PharmaPhaggot
Busy slaying stacies, brb
- Joined
- Oct 14, 2024
- Posts
- 12,738
- Reputation
- 17,300
Now ive seen a lot of people calling it shit and not just new users, now ive done quite a bit of research on the compound and i cant find a valid reason to hate on it. Now it just seems more likely that im just wrong due to the amount of lr3 haters and ive just missed something but i cant find what ive missed do could someone help clear this up
pubmed.ncbi.nlm.nih.gov
Heres a study that showed lr3 being able to cause growth 3x better than native igf and its better dor protein synthesis
Also the reduced binding to igfbp's should mean that it more easily stimulates tissues that is more reliant on free range igf,like muscle and not cartiledge so you have a smaller risk of getting a jew nose
ttheres a study that also comfirms the claim that its more stable and more effective for igfr activation and also repair and cause more growth promotion
pubmed.ncbi.nlm.nih.gov
And igfr are replaced often which avoids quick desensitization and downstream effects recover quickly dince phophate,the main molecule in the pi3k/act pathways protein has a short halflife so rapid signaling can happen and youll recover quick,just let the deug clear in your system wait a bit and go on again to avoid having desensitized cells and therefore wasting your money
And even if the desensitization or negative feedback was an issue you could do a much lower dosage so it stimulates igfr's to ish the same degree of native igf which should be cheaper you get the other mentioned benefits
Please tell me if i have in fact missed something and provide the evidence
Insulin-like growth factor-I and more potent variants restore growth of diabetic rats without inducing all characteristic insulin effects - PubMed
The effects of graded doses of insulin-like growth factor-I (IGF-I) and two variants which bind poorly to IGF-binding proteins were investigated in 160 g streptozotocin-induced diabetic rats. The two variants were the truncated form, des(1-3)IGF-I, and another with arginine at residue 3 and an...
pubmed.ncbi.nlm.nih.gov
Also the reduced binding to igfbp's should mean that it more easily stimulates tissues that is more reliant on free range igf,like muscle and not cartiledge so you have a smaller risk of getting a jew nose
ttheres a study that also comfirms the claim that its more stable and more effective for igfr activation and also repair and cause more growth promotion
Design and characterisation of long-R3-insulin-like growth factor-I muteins which show resistance to pepsin digestion - PubMed
Site-directed mutagenesis was used to construct pepsin-resistant, single-point mutations of the N-terminal extended IGF-I analogue, long-R3-IGF-I. In order to identify the most susceptible sites, the kinetics of long-R3-IGF-I digestion by purified porcine pepsin were determined. Pepsin initially...
pubmed.ncbi.nlm.nih.gov
And igfr are replaced often which avoids quick desensitization and downstream effects recover quickly dince phophate,the main molecule in the pi3k/act pathways protein has a short halflife so rapid signaling can happen and youll recover quick,just let the deug clear in your system wait a bit and go on again to avoid having desensitized cells and therefore wasting your money
And even if the desensitization or negative feedback was an issue you could do a much lower dosage so it stimulates igfr's to ish the same degree of native igf which should be cheaper you get the other mentioned benefits
Please tell me if i have in fact missed something and provide the evidence
