T
timfa
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DISCLAIMER
i am not a medical professional
i do NOT condone the use of anything here
PLEASE consult a medical professional before doing anything like this
i am not a medical professional
i do NOT condone the use of anything here
PLEASE consult a medical professional before doing anything like this
Introduction:
HGH is probably the compound most discussed in the LM community and there are alot of misconceptions about GH that need to be cleared.
Im gonna be talking about multiple things in this guide.
1. How does rHGH work in the human body?
2. Dosing
3. Ancillaries needed for rHGH
4. rHGH's synergy with other compounds
5. Sourcing
6.1. Protocol (How to inject, when to do bloodwork etc.)
6.2. Cycle Example
1. How does rHGH work in the human body?:
HGH is THE treatment for short stature, but no one really knows how it works.
Once you inject your GH it binds to two GHRs And dimerizes them.
The GHRs have two JAK2 enzymes attached to the GHR which dimerize and activate.
Afterwards, STAT5B arrives to those activated spots and gets activated (tagged) by JAK2 which leads to the the activated STAT5B to travel into the cell nucleus to turn the gene that synthesises IGF1 on.
Once IGF1 is produced it binds to an IGF1R and recruits IRS1 and IRS2 which when activated recruits an enzyme called PI3K. PI3K converts certain membrane lipids which recruit and activate Akt. Active Akt disables certain proteins (TSC2 and GSKb) that suppress mTORC1. And since nothing is suppressing mTORC1 it activates and signals to the cells ribosomes to step up protein synthesis and grow in size. IGF1 also goes through the MAPK/ERK pathway which is one of the main drivers of chrodrocytes proliferation.
Basically MAPK/ERK make chrodrocytes multiply while PI3K/Akt/mTOR increases the size of chrodrocytes until they’re ready to fuse into bone and result in height growth
2. Dosing
GH dosing is a very “controversial” topic in the LM space. Some say you only need 6ius to grow and some say that even 20 isn’t enough. So what really is the perfect dose for non growth hormone deficient teens?
Many studies about low dose GH in non GHD patients show that low dose GH actually stunts your height growth dramatically.
For example:
Bierich 1992
Children with no GHD were given ~0.0222mg/kg/day for 3 years on average
Showed no increase in final adult height
Kaplowitz 1995
Children with no GHD were given DOUBLE the dosage used in the previous study (so they were given 0.0444mg/kg/day) and still saw NO changes in final adult height AND saw meaningful bone age advancement
Loche 1994
Kids with no GHD were given either ~0.024mg/kg/day or ~0.048mg/kg/day
For 4-10 years and exhibited no change in final adult height
Kawai 1997
Used 0.0222mg/kg/day in non GHD children and saw no improvement in final adult height AND even reported 2-3cm decrease in FAH and a 8cm decrease from PAH.
These are simply a couple examples out of many studies that suggest that low dose GH is NOT beneficial for non GHD patients.
So now let’s see what would happen if we pushed the dose up a bit..
Rothenbuhler 2015
ISS non GHD children were given 0.07mg/kg/day of gh during late puberty (in 15.5 year old boys !!!) for the duration of 11 months and they grew 8.5cm in total and 6.8cm over predicted adult height. Its important to mention that these kids were at the end of puberty with fused wrist plates. This study is the most applicable to most of the people on here reading this guide.
A BMJ ISS systematic review also showed that higher dose gh performs better then low dose gh (0.067mg/kg/day vs 0.033)
And the 0.067 group grew roughly 2cm more then the 0.033 group.
Another study was done on girls with turner syndrome. Three groups were given either :
0.045mg/kg/day
0.067mg/kg/day
And 0.09mg/kg/day
The high dose group grew 3.6 more cm then the low dose group but had a small difference from the mid dose group (1cm)
Growth hormone treatment regimens in girls with Turner syndrome. Dutch Advisory Group on Growth Hormone - PubMed
To optimize growth hormone (GH) treatment in girls with Turner syndrome, two multicentre studies were carried out in The Netherlands: a frequency-response study (study 1) and a dose-response study (study 2). In study 1, 19 girls with Turner syndrome, aged 11 years or older, were treated with one...
pubmed.ncbi.nlm.nih.gov
So what’s the best dosage?
The average between the 3 groups with the most growth is 0.076mg/kg/day
But you can see that 0.07mg/kg/day is adequate for growth so we can set that as our minimum.
The optimal dosing for HGH is 0.07mg+/kg/day, Anything lower would most likely stunt your growth.
1mg of HGH = 3IU so take that into account while calculating your dosage.
