Vitamin A destroys your testiclez and causes ovarian tissue to grow. Bad news for egg, dairy, and liver eaters

[VeryFuglyNiyguhs]

Gonadal [related to eggs/ovaries or sperm/testicles]organ culture experiments suggested that RA [retinoic acid] promotes expression of some ovarian markers and suppresses expression of some testicular markers...
[...]
XY Cyp26b1-null embryos, in which endogenous RA is not degraded [this means that "active vitamin A" made from "vitamin" A retinoids INSIDE the BODY is not properly DETOXED and sticks around too long causing DAMAGE], develop mild ovotestes [OVARIAN tissue was found INSIDE the TESTICLES], but more important, steroidogenesis is impaired [they couldn't make hormones properly] and the reproductive tract feminized [FEMINIZATION of the MALE reproductive organs is BAD, REAL BAD for fertility, DUH

Stop eating organ meats, eggs, and dairy. Also avoid any fruit or vegetables yellow orange or red. You are castrating yourself.

 

[perpetuallytired]

Gonadal [related to eggs/ovaries or sperm/testicles]organ culture experiments suggested that RA [retinoic acid] promotes expression of some ovarian markers and suppresses expression of some testicular markers...
[...]
XY Cyp26b1-null embryos, in which endogenous RA is not degraded [this means that "active vitamin A" made from "vitamin" A retinoids INSIDE the BODY is not properly DETOXED and sticks around too long causing DAMAGE], develop mild ovotestes [OVARIAN tissue was found INSIDE the TESTICLES], but more important, steroidogenesis is impaired [they couldn't make hormones properly] and the reproductive tract feminized [FEMINIZATION of the MALE reproductive organs is BAD, REAL BAD for fertility, DUH

Stop eating organ meats, eggs, and dairy. Also avoid any fruit or vegetables yellow orange or red. You are castrating yourself.

Literal water. Hyper dosing Vitamin A is retarded.

But most people won't get that from dietary intake alone. It's only if you're on accutane or take excessive amounts of beta carotene where it will become a problem.

 

[Detective]

we need more study

 

[9898]

not my problem

on the 7th day god created isotretinoin

 

[LVZZO]

Gonadal [related to eggs/ovaries or sperm/testicles]organ culture experiments suggested

All it took was 30s of research to find that was complete BS
You can't take conclusions from a petri dish, or better, you can but you need to make the right conclusions

Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly involved in rodents. It is essential for sperm production. Vitamin A deficiency adversely affects testosterone secretion. Adult Leydig cells are responsible for testosterone production in male. The role of vitamin A in regulating the differentiation of Leydig cells is still unknown. In this study, we explored the roles and underlying mechanisms of vitamin A in Leydig cell differentiation. We found that vitamin A could regulate the Leydig cells differentiation. Leydig cell differentiation is adversely affected in mice maintained on a vitamin A-free diet. This effect is mediated by alcohol dehydrogenase 1 (ADH1). ADH1 could increase retinoic acid (RA) synthesis, then RA facilitates Leydig cell differentiation by activating the steroidogenic factor 1 gene (Nr5a1) promoter activity, which consequently promotes Leydig cell specific gene expression, resulting in progenitor Leydig cells differentiation into functional Leydig cells. This is the first study connecting a metabolic enzyme of retinol (ADH1) to the the regulation of Leydig cell differentiation, which will provide experimental evidence for the development of therapeutics to promote Leydig regeneration through the administration of a RA signaling regulator or a vitamin A supplement.

In testis, vitamin A (retinol) and its principal biologically active derivative (RA) are clearly involved in the regulation of testicular functions in rodents (14). And the role of dietary vitamin A/retinol in normal spermatogenesis has been recognized for decades (15). Spermatogenesis can be inhibited by removing vitamin A from the diet of a mouse, and spermatogenesis can be reinitiated with vitamin A replacement. Vitamin A deficiency adversely affects testosterone secretion (14, 16). Adult Leydig cells are response for testosterone production (17). The role of vitamin A in regulation of Leydig cells differentiation is still unknown. And its mechanism of action in Leydig cells differentiation has not been elucidated.

