What would you do for "Perfect genetics"

[batman1997]

Title

 

[Sceptical]

no such thing as perfect

 

[RussianWarCriminal]

I would kill billions of people in Minecraft for entertainment purposes only

 

[batman1997]

no such thing as perfect

Me

 

[Sceptical]

Me

 

[xovamogger]

Title

india gone.

 

[batman1997]

View attachment 4501685

I haven't been sick in 7 years

 

[enchanted_elixir]

Title

Blackmail the motherfuckers on www.genscript.com to give me access to modified CRISPRs (CRISPR, CRISPRi, CRISPRa, etc.) and virus vectors and blackmail Google to give me unrestricted full access to AlphaFold and make synthetic genes (or code it myself) with their desired effects, print them and install them in various varieties of CRISPRs to change my genes and gene expression at will.

And blackmail nebula genomics to give me full genome sequencing for free.

This way, I can make viruses with CRISPR in them and change genes and gene expression of anything I want.

 

[MoggedSubhuman]

Blackmail the motherfuckers on www.genscript.com to give me access to modified CRISPRs (CRISPR, CRISPRi, CRISPRa, etc.) and virus vectors and blackmail Google to give me unrestricted full access to AlphaFold and make synthetic genes (or code it myself) with their desired effects, print them and install them in various varieties of CRISPRs to change my genes and gene expression at will.

And blackmail nebula genomics to give me full genome sequencing for free.

This way, I can make viruses with CRISPR in them and change genes and gene expression of anything I want.

You get cancer from the gene editing instead.

The monkey's paw curls.

 

[enchanted_elixir]

You get cancer from the gene editing instead.

The monkey's paw curls.

I can't unless I'm messing with the genes that could play a role in it in the wrong manner, or give myself genes that are overpowered and the cancer inherits those genes.

 

[batman1997]

I can't unless I'm messing with the genes that could play a role in it in the wrong manner, or give myself genes that are overpowered and the cancer inherits those genes.

IS gene editing SAFE?

 

[enchanted_elixir]

IS gene editing SAFE?

You're playing with fire if you do it.
If you do it right though, you are MASSIVELY enhancing yourself.

You're going to have to get a CRISPR system,
then boot in the gene you want to target,
replace the dna of a virus with your assembled gene editing system
inject (better if you have a bad immune system so it can work better)
and then the crispr system will do the function
it'll infect as many cells as possible and carry out the function.
that is pretty much irreversible, you can create a new one to undo it but it won't infect every cell that was already infected and it may infect cells that were never infected

Thing is, you have to be able to predict if it'll work and if your CRISPR system is efficacious and robust.
You also don't want to be messing with genes that have a small margin for error unles you're smart/can predict safety.

Ex, you seek to increase your IGF-1 receptor gene expression using CRISPRa, you underestimated how much it'll amplify it and now, if you can't reverse it using CRISPRi targeted at the IGF-1 receptor gene in time, you will have way too many IGF-1 receptors.

And die of acromegaly rapidly.

Alternatively, if you swap your version of, for example, DRD1 gene
DRD1 = Dopamine Receptor D1
Basic Function:DRD1 is a protein on brain cells that responds to dopamine (the "reward/motivation" chemical). When dopamine binds to it, the cell becomes more active.
What It Controls:

• Motivation and reward: Makes you want to do things, feel pleasure
• Learning and memory: Helps you remember what's worth doing again
• Movement: Works with motor control circuits
• Attention and focus: Helps you concentrate on tasks
• Working memory: Keeps information "in mind" temporarily

...for a superior one (in this case, your variant is worse), you'll be more motivated, can think of more things at once, focused, and have a better reward system.

ex. you use SpCas9 (it edits or knocks out genes - standard), boot it in the gene target,

Spoiler: Types of CAS9s

Most Commonly Used CRISPR Systems​

Top 5 Most Used​

1. SpCas9(Streptococcus pyogenes Cas9)
   • Function: Standard gene knockout/editing
   • Why most used: First widely adopted, extensive protocols, reliable
2. dCas9-based tools
   • Function: Gene activation (increase expression) (CRISPRa) or repression (decrease expression) (CRISPRi)
   • Why most used: Non-cutting alternative for gene regulation studies
3. Cas9 nickase (nCas9)
   • Function: Single-strand breaks for safer editing
   • Why most used: Reduces off-target effects, required for base/prime editing
4. Base Editors (BE3, BE4, ABE7.10/ABE8e)
   • Function: C→T or A→G conversions without double-strand breaks
   • Why most used: Precise single-nucleotide changes, growing rapidly
5. Cas12a/Cpf1(LbCpf1, AsCpf1)
   • Function: Alternative nuclease with different PAM, processes own gRNA array
   • Why most used: Multiplexing capability, staggered cuts

Other Frequently Used​

1. SaCas9 - Smaller size for viral delivery
2. Prime Editors (PE2, PE3) - Versatile insertions/deletions/substitutions
3. Cas13 variants - RNA targeting and knockdown
4. High-fidelity variants (SpCas9-HF1, eSpCas9) - Reduced off-targets
5. dCas9-KRAB - Standard CRISPRi repression

SpCas9 remains dominant (~70-80% of published studies), with base editors and prime editors rapidly increasing in adoption.

 

[iblamexyz]

no such thing as perfect

 

[turkcelfatcel]

Anything