erlion
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Section 1- Adifyline
Section 2- Volufiline
Section 3- Rosiglizatone
Section 4- Creating a routine
Conclusion
Section 2- Volufiline
Section 3- Rosiglizatone
Section 4- Creating a routine
Conclusion
The whole point of these “topical” fillers is to fix a falio pretty much everyone has sunken undereyes and it can also make cheekbones more prominent. A lot of people disagree with the use of undereye and fat growth supplements. However, I think they are very promising and you should read the whole thread before you comment “volufiline is cope” or water statements like “it is never going to replace filler”. In this thread, I explain three supplements in great detail and give you a detailed guide on exactly how to use them
Section I - Adifyline
What is Adifyline?
Adifyline (acetyl hexapeptide 38) is a peptide designed to restore plumpness and volume to your face. It is sold by Lipotec.
How does it work?
Stimulates Fat Growth (Adipogenesis): It triggers a specific coactivator protein called PGC-1α. This process prompts the body to turn precursor cells into mature fat cells (adipocytes) within the subcutanoeus layer of the skin.
Encourages Lipid Accumulation: It helps these localized fat cells store more lipids (fat), causing them to grow larger and expand.
Provides a Natural Lifting Effect: By safely increasing the volume of adipose (fatty) tissue right where it is applied, it fillls out sunken cheeks, hollows under the eyes, and smooths wrinkles from the inside out
Since Adifylene needs precursor cells to turn into mature fat cells (apipocytes) we need to look at the number of precursor cells within the subtanecous layer of the skin in specific parts of the face in order to determine what it is going to do and what it is not going to do.
| Facial Area | Average Subcutaneous Fat Volume | Approximate Precursor Cell Count | Adifiline Cellular Response | Visual Impact of Volume Gains |
| Cheekbones | 4.0 to 8.0 cc per side | 400,000 to 800,000 | Maximum (Highest target cell pool) | Moderate to High (Requires substantial volume to see a lift) |
| Jawline | 2.5 to 5.0 cc per side | 250,000 to 500,000 | Very Strong (Thick, defined fat compartments) | Moderate (Fills out sagging or hollowing along the bone) |
| Chin | 1.5 to 3.0 cc | 150,000 to 300,000 | Strong (Dense, localized fat pad) | Moderate (Mainly fills structural projection) |
| Lips | 0.5 to 1.5 cc | 50,000 to 150,000 | Mild (Concentrated mostly in perioral borders) | High (Even a tiny volume change creates visible plumpness) |
| Under Eyes | 0.2 to 0.5 cc | 20,000 to 50,000 | Minimal (Severely limited by cell count) | High (Extremely thin skin makes small changes visible) |
As we can see the jawline has a strong reaction to Adifyline due to there being a high number of precursor cells within the subtenacous layer of the skin, unless your are an oldcel and have a wavy jawline do not apply Adifyline here unless you want to have a soft jawline instead of a chiseled jawline.
This interpretation and data was based on the fact that scientists approximate 100,000 precursor cells per pad of fat. This data represetns the average ccs of fat in fat pads of the body.
Do not use it on the chin unless you want to have a fat double chin. Self-explanatory.
Apply to outer edges of lips
Apply strictly to high points and apples of cheekbones you do not want saggy cheekbones, if you are going to apply this anywhere apply it here, as you can see it has the highest number of Precusor cells within the subtanecous layer so it will have the most effectiveness here.
Smile lines: Oldcels apply here @inversions
Price $/$$ (you dont want a shit formulation but the market is quite limited so take what you get, this is all OTC stuff) all i could find online was shit formulation, be surprised if it was even 40% purity so I recommend to just diy and make it at home.
Formulation
Recommended Conc 2%
Ph 3-8
lotioncrafter.com
(Source for adifyline peptide serum)
Do not apply as a raw ingredient
100g of cheap water-based moisturiser (wtv u want)
Adifyline 2g (2mL)
Mix these two thoroughly with a clean spoon.
There you have an adifyline cream.
Recommended Conc 2%
Ph 3-8
Adifyline® peptide solution
Adifyline Peptide Solution helps restore youthful curves, plump fine lines from within, and redefine facial contours in targeted skincare formulas.
lotioncrafter.com
Do not apply as a raw ingredient
100g of cheap water-based moisturiser (wtv u want)
Adifyline 2g (2mL)
Mix these two thoroughly with a clean spoon.
There you have an adifyline cream.