Frontiers | Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1

Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly inv...

www.frontiersin.org

Vitamin A excess is what impairs testes cells

In addition to playing a fundamental role in very diverse processes such as vision and the growth and differentiation of numerous types of cell, vitamin A (retinol) and its principal biologically active derivative, retinoic acid, are clearly involved in the regulation of testicular functions in rodents. An excess of vitamin A leads to testicular lesions and spermatogenetic disorders, and a deficiency induces early cessation of spermatogenesis and adversely affects testosterone secretion. Furthermore, mice mutant for retinoic acid alpha receptors and retinoid X beta receptors are sterile. Retinoids appear to exert an action on the three main testicular types of cell (Sertoli, germinal and Leydig cells), as they act on the signalling pathways and Sertoli cell metabolism, and modify numerous factors secreted in Sertoli cells. Retinoids also appear to be necessary for the proliferation and differentiation of A spermatogonia, and for spermiogenesis. In addition, vitamin A deficiency leads to atrophy of the accessory sex organs after decreased testosterone production. Recent studies have shown that retinoids already affect these three types of cell in fetuses. Curiously, the effects of retinoids on fetal and adult testis seem opposed.

Regulation and perturbation of testicular functions by vitamin A - PubMed

In addition to playing a fundamental role in very diverse processes such as vision and the growth and differentiation of numerous types of cell, vitamin A (retinol) and its principal biologically active derivative, retinoic acid, are clearly involved in the regulation of testicular functions in...

pubmed.ncbi.nlm.nih.gov

 

[VeryFuglyNiyguhs]

All it took was 30s of research to find that was complete BS
You can't take conclusions from a petri dish, or better, you can but you need to make the right conclusions

Frontiers | Vitamin A Promotes Leydig Cell Differentiation via Alcohol Dehydrogenase 1

Vitamin A (retinol) is important for multiple functions in mammals. In testis, the role of vitamin A in the regulation of testicular functions is clearly inv...

www.frontiersin.org

Vitamin A excess is what impairs testes cells

Regulation and perturbation of testicular functions by vitamin A - PubMed

In addition to playing a fundamental role in very diverse processes such as vision and the growth and differentiation of numerous types of cell, vitamin A (retinol) and its principal biologically active derivative, retinoic acid, are clearly involved in the regulation of testicular functions in...

pubmed.ncbi.nlm.nih.gov

Vitamin A is actually a toxin that can accumulate overtime whether you eat liver once or eat shit like dairy, eggs, and yellow/orange/red plants it will still accumulate and be toxic. Just at a slower pace.

 

[beniman]

Gonadal [related to eggs/ovaries or sperm/testicles]organ culture experiments suggested that RA [retinoic acid] promotes expression of some ovarian markers and suppresses expression of some testicular markers...
[...]
XY Cyp26b1-null embryos, in which endogenous RA is not degraded [this means that "active vitamin A" made from "vitamin" A retinoids INSIDE the BODY is not properly DETOXED and sticks around too long causing DAMAGE], develop mild ovotestes [OVARIAN tissue was found INSIDE the TESTICLES], but more important, steroidogenesis is impaired [they couldn't make hormones properly] and the reproductive tract feminized [FEMINIZATION of the MALE reproductive organs is BAD, REAL BAD for fertility, DUH

Stop eating organ meats, eggs, and dairy. Also avoid any fruit or vegetables yellow orange or red. You are castrating yourself.

Good day to not be a fucking mice i guess

 

[jоrdan]

Gonadal [related to eggs/ovaries or sperm/testicles]organ culture experiments suggested that RA [retinoic acid] promotes expression of some ovarian markers and suppresses expression of some testicular markers...
[...]
XY Cyp26b1-null embryos, in which endogenous RA is not degraded [this means that "active vitamin A" made from "vitamin" A retinoids INSIDE the BODY is not properly DETOXED and sticks around too long causing DAMAGE], develop mild ovotestes [OVARIAN tissue was found INSIDE the TESTICLES], but more important, steroidogenesis is impaired [they couldn't make hormones properly] and the reproductive tract feminized [FEMINIZATION of the MALE reproductive organs is BAD, REAL BAD for fertility, DUH

Stop eating organ meats, eggs, and dairy. Also avoid any fruit or vegetables yellow orange or red. You are castrating yourself.

Bowlshet

Vitamin A decreases esterogen production into the body and is crucial for testosterone as it helps convert cholesterol into pro-hormone "Pregnanolone"

pregnanolone - supports the activity of enzymes in leydig cells stimulation

leydig cells - essential and crucial cells located in the male testes. testes consist of seminiferous tubes where spermatogenesis takes place.

the interstitial cells of the testes. basically the cells that lie between the spaces of functional cells of any tissues are the once that produce testosterone. in the testes they are called leydig cells who are responsible for testosterone and sperm production.

conclusion:
no vitamin a = no pregnanolone = no leydig cell activity = no testosterone = weak and gay man who prefers to date men instead of women.

Correct me if im wrong.

 

[Achilles]

Garret Smith is a anti vitamin A nutjob. its a cult that follows that nonsense that vitamin a is toxic in any amount lol. Complete bullshit