asdvek
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The Randle Cycle, also called The Glucose-Fatty Acid Cycle describes the interaction between the 2 main dietary energy sources humans eat: Fat and Carbohydrates, more exactly the fact that they cannot both be used as an energy source.
When a person consumes both Fat and Carbohydrates in a single meal, more than half of both will be stored as fat (with a high percentage of Glucose being converted into Fat trough De Novo Lipogenesis and preferentially and stored in the Liver, causing NAFLD). That is because:
1) Fat inhibits the ability for Glucose to be used as an energy source: This is bypassed by exercise, thanks to the presence of Catecholamines (Adrenaline, Cortisol, ...) in the blood. If a person starts fasting, none of the stored Glycogen will be used as energy until all of the stored fat is completely used up.
2) Fat impairs the absorbtion of Glucose in the muscle by more than half
The consumption of both Fat and Carbohydrates leads to:
1) Impaired energy production and increased fat depositing
2) Widespread cell death due to Mitochondrial Damage
3) Increased inflammation troughout the body:
3.1) Hypothalamic Inflammation: Lowers the release of Growth Hormone Releasing Hormone (Growth Hormone), Thyrotropin Releasing Hormone (TSH -> T3 + T4 and Prolactin), Gonadotropin Releasing Hormone (FSH/LH -> Androgens/Estrogens), Prolactin Inhibiting Hormone (Dopamine), Corticotropin Releasing Hormone (ACTH), Vasopressin, ... which will also lead to the subsequent decrease of the number of receptors for most of these hormones (The ones released by the Pituitary) to decrease in the body.
It will also subsequently lead to decreased production of Collagen, Elastin (GH, Estrogen) and maintenance of blood water and mineral content (Vasopressin), which combined to the increased inflammation will decrease skin quality.
The lack of Androgens and Estrogen
3.2) Reduced insulin sensitivity
3.3) Reduced Albumin production, thus increased bioavailable Androgens and Estrogens, and other Sterols and Fatty Acids; increased Thyroid levels, etc.
3.4) Can possibly affect mood. It has been shown that anti-inflamatory drugs can improve symptoms of Depression which implies a link between the two
...
So which should you consume?:
A diet with very low to no fat will allow a person to lose weight while eating a relatively high amount of food and will greatly lower inflammation in the body, explaining the N=1 reports from people reporting quick weight loss, lowered depression and anxiety as well as the numerous scientific papers showing a short-term low-fat vegan diet reversing Insulin Resistance, Heart Disease, etc.
There are a few problems with this, however:
- You will still only use your body fat as an energy source for most of the body, but it will be impaired by Insulin in the short-term, although your sensitivity to it will be increased thanks to lowered inflammation and it may not be fully noticeable
- You will be deficient in many fat-soluble vitamins which are found in animal fats (I do not support the consumption of plant oils to anybody as they are inflammatory, contain an increased level of Omega 6s which should be kept as low as possible and cannot be offset by increased Omega 3s, as some would say, and they lack many nutrients that only animal fats have, or do contain them but in different forms with little to no use to the body): Vitamin A as Retinyl Esters, Vitamin D3, Vitamin K2, Vitamin E, Omega 3 as DHA/EPA, 6 as ARA, 7, 9 Animal FAs, Saturated and Unsaturated Animal FAs, Cholesterol
A diet with very low to no carbohydrates offers the same benefits as a low-fat diet, with the increased benefits of
- Acquiring all needed macro and micro nutrients required
- Not interrupting production of of hormones (which is influenced both ways by Insulin and other hormones strongly triggered by Carbohydrate consumption)
- Having stable energy troughout the day
- Having increased fat-burning and body temperature due to the effects of Fat in the Mitochondria (Causing a loss of energy causing heat and an increased caloric need).
- Avoiding many Xenoestrogens from plants and other food wrapping that will cause an imbalance of Estrogens/Androgens, possibly even lowering testosterone production in some cases due to Estrogen's effects interaction with the Hypothalamus and its control of the release of more Gonadotropins. Also reduced feminization of men in growing children.
...
You will also be able to create all Glucose you need trough Gluconeogenesis from Fat (Protein will only be used once there is no body or dietary Fat to be converted) and no dietary Carbohydrates are required, although it takes 1-2 weeks for your cells to adapt to the new energy source.
Does this apply to everyone?:
Clearly it does not. We have barely started to understand more about nutrition and how it affects the body mechanistically. There is no reason to doubt there are people out there with increased tolerances to this sort of feeding patterns, possibly an adaptation to the person's ancestors (parents, grandparents, ...) having similar mixed diets. There might also be other certain genes involved in this, but we also know very little about genetics at this point.
If you find that a mixed diet does not work for you and you want to see if there is anything to the kind of diet I am promoting here, you can try it out. Otherwise, you still have information in this thread trough which you can continue your own research if you wish to.
Real Life Examples:
Fruitarians
Fruitarians only eat Sugar. According to the findings surrounding The Randal Cycle, Glucose cannot be used by most of the body's cells and is only used as a fuel source during exercise, trough Cathecholamines, so the body will go a fasting-like state where the body fat of the person is used as energy, leaving the person looking skeleton-like.
When a person consumes both Fat and Carbohydrates in a single meal, more than half of both will be stored as fat (with a high percentage of Glucose being converted into Fat trough De Novo Lipogenesis and preferentially and stored in the Liver, causing NAFLD). That is because:
1) Fat inhibits the ability for Glucose to be used as an energy source: This is bypassed by exercise, thanks to the presence of Catecholamines (Adrenaline, Cortisol, ...) in the blood. If a person starts fasting, none of the stored Glycogen will be used as energy until all of the stored fat is completely used up.
2) Fat impairs the absorbtion of Glucose in the muscle by more than half
The consumption of both Fat and Carbohydrates leads to:
1) Impaired energy production and increased fat depositing
2) Widespread cell death due to Mitochondrial Damage
3) Increased inflammation troughout the body:
3.1) Hypothalamic Inflammation: Lowers the release of Growth Hormone Releasing Hormone (Growth Hormone), Thyrotropin Releasing Hormone (TSH -> T3 + T4 and Prolactin), Gonadotropin Releasing Hormone (FSH/LH -> Androgens/Estrogens), Prolactin Inhibiting Hormone (Dopamine), Corticotropin Releasing Hormone (ACTH), Vasopressin, ... which will also lead to the subsequent decrease of the number of receptors for most of these hormones (The ones released by the Pituitary) to decrease in the body.
It will also subsequently lead to decreased production of Collagen, Elastin (GH, Estrogen) and maintenance of blood water and mineral content (Vasopressin), which combined to the increased inflammation will decrease skin quality.
The lack of Androgens and Estrogen
3.2) Reduced insulin sensitivity
3.3) Reduced Albumin production, thus increased bioavailable Androgens and Estrogens, and other Sterols and Fatty Acids; increased Thyroid levels, etc.
3.4) Can possibly affect mood. It has been shown that anti-inflamatory drugs can improve symptoms of Depression which implies a link between the two
...
So which should you consume?:
A diet with very low to no fat will allow a person to lose weight while eating a relatively high amount of food and will greatly lower inflammation in the body, explaining the N=1 reports from people reporting quick weight loss, lowered depression and anxiety as well as the numerous scientific papers showing a short-term low-fat vegan diet reversing Insulin Resistance, Heart Disease, etc.
There are a few problems with this, however:
- You will still only use your body fat as an energy source for most of the body, but it will be impaired by Insulin in the short-term, although your sensitivity to it will be increased thanks to lowered inflammation and it may not be fully noticeable
- You will be deficient in many fat-soluble vitamins which are found in animal fats (I do not support the consumption of plant oils to anybody as they are inflammatory, contain an increased level of Omega 6s which should be kept as low as possible and cannot be offset by increased Omega 3s, as some would say, and they lack many nutrients that only animal fats have, or do contain them but in different forms with little to no use to the body): Vitamin A as Retinyl Esters, Vitamin D3, Vitamin K2, Vitamin E, Omega 3 as DHA/EPA, 6 as ARA, 7, 9 Animal FAs, Saturated and Unsaturated Animal FAs, Cholesterol
A diet with very low to no carbohydrates offers the same benefits as a low-fat diet, with the increased benefits of
- Acquiring all needed macro and micro nutrients required
- Not interrupting production of of hormones (which is influenced both ways by Insulin and other hormones strongly triggered by Carbohydrate consumption)
- Having stable energy troughout the day
- Having increased fat-burning and body temperature due to the effects of Fat in the Mitochondria (Causing a loss of energy causing heat and an increased caloric need).
- Avoiding many Xenoestrogens from plants and other food wrapping that will cause an imbalance of Estrogens/Androgens, possibly even lowering testosterone production in some cases due to Estrogen's effects interaction with the Hypothalamus and its control of the release of more Gonadotropins. Also reduced feminization of men in growing children.
...
You will also be able to create all Glucose you need trough Gluconeogenesis from Fat (Protein will only be used once there is no body or dietary Fat to be converted) and no dietary Carbohydrates are required, although it takes 1-2 weeks for your cells to adapt to the new energy source.
Does this apply to everyone?:
Clearly it does not. We have barely started to understand more about nutrition and how it affects the body mechanistically. There is no reason to doubt there are people out there with increased tolerances to this sort of feeding patterns, possibly an adaptation to the person's ancestors (parents, grandparents, ...) having similar mixed diets. There might also be other certain genes involved in this, but we also know very little about genetics at this point.
If you find that a mixed diet does not work for you and you want to see if there is anything to the kind of diet I am promoting here, you can try it out. Otherwise, you still have information in this thread trough which you can continue your own research if you wish to.
Real Life Examples:
Fruitarians
Fruitarians only eat Sugar. According to the findings surrounding The Randal Cycle, Glucose cannot be used by most of the body's cells and is only used as a fuel source during exercise, trough Cathecholamines, so the body will go a fasting-like state where the body fat of the person is used as energy, leaving the person looking skeleton-like.
