a person's height. Dysregulation of this pathway can lead to growth disorders and skeletal abnormalities that can affect an individual's final height. However, it's important to note that the Wnt pathway is just one of many factors that influence height, and genetics, nutrition, hormones, and other factors also play significant roles.



the cxxc5 gene:

The CXXC5 gene, also known as IDAX (Inhibition of the Dvl and Axin complex protein), primarily functions as a regulator of the Wnt signaling pathway, as mentioned earlier. Here's a summary of what the CXXC5 gene does:

1. Negative Regulation of Wnt Signaling: CXXC5/IDAX acts as a negative regulator of the Wnt signaling pathway. It does so by interacting with key components of the pathway, including Disheveled (Dvl) and Axin. This interaction helps inhibit the Wnt signaling cascade, which is involved in various cellular processes, including cell proliferation and differentiation.

the cxxc5 gene is like the myostatin of chondrocyte proliferation and differentiation.




now vosoritide is this:

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research[1][2][3].
In Vitro	Vosoritide (0.1 μM; 1 h) decreases NPR2 phosphorylation in chondrocytes[2]. Vosoritide (0.1 μM; 6 d) improves chondrocyte differentiation and increases the proliferative growth plate area of cultured Fgfr3Y367C/+ femurs[2]. Vosoritide (10 μM; overnight) reduces ERK1/2 activation in ACH growth-plate chondrocytes[

the only problem is that you are going to have to work around the "For research use only. We do not sell to patients." thing.
and yeah normal vosoridite costs like $10,000+ usd but vosoritide acetate (its the same thing but instead of being in a liquid, its just powder/salt form) which is beneficial for dosing, can cost like $600 usd for 10mg. normal injection dose is 0.4mg.
So yeah all we need is to find out a way to bypass the "For research use only. We do not sell to patients."
LINKS

Vosoritide (BMN 111) | CNP Analogue | MedChemExpress

Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research. - Mechanism of...

www.medchemexpress.com

KY19382 (A3051) | CXXC5-DVL Inhibitor | MedChemExpress

KY19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β, with IC50s of 19 and 10 nM, respectively. KY19382 activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet...

www.medchemexpress.com

So what would be the best stack ???

 

[20/04/2008]

bro vosoritide on a 62kg guy is like 0.9mcg which is almost 1mg; meaning you would only get 10 days before it runs out even though its fricking 600$

Same for igf-1

 

[dellimogger9867]

I have pretty cheap (as in comparison to the 12-14,000$ sources) pharma vosoritide links.

does this work for post puberty? (closed growth plates)

 

[dellimogger9867]

Tldr; doesn't work on closedplatecels

what works for closed platecels?

 

[futureashtray]

does this work for post puberty? (closed growth plates)

obviously not.

there hasn’t been a single way to reopen growth plates

 

[übermog]

how much lr3 per day?