The obsession about DHT needs to end

How’s this ragebait? What do u have to contribute to this thread?
“The use of non‐aromatizable androgens, such as the use of the use of dihydrotestosterone in cis‐gender boys and oxandrolone in girls with Turner syndrome, has been found to increase height without advancing the bone age.”


"DHT increased skeletal mass by promoting bone growth and formation with concomitant increases in total body mass. DHT had greater effects on cortical bone and partially mitigated the suppressive effects of estrogen on bone growth and formation in the female skeleton."

 
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“The use of non‐aromatizable androgens, such as the use of the use of dihydrotestosterone in cis‐gender boys and oxandrolone in girls with Turner syndrome, has been found to increase height without advancing the bone age.”


"DHT increased skeletal mass by promoting bone growth and formation with concomitant increases in total body mass. DHT had greater effects on cortical bone and partially mitigated the suppressive effects of estrogen on bone growth and formation in the female skeleton."

Thanks bro
 
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and avoiding hairloss is easy with oral minox
dude holy fuck i genuinely thought your iq was 2x higher than that

how can you lack such basic surface level knowledge on mpb
 
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dude holy fuck i genuinely thought your iq was 2x higher than that

how can you lack such basic surface level knowledge on mpb
Its not wrong minox can slow down visible affects of MPB also were talking in puberty where MPB is very rare, and fin and dut would do the opposite of what im tryna support in my point since they both suppress dht
 
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Its not wrong minox can slow down visible affects of MPB
what the fuck does it matter if it doesnt slow it down, if you glue someone elses hair to your fucking scalp it will "stop the visible affects of mpb" too

the hairloss keeps progressing and every day this useless hormones keeps choking your hair follicles it will only become worse and worse you are not slowing shit you are temporarily inducing hair growth
were talking in puberty where MPB is very rare
not that rare for caucasians
fin and dut would do the opposite of what im tryna support in my point since they both suppress dht
and what are you trying to achieve? what is the almighty effect of DHT during puberty?
 
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make a dut sollution with raw powder from QSC or LDAR

i even got a precription for dut ( avodart in estonia ) 0.5mg pills, but i just CBA to renew it and im happy with the sollution

now i take 1mg EOD, and my dick is completely fine, if anything i think my sex drive is higher after taking dut
 
what the fuck does it matter if it doesnt slow it down, if you glue someone elses hair to your fucking scalp it will "stop the visible affects of mpb" too

the hairloss keeps progressing and every day this useless hormones keeps choking your hair follicles it will only become worse and worse you are not slowing shit you are temporarily inducing hair growth
I mean if u get MPB u can use fin i js didnt bother to elaborate since its rare in puberty
not that rare for caucasians
Yeh not that rare for caucus adultd
and what are you trying to achieve? what is the almighty effect of DHT during puberty?
?????
Its 5-10 times more potent than test cause of non aromatizable interaction with ARs in the urogenital tract, larynx, sebaceous glands, and osteoblasts in puberty SRD5A2 converts test to DHT in high concentrations then starts AR driven transcription of genes responsible for urogenital morphogenesis causing penis growth also in sebaceous glands it activates the MAPK/ERK signaling paths causes sebocyte differentiation and hyperplasia which relates with the onset of pubertal acne, AR mediated activation of the Wnt/B-catenin path within hair follicles cause terminal differentiation of hair into androgen sensitive regions affects mandibular beard region and thoracic hair which test on its own would fail to cause without the boost from DHT. Also DHT in bone development interacts with Runx2 transcription factors to cause the endochondral ossification of the mandibular condyles and maxillary processes thickening and angular projection of ur jawline, which everyone on here should know is important for male sexual dimorphism and this heightened androgenic activity boosts development of laryngeal prominence and subsequent laryngeal cartilage growth, which deepens ur voice thru DHT hypertrophy of the thyroarytenoid muscles in the larynx, thats the almight affect? Whyd u get so pissed at me dawg whatd i do to u 🤦‍♂️
 