The optimal HGH dosage for a 70kg individual would be:
0.07x70 = 4.9mg a day which is equivalent to ~15IU of GH a day
You can always go above 0.07mg/kg/day as you can see more gh is almost always better.
3. Side effects (and how to prevent them):
HGH actually has a really good safety profile with ur only main concern being insulin sensitivity.
How does rHGH cause insulin resistance?
Chronic levels of elevated GH leads to activation of the Ras-Raf-MEK-ERK pathway which dominates other signaling pathways. As a result, phopshorylated ERK translocates to nucleus and phosphorylates PPARy. Phopshorylated PPARy is targeted for degradation leading to downregulation of anti lipolytic genes like FSP27 and G0S2. Chronic levels of FFAs as a result of deregulated lipolysis cause lipotoxicity and make it easier to develop insulin resistance and diabetes.
One of the best ways to treat this is through
Acipimox:
Acipimox is a drug that reduces FFAs which mess with insulin sensitivity and growth hormone secretion.
A dose of 1-1.5g a day split into two to three doses is the optimal dosage.
Empagliflozin:
You can also use Empagliflozin for high blood glucose. Empagliflozin is an amazing drug to regulate blood sugar but it doesn’t treat the root cause of gh mediated IR.
Dosing for empag normally starts at 10mg and goes up to 25mg if tolerated
10-25mg empag/1-1.5g acipimox + cardio and exercise is enough to keep ur insulin sensitivity at check on cycle.
I do suggest having a blood glucose monitor at home so you can check your blood glucose daily and see that everythings alright.
4. Synergy With Other compounds
The great thing about rHGH is that it can be very synergistic with other compounds for height growth.
HGH + Anastrozole
When people talk about GH with ais they always say that letrozole is best because of its potent aromatase inhibition (suppressing estrogen by 98%) but in practice we can see that Anastrozole is more effective alongside hgh.
An article written in 2015 reviews a study that collected data over 7 years form 96 boys with ISS who were treated with either Letrozole,Anastrozole or gnRHa paired with HGH. Results showed that the adult height increase was largest with Anastrozole at about ~11.06 cm vs letrozole ~9.77cm.
These results might've been from the increase in testosterone in the letrozole group leading to local aromatization in the growth plate leading to faster gp closure so if youre running any sort of AAS + Low/No test base with GH, letrozole could be better then anastrozole.
HGH+Tren
Tren is known to increase IGF1 and IGF1R levels via AR activity. Since Tren is a non aromatizable androgen it can be utilized in a height stack for accelerated growth and less bone age advancement.
Trenbolone acetate - Wikipedia
HGH+Anavar
HGH and Microdosed Anavar are used together mostly in patients with turner syndrome and it actually shows a good amount of growth paired with gh
Anavar therapy increased growth velocity by 9.6 cm a year and when paired with gh it increased FAH by 4.6cm
Anavar was dosed at maximum 0.06mg/kg/day (4.2 mg a day for a 70kg individual) and side effects like Bone age advancement were only significant over 0.06mg/kg/day.
HGH+Erdafitinib+KY19382
In this stack HGH and erda will drive chondrocyte proliferation/hypertrophy while Ky19382 will keep the growth “organized” by regulating the transition from hypertrophic chondrocytes to osteoblasts. KY19382 could also theoretically maintain the resting zone progenitor niche so the growth plates stem cells don’t deplete prematurely.
There is no source for this section since Erdafitinib Hasnt been used together with HGH in any studies on non GHD children and because all of the research about KY19382 is still preclinical.
5. Sourcing
This is literally the easiest part of the whole guide, sourcing HGH is extremely simple unless you live in some unknown country or live in a country thats constantly/currently in war.
The best way to source good HGH is by going thru bodybuilder forums, asking around and looking in the sections where sources promote themselves.
Community powered steroid source reviews, forums and more.
We're a steroid source review community. Here since 2009 because unbiased and unpaid opinions are hard to come by.
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anabolicminds.com
How do i know if my source is legit?
If your source has janoshink tests, overall good reviews and pricing that isnt too good to be true (over or equal to 0.3$ per iu)
then your source is probably legit and reputable.
IF YOU CANT SOURCE YOU PROBABLY SHOULDNT HOP ON
ITS THAT SIMPLE
sourcing is the simplest part of all of this. if you cant source, dont hop on.
6.1. Protocol
What do you need for a HGH cycle?
- 200-400x 31G 1ml 6mm-8mm insulin syringes
- rHGH
- 200-400x Alcohol wipes
- BAC Water
- Glucose Monitor (Could be constant or a normal BG monitor)
- Testing strips (For BGM)
- Lancets (For BGM)
- 1X Sharps container or an empty bottle made out of hard plastic (ie. Laundry detergent, shampoo bottle)
How do you reconstitute your HGH vial?
