The truth about Minoxidil - The holy grail or overhyped Looksmin?

Jonasㅤㅤ

Jonasㅤㅤ

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1745703810980

The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.


1745703908154
1745703916272


This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

1745704037400


Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

1745702788170


It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.

Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).



Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
1745703172590




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

1745703297531


I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


1745704882337

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

1745703493347


In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer
 
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Heh, atleast I have long eyelashes

1745707016826
 
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thank you god for giving me thick Mediterranean eyebrows and eyelashes. only positive traits i have
 
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@Drugsmaxxer @MyDreamIsToBe183CM @Daddy's Home @JeanneDArcAlter @ThisCat
 
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@Drugsmaxxer @MyDreamIsToBe183CM @Daddy's Home @JeanneDArcAlter @ThisCat
Thanks man. Go read the thread y'all. :smonk:

@Gengar @wishIwasSalludon @sensitive young man @copercel123 @shia.jihadist
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

mirin hard, bookmarked
 
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Good thread man, detailed explanation ngl :love:
 
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Good thread man, detailed explanation ngl :love:
Thank you man, put a lot of effort into this as you can sense. :Comfy:

Can you tag a few more people please, thread's getting no engagement. :smonk:

@R@m@ @Mess @wastedspermcel @vrilmaxxer @You @Quncho atleast leave a comment alr :feelswhat:

 
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Are there other things that can grow ur eye area hair?
 
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Read every word. Good thread, thanks OP
 
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W thread
 
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Thank you man, put a lot of effort into this as you can sense. :Comfy:

Can you tag a few more people please, thread's getting no engagement. :smonk:

@R@m@ @Mess @wastedspermcel @vrilmaxxer @You @Quncho atleast leave a comment alr :feelswhat:

View attachment 3682573
You posted the thread a little late man but I’ll tag, it will for sure get more engagement tomorrow tho.

@copercel123 @Neucher @Bl0odKn1ght @BudgetBarrett @iblameCopecels
 
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You posted the thread a little late man but I’ll tag, it will for sure get more engagement tomorrow tho.

@copercel123 @Neucher @Bl0odKn1ght @BudgetBarrett @iblameCopecels
Brutal timezonepill tbh. Tomorrow is another day and shit :feelsbadman:
 
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bump bumpy
 
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bumpy
 
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Topical Minoxidil on eyebrows, which also affects your Lashes
Good thread but how would applying on eyebrows also affect lashes? Explain :owo:
 
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Read every molecule, and only understood 60% of it. :fuk:
Good work, Jonas, keep it up!
 
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Bookmarked

Good thread its keeps this dead Forum up :feelsautistic::feelsautistic:
 
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Good thread but how would applying on eyebrows also affect lashes? Explain :owo:
The Minoxidil applied on the eyebrows goes partially systemic affecting the blood vessels that supply the eyelashes with nutrients.
Read every molecule, and only understood 60% of it. :fuk:
Good work, Jonas, keep it up!
TL;DR: Only use topical Minoxidil on your eyebrows or oral Minoxidil ONLY with an Aldosterone-Antagonist.
Bookmarked

Good thread its keeps this dead Forum up :feelsautistic::feelsautistic:
Wonder what'll happen when I'm gone :feelsbadman:
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

Imagine getting bloated while on minox
Could never be me nigga
 
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@PrimalPlasty @4lt.Real @Fusionxz @Panzram @R@m@ read the thread :cop:
 
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Me after writing this thread and nobody even engages in the slightest :feelskek:

4500164 830341C0 4A02 46FE BBF8 9F962258B1C2

I hate mass-tagging but sometimes it has to be done type shit

@Bitchwhipper2 @TheLightOfMyLife @Evgeniy291 @castizo_ascender @itzyaboyJJ
 
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Me after writing this thread and nobody even engages in the slightest :feelskek:
(nobody cares) this thread got 30 rep bro

here's another +2 rep from me :)👍
 
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dnr minox bloats me even on 100mg eplerenone fuck minox
 
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I
Me after writing this thread and nobody even engages in the slightest :feelskek:

View attachment 3683817

I hate mass-tagging but sometimes it has to be done type shit

@Bitchwhipper2 @TheLightOfMyLife @Evgeniy291 @castizo_ascender @itzyaboyJJ
People don’t appreciate enough the effort someone give into threads.
I had threads that I worked hours on and still got maximum 20 replies (including me replying to other people:lul:)

But hey at least you reduce the competition jfl since everybody here are concise enjoyers :feelsuhh:

(I wrote all this shi for you to get bumped so rep me nigger)
 
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I

People don’t appreciate enough the effort someone give into threads.
I had threads that I worked hours on and still got maximum 20 replies (including me replying to other people:lul:)

But hey at least you reduce the competition jfl since everybody here are concise enjoyers :feelsuhh:

(I wrote all this shi for you to get bumped so rep me nigger)
i love your high iq takes
 
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I

People don’t appreciate enough the effort someone give into threads.
I had threads that I worked hours on and still got maximum 20 replies (including me replying to other people:lul:)

But hey at least you reduce the competition jfl since everybody here are concise enjoyers :feelsuhh:

(I wrote all this shi for you to get bumped so rep me nigger)
Agreed, I rep you either way nigga tho
 
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I use topical minoxidil on brows never got bloated using that shi, maybe it’s only oral that does it.
 