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what the fuck does it matter if it doesnt slow it down, if you glue someone elses hair to your fucking scalp it will "stop the visible affects of mpb" too

the hairloss keeps progressing and every day this useless hormones keeps choking your hair follicles it will only become worse and worse you are not slowing shit you are temporarily inducing hair growth

not that rare for caucasians

and what are you trying to achieve? what is the almighty effect of DHT during puberty?
Mb ranted for no reason, it affects jawline, penis growth, voice deepening, bone density (no proof if test or dht affects more), and adams apple
 
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Its 5-10 times more potent than test cause of non aromatizable interaction with ARs in the urogenital tract, larynx, sebaceous glands, and osteoblasts in puberty SRD5A2 converts test to DHT in high concentrations then starts AR driven transcription of genes responsible for urogenital morphogenesis causing penis growth also in sebaceous glands it activates the MAPK/ERK signaling paths causes sebocyte differentiation and hyperplasia which relates with the onset of pubertal acne, AR mediated activation of the Wnt/B-catenin path within hair follicles cause terminal differentiation of hair into androgen sensitive regions affects mandibular beard region and thoracic hair which test on its own would fail to cause without the boost from DHT. Also DHT in bone development interacts with Runx2 transcription factors to cause the endochondral ossification of the mandibular condyles and maxillary processes reinforcing thickening and angular projection of ur jawline, which everyone on here should know is important for male sexual dimorphism and this heightened androgenic activity boosts development of laryngeal prominence and subsequent laryngeal cartilage growth, which deepens ur voice thru DHT hypertrophy of the thyroarytenoid muscles in the larynx
i find it extremely funny how many words u needed to say it aromatizes from test and grows a beard

what the actual fuck does it matter if its 5-10 more potent if its not present in significant amounts in tissue that MATTER?

holy fuck wow u will get a beard. are you a recessed subhuman that you need a beard?

DHT is not even proven to cause dick to grow in a non deficient male
same with bones natural dht does aboslute jack shit for bone growth because its present there in laughable amounts

both of these points can be confirmed by the fact you have people with no 5ar enzyme and their dick voice and male charesteristics are all completly normal, besides having no beard which would be a blessing for non frauding cucks

you can cope with all this theory but unless its proven to work and studied its complete cope, especially when all available practical evidence suggests the opposite
 
I mean if u get MPB u can use fin i js didnt bother to elaborate since its rare in puberty
no lil nigger you said the side effect of hairloss can be "visually slowed with oral minox" which is a completly retarded sentence for the reasons i stated above
 
i find it extremely funny how many words u needed to say it aromatizes from test and grows a beard
Nigga what DHT doesnt aromatize… that’s test
what the actual fuck does it matter if its 5-10 more potent if its not present in significant amounts in tissue that MATTER?
Ur wrong its synthesized locally in androgen responsive tissues like skin, genitalia, prostate, and hair follicles
holy fuck wow u will get a beard. are you a recessed subhuman that you need a beard?
Thats not the 1 reason i said
DHT is not even proven to cause dick to grow in a non deficient male
Yes it is
same with bones natural dht does aboslute jack shit for bone growth because its present there in laughable amounts
It still affects bone density cause it interacts with androgen receptors in osteoblasts which boosts bone mineralization
both of these points can be confirmed by the fact you have people with no 5ar enzyme and their dick voice and male charesteristics are all completly normal, besides having no beard which would be a blessing for non frauding cucks
Ur so wrong here they have ambiguous genitalia at birth, also they could develop some male characteristics from test but they still get impaired
you can cope with all this theory but unless its proven to work and studied its complete cope, especially when all available practical evidence suggests the opposite
This isnt a theory?
 
