THE ULTIMATE ACCUTANE / ISOTRETINOIN GUIDE

[pentaChad_doomer]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding

Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products

Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay

Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption

In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

 

[pentaChad_doomer]

title

 

[pentaChad_doomer]

bump this

 

[orbitro]

mirin

 

[unon]

Nice use of colours

 

[richoxne]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

MIRIN

 

[orbitro]

Nice use of colours

fr very impressive formatting for a grey

 

[neuroincelvergent44]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

thanks g

 

[RODER]

1000th accutane guide
i just take it and sleep and i barely go out in the morning so i skip the sunscreen part
mirin effort tho
good post

 

[xandylooksmaxs]

mirin bhai

 

[bigseedy]

good thread

 

[pentaChad_doomer]

thanks man

good thread

 

[appealisLAW]

is 20mg a day good dosage for very mild occasional breakouts and neck/scalp acne that are very mild also? i might up the dosage to 30 later for faster cumulative dose reach (8,5-9g)

 

[pentaChad_doomer]

is 20mg a day good dosage for very mild occasional breakouts and neck/scalp acne that are very mild also? i might up the dosage to 30 later for faster cumulative dose reach (8,5-9g)

yes bro

 

[vzk]

Whats the isotret dosing protocol for shrinking my nose?

 

[pentaChad_doomer]

10-16mg would nice

Whats the isotret dosing protocol for shrinking my nose?

 

[UMIRIN]

preciate it G hopefully getting it prescribed soon

 

[notaTQ]

W very informative for beginners, mirin the effort.

 

[StyIix]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

I MEEDED this so fucking bad literally couldn’t find another guide. Buying accutane very soon

 

[StyIix]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

for 63.5kg low dose 20 how long would that take?

 

[cometohaunted]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

DNR but finally a good fucking accutane guide thats actually teaching people about cumulative dosing FUCKING MIRIN REP THIS GUY FOR U LOWIQ GREYCELS!!^^^

 

[cometohaunted]

1000th accutane guide
i just take it and sleep and i barely go out in the morning so i skip the sunscreen part
mirin effort tho
good post

best one yet

 

[cometohaunted]

I genuinely can't fucking stress how much people on org discord server and on this forum don't fucking understand and give the worst advice like "just low dose accutane brah" or "just do 1mg ur body weight brah!!!" when it's not that simple you need to understand cumulative dosing and how derms actually prescribe this treatment. Thank fucking God bro

 

[pentaChad_doomer]

preciate it G hopefully getting it prescribed soon

Good luck man

 

[pentaChad_doomer]

I MEEDED this so fucking bad literally couldn’t find another guide. Buying accutane very soon

im glad u liked it

 

[pentaChad_doomer]

for 63.5kg low dose 20 how long would that take?

it’s gonna be about 12 months.
So yeah, on a dose like 20 mg, the treatment is much longer, but usually with fewer side effects compared to higher doses

 

[billiardcell]

I have a question please, knowing that higher doses of isotretinoin reach the cumulative dose faster, will that make the results better ?

 

[pentaChad_doomer]

I have a question please, knowing that higher doses of isotretinoin reach the cumulative dose faster, will that make the results better ?

not necessarily better just faster and rougher

 

[pentaChad_doomer]

not necessarily better just faster and rougher

they just compress the timeline and increase risk
If u can tolerate it, fine

 

[1966Ford]

Worthy thread

 

[billiardcell]

not necessarily better just faster and rougher

thank you!

 

[pentaChad_doomer]

thank you!

np bro

 

[Mazilias]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

DNR but looks good

 

[Shanny]

Accutane and Isotretinoin
Mega Guide
​

This guide is meant for people who are currently taking isotretinoin or are considering starting it. In this guide im gonna explain u everything in one place:

• how dosing actually works​
• what side effects to expect​
• how long the treatment should last​
• how to reduce side effects​

1. What Accutane (Isotretinoin) actually is
Isotretinoin is the strongest acne medication currently available. It works through several mechanisms:

• Reduces oil production
• Decreases acne-causing bacteria
• Normalizes skin cell turnover

Because of this, isotretinoin can permanently clear acne in around 80–90% of patients after a full course.

View attachment 4739012 View attachment 4739014


2. The most important concept: Cumulative dose
One of the biggest misunderstandings about isotretinoin is dosing. Many people think the treatment depends on daily dose.
But in reality, derms focus on total cumulative dose over the entire treatment.

Most dermatology guidelines recommend a cumulative dose of:
120–150 mg per kilogram of body weight
Example calculation:
If someone weighs 70 kg

70 × 120 = 8400 mg
70 × 150 = 10500 mg

So the total course should reach around 8400–10500 mg.
Stopping treatment before reaching this cumulative dose significantly increases the risk of acne relapse.
3. Typical isotretinoin dosing strategies
There are generally three dosing approaches used by dermatologists.