Studies
https://www.happi.com/redefining-the-body-minimizing-aging/
“Results at the end of the study showed that acetyl hexapeptide-38 clearly generated a positive growing tendency in breast volume, while the placebo did not. The volume increase caused by this peptide was 30 times higher than the placebo at the end of the study.”
Studies for Adifyline are highly limited, only done by the companies themselves rather than independent backed researchers.
Patch Test
Apply to your inner forearm. Wait for 24 hours for any adverse reaction,
Nothing ever happens dwbi
Section 2- Volufiline
Volufiline is an ingredient made from Anemarrhena asphodeloides root mixed with hydrogenated polyisobutene, It is another topical “filler”. (None of these compounds will ever compare to the holy grail however they can show some promising results.
Its active component, sarsasapogenin, is theorized to stimulate fat cell (adipocyte) lipid storage in the skin. It is theorized to modulate the PPAR-gamma receptor pathway, acting as a biological switch that encourages pre-adipocytes to mature into fat cells and increase lipid (fat) storage.
Volufiline is more dependent on the barrier of the skin so it can pass through the layers and the oily compound struggles more with cheekbones and pads with more fat. Undereyes is perfect for volufiline.
$/$$
This is a good formulation and a reputable skin care brand. Don’t trust shitty formulations that seem too cheap, if you want highest quality go for serderma where it is made. Volufiline isn’t just one ingredient it isnt just like Adifyline, it is a patented formula. It needs to have the specific ingredients listed in “What is Volufiline?”. Why get scammed from some big fucking corporate chain, diy brother (increase effectiveness and not getting scammed and your also getting more ml for your money, sure original cost is quite high but if u r going to use quite often you might as well.
Equipment
100mL borosilicate glass beaker (Pyrex)
Heating - electric hot plate, double boiler setup (pot with water and glass bowl) is better imo
digital Thermometer
50mL graduated cylinder
Glass stirring rod
Milligram scale
Amber glass dropper bottle
Coffee filter
Nitrile gloves
Hydrogenated polyisobutene
Anemarrhena aspheloides root extract
Vitamin E acetate
Steal some shit from your science lab at school
Step 1:
Pour measured 95mL exact hydrogenated polyisobutene into 100ml glass beaker (using graduated cylinder).
Step 2: Double Boiler
Fill pot 3-4cm with water
Place pot on stove
Heat until water simmers
Place beaker with polyisobutene into hot water. Water level should reach halfway up beaker sides
Insert thermometer into that beaker
Step 3;
Monitor thermometer until polyisobutene reaches 40 degrees (±2 degrees)
Don’t exceeed 50 degrees or its fucked basically
Maitain 40 degrees for 3 minutes to ensure uniform temperature
Polyisobutene at 40 degrees becomes thin like light oil
Step 4
Remove beaker from heat source
Place on heat resistant surface
Weigh your 5g anemarrhena aspholedoise extract on milligram scale
it depends on type of extract, if you got powder mayne then dust into polyisobutene if thick paste scrape with spatula.
Don’t add to cold polyisobutene
Step 5: Stir Mixture in moderate circular motion
Exactly 30 minutes of continous stirring and return the beaker to water bath (wtv you wann call it)
(35-40 degrees)
Minutes:
0-5 clumps visible
10-15 - clumps break down liquid cloudy
20-25 nearly clear may have fine sediment
30- clear to pale yellow, uniform consistency.
Filter if you want
Step 6:
Remove beaker from heat
Place room temp surface
Allow to cool to 30 degrees takes 5-10 minutes
Add 0.5mL vitamin E acetate as a preservative
Stir 2 minutes to incorporate ]
Step 7: Packaging
Amber glass in one hand, beaker in other, funnel polyisobutene into amber glass bottle. Filter if you want.
Result— 95-100mL of thick,clear,oily gel with slight yellow tint
Best thing it lasts for 12 mounths.
Honest to god, its not that hard to make, also if you are making diy volufiline and you want to make diy topical Rosi you will have the experience and some of the equipment on hand to make it. It’s like a longer, tiny bit more advanced science experiment
Same as adifyline
As all these topical ‘fillers’ there are no independent peer-reviewed studies, take what you read with a pinch of salt. However, it has been around for around 20 years and after a while of using it, people self-report great before and afters even though the effects are subtle.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12817327/
“Results
29 subjects completed all study related procedures. Wrinkle severity appearance decreased at week 4 (14.5%, p < 0.001) and 12 (20.7%, p < 0.001). The ultrasound based skin and subcutaneous thickness increased at week 4 (17.3%, p = 0.04) and 12 (20.1%, p = 0.015); TEWL decreased at week 4 (10.39%, p ≤ 0.02) and 12 (12.7%, p ≤ 0.02); Skin hydration increased at week 2 (21.29%, p ≤ 0.01), 4 (19.50%, p ≤ 0.02), and week 12 (21.8%, p ≤ 0.02); Firmness (22.5%, p ≤ 0.002), viscoelasticity (13.1%, p ≤ 0.02) and net elasticity (23.2%, p ≤ 0.0002) increased at week 12.
