why do people use Accutane/Isotretinoin while it reduces igf1?

[Zeyad Mohamed]

sources:
https://pubmed.ncbi.nlm.nih.gov/20128787/
https://www.jddonline.com/articles/...n-effect-of-isotretinoin-an-S1545961611P0793X
https://www.longdom.org/open-access...unctions-of-sz95-sebocytes-emin-vi-16046.html

Does isotretinoin have an effect on glucose metabolism, insulin growth factor-1 and insulin-like growth factor-3 binding protein?

Introduction Isotretinoin is the only effective agent at all stages of acne vulgaris, but its effects on certain systems remain unkown. Objective To evaluate the effects of isotretinoin and other acne treatments on insulin growth factor-1 (IGF-1), insulin-like growth factor-3 binding protein...

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[Evgeniy291]

is it bc they stopped growing?