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no lil nigger you said the side effect of hairloss can be "visually slowed with oral minox" which is a completly retarded sentence for the reasons i stated above
Ur reasons were incorrect
 
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?????
Its 5-10 times more potent than test cause of non aromatizable interaction with ARs in the urogenital tract, larynx, sebaceous glands, and osteoblasts in puberty SRD5A2 converts test to DHT in high concentrations then starts AR driven transcription of genes responsible for urogenital morphogenesis causing penis growth also in sebaceous glands it activates the MAPK/ERK signaling paths causes sebocyte differentiation and hyperplasia which relates with the onset of pubertal acne, AR mediated activation of the Wnt/B-catenin path within hair follicles cause terminal differentiation of hair into androgen sensitive regions affects mandibular beard region and thoracic hair which test on its own would fail to cause without the boost from DHT. Also DHT in bone development interacts with Runx2 transcription factors to cause the endochondral ossification of the mandibular condyles and maxillary processes thickening and angular projection of ur jawline, which everyone on here should know is important for male sexual dimorphism and this heightened androgenic activity boosts development of laryngeal prominence and subsequent laryngeal cartilage growth, which deepens ur voice thru DHT hypertrophy of the thyroarytenoid muscles in the larynx, thats the almight affect? Whyd u get so pissed at me dawg whatd i do to u 🤦‍♂️

Nigga what DHT doesnt aromatize… that’s test

Ur wrong its synthesized locally in androgen responsive tissues like skin, genitalia, prostate, and hair follicles

Thats not the 1 reason i said

Yes it is

It still affects bone density cause it interacts with androgen receptors in osteoblasts which boosts bone mineralization

Ur so wrong here they have ambiguous genitalia at birth, also they could develop some male characteristics from test but they still get impaired

This isnt a theory?
@MA_ascender @wastedspermcel @Outerz14 gtfih he’s eviscerating the uncle
 
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Nigga what DHT doesnt aromatize… that’s test
already corrected u nigger
Ur wrong its synthesized locally in androgen responsive tissues like skin, genitalia, prostate, and hair follicles
YES YOU MOTHERFUCKING FUCKING NIGGER

YOU WANT TO HAVE FUCKING ACNE, HAIR LOSS AND ENLARGED PROSTATE SO MUCH?
Ur reasons were incorrect
yes they fucking were

you said something in the lines of "hair loss and acne sides can be easily fixed with oral minox and tane"
with accutane i agree.

but the hair loss part is completly retarded. as i said, you can GLUE some fucking hair on your head and you will "slow down visual effects of hair loss" too, it just completly misses the point, the hair loss is STILL progressing at the SAME rate you fucking nigger and it will only get worse and worse.
You are NOT fucking treating the side of hair loss, you are temporarily causing hair hair growth which does NOTHING for the actual hair loss thats happening.
 
Ur reasons were incorrect
you also said "muh if u have hair loss u can just go on fin i didnt tell u not too" or whatever the fuck

completly fucking retared

NIGGER THEN WHAT TYPE OF HAIR LOSS CAUSED BY DHT ARE YOU CORRECTING WITH THE FUCKING ORAL MINOX THEN? DO YOU HAVE TELLOGEN EFFLUVIUM OR SOME SHIT?
holy fuck nigger wow didnt know u can get other type of hair loss from dht
 
you also said "muh if u have hair loss u can just go on fin i didnt tell u not too" or whatever the fuck

completly fucking retared

NIGGER THEN WHAT TYPE OF HAIR LOSS CAUSED BY DHT ARE YOU CORRECTING WITH THE FUCKING ORAL MINOX THEN? DO YOU HAVE TELLOGEN EFFLUVIUM OR SOME SHIT?
holy fuck nigger wow didnt know u can get other type of hair loss from dht
808
 
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already corrected u nigger

YES YOU MOTHERFUCKING FUCKING NIGGER

YOU WANT TO HAVE FUCKING ACNE, HAIR LOSS AND ENLARGED PROSTATE SO MUCH?
DHT is synthesized in androgen sensitive tissues its the cause of both beneficial androgenic effects and some sides, acne and hair loss isnt guaranteed in everyone those issues are mainly genetically predisposed, DHT can cause hair loss in people with androgen sensitivity in their scalp but it affecting penis growth, jawline, and facial hair is more important
yes they fucking were
I was mainly talking about how DHT influences male development not only focusing on the sides
you said something in the lines of "hair loss and acne sides can be easily fixed with oral minox and tane"
with accutane i agree.

