Why HGH is cope and will NOT work for you!!!! (HGH USERS GTFIH!!!)

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Spoiler: How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.

2. What the Studies ACTUALLY Show

Spoiler: What the studies ACTUALLY show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:

• Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency
• Use of growth hormone in children with GHD
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
• National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries
• Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
• Effect of different doses of recombinant human growth hormone therapy on children with growth hormone deficiency: a retrospective observational study
• Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency

VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):

• Long-term results of growth hormone therapy in children with idiopathic short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group
• THE IMPACT OF DOSAGE ON THE EFFECT OF GROWTH HORMONE THERAPY IN CHILDREN WITH IDIOPATHIC SHORT STATURE
• Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency
• Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center

B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.

3. Why HGH does NOT work for healthy normal children with PROOF

Spoiler: Why HGH does NOT work for healthy normal children

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:

• GH does not create new growth potential.
  The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
• GH cannot override genetic determinants of stature.
  Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
• Endocrine feedback loops limit excessive growth signaling.
  The GH–IGF-1 axis is tightly regulated:
  • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
  • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
• Physiologic ceiling effect.
  In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration

EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.

4. Why people think it works!!!!!!

Spoiler: Why most people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

5. What you actually get and are paying for: Side Effects

Spoiler: What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

• Insulin resistance
• Increased risk of type 2 diabetes
• Fluid retention and edema
• Joint pain
• Carpal tunnel syndrome
• Hip growth plate injury
• Benign intracranial hypertension (severe headaches and vision changes)
• Abnormal IGF‑1 elevations
• Theoretical increased cancer risk due to chronic IGF‑1 stimulation

​

6. Summary

Spoiler: Summary

HGH only works in:

• Documented GH deficiency
• Select ISS cases

HGH does NOT:

• Make normal kids taller than their genetics allow
• Extend growth plates
• Increase final adult height
• Create height out of nowhere

If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.

 

[tenmoreminutes]

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Spoiler: How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.

2. What the Studies ACTUALLY Show

Spoiler: What the studies ACTUALLY show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:

• Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency
• Use of growth hormone in children with GHD
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
• National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries
• Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
• Effect of different doses of recombinant human growth hormone therapy on children with growth hormone deficiency: a retrospective observational study
• Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency

VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):

• Long-term results of growth hormone therapy in children with idiopathic short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group
• THE IMPACT OF DOSAGE ON THE EFFECT OF GROWTH HORMONE THERAPY IN CHILDREN WITH IDIOPATHIC SHORT STATURE
• Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency
• Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center

B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.

3. Why HGH does NOT work for healthy normal children with PROOF

Spoiler: Why HGH does NOT work for healthy normal children

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:

• GH does not create new growth potential.
  The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
• GH cannot override genetic determinants of stature.
  Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
• Endocrine feedback loops limit excessive growth signaling.
  The GH–IGF-1 axis is tightly regulated:
  • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
  • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
• Physiologic ceiling effect.
  In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration

EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.

4. Why people think it works!!!!!!

Spoiler: Why most people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

5. What you actually get and are paying for: Side Effects

Spoiler: What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

• Insulin resistance
• Increased risk of type 2 diabetes
• Fluid retention and edema
• Joint pain
• Carpal tunnel syndrome
• Hip growth plate injury
• Benign intracranial hypertension (severe headaches and vision changes)
• Abnormal IGF‑1 elevations
• Theoretical increased cancer risk due to chronic IGF‑1 stimulation

​

6. Summary

Spoiler: Summary

HGH only works in:

• Documented GH deficiency
• Select ISS cases

HGH does NOT:

• Make normal kids taller than their genetics allow
• Extend growth plates
• Increase final adult height
• Create height out of nowhere

If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.

makes a lot of sense, good post

 

[reqlorx]

Yeah but still your grow faster to the genetic ceiling. Or maybe you normally couldn’t reach it because of bad habits like not sleeping or eating good but with hgh you could atleast use your potential

 

[Associatee]

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Spoiler: How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.

2. What the Studies ACTUALLY Show

Spoiler: What the studies ACTUALLY show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:

• Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency
• Use of growth hormone in children with GHD
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
• National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries
• Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
• Effect of different doses of recombinant human growth hormone therapy on children with growth hormone deficiency: a retrospective observational study
• Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency

VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):

• Long-term results of growth hormone therapy in children with idiopathic short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group
• THE IMPACT OF DOSAGE ON THE EFFECT OF GROWTH HORMONE THERAPY IN CHILDREN WITH IDIOPATHIC SHORT STATURE
• Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency
• Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center

B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.

3. Why HGH does NOT work for healthy normal children with PROOF

Spoiler: Why HGH does NOT work for healthy normal children

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:

• GH does not create new growth potential.
  The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
• GH cannot override genetic determinants of stature.
  Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
• Endocrine feedback loops limit excessive growth signaling.
  The GH–IGF-1 axis is tightly regulated:
  • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
  • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
• Physiologic ceiling effect.
  In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration

EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.

4. Why people think it works!!!!!!

Spoiler: Why most people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

5. What you actually get and are paying for: Side Effects

Spoiler: What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

• Insulin resistance
• Increased risk of type 2 diabetes
• Fluid retention and edema
• Joint pain
• Carpal tunnel syndrome
• Hip growth plate injury
• Benign intracranial hypertension (severe headaches and vision changes)
• Abnormal IGF‑1 elevations
• Theoretical increased cancer risk due to chronic IGF‑1 stimulation

​

6. Summary

Spoiler: Summary

HGH only works in:

• Documented GH deficiency
• Select ISS cases

HGH does NOT:

• Make normal kids taller than their genetics allow
• Extend growth plates
• Increase final adult height
• Create height out of nowhere

If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.

all these doses in the sources are INCREDIBLY small though, this will have an impact , wont it?

 

[d99lotus]

Genuinely asking, but gigantism is caused from excessive gh secretion in growing children before growth plates have fused and it completely overrides your genetic limit so wont this have any correlation here or is it different because this is exogenous?

 

[Ahmed88]

all these doses in the sources are INCREDIBLY small though, this will have an impact , wont it?

The dosing was not small. HGH dosing is weight and size based in pedriatic medicine.

A smaller body would produce a greater reaction then a bigger bodied individual (obviously). Taking that conclusion all the studies except one had doses that were high enough.

Although i have a new improved thread planned, with wayyy more studies and different dosing.

Genuinely asking, but gigantism is caused from excessive gh secretion in growing children before growth plates have fused and it completely overrides your genetic limit so wont this have any correlation here or is it different because this is exogenous?

I have explained this countless times in this thread, a tumor isn't comparable to injecting chinese lab-made HGH. So yes, it is different, if you want to know why, you can look through this thread or even other threads showing why.

 

[Joeseminate]

I can no longer fit my hand around my wrist

 

[Ahmed88]

I can no longer fit my hand around my wrist

What about your organs?

 

[Joeseminate]

What about your organs?

probably a bit of growth, none ive noticed tho

 

[Ahmed88]

probably a bit of growth, none ive noticed tho

Aren't you like 19 with fused growth plates?

 

[Joeseminate]

Aren't you like 19 with fused growth plates?

Yes I just use for gymcelling, same with test thats why I dont crash my e2 on top of it

 

[aac21]

The dosing was not small. HGH dosing is weight and size based in pedriatic medicine.

A smaller body would produce a greater reaction then a bigger bodied individual (obviously). Taking that conclusion all the studies except one had doses that were high enough.

Although i have a new improved thread planned, with wayyy more studies and different dosing.



I have explained this countless times in this thread, a tumor isn't comparable to injecting chinese lab-made HGH. So yes, it is different, if you want to know why, you can look through this thread or even other threads showing why.

this is just false, i clicked one study and compared the dose (0.5 IU/kg/week, 0.167 mg/kg/week) to my weight which is 150 pounds

and its calcualted to 4 iu per day lol

JFL at this post

 

[justine]

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Spoiler: How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.

2. What the Studies ACTUALLY Show

Spoiler: What the studies ACTUALLY show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:

• Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency
• Use of growth hormone in children with GHD
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
• National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries
• Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
• Effect of different doses of recombinant human growth hormone therapy on children with growth hormone deficiency: a retrospective observational study
• Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency

VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):

• Long-term results of growth hormone therapy in children with idiopathic short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group
• THE IMPACT OF DOSAGE ON THE EFFECT OF GROWTH HORMONE THERAPY IN CHILDREN WITH IDIOPATHIC SHORT STATURE
• Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency
• Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center

B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.

3. Why HGH does NOT work for healthy normal children with PROOF

Spoiler: Why HGH does NOT work for healthy normal children

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:

• GH does not create new growth potential.
  The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
• GH cannot override genetic determinants of stature.
  Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
• Endocrine feedback loops limit excessive growth signaling.
  The GH–IGF-1 axis is tightly regulated:
  • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
  • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
• Physiologic ceiling effect.
  In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration

EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.

4. Why people think it works!!!!!!

Spoiler: Why most people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

5. What you actually get and are paying for: Side Effects

Spoiler: What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

• Insulin resistance
• Increased risk of type 2 diabetes
• Fluid retention and edema
• Joint pain
• Carpal tunnel syndrome
• Hip growth plate injury
• Benign intracranial hypertension (severe headaches and vision changes)
• Abnormal IGF‑1 elevations
• Theoretical increased cancer risk due to chronic IGF‑1 stimulation

​

6. Summary

Spoiler: Summary

HGH only works in:

• Documented GH deficiency
• Select ISS cases

HGH does NOT:

• Make normal kids taller than their genetics allow
• Extend growth plates
• Increase final adult height
• Create height out of nowhere

If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.

But would it and could it get u at least to your genetic potential ?

 

[Ahmed88]

this is just false, i clicked one study and compared the dose (0.5 IU/kg/week, 0.167 mg/kg/week) to my weight which is 150 pounds

and its calcualted to 4 iu per day lol

JFL at this post

Oh my fucking god

First of all, you litterally took the study with the lowest fucking dose


Second of all, you didn't even fucking calculate it right, its 5IU for 150 pounds which is a scientifically significant difference compared to 4IU.


Third of all, there's a study which would equal TEN FUCKING IUS for a 150 pounds fag


"Muh muh, you didn't do the right right and shieet"

If you want i can bring you other studies, faggot, if i have time that is

But would it and could it get u at least to your genetic potential ?

There's no proof it will or won't, but in theory it wouldn't.

 

[justine]

Oh my fucking god

First of all, you litterally took the study with the lowest fucking dose


Second of all, you didn't even fucking calculate it right, its 5IU for 150 pounds which is a scientifically significant difference compared to 4IU.


Third of all, there's a study which would equal TEN FUCKING IUS for a 150 pounds fag


"Muh muh, you didn't do the right right and shieet"

If you want i can bring you other studies, faggot, if i have time that is


There's no proof it will or won't, but in theory it wouldn't.

Idk cuz I may be gullaulible or the results are real I’ve seen lots of men get taller on gh that’s the thing I can’t say for 100 percent it’s the gh or the puberty there still in but it can reach ur genetic potential height

And if that can’t happen explain why

 

[Ahmed88]

Idk cuz I may be gullaulible or the results are real I’ve seen lots of men get taller on gh that’s the thing I can’t say for 100 percent it’s the gh or the puberty there still in but it can reach ur genetic potential height

And if that can’t happen explain why

GH causes faster hight velocity, that's why it looks like it's working

 

[justine]

GH causes faster hight velocity, that's why it looks like it's working

What about erda and tyra

 

[Ahmed88]

What about erda and tyra

Same thing, lack of evidence, plus the genetic limit still exists

 

[U1fur]

so if i would take a shit load of HGH and my twin would not take a shit load and just skip it we will end up with the same height?

and isint gigantism just people that have much more GH than normal humans??

this makes sense but sounds also cope

 

[Ahmed88]

so if i would take a shit load of HGH and my twin would not take a shit load and just skip it we will end up with the same height?

As the evidence suggests, if a 1:1 replica of you, given he's in the same environment and receives the same adequate nourishment, then yes, he'll grow faster, but eventually you'll be the same height.

and isint gigantism just people that have much more GH than normal humans??

No, it's a tumor. Even exogenous and endogenous HGH have vast differences, nevertheless a tumor. Me and other users explained this multiple times in this thread and others on this forum.

this makes sense but sounds also cope

But an unknown compound formulated in the slums of wuhan, that increases your height like some compound V seems true?

 

[guts000]

Buzzword unless u prove that hgh can increase final height in non deficient children

Pretty Sure there are plently of Studies where gh increases fah and Non GHD kids

 

[Ahmed88]

Pretty Sure there are plently of Studies where gh increases fah and Non GHD kids

You know it's customary to atleast leave a fucking link.

 

[threete]

A lot of People continue to believe that healthy children who lack growth hormone deficiency will experience height increases through HGH injections.

It won’t.

Why?

Let’s get into this


1. How Growth Hormone Actually Works

Spoiler: How Growth Hormone Actually Works

Human growth hormone (HGH), also called somatotropin, is a hormone that the pituitary gland, which is about the size of a pea and found at the base of your brain, makes and releases

Its main job?

Human growth hormone triggers growth in almost every tissue and organ in your body. It’s mostly known for its growth-promoting effect on cartilage and bone, especially in puberty. Cells in cartilage called chondrocytes and cells in bones called osteoblasts, receive signals from HGH to increase replication and thus allow for growth in size.

2. What the Studies ACTUALLY Show

Spoiler: What the studies ACTUALLY show

People often cite studies claiming “HGH increases height.” Let’s clarify what these studies actually studied.

Most research involves children who are GH-deficient children who cannot produce normal levels of GH due to medical conditions. Examples:

• Short and Long-Term Effects of Growth Hormone in Children and Adolescents With GH Deficiency
• Use of growth hormone in children with GHD
• Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation
• National Cooperative Growth Study: 25 Years of Growth Hormone Data, Insights, and Lessons for Future Registries
• Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
• Effect of different doses of recombinant human growth hormone therapy on children with growth hormone deficiency: a retrospective observational study
• Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency

VERY Important: These studies are on children who are medically short due to GH deficiency, and do NOT produce enough HGH not normal kids. The effect is correcting a deficiency, not surpassing genetic potential.



Some other studies explore ISS (Idiopathic Short Stature):

• Long-term results of growth hormone therapy in children with idiopathic short stature, subnormal growth rate and normal growth hormone response to secretagogues. Dutch Growth Hormone Working Group
• THE IMPACT OF DOSAGE ON THE EFFECT OF GROWTH HORMONE THERAPY IN CHILDREN WITH IDIOPATHIC SHORT STATURE
• Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency
• Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center

B-B-But ISS Children Grew Taller why can’t i?

Let’s clarify: ISS children are not short simply because of genetics. ISS is defined as short stature without a known cause, that INCLUDES GENETICS and many children diagnosed as having ISS have partial GH insensitivity (Evidence: Idiopathic short stature)

Bottom line: if you are within normal growth ranges and are not diagnosed as ISS, these studies do NOT apply to you.

3. Why HGH does NOT work for healthy normal children with PROOF

Spoiler: Why HGH does NOT work for healthy normal children

For children with normal growth hormone (GH) levels, exogenous GH administration cannot increase final adult height. Here’s why:

• GH does not create new growth potential.
  The growth plates in long bones experience linear growth through their epiphyseal plates. The genetic code determines both number and proliferative capacity of chondrocytes present at these growth plates. GH promotes the growth of chondrocytes and their development into mature cells, yet it cannot boost these cells' genetic-based growth capacity beyond their existing limits.
• GH cannot override genetic determinants of stature.
  Height is a polygenic trait which multiple genetic loci control its development. The treatment of GH-sufficient children with GH therapy does not affect their gene expression or the genetic skeletal structure which their genome contains.
• Endocrine feedback loops limit excessive growth signaling.
  The GH–IGF-1 axis is tightly regulated:
  • Elevated serum IGF-1 inhibits hypothalamic GHRH secretion and stimulates somatostatin release, reducing endogenous GH production.
  • Peripheral tissues exhibit receptor-mediated resistance to supra-physiologic GH and IGF-