The Cure For Hair Loss - The Truth About 5α-Reductase Inhibitors and Topical Anti-Androgens

[chadisbeingmade]

Also I did some searching on this and found a comment on reddit which mentions the MPMD thing you mentioned. Lemme post it right starting after the colon:

Good posts and I agree there is no real evidence that Test causes hair loss. Doesn’t mean it doesn’t. There is a lack of evidence.

He also says “a foolish conclusion” when referencing MPMDs conclusion of Test causing loss yet says “normal physiological levels is not associated with hair loss”. Normal levels sure, maybe, again, lack of evidence, even if slight. MPMD didn’t have normal levels, and neither do I (I roid).

Regardless of that, I don’t see how it makes any practice difference, do you? How does he suppose you deal with said “5ar activity in the dermal papilla”? You have 3 options. Dut (or Fin), RU and potentially topical Dut. I see Dut and RU as the ideal solution regardless especially when you do have supraphysiological test levels. Or fuck it and run all 3.

Again, if that’s the case, then why does finasteride/dutasteride only cycles work?

Fin/dut ONLY stops DHT, not test. In fact, like you said, they increase test since there’s less test converting to DHT. Every study and every doctor says DHT is the culprit for hair loss, not test. Even chad gpt agrees.

Despite above, I do still believe DHT is the MAIN culprit of hair loss. There is no denying that. I still think scalp T will play a part, even if small. I don’t believe what doctors say nor chatgpt. chatgpt tells me a vegan diet is healthy also.

 

[AbuSdanteet]

Good posts and I agree there is no real evidence that Test causes hair loss. Doesn’t mean it doesn’t. There is a lack of evidence.

He also says “a foolish conclusion” when referencing MPMDs conclusion of Test causing loss yet says “normal physiological levels is not associated with hair loss”. Normal levels sure, maybe, again, lack of evidence, even if slight. MPMD didn’t have normal levels, and neither do I (I roid).

Regardless of that, I don’t see how it makes any practice difference, do you? How does he suppose you deal with said “5ar activity in the dermal papilla”? You have 3 options. Dut (or Fin), RU and potentially topical Dut. I see Dut and RU as the ideal solution regardless especially when you do have supraphysiological test levels. Or fuck it and run all 3.

Despite above, I do still believe DHT is the MAIN culprit of hair loss. There is no denying that. I still think scalp T will play a part, even if small. I don’t believe what doctors say nor chatgpt. chatgpt tells me a vegan diet is healthy also.

The importance of dual 5alpha-reductase inhibition in the treatment of male pattern hair loss: results of a randomized placebo-controlled study of dutasteride versus finasteride - PubMed

Dutasteride increases scalp hair growth in men with MPHL. Type 1 and type 2 5alpha-reductase may be important in the pathogenesis and treatment of MPHL.

pubmed.ncbi.nlm.nih.gov

1. This Study comparing fin and dut at different doses shows that 2.5 mg of dut increases scalp testosterone by a whopping 222% while 5 mg of fin increases scalp testosterone by only 23%. So if we were to assume testosterone is bad for hair then the 222% increase in scalp T must be terrible. Well turns out despite all that 2.5 mg of dut showed by far the best result out of all treatments and dosages.

All the evidence he provided seems to showcase T has nothing to do with it.

 

[AbuSdanteet]

Good posts and I agree there is no real evidence that Test causes hair loss. Doesn’t mean it doesn’t. There is a lack of evidence.

He also says “a foolish conclusion” when referencing MPMDs conclusion of Test causing loss yet says “normal physiological levels is not associated with hair loss”. Normal levels sure, maybe, again, lack of evidence, even if slight. MPMD didn’t have normal levels, and neither do I (I roid).

Regardless of that, I don’t see how it makes any practice difference, do you? How does he suppose you deal with said “5ar activity in the dermal papilla”? You have 3 options. Dut (or Fin), RU and potentially topical Dut. I see Dut and RU as the ideal solution regardless especially when you do have supraphysiological test levels. Or fuck it and run all 3.

Despite above, I do still believe DHT is the MAIN culprit of hair loss. There is no denying that. I still think scalp T will play a part, even if small. I don’t believe what doctors say nor chatgpt. chatgpt tells me a vegan diet is healthy also.

And again. If T played a role, then why does hair loss medication only lower dht and not T?

It wouldn’t be good if T was a culprit too. DHT may be utter trash, but we definitely need T in our bodies