but the hair loss part is completly retarded. as i said, you can GLUE some fucking hair on your head and you will "slow down visual effects of hair loss" too, it just completly misses the point, the hair loss is STILL progressing at the SAME rate you fucking nigger and it will only get worse and worse.
You are NOT fucking treating the side of hair loss, you are temporarily causing hair hair growth which does NOTHING for the actual hair loss thats happening.
If u read the part i said right after that i stated that its extremely rare in puberty, i was being sarcastic if u couldnt tell, doesnt make me incorrect, u think i dont know that minox wouldnt supress dht? Ive had like 50 posts on this topic here…
Idk why u got so angry and u started reaching plus u made urself look stupid by making incorrect points
 
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If u read the part i said right after that i stated that its extremely rare in puberty, i was being sarcastic if u couldnt tell, doesnt make me incorrect, u think i dont know that minox wouldnt supress dht? Ive had like 50 posts on this topic here…
nigger WHAT? you literally did not fucking adress anything about the retarded fucking claim about hair loss caused by dht u said

again you fucking nigger "hair loss side from dht can be easily treated with oral minox" literally 0
it liteally wont do absolute fucking shit

i dont even give the fuck to argue about your retarded theoritical unproven effects of natural dht on bone growth, i literally couldnt give less fuck

please adress the retarded claim about hair loss
Idk why he crashin out over sarcasm he also looked stupid buddy said dht aromatizes 💀
i already corrected this i cba fucking read this shit 10 times i already wasted way too much time talking to you and reading your retarded rambling

what fucking nigger needs 10 lines of text to say dht grows beard, no sane person will care to discuss with you
 
nigger WHAT? you literally did not fucking adress anything about the retarded fucking claim about hair loss caused by dht u said

again you fucking nigger "hair loss side from dht can be easily treated with oral minox" literally 0
it liteally wont do absolute fucking shit

i dont even give the fuck to argue about your retarded theoritical unproven effects of natural dht on bone growth, i literally couldnt give less fuck

please adress the retarded claim about hair loss

i already corrected this i cba fucking read this shit 10 times i already wasted way too much time talking to you and reading your retarded rambling

what fucking nigger needs 10 lines of text to say dht grows beard, no sane person will care to discuss with you
and inb4 u pull out some study in some fucking petri dish or some shit by unproven i mean exactly that scenario

if u pull an actual study with a good sample size of HUMANS with natural DHT vs with no 5ar activity and get consistent, significant bone size differences only then you can claim its proven. not muh muh osteoblasts muh muh u fucking nigger, because its not how you determine if a drug or hormone or whatever substance is effective
 
nigger WHAT? you literally did not fucking adress anything about the retarded fucking claim about hair loss caused by dht u said

again you fucking nigger "hair loss side from dht can be easily treated with oral minox" literally 0
it liteally wont do absolute fucking shit

i dont even give the fuck to argue about your retarded theoritical unproven effects of natural dht on bone growth, i literally couldnt give less fuck

please adress the retarded claim about hair loss

i already corrected this i cba fucking read this shit 10 times i already wasted way too much time talking to you and reading your retarded rambling

what fucking nigger needs 10 lines of text to say dht grows beard, no sane person will care to discuss with you

Its not wrong minox can slow down visible affects of MPB also were talking in puberty where MPB is very rare, and fin and dut would do the opposite of what im tryna support in my point since they both suppress dht

Howd u quote me wrong i never said that i said like 10 words “for hairloss and acne” i was never referring to MPB

Again its not theoretical its science and i literally explained the science in my long first reply


Again u clearly didnt read it since i didnt only say dht causes beard growth
 
i was never referring to MPB
THEN TO FUCKING WHAT NIGGER? WHAT OTHER TYPE OF FUCKING HAIR LOSS DO YOU GET FROM DHT?

