topical anti estrogen.

[Orc]

dumping this here before I forget.

I was reading on cock growth in rats caused by metribolone.

Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis - PubMed

Smooth-muscle cells cultured from the penis of sexually immature (I-PSMC) and adult (A-PSMC) rats express similar high levels of the androgen receptor (AR) mRNA. This contrasts with the marked in vivo decline of both AR mRNA and androgen binding in the penile smooth muscle of adult rats, which...

pubmed.ncbi.nlm.nih.gov

but there's a little issue because testosterone (not metribolone, this doesn't convert into estrogen it seems) can down regulate the expression.

Testosterone down-regulates the levels of androgen receptor mRNA in smooth muscle cells from the rat corpora cavernosa via aromatization to estrogens - PubMed

Androgens down-regulate the levels of androgen receptors (AR) and AR mRNA in the penis and prostate of castrated rats, and are assumed to cause their decrease during sexual maturation in the penile smooth muscle of intact rats. In order to determine whether these effects occur directly at the...

pubmed.ncbi.nlm.nih.gov

to combat this I figured maybe I could prep a topical anti-estrogen, and I was initially going with aromasin, but this wouldn't work because it doesn't dissolve all that well and also doesn't penetrate the skin much.

anastrozole is a better option because it absorbs through the skin better and is water soluble.

and someone is already trying to do something similar: https://patents.google.com/patent/US11185504B2/en

okay, so.

since it dissolves readily, all you'd have to do is mix the anastrozole with propylene glycol + alcohol.

and then mix it with a PLO gel.

''Lecithin Organogel is a ready-made mixture of Lecithin and Isopropyl Palmitate. Together they are an absorption enhancer, emulsifier and a solvent. Lecithin Organogel is commonly used with Pluronic Gel 20% or 30% to form a PLO transdermal gel''

concentration would be roughly 1mgml, so if you have 100ml of it prepped you'd need 100mg of anastrozole.

don't ask me why I'm looking into this, it's not for myself.

 

[gymcel64]

so you trynna cook up a magic potion to grow people's dicks?

 

[Orc]

so you trynna cook up a magic potion to grow people's dicks?

actually this would be the most effective for inducing bottom growth in clitoral tissue.

but yes basically.

 

[charliewillascend]

no more 2 inches

 

[Orc]

no more 2 inches

luckily I don't have to worry about my own.

 

[asdvek]

This will fuck up the skin i bet and u wont be able to explain it to the doctor

 

[Orc]

This will fuck up the skin i bet and u wont be able to explain it to the doctor

none of these ingredients will do much besides cause some dryness but yes starving tissue of estrogen probably isn't a good idea unless you've got a reason for it.


these are just theoretical ramblings I'm cooking up while high.

 

[asdvek]

starving tissue of estrogen probably isn't a good idea

 

[HostSamurai]

so you trynna cook up a magic potion to grow people's dicks?

reminds me of ads in the early 10s

'this fruit will make your dick bigger!" lol

 

[albanianblackguy]

dumping this here before I forget.

I was reading on cock growth in rats caused by metribolone.

Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis - PubMed

Smooth-muscle cells cultured from the penis of sexually immature (I-PSMC) and adult (A-PSMC) rats express similar high levels of the androgen receptor (AR) mRNA. This contrasts with the marked in vivo decline of both AR mRNA and androgen binding in the penile smooth muscle of adult rats, which...

pubmed.ncbi.nlm.nih.gov

but there's a little issue because testosterone (not metribolone, this doesn't convert into estrogen it seems) can down regulate the expression.

Testosterone down-regulates the levels of androgen receptor mRNA in smooth muscle cells from the rat corpora cavernosa via aromatization to estrogens - PubMed

Androgens down-regulate the levels of androgen receptors (AR) and AR mRNA in the penis and prostate of castrated rats, and are assumed to cause their decrease during sexual maturation in the penile smooth muscle of intact rats. In order to determine whether these effects occur directly at the...

pubmed.ncbi.nlm.nih.gov

to combat this I figured maybe I could prep a topical anti-estrogen, and I was initially going with aromasin, but this wouldn't work because it doesn't dissolve all that well and also doesn't penetrate the skin much.

anastrozole is a better option because it absorbs through the skin better and is water soluble.

and someone is already trying to do something similar: https://patents.google.com/patent/US11185504B2/en

okay, so.

since it dissolves readily, all you'd have to do is mix the anastrozole with propylene glycol + alcohol.

and then mix it with a PLO gel.

View attachment 3485155

''Lecithin Organogel is a ready-made mixture of Lecithin and Isopropyl Palmitate. Together they are an absorption enhancer, emulsifier and a solvent. Lecithin Organogel is commonly used with Pluronic Gel 20% or 30% to form a PLO transdermal gel''

concentration would be roughly 1mgml, so if you have 100ml of it prepped you'd need 100mg of anastrozole.

don't ask me why I'm looking into this, it's not for myself.

too many complicated words funny plant man but can this fix gyno

 

[roider122]

actually this would be the most effective for inducing bottom growth in clitoral tissue.

but yes basically.

Estrogen deficiencyfucked my pumps

-0. 5 inch

 

[Orc]

too many complicated words funny plant man but can this fix gyno

I've seen people do that with topical dht, which you can produce similarly to this using proviron.

Estrogen deficiencyfucked my pumps

-0. 5 inch

I can imagine yes, however this would be temporally.

 

[roider122]

I've seen people do that with topical dht, which you can produce similarly to this using proviron.

I can imagine yes, however this would be temporally.

Btw my dick didnt grow single milimeter while on hgh+ai for 9 months at 16

Went 15.5 to 14

 

[Orc]

Btw my dick didnt grow single milimeter while on hgh+ai for 9 months at 16

Went 15.5 to 14

I mostly formulated this with the idea of growing clits, not cocks to be honest.

not the weirdest thought I've had while high.

 

[roider122]

I think that if we keep estrogen at a level that will not prevent the pump effect, 20-60 and androgen levels at supra physiological levels, we will achieve the greatest dickmaxxing. My ascension was delayed because of heightmaxxers who said that you should lower your estrogen below 20. @tempelcat4 should be banned gaslighter faggot. ..

I mostly formulated this with the idea of growing clits, not cocks to be honest.

not the weirdest thought I've had while high.

 

[Orc]

I think that if we keep estrogen at a level that will not prevent the pump effect, 20-60 and androgen levels at supra physiological levels, we will achieve the greatest dickmaxxing. My ascension was delayed because of heightmaxxers who said that you should lower your estrogen below 20. @tempelcat4 should be banned gaslighter faggot. ..

this would be localized, rather than killing all the estrogen in your body.

 

[roider122]

this would be localized, rather than killing all the estrogen in your body.

Then thanks u discovered biggest heightmaxxing method right now

I will try this week and will apply on my knee

 

[AstroSky]

Estrogen deficiencyfucked my pumps

-0. 5 inch

I noticed my dick gets bigger when estrogen is on the higher side. Bigger total overall girth.

 

[roider122]

I noticed my dick gets bigger when estrogen is on the higher side. Bigger total overall girth.

yeah u get higher pump

estrogen only makes ur dick smaller at 80>pgml

 

[AstroSky]

yeah u get higher pump

estrogen only makes ur dick smaller at 80>pgml

but the weird thing is if my estrogen lowers my libido and orgasm intensity increases. So its like you ether get a bigger dick or better orgasm

 

[roider122]

but the weird thing is if my estrogen lowers my libido and orgasm intensity increases. So its like you ether get a bigger dick or better orgasm

can u explain it with 2023chico mewing terms i didnt understand single word

 

[AstroSky]

can u explain it with 2023chico mewing terms i didnt understand single word

me estrogen rasise me bigger dick

me estrogen lower a little i get bigger cum

 

[roider122]

w

me estrogen rasise me bigger dick

me estrogen lower a little i get bigger cum

whats ur exact cycle rn?

 

[AstroSky]

w

whats ur exact cycle rn?

Trt. Not a meme. Literally 200mg every 2 weeks. I'll run a blast soonner or later when I'm ready to bulk but I like to lower my stuff when I'm cut. Lower water. Lower stress. Focus on fat burning Compounds and recomp before I'll use a cycle again. I got the mass I wanted just not lean so I need focus more on fat loss and maintenance for now. Dnp run happens again soon. I take short breaks with it don't wanna fuck up.

 

[roider122]

Trt. Not a meme. Literally 200mg every 2 weeks. I'll run a blast soonner or later when I'm ready to bulk but I like to lower my stuff when I'm cut. Lower water. Lower stress. Focus on fat burning Compounds and recomp before I'll use a cycle again


View attachment 3489953

u need pin cyp/enanthate every 3 days minimum

 

[AstroSky]

u need pin cyp/enanthate every 3 days minimum

I use testosterone undecanoate. 400mg per ml. Half a syringe. Custom formulation


Half life 50 days. My current injection protocol is equivalent to test cyp every 3 days.

Notice the falloff. This is not anything like cyp or any normie hormone.


A bonus of this method of trt. Lower red-blood cells. Lower total estrogen. Lower water retention. Smooth up. Smooth out. Never huge swings. I can come off and have time to jump on and I'll hardly feel it. So much time. Good for vacation.

Downside. Takes forever to get stable which worked around by front loading double your dose.

 

[roider122]

I use testosterone undecanoate. 400mg per ml. Half a syringe. Custom formulation


Half life 50 days. My current injection protocol is equivalent to test cyp every 3 days.

Notice the falloff. This is not anything like cyp or any normie hormone.
View attachment 3489961



View attachment 3489957View attachment 3489958

better than ugly e3d cyp injections

im doing eod cyp injections even e3d makes e2 - dht peaks ugly ah ester