Why does dutasteride have to be taken daily if the half-life is 5 weeks?

[aztecas]

title. Just wondering as i’m taking 0.5 daily

 

[Deleted member 322807]

to maintain stability (rep + solution)

 

[eyezen]

isnt half life 4 radioactive stuff?

 

[aztecas]

@SlayerJonas
@Chad
@Rabbi
@ActualMax
@Seth Walsh
@androgenic

 

[SlayerJonas]

@SlayerJonas
@Chad
@Rabbi
@ActualMax
@Seth Walsh
@androgenic

ideally frontload with 40mg due to the long half life, then maintain with a daily dose of 2-3mg. you could realistically dose less frequently, but everyone sticks to daily dosing. there's no real reason besides it being a little more stable.

 

[Rabbi]

Technically a higher half life means a longer time to reach steady state concentrations in blood. If you space them out maximally saturation will be lower not by an insane amount but still. I won’t bore you with the pharmacokinetics.

you could load for 6 months reach steady state suppression of ~95% and then maintain at Every third day.