Tired of iqlets coping with erda

[FoidRaper333SS]

Recently, I've been seeing a lot of iqlets coping with Erdafitinib, thinking it's somehow going to change their height or make them taller. This seems to come from the assumption that FGFR3 inhibition alone will promote growth, while ignoring the fact that Erdafitinib is a pan-FGFR inhibitor with significant effects on multiple FGFR pathways.
Erdafitinib inhibits FGFR2, which directly governs growth plate biology. Silencing FGFR2IIIc narrows the proliferative and hypertrophic chondrocyte zones, reduces IHH and PTHrP expression, delays ossification, and suppresses RUNX2/SPP1 all essential for longitudinal growth. FGFR3 inhibition in isolation could theoretically be growth promoting, but the simultaneous FGFR2 damage far outweighs any benefit and Erdafitinib even inhibits fgfr4, wich can cause severe eye damages. So probably the worst fgfr3

 

[25 m-a-x]

Recently, I've been seeing a lot of iqlets coping with Erdafitinib, thinking it's somehow going to change their height or make them taller. This seems to come from the assumption that FGFR3 inhibition alone will promote growth, while ignoring the fact that Erdafitinib is a pan-FGFR inhibitor with significant effects on multiple FGFR pathways.
Erdafitinib inhibits FGFR2, which directly governs growth plate biology. Silencing FGFR2IIIc narrows the proliferative and hypertrophic chondrocyte zones, reduces IHH and PTHrP expression, delays ossification, and suppresses RUNX2/SPP1 all essential for longitudinal growth. FGFR3 inhibition in isolation could theoretically be growth promoting, but the simultaneous FGFR2 damage far outweighs any benefit and Erdafitinib even inhibits fgfr4, wich can cause severe eye damages. So probably the worst fgfr3

true but who is taking erda alone tho?

 

[FoidRaper333SS]

That's exactly my point. If Erda only 'works' when stacked with several other compounds, then attributing any height gains to Erda itself becomes questionable

 

[nwed]

Recently, I've been seeing a lot of iqlets coping with Erdafitinib, thinking it's somehow going to change their height or make them taller. This seems to come from the assumption that FGFR3 inhibition alone will promote growth, while ignoring the fact that Erdafitinib is a pan-FGFR inhibitor with significant effects on multiple FGFR pathways.
Erdafitinib inhibits FGFR2, which directly governs growth plate biology. Silencing FGFR2IIIc narrows the proliferative and hypertrophic chondrocyte zones, reduces IHH and PTHrP expression, delays ossification, and suppresses RUNX2/SPP1 all essential for longitudinal growth. FGFR3 inhibition in isolation could theoretically be growth promoting, but the simultaneous FGFR2 damage far outweighs any benefit and Erdafitinib even inhibits fgfr4, wich can cause severe eye damages. So probably the worst fgfr3

thats why erda is mid

 

[bluebandz]

That's exactly my point. If Erda only 'works' when stacked with several other compounds, then attributing any height gains to Erda itself becomes questionable

Not necessarily. The other compounds would also not work alone

 

[birthdefect]

Recently, I've been seeing a lot of iqlets coping with Erdafitinib, thinking it's somehow going to change their height or make them taller. This seems to come from the assumption that FGFR3 inhibition alone will promote growth, while ignoring the fact that Erdafitinib is a pan-FGFR inhibitor with significant effects on multiple FGFR pathways.
Erdafitinib inhibits FGFR2, which directly governs growth plate biology. Silencing FGFR2IIIc narrows the proliferative and hypertrophic chondrocyte zones, reduces IHH and PTHrP expression, delays ossification, and suppresses RUNX2/SPP1 all essential for longitudinal growth. FGFR3 inhibition in isolation could theoretically be growth promoting, but the simultaneous FGFR2 damage far outweighs any benefit and Erdafitinib even inhibits fgfr4, wich can cause severe eye damages. So probably the worst fgfr3

it still significantly increases height velocity
although at cancer patient doses but still
not recommending it tho, just save for tyra