WERE YOU REFFERING TO FUCKING TELLOGEN EFFLUVIUM FROM FUCKING DHT OR WHAT?
 
and inb4 u pull out some study in some fucking petri dish or some shit by unproven i mean exactly that scenario

if u pull an actual study with a good sample size of HUMANS with natural DHT vs with no 5ar activity and get consistent, significant bone size differences only then you can claim its proven. not muh muh osteoblasts muh muh u fucking nigger, because its not how you determine if a drug or hormone or whatever substance is effective
I dont need a study nigga takes 1 google search
 

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THEN TO FUCKING WHAT NIGGER? WHAT OTHER TYPE OF FUCKING HAIR LOSS DO YOU GET FROM DHT?

WERE YOU REFFERING TO FUCKING TELLOGEN EFFLUVIUM FROM FUCKING DHT OR WHAT?
telogen effluvium is unrelated to DHT
I wasnt being hyper serious super strict when i said oral minox it was sarcasm, and again as i stated recommending dut and fin would be counterintuitive to my original point

Also ur pulling the 9898 strat by ignoring all my main points ur not a good debater bud
 
I dont need a study nigga takes 1 google search
ok you are actually braindead, and im not even talking about the fact u can google the most retarded shit and google will give u the most retarded and wrong anwser

you just dont understand that to be decided if a drug, hormone, whatever substance is effective in its theorhetical mechanism you need a proper study with good sample size, ideally clinical trial but bare fucking minimum a controlled study on humans, in this case:

people with no 5ar activity vs people with normal dht with a sample size of 2000 and in order to prove your claims you need to find consistent significant bone size difference
every single fucking neckbeard retard or an egghead can come up with muh science and mu theory, what matters is the results

i genuinely think you might be hoping no one realizes that and just listens to your blabbering with 0 fucking results behind it because it sounds smart, be a little pragmatic nigger please
 
telogen effluvium is unrelated to DHT
no fucking shit
Also ur pulling the 9898 strat by ignoring all my main points ur not a good debater bud
ur points are unsupported by fucking ANYTHING besides theory do you fucking get it? NOTHING, besides muh oseoblasts this muh that

it doesnt fucking mean shit unless you prove it consisntently with RESULTS
 
ok you are actually braindead, and im not even talking about the fact u can google the most retarded shit and google will give u the most retarded and wrong anwser
@halloweed @Outerz14 @MA_ascender
Is unc saying that dht doesnt interact with androgen receptors?
you just dont understand that to be decided if a drug, hormone, whatever substance is effective in its theorhetical mechanism you need a proper study with good sample size, ideally clinical trial but bare fucking minimum a controlled study on humans, in this case:

people with no 5ar activity vs people with normal dht with a sample size of 2000 and in order to prove your claims you need to find consistent significant bone size difference
every single fucking neckbeard retarded or an egghead can come up with muh science and mu theory, what matters is the results

i genuinely think you might be hoping no one realizes that and just listens to your blabbering with 0 fucking results behind it because it sounds smart, be a little pragmatic nigger please
Cases of complete 5AR deficiency are extremely rare, ur requesting a study thats impossible to do because u want to be right lmao
 
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@halloweed @Outerz14 @MA_ascender
Is unc saying that dht doesnt interact with androgen receptors?
Nah uncle has lost his mind DHT is literally potent because it binds to AR’s more than test.
 
