hej1377
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I would like to start of by saying that theres a reason its marked as theory because this is all very speculative
What is TLQP-62?
TLQP is a peptide which comes from vgf protein, TLQP then stimulates bdnf release
The full procces is TLQP gets to the hippocampus, stimulates bdnf to be released and then act on the PI3K/AKT,MAPK/ERK and PLCy pathways and it does all this by first binding to the trkb receptor and requires glutamate and ndma signaling to do this
Now all this leads to neural survival more,stronger and stable synapses. Now i bet this doesnt seem revolutionairy because it seems very similar to the bdnf part of cerebrolysin but the diffrence is that cerebrolysin just contains a similar compound to mimic bdnf so this will have huge effect on damaged brains that are unable to replenish these neurotrophic factors
But somewhat healthy brains most likely can produce these somewhat close to the max of what you can use. The diffrence between the max and what youre likely to be able to produce is still there which is why cerebrolysin shows great results but youll still have a "celling". This could possibly be better due to it directly stimulating bdnf to actually be released and not just sit there
What are the limitations?
This peptide has only been in preclinicals and never been tested by humans, atleast from what we know since all the studies are on mice and i couldnt find anyone talking about this anywhere.
What would dosing look like?
This is a bit speculative but if we adjust it for humans its about 0,2-0,5mg that what we want in the hypocampus and when its in lyophilized form even tho its fucking huge(≈kda) i think its fair to eatimate that about 5% gets into the brain which would be 4-10mg intranasaly
pubmed.ncbi.nlm.nih.gov
According to this effects can last a week
www.nature.com
And according to this changes start happening very quick,just minutes 10-30,but it still seems unknown when noticeable effects start happening and not just an observable increase in vgf and cgb proteins
Sourcing?
Surprisingly this seems petty easy to source,found 20mg lyophilized for ish 60$ and another lab selling it in higher quantities,this may indicate a pretty low price per mg but ill see how much it is when they answer my enquiry
Is it better than cerebrolysin? Final verdict
I think that i cant say thats it definitely better even if it is as good as its promising since cerebrolysin is more broad and helps with creating veins,GDNF,CNTF,NGF and a few more but bdnf seems most responsible for the effects that most people use cere for. And TLQP-62 seems better strictly for BDNF which is the biggest reason for the massive increase in memory and learning and if cerebrolysin already can have such drastic effects im very interested in what TLQP can do
But imo it seems atleast very very interesting, more interesting than cerebrolysin for me atleast. I also feel very inclined to just take for the team and try this out but its still a bit scary since no one has tried it so i hope someone is low inhib enough to try it before me
What is TLQP-62?
TLQP is a peptide which comes from vgf protein, TLQP then stimulates bdnf release
The full procces is TLQP gets to the hippocampus, stimulates bdnf to be released and then act on the PI3K/AKT,MAPK/ERK and PLCy pathways and it does all this by first binding to the trkb receptor and requires glutamate and ndma signaling to do this
Now all this leads to neural survival more,stronger and stable synapses. Now i bet this doesnt seem revolutionairy because it seems very similar to the bdnf part of cerebrolysin but the diffrence is that cerebrolysin just contains a similar compound to mimic bdnf so this will have huge effect on damaged brains that are unable to replenish these neurotrophic factors
But somewhat healthy brains most likely can produce these somewhat close to the max of what you can use. The diffrence between the max and what youre likely to be able to produce is still there which is why cerebrolysin shows great results but youll still have a "celling". This could possibly be better due to it directly stimulating bdnf to actually be released and not just sit there
What are the limitations?
This peptide has only been in preclinicals and never been tested by humans, atleast from what we know since all the studies are on mice and i couldnt find anyone talking about this anywhere.
What would dosing look like?
This is a bit speculative but if we adjust it for humans its about 0,2-0,5mg that what we want in the hypocampus and when its in lyophilized form even tho its fucking huge(≈kda) i think its fair to eatimate that about 5% gets into the brain which would be 4-10mg intranasaly
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine - PubMed
Patients with major depressive disorder (MDD) often have structural and functional deficits in the ventromedial prefrontal cortex (vmPFC), but the underlying molecular pathways are incompletely understood. The neuropeptide precursor VGF (non-acronymic) plays a critical role in depression and...
pubmed.ncbi.nlm.nih.gov
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function - Translational Psychiatry
The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo molecules. The expression of the VGF protein...
www.nature.com
Sourcing?
Surprisingly this seems petty easy to source,found 20mg lyophilized for ish 60$ and another lab selling it in higher quantities,this may indicate a pretty low price per mg but ill see how much it is when they answer my enquiry
Is it better than cerebrolysin? Final verdict
I think that i cant say thats it definitely better even if it is as good as its promising since cerebrolysin is more broad and helps with creating veins,GDNF,CNTF,NGF and a few more but bdnf seems most responsible for the effects that most people use cere for. And TLQP-62 seems better strictly for BDNF which is the biggest reason for the massive increase in memory and learning and if cerebrolysin already can have such drastic effects im very interested in what TLQP can do
But imo it seems atleast very very interesting, more interesting than cerebrolysin for me atleast. I also feel very inclined to just take for the team and try this out but its still a bit scary since no one has tried it so i hope someone is low inhib enough to try it before me
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