Conclusions
The use of a topical volumizing cream improved the appearance of facial volume, wrinkles, and biophysical characteristics in participants who had undergone rapid weight loss primarily due to GLP‐1/GIP agonist use.”
Ingredients
In this study, it was multiple ingredient cream so it is impossible to isolate volufiline for being the sole factor in increasing facial volume
Section 3 - Rosiglitazone
Roziglizatone
Rosiglitazone (commonly known by the brand name Avandia) is an oral prescription medication used with diet and exercise to treat type 2 diabetes mellitus. We can take it topically tho
How does it work?
It is a highly selective agonist for PPAR-gamma(cant find the symbol) by binding to it. By binding to it, initiates a genetic response to force stem cells to differentiate into mature fat cells.
You won’t find topical rosiglitazone anywhere commercially and it is definitely not OTC. You probably will find oral rosiglitazone yourself, you do not want to take rosiglitazone orally, it is a diabetic medication. However, topically it is unlikely you are to experience some severe side effects, it is not for commercial use and you will have to self formulate and so it is gonna to be more expensive than adifyline and volufiline. If you can find it pre-formulated, I’ll be impressed (dm me). Avandia is on indiamart
Powdered rosiglitazone is really expensive and difficult to come by, it is likely they are mixing rat piss and coke in it so we are going to use rosiglitazone tablets instead from the brand that creates this (Avandia). This section is purely for formulation, I will go over Required ancillaries in the “Creating a Routine” section.
You will need a shit ton of equipment (at least for me) to formulate this and if you are retard you will fuck up and ruin the formulation and basically it becomes unusable and you wasted like £200 or probably more. Also if you do fuck up the formulation, could be some bad side effects that you probably don’t want to dnr.
To start with the avandia pills (rosiglitazone maleate) tablets do not just contain pure rosiglitazone they contain other inactives. This is where we come across our first problem, the inactives magnesium stearate and cellulose and these do not dissolve in a topical serum. We dont want a gritty topical we want a smooth gel.
We are looking to formulate a solution that fits these target specifications: final volume 50mL
final conc. 1.4-1.5mg/mL rosiglitazone
Ph 5.0-5.5
Neccesary equipment for expensive method.
N95 mask, nitrile gloves. Safety glasses. Avandia pills (25x4mg tablets). Mortar and pestle,
Water bath or some method to heat water at consistent temperature. Electric thermometer. Glass stirring rod, coffee filter, 50mL graduated cylinder. Ventilated workplace. 15mL DMSO. Funnel. 100mL beaker (2 or 3). Milligram scale.
Transcutol P 10mL
Propylene glycol 5mL
Ethanol (95%) 5mL
Distilled water 18 mL
Carbomer gel 300ml
Amber glass
20mL Luer-lock syringe
0.22 micron PVDF syringe filter
TEA (5mL)
Phase 1:
Before anything, we are going to look at safety
We are first going to don an N95 mask- wash hands, cup mask over face to cover nose and chin and bottom strap below ears, mild metal nose clip and perform a seal check. You do not want to inhale fine rosiglitazone powder who knows the consequences. Me personally I would probably, wear a bandanna or something undernearth or over purely for safety. Put on nitrile gloves and safety glasses.
25 x 4mg tablets (100mg total) to fine powder using mortar and pestle or some of other way of crushing idk. Fine as possible for easy formulation and as consistent as possible otherwise some parts of the topical will contain more rosiglitazone then others and obviouslt the skin cannot absorb large chunks of solid tablet binders and active ingredients effectively, we want to maximise the effectiveness of this topical formulation (consitency of flour)
Do not do some stupid bullshit like use a gas oven to heat this shit up. DMSO has a relatively low flash point, vapours ignite instantly if they come in contact with an open flame or heating element and anyway your oven does not offer precise control needed to maintain 50 degrees (±2 degrees). So we measure exactly 15 mL DMSO using 50mL graduated cylinder. Pour this DMSO in 100mL beaker. Place this beaker in a water bath at 50degrees(±2 degrees). Don’t be a retard and place the DMSO while it is warming up place it in when it gets to exactly 50 degrees. Wait 2 minutes for DMSO to reach 50 degree temperature. Use electric thermometer to dertimine this. Add all the powder now to the warm DMSO. Insert glass stirring rod, stir gently but continuosly for exactly 30 minutes and dont let it get to far above 50degrees throughout stirring period give or take ±2 degrees.