For those who dont know, HGH comes in powder form inside of a vial. You need something called BAC water to make sure your GH is ready for injection.
For example
You ordered a 36iu HGH vial and a 10ml BAC water vial
- You take an alcohol wipe and wipe the top of the BAC water vial and draw 3ml of BAC water with an insulin syringe (or multiple depending on your syringe volume)
- You slowly stick the syringe into the top of your HGH vial and you drip the BAC water slowly into the vial while tilting the vial so the BAC water falls from the sides of the vial onto the GH
- Once you're done injecting the BAC water into your GH, pull the syringe out and start slowly rolling the GH vial inbetween your hands to mix the powder with the bac water gently. DO NOT SHAKE THE VIAL THIS WILL RUIN THE HGH
- Now you're done! You have a vial of 36ius of GH with the ratio of 12IU per ML of HGH
How do you inject HGH?
HGH is administered through a SubQ injection normally in your belly fat.
After reconstitution, Wipe the top of your HGH vial and draw your dose out of the vial. After you got your HGH into the needle, take another alcohol wipe and wipe your belly around 3 fingers away from the navel. After wiping the injection site pinch the fat and skin in that area and insert the needle into you and start injecting the GH slowly.
Once you're done injecting your gh you can take your needle out and throw it straight into the sharps container.
When should you get bloodwork?
In total you only need about 3 blood tests for a HGH only cycle.
- One before hopping on
- One after titrating to your highest dose
- One 48 hours after your last injection
IGF1
HGH
Testosterone
E2
Free Testosterone
DHT
Thyroid Hormones
Cortisol
Prolactin
Liver enzymes
HbA1c
Blood glucose
Your second blood test should serve as a mark of how far you pushed your IGF1 since getting to your highest dose.
If you titrated up to 15IUs and have been on 15IUs for 1 week and you get a blood test and your IGF1 hasnt moved much, its a sign that either your GH is fake, underdosed or that you just have to up the dose. If your IGF1 levels are in supra physiological levels (800+) then you are good and you can continue at your dose.
The third blood test should serve as a "recovery" test. You should expect lower levels of IGF1 then baseline after hopping off but thats just your pituitary getting used to producing GH again after months of inactivity.
How do i titrate my dose?
I suggest starting at around 3IUs and slowly titrating up 1-2IUs every 2-5 days depending on how well you tolerate the GH
If the side effects get bad because you're titrating up too fast, calm down and start titrating slowly. You shouldnt potentially harm yourself just because you're impatient.
Example:
Days 1-3: 3IU
Days 3-5: 4IU
Days 5-7: 6IU
Days 7-8: 8IU
Days 8-10: 9IU
Days 10-11:10IU
Days 11-12: 12IU
Days 12-13: 14IU
Days 13-End of cycle : 15IU
Medium/Minimalist Example Cycle
(For a 70kg male)
| Compound | Dosage | Frequency | Route | Purpose |
| HGH | 15iu | ED | Subq | Main driver of growth |
| Erdafitinib | 2-4mg | ED | Oral | FGFR3 inhibition to drive chondrocyte proliferation |
| KY19382 | 0.2-1mg | ED | Subq | Organize growth and prevent stem cell depletion |
| Test E | 30-70mg | Weekly | IM | Low dose test base to minimize aromatization |
| Tren E | 100-350mg | Weekly | IM | Non aromatizing androgen for dimorphism + IGF1 increase |
| Anastrozole | 1MG | ED | Oral | Lower estrogen and prevent plate closure |
| Anavar | 4.2-5mg | ED | Oral | Microdose Anavar has been proven to increase FAH when paired with rHGH |
Risk/Side effects:
The stack I just mentioned has many potential side effects such as
Mental Sides
Prolactin issues
Cardiovascular Strain
Renal stress
Ocular toxicity
Insulin resistance
Oxidative stress
And more
You NEED to research every compound you run thoroughly before even thinking about ordering it.
CONCLUSION:
rHGH can be beneficial for height when used correctly and with the right compounds.
You need to do bloodwork, research and evaluations to make sure you're ready to take HGH and
Most of the side effects caused by HGH can be mitigated easily with cheap ancillaries.
this is my first guide so tell me what i could fix/improve
ik this is water for most ppl but i wanted to share this guide since i got positive feedback on tiktok.
ty for reading
@2s2f @calcified @ltnriley
@Zagro whatchu think