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Great thread, thanks for your contribution!
 
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What do you think about low dose oral minoxidil ? Should i still use a aldosterone antagonist on a low dose or will i be fine ?

@chadisbeingmade @Jonas2k7
 
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What do you think about low dose oral minoxidil ? Should i still use a aldosterone antagonist on a low dose or will i be fine ?

@chadisbeingmade @Jonas2k7
The bloat caused by Minoxidil in combination with an aldosterone-antagonist makes it like you are neither bloated nor debloated. So it equals out to 0.

@chadisbeingmade and I talked about this before. If the bloat is worth it for you then do it, like I mentioned in the thread decide what is more worth for you personally.
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

Eyebrows & lashes w bloat > bad eyebrows & lashes w no bloat tbh
IMG 1445
 
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Great thread brother read every molecule. Been wondering why my face has been so bloated despite being very lean, now i see it’s the 20mg of oral minoxidil ive been running for a year. Switching to topical minox + dut asap
 
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Great thread brother read every molecule. Been wondering why my face has been so bloated despite being very lean, now i see it’s the 20mg of oral minoxidil ive been running for a year. Switching to topical minox + dut asap
I hope the mechanism behind it was clear too, I tried my best explaining.

And yes, the 20mg of oral Minoxidil ed made you a bloatlord, topical Minoxidil and Dut sounds like a good plan.
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

mirin knowledge
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

wait, so my topical minoxidil is causing fatloss like lattise?

i always thought this wasnt the case
 
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mirin knowledge
Thanks bro. :feelsokman:
wait, so my topical minoxidil is causing fatloss like lattise?

i always thought this wasnt the case
Exactly, primarely because topical Minoxidil increases factors like PGE2 (same one in Latisse) like I mentioned in the thread.

So Minoxidil doesn't only "improve bloodflow to the hair follicles causing more nutrients to get to the hair follicle", but it also causes changes in gene expression to cause a better environment for the hair follicle.

Minoxidil increases PGE2.

There are a few studies suggesting Minoxidil may even decrease AR-mediated effects.


@chadisbeingmade @Donkeyballs @Clavicular @halloweed @DORIAN
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

1745842775130

I barely eat carbs. So no issue
 
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View attachment 3682319
The truth about Minoxidil - Part 1



Growing your eyelashes and eyebrows is one of the best and only true softmaxxes.

Because of that, many people choose compounds like Minoxidil to grow hairs in their eye area or even on the scalp.



This thread will reveal why you should be cautious with Minoxidil - And how it could actually harm your looks.



History
Minoxidil was developed for antihypertensive and vasodilative purposes.

View attachment 3682339

Though this use case was later dropped as even the developing scientists figured out that it isn't efficient at what it does.

It's the last resort when it comes to hypertension - Only being used when two agents and/or a diuretic aren't enough.


And not even monotherapy is a valid option. It has to be combined with a loop diuretic either way because of the sodium and potassium retention it causes. :feelskek:

Appeal in PSL-Spaces
The other use case beside hypertension is hair growth.

Unfortunately it's not the best option for stopping scalp hair loss as that is a mainly AR-mediated pathway.

That means it won't prevent any miniaturization of the hair follicle, @chadisbeingmade is going to make a thread covering the topic of 5ARIs.

The other use case is like I mentioned previously, growing the hairs in your eye area.

View attachment 3682266

It's an exaggerated example removing the hair completely obviously, but I hope you can see how important they are.

There are two ways you can grow them via Minoxidil: Topical and Oral.


Topical
Topical Minoxidil is pretty harsh on your eyes, that's why you should only apply it on your eyebrows.

Another thing is that Minoxidil can cause fat loss in your upper eyelid as Minoxidil stimulates factors like PGE2 (The active ingredient in Latisse).


Oral
Oral Minoxidil is very effective in growing your eyelashes, but more of that in the biology section.

[Brutal UEE right there, just look at the lashes duh :feelswhat:]
View attachment 3682288




Biology
The unfortunate truth is, if you are using Minoxidil you are going to retain a ton more water and be bloated.

This is primarely mediated by the activation of the Renin-Angiotensin-Aldosterone-System.

View attachment 3682292

I'll try to keep it short:

  1. Minoxidil vasodilates blood vessels
  2. Activation of RAAS
  3. Aldosterone increase
  4. Sodium, potassium and water retention

In short, this means your Aldosterone skyrockets making you retain a ton more sodium/potassium and consequently more water.