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no fucking shit

ur points are unsupported by fucking ANYTHING besides theory do you fucking get it? NOTHING, besides muh oseoblasts this muh that

it doesnt fucking mean shit unless you prove it consisntently with RESULTS
Its not theory its mechanisms, the mechanisms are supported its the same reason i showed u the google AR pic and not a direct bone study, its because thats how the mechanism works
 
Cases of complete 5AR deficiency are extremely rare, ur requesting a study thats impossible to do because u want to be right lmao
then show fucking SOMETHING atleast

atleast 10 fucking people studied, ANYTHING u fucking nigger PLEASE dont be a fucking couch philosopher
 
Its not theory its mechanisms, the mechanisms are supported its the same reason i showed u the google AR pic and not a direct bone study, its because thats how the mechanism works
nigger dont act like a retard

u seriously think all those theories are not considered "mechanisms" by people who spew it?
 
nigger dont act like a retard

u seriously think all those theories are not considered "mechanisms" by people who spew it?
No because most ppl who make theories on here dont know anything they say, i study this not only as a hobby but soon as a job as im going into Med
 
No because most ppl who make theories on here dont know anything they say, i study this not only as a hobby but soon as a job as im going into Med
nigger you think being in med does anything to the effectivness of your theory? you think doctors arent wrong? you think what they say is always right?

apparently people in medicine can up with the most unsupported claim of all time by ZERO fucking proper research and claim it as fact
insane iq nigger
 
then show fucking SOMETHING atleast

atleast 10 fucking people studied, ANYTHING u fucking nigger PLEASE dont be a fucking couch philosopher
I never said that DHT itself causes significant changes in bone size in a way that would require large scale human studies to verify, in my original reply i talk about bone growth in mandibular condyles and maxillary processes as i stated and as is true DHT interacts with Runx2 transcription factors which affecfs jawline structure and sexual dimorphism
 
You are ALL gay faggots. Playing with your hormones during puberty is a BIG mistake.
 
nigger you think being in med does anything to the effectivness of your theory?
????? Yes? I study this?
you think doctors arent wrong? you think what they say is always right?
No theyre often wrong but i know im right
apparently people in medicine can up with the most unsupported claim of all time by ZERO fucking proper research and claim it as fact
insane iq nigger
Not medicine, medical
 
bone growth in mandibular condyles and maxillary processes as i stated and as is true DHT interacts with Runx2 transcription factors which affecfs jawline structure and sexual dimorphism
nigger you still dont get it? EVERYTHING CAN THEORETHETICALLY AFFECT BONE GROWTH

but fact of the matter is the bone growth is fucking LAUGHABLE even if the mechanism and theory is correct and it does jack fucking shit

thats why you need CONSISTENT and significant human research and improvement from said mechanism
 
and u say i dont adress ur points, ur a joke
I addressed all ur points? Maybe at most missed 1? U literally tried to change my words to support ur arguement didnt u try 3x to say that i only said that dht only affects hair growth? U completely ignored everything i said for 99% of this debate ur a loser
 
I addressed all ur points? Maybe at most missed 1? U literally tried to change my words to support ur arguement didnt u try 3x to say that i only said that dht only affects hair growth? U completely ignored everything i said for 99% of this debate ur a loser
i adressed all ur points and ur fucking "mechanisms" with what i said above

you literally dont have anything to say now because as med student you probably know im correct about the scale of your "mechanisms"
 
nigger you still dont get it? EVERYTHING CAN THEORETHETICALLY AFFECT BONE GROWTH
Wrong?
but fact of the matter is the bone growth is fucking LAUGHABLE even if the mechanism and theory is correct and it does jack fucking shit
So ur admitting i was right about it affecting bones growth?
thats why you need CONSISTENT and significant human research and improvement from said mechanism

Theres not gonna be human research, no issue with rat research
 
i adressed all ur points and ur fucking "mechanisms" with what i said above
No u didnt u just called me a nigger and thats about it? Pls show me where u addressed any of my points?
you literally dont have anything to say now because as med student you probably know im correct about the scale of your "mechanisms"
No ur incorrect? Again ur answers are the equivalent of saying “nuh uh im right”
 
Again u dont address my point or read the study ur unbelievable
wait till you find out dht has different effects on rats, you probably hope i dont know this since u thrive in scientific ignorance of this site

retards get impressed with 30 lines of text that pragmatically equals to nothing
 

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