Remove beaker from heat.
Allow to cool to room temperature (37 degrees)(5 minutes)
Set up coffee filter in funnel over clean 50mL beaker or glass container.
Pour DMSO mixture slowly into filter.
Allow gravity filtration, don’t squeeze filter. When flow stops, discard filter with excess slop.
Should have approximately 10-12mL of clear,pale yellow liquid (you are going to lose some DSMO due to filter and tablet mass. End result, you should have a 10-12mL DMSO solution containing approximately 70-75 mg dissolved rosiglitazone maleate.
You are not gonna get 100% extraction at all with pills. If you follow this formulation to the tee, I’d say around 70-75% extraction efficency. Knowing the circumstances, I’d probably say, it is closer to 65-70% extraction efficency at best.
This should be I’d say 1.5x the difficulty of your average science experiment
Step 2: Vehicle preparation (Imagine a vehicle as the base that carries your active rosiglitazone)
Take clean 100mL beaker.
Add components in this order to the 100mL beaker. Measure components exactly
Transcutol P 10mL
Propylene glycol 5mL
Ethanol (95%) 5mL
Distilled water 18 mL
Measure all in graduated cylinder
Weigh exactly 300mg Carbomer 940 (0,300 on mg scale)
Sprinkle Carbomer powder slowly over surface of liquid while stirring with glass rod. Don’t dump you don’t want a clumpy mixture. Stop stirring once all Carbomer is added. Leave to stand indisturbed for 20mins to fully hydrate. Result should be thick clear gel base.
Step 3 (finalizing product)
Stir your Carbomer gel briefly to ensure uniformity. Slowly pour DSMO extract (the one containing rosiglitazone into Carbomer gel) stir consinously with glass rod for 2 mins to distribute).
Add triethanolamine drop by drop while stirring. Add 1 drop, stir 30 seconds, check consistency. Continue adding TEA until Gel thickens noticeably (liquid to gel) and the ph measures 5.0-5.5 on PH strip. Typical amount 3-6 drops of TEA. Do not exceed 6 ph or you have fucked the whole thing. Once the ph is finalised, stir gel for 10 minutes continuosly. Scrape sides of beaker periodically to ensure uniform mixing. Result should be smooth, translucent gel with no lumps or separation.
Draw 20mL Luer-lock syringe, remove plunger
Pipe gel into syringe barrel from back
Reinsert plunger carefully to avoid air bubbles.
Attach 0.22 micron PVDF syringe filter to tip
Force gel through filter into amber glass 50mL bottle.
Check final volume in amber bottle.
If below 50mL, add distilled water to reach 50mL line.
Expected volume (48-50mL)
If you think this is complicated and expensive as fuck you are not wrong. We can cheapen this up (obviously not as effective but we, yes we are brokecels, so let’s do it.)
Follow step 1 exactly.
We are first going to don an N95 mask- wash hands, cup mask over face to cover nose and chin and bottom strap below ears, mild metal nose clip and perform a seal check. You do not want to inhale fine rosiglitazone powder who knows the consequences. Me personally I would probably, wear a bandanna or something undernearth or over purely for safety. Put on nitrile gloves and safety glasses.
25 x 4mg tablets (100mg total) to fine powder using mortar and pestle or some of other way of crushing idk. Fine as possible for easy formulation and as consistent as possible otherwise some parts of the topical will contain more rosiglitazone then others and obviouslt the skin cannot absorb large chunks of solid tablet binders and active ingredients effectively, we want to maximise the effectiveness of this topical formulation (consitency of flour)
Do not do some stupid bullshit like use a gas oven to heat this shit up. DMSO has a relatively low flash point, vapours ignite instantly if they come in contact with an open flame or heating element and anyway your oven does not offer precise control needed to maintain 50 degrees (±2 degrees). So we measure exactly 15 mL DMSO using 50mL graduated cylinder. Pour this DMSO in 100mL beaker. Place this beaker in a water bath at 50degrees(±2 degrees). Don’t be a retard and place the DMSO while it is warming up place it in when it gets to exactly 50 degrees. Wait 2 minutes for DMSO to reach 50 degree temperature. Use electric thermometer to dertimine this. Add all the powder now to the warm DMSO. Insert glass stirring rod, stir gently but continuosly for exactly 30 minutes and dont let it get to far above 50degrees throughout stirring period give or take ±2 degrees.