This means it's a big trade off, hair growth or bloat. What do you choose, no water retention or mogger eyelashes?


View attachment 3682392

Conclusion
The only possible solution to solve the bloat is using an aldosterone-antagonist.

View attachment 3682299

In theory using an aldosterone-antagonist like Eplerenone or Spironolactone should work, but even then there is quite some anecdotal evidence that this doesn't work.



TL;DR: There are only two viable options now:

  • Topical Minoxidil on eyebrows, which also affects your lashes.
  • Oral Minoxidil only in combination with an aldosterone-antagonist.




I hope you learned something new today. :feelsping:

Feel free to AMA.


@halloweed @menas @Zagro @Drugsmaxxer

Should I steam my face or use hot water first to open up my pores then apply minox for better effect? Aspie idea
 
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Good thread OP, ill move to BOTB in a few days. I like the part about aldosterone antagonism, but dont use spiro as its an anti androgen. EPL is much better and I know PSLers that use high doses daily to counteract roid bloat.
 
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Good thread OP, ill move to BOTB in a few days. I like the part about aldosterone antagonism, but dont use spiro as its an anti androgen. EPL is much better and I know PSLers that use high doses daily to counteract roid bloat.
Thank you very much bro.

About the spiro: Yeah I wouldn't recommend Spiro for long-term use, Epleronone just mogs.

"Eplerenone's selectivity reduces sex hormone-related adverse effects."

Spironolactone appears to agonize a multitude of different receptors, just going to cite Wikipedia for the sake of simplicity.

1745846136183


"The degree of feminization of the male foetuses which is achieved under the influence of sp (40 mg/day) is the same as that which can be induced by 1-3 mg cyproterone acetate."

For reference: Cyproterone acetate = anti androgen


Natties should only use Epleronone, though enhanced individuals could try to cope with Spiro if sourcing of Epleronone isn't an option during the cycle. (temporarily)

The anti androgenic effect of Spiro could be compared to how some ARBs like telmisartan reduce mTOR signalling, if the benefits outweigh the potential sides it could be considered a secondary option.

@chadisbeingmade
 
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only about 10% of oral min users get peripheral edema/bloating though so
 
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it's pretty rare with standard dosing btw what do you think of the interaction between propranolol and minoxidil? does one obstruct the other and what about cialis too
 
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only about 10% of oral min users get peripheral edema/bloating though so
Studies don't include the usual increase in water retention as it isn't statistically significant, they only care about safety concerns for the most part which is the case with severe edemas like in the cases below.

1745855488270


Breaking it down in numbers has nothing to do with the reality, Minoxidil does bloat just by the way it works.

it's pretty rare with standard dosing btw what do you think of the interaction between propranolol and minoxidil? does one obstruct the other and what about cialis too
Propranolol causes vasoconstriction, exactly the opposite of what Minoxidil does. @NorwoodAscender reported some kind of tellogen effluvium after abusing a bunch of vasocontricting compounds, he can correct me if I'm wrong.

Cialis is also a vasodilator, like with Minoxidil keep your blood pressure in check and watch out for any changes.

Also regarding your original statement, most users on here and reddit reported some kind of bloating. It surely isn't just 10% LOL.

1745855987378
1745856019204
1745856062928
1745856108943


They can update me if they changed their mind. @albanianblackguy @chadisbeingmade

1745856230792
1745856271196
1745856350843
 
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Studies don't include the usual increase in water retention as it isn't statistically significant, they only care about safety concerns for the most part which is the case with severe edemas like in the cases below.

View attachment 3687282

Breaking it down in numbers has nothing to do with the reality, Minoxidil does bloat just by the way it works.


Propranolol causes vasoconstriction, exactly the opposite of what Minoxidil does. @NorwoodAscender reported some kind of tellogen effluvium after abusing a bunch of vasocontricting compounds, he can correct me if I'm wrong.

Cialis is also a vasodilator, like with Minoxidil keep your blood pressure in check and watch out for any changes.

Also regarding your original statement, most users on here and reddit reported some kind of bloating. It surely isn't just 10% LOL.

View attachment 3687292View attachment 3687295View attachment 3687299View attachment 3687300

They can update me if they changed their mind. @albanianblackguy @chadisbeingmade

View attachment 3687308View attachment 3687310View attachment 3687313
i do not regret my decision at all, tho it kinda affected my leanmaxxing cuz i was debloated in my face i no longer wanted to lose fat but that aside i will never use minox again
 
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Studies don't include the usual increase in water retention as it isn't statistically significant
take a wild guess on what edema is bro
Also regarding your original statement, most users on here and reddit reported some kind of bloating. It surely isn't just 10% LOL.
anyone can pick out some anecdotes of people that had these adverse reactions but unless you have a non uniform sample space to look at and derive quantitative data (which is what these meta analytical studies do) then your anecdotes are effectively just polluted by confirmation bias and can be used the other way around
 
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