Low-dose Protocol
0.1 – 0.3 mg/kg/day

Pros:
• fewer side effects
• easier to tolerate

Cons:
• longer treatment duration (sometimes up to 12–18 months)

Standart Protocol
0.5 – 1 mg/kg/day

Example:
70 kg person: 35 – 70 mg per day

Typical treatment length: 4–6 months.

High-dose Protocol
Up to 2 mg/kg/day

Usually used for severe nodulocystic acne.
Higher doses may reduce relapse rates but usually increase side effects.


4. Isotretinoin dosing table by body weight

Weight	Low dose	Standard dose	High dose
50 kg	15 mg/day	25 mg/day	50 mg/day
60 kg	20 mg/day	30 mg/day	60 mg/day
70 kg	20–25 mg/day	35 mg/day	70 mg/day
80 kg	25 mg/day	40 mg/day	80 mg/day
90 kg	30 mg/day	45 mg/day	90 mg/day
100 kg	30–35 mg/day	50 mg/day	100 mg/day

5. Example cumulative dose calculation
Example:
Someones weight = 70 kg

Target cumulative dose:
8400 – 10500 mg

If someone takes 40 mg per day
8400 ÷ 40 = 210 days
10500 ÷ 40 = 262 days

Estimated treatment duration:
7–9 months
(This is exactly the way for u or ur derm to calculate the cumulative dose)


6. What to expect month by month
Many people panic because they don't know what the treatment timeline looks like.
Here’s the typical progression:

Month	What Usually Happens
Month 1	Most people start experiencing very dry lips, dry skin, dry nose, and irritation. Many patients go through a purge phase, where acne temporarily gets worse. This happens because isotretinoin accelerates skin cell turnover and pushes clogged pores to the surface faster.

Month	What Usually Happens
Month 2–3	Oil production begins to drop significantly. Breakouts become less frequent, and skin becomes noticeably less greasy. Dryness usually becomes more noticeable during this period.

Month	What Usually Happens
Month 4–5	Many patients become almost completely clear at this stage. Remaining issues may include redness or post-acne marks rather than active acne.

Month	What Usually Happens
Month 6+	Once the target cumulative dose is reached, treatment usually ends. Skin may continue improving for 1–2 months after finishing the medication.

7. Things you should always do on Accutane ​

Moisturize aggressively
Because ur skin barrier becomes very fragile. U MUST-HAVE products like:

View attachment 4739081 View attachment 4739085
U should definitely have lip balm or even just vaseline, otherwise ur lips will get so dry and start bleeding


View attachment 4739131 View attachment 4739136
Then we go to moisturizer. U can buy any other good moisturizers, but i would recommend u to buy these products


View attachment 4739142
Next, it's crucial to buy a good SPF, as u simply can't go outside without it. Most importantly, don't forget to reapply it every 2-3 hours if u do go outside. Buy 50+ SPF. In my case its La Roche-Posay


View attachment 4739155
Also u should have any topical tretinoins. This will help ur skin actively get rid of pimples that will appear for the first 2 months. (U CAN USE IT ONLY AT NIGHT)

Take isotretinoin with food
Isotretinoin is fat soluble. Taking it with food significantly improves absorption
View attachment 4739229
In other words, without fat you may be missing out on approximately 50-60% of your intake

8. Basic Skincare Routine on Isotretinoin​

Your skin becomes much more sensitive and fragile during treatment because isotretinoin dramatically reduces oil production and weakens the skin barrier.
if u keep using the same aggressive products u used before, u will likely end up with:

• irritation
• redness
• burning skin
• extreme dryness

Ur routine should stay very simple.

Morning routine:
1. Gentle cleanser (U also can wash ur face with water)
2. Moisturizer (then wait for 15min)
3. SPF

Night routine:
1. Gentle cleanser
2. Topical Tretinoin (be sure to wait 15-20 minutes for the tretinoin to be absorbed fully)
3. Moisturizer

That’s usually enough. Also dont forget about lip balm, u need to reapply it every hour.
Overcomplicating ur routine while on isotretinoin often makes things worse

9. Will acne come back?​

Statistics suggest:
• around two thirds of patients remain clear long term
• around one third may need another course

So, after u complete the course, u and ur derm wait a month for clear skin. Basically, u're doing absolutely nothing for ur skin. it's supposed to stay clear forever, and then u'll go into remission. Don't forget that acne is a chronic condition that has no cure, and if even a course of systemic retinoids doesn't help, it's all down to ur genetics. So yeah, that’s basically everything u must learned about isotretinoin and what to expect during the course.

BUMP BUMP THIS

Kind of general knowledge atp but I guess it's a good guide for someone that might be clueless regarding the topic. Also the skincare routine you dropped at the end to use during your isotretinoin course is unnecessary imo, one of the attractive things about accutane is precisely not having to do anything topical. And most importantly tretinoin while on isotretinoin is generally not recommended because tretinoin is kind of harsh and isotretinoin already makes the skin more sensitive while on it, also kinda unnecessary.