The truth about Minoxidil - The holy grail or overhyped Looksmin?

[harmonytingfam]

Grey

Joined Jul 1, 2025 Posts 4 Reputation 0

 

[Plushie]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Jonas, I gotta ask why do you have satan eating people as your signature

 

[Tigermoggerlol]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Manoxadil is cope

 

[joebart101]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

if u take potasium dont it make u less bloated? and remove the water

 

[Deleted member 249796]

Manoxadil is cope

retarded take

 

[Grievous]

if u take potasium dont it make u less bloated? and remove the water

 

[KKamikaze]

DNR+grey post.

 

[xSenii]

Should i use dermastamp with topical minox?
@SlayerJonas

 

[Alfons0_7252_]

Heh, atleast I have long eyelashes

View attachment 3682486

U look like clav

 

[buddy]

this is what people like me signed up for

 

[borninmay]

what if use oral minox and diuretics together?

 

[overheaveen]

Obviously yeah. MSM, 1-2ml castor oil orally every day, any oil topically and some other methods.

Hey jonas , is the effects from oral permanent? And will my supras loose fat from applying on eyebrows? And is castor oil really effective or just cope

I have decently long eyelashes I wanna push them so they became a halo

 

[Starborn]

Hey jonas , is the effects from oral permanent? And will my supras loose fat from applying on eyebrows? And is castor oil really effective or just cope

I have decently long eyelashes I wanna push them so they became a halo

nigga dragged and dropped @SlayerJonas avi

 

[overheaveen]

nigga dragged and dropped @SlayerJonas avi

Wdym

 

[Ezzah]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Ty

 

[Dagoyslopper]

i like minoxidil but i cant use it because ill get fat

 

[axttt_]

Can surely offset the bloat with diuretics no

 

[overheaveen]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Are the eyelash and brow effects from oral permanent?

 

[iblamemyhabits]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

wouldnt aldosterone make u excrete more potassium?

 

[iblamemyhabits]

Are there other things that can grow ur eye area hair?

castor oil + dermastamp is a good alternative

 

[iblamemyhabits]

dnr minox bloats me even on 100mg eplerenone fuck minox

switch to topical minox + dut

 

[KingFlingKong]

Obviously yeah. MSM, 1-2ml castor oil orally every day, any oil topically and some other methods.

what would you say is the best option

 

[TitusA]

Most of you are just fat slobs/copers with shit diets and you think you are lower bf than you are-vast majority of people underestimate their own bf%. If you actually got to a low bf% you would realise bloating isnt an issue on low doses. I got no bloat, also just saw an interview where clavicular said he uses it, doesnt look bloated in the face at all.

I refuse to believe that people that are low bf, active and not eating garbage are getting noticeable bloating from 2.5mg oral min.

 

[nr1fraudmaxxer]

combined with a loop diuretic either way because of the sodium and potassium retention it causes.

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone

So what are you saying a loop diuretic like furo or alodsterone antagonist like eplerenone? The bloat is mainly from excess sodium absorption earlier in the nephron like in the loop of henle which handles a big part of sodium absoption. So thats why eplerenone is so weak for oral min even though its an aldosterone antagonist and it works in the last part of the nephron where just a small fraction of the sodium is being handled.

 

[lightswinning]

@SlayerJonas Do you think applying vaseline/ aquaphor or similar barrier agents for the undereye and uppereyelid fat region can prevent most of the minox migration into the skin and one can keep abusing tropical minox for both lashes and brows with no sides? Curious to know what you think

 

[Trensticles]

m

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

Mirin the iq. Pt2 on the effects of minox on the scalp? topical and oral?

 

[whiteperson]

Old thread ik but where does one buy oral minox and Epleronone

 

[duromaxxing]

been on oral minox 2.5 mg for 2 months zero bloat

how about now?

 

[duromaxxing]

Most of you are just fat slobs/copers with shit diets and you think you are lower bf than you are-vast majority of people underestimate their own bf%. If you actually got to a low bf% you would realise bloating isnt an issue on low doses. I got no bloat, also just saw an interview where clavicular said he uses it, doesnt look bloated in the face at all.

I refuse to believe that people that are low bf, active and not eating garbage are getting noticeable bloating from 2.5mg oral min.

I sorta think the same way as you. clav is decently chiseled while on oral minoxidil, but at the same time this nigga is on crazy stimulants

 

[keegan]

Most of you are just fat slobs/copers with shit diets and you think you are lower bf than you are-vast majority of people underestimate their own bf%. If you actually got to a low bf% you would realise bloating isnt an issue on low doses. I got no bloat, also just saw an interview where clavicular said he uses it, doesnt look bloated in the face at all.

I refuse to believe that people that are low bf, active and not eating garbage are getting noticeable bloating from 2.5mg oral min.

People will listen to bro-science and stick to their castor oil routine and go bald because someone told them min bloated them. Myself and two of my longtime friends have been on min and fin/dut for YEARS and are leaner than 99.5% of the population. The only reliable lean scale is you having visible abs or not, we got people with no abs dropping min cause it "bloated" them.

 

[ssxjdgh]

View attachment 3682319
The truth about Minoxidil - Part 1​

Spoiler: Previous Part

The truth about ... - The new thread series, AMA

The truth about ... - Part 0 This thread series will cover compounds/concepts that are discussed daily on here. It's a crossover between @chadisbeingmade and me. Potentially other users too, lmk. The purpose is to shed light on the reality behind these compounds/concepts. The first...

looksmax.org

Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.

View attachment 3682324View attachment 3682326
​

This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.

---

History

Spoiler: History

Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.

Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension - PMC

Minoxidil is a direct vasodilator introduced in the early 1970s for the treatment of hypertension. It is capable of reducing blood pressure in most persons with resistant hypertension where therapy has failed with multidrug regimens. Minoxidil's ...

pmc.ncbi.nlm.nih.gov

And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes.

Appeal in PSL-Spaces

Spoiler: Appeal in PSL-Spaces

The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical

Spoiler: Topical

Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).

HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - PMC

Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that ...

pmc.ncbi.nlm.nih.gov

Oral

Spoiler: Oral

Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh ]
View attachment 3682288

Biology

Spoiler: Biology

The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

1. Minoxidil vasodilates blood vessels
2. Activation of RAAS
3. Aldosterone increase
4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?

View attachment 3682392

Conclusion

Spoiler: Conclusion

The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

• Topical Minoxidil on eyebrows, which also affects your lashes.
• Oral Minoxidil only in combination with an aldosterone-antagonist.

---

I hope you learned something new today.

Feel free to AMA.

Spoiler: Tags

@halloweed @menas @Zagro @Drugsmaxxer

@SlayerJonas is that you in your pfp?

 

[renn]

how about now?

i realized it was bloating me and switched back to topical

 

[Bl0odKn1ght]

@TR_prettyboymaxx789

 

[duromaxxing]

i realized it was bloating me and switched back to topical

 

[duromaxxing]

i realized it was bloating me and switched back to topical

So how long did it take u to bloat? and how ling till you switched to topical and start seeing the bloat decrease?

 

[Asterma]

Obviously yeah. MSM, 1-2ml castor oil orally every day, any oil topically and some other methods.

can you open up what you are sayin, How can you ascend your eyebrows without minoxidil then

 

[TitusA]

People will listen to bro-science and stick to their castor oil routine and go bald because someone told them min bloated them. Myself and two of my longtime friends have been on min and fin/dut for YEARS and are leaner than 99.5% of the population. The only reliable lean scale is you having visible abs or not, we got people with no abs dropping min cause it "bloated" them.

Yeah I think its for sure plausible that high dose oral minox (like used for blood pressure control previously) could cause bloat, but i dont see it in the microdoses used for hair loss.

 

[Grievous]

@SlayerJonas is that you in your pfp?

Bro