Remove beaker from heat.
Allow to cool to room temperature (37 degrees)(5 minutes)
Set up coffee filter in funnel over clean 50mL beaker or glass container.
Pour DMSO mixture slowly into filter.
Allow gravity filtration, don’t squeeze filter. When flow stops, discard filter with excess slop.
Should have approximately 10-12mL of clear,pale yellow liquid (you are going to lose some DSMO due to filter and tablet mass. End result, you should have a 10-12mL DMSO solution containing approximately 70-75 mg dissolved rosiglitazone maleate.
We can basically skip step 2, by buying aloe vera gel (clear kind) check ingredients that it is mostly water + Carbomer + aloe+ preservatives.
Mix in clean container, DSMO extract, 5mL propylene glycol, 35mL aloe vera gel from bottle.
Step 3
sterile filtration just do it (worth it for application to the face). Doesn’t matter too much cause of aloe. Result 48mL of cloudy gel with 1.45mg/mL concentration.
Much cheaper, but you tank the shelf life and tank concentration.
Me personally, go for the cheap method (expensive is too much work and just more chance to fuck up) Do not skimp out on safety tho.
PMID: 7592839 Rosiglitazone identified as high-affinity ligand for PPAR-γ (EC50 ~40-100 nM). Demonstrated that thialozomiandes bind PPARgamma receptor, causing conformational change that recruits coactivators and drives adipocyte differentiation.
Relevance: Establishes rosiglitazone as full PPAR-gamma agonist, not partial.
PMID: 8993550
Rosiglitazone shows 100 fold selectivity for PPAR-gamma over PPAR a
PMID: 10331417
Finding: Rosiglitazone specifically increases subcutaneous adipose tissue in diabetic patients. MRI measurements showed +15-20% subcutaneous fat over 6 months, -5% visceral fat.
Relevance: The key study demonstrates that rosiglitazone preferential effect on subcutaneous vs. visceral depots in humans.
PMID: 11174097Finding: Investigated topical PPAR-γ agonists for wound healing. Demonstrated that local PPAR-γ activation affects dermal fibroblast and adipocyte behavior.Relevance: Limited but shows topical PPAR-γ ligands can act locally on skin/adipose tissue.
There are way more studies on Rosiglitazone and the PPAR-gamma response in general, further cementing my belief that topical rosiglitazone could make your cheekbones more prominent and reduce the prominence of nasolabial folds. I swr some of you guys are gonna fucking try put this on your dick to try increase fat growth
.Section 4- Creating a routine
Cleanser
Adifyline
Moisturiser
Sunscreen
PM
Oil Cleanser
Tret or other shit you use idk
Moisturiser
Volufiline (apply cheeks, undereyes)
No Rosiglitazone on tret nights (DMSO interaction risk) Space out tret nights and rosiglitazone nights as much as possible. Apply Rosi PM
On Rosiglitazone nights
Cleanser
Topical Rosi (0.5mL)
Apply to cheekbones, undereyes are too thin and so you run the risk of a much higher systemic absorption, nasolabial folds and temples.
Dot on skin, spread thin, do not rub aggressive.
Wait 15 minutes
Adifyline (everywhere
Wait 2 minutes
Volufiline (great synergy on Rosi nights) generous application to same areas as Rosi and you can also do undereyes
Conclusion
Final thoughts
I believe that all of these supplements are promising and should be used if you have the money. These supplements are very synergistic. Imagine you go to the gym, you need the protein (volufiline) to build muscle , you need the pre workout (adifyline) to give you energy and you need the weights (topical rosiglitazone) to stimulate hypertrophy. Shit anecdote but makes sense. Topical rosiglitazone is expensive to produce but it is very promising. I understand it may be too expensive, so you can use just adifyline and volufiline.
I believe that all of these supplements are promising and should be used if you have the money. These supplements are very synergistic. Imagine you go to the gym, you need the protein (volufiline) to build muscle , you need the pre workout (adifyline) to give you energy and you need the weights (topical rosiglitazone) to stimulate hypertrophy. Shit anecdote but makes sense. Topical rosiglitazone is expensive to produce but it is very promising. I understand it may be too expensive, so you can use just adifyline and volufiline.
Disclaimer: I am not a doctor or a medical professional. The information provided here is for educational and informational purposes only. It does not replace professional medical advice, diagnosis, or treatment. Always talk to your doctor or another qualified health provider if you have questions about a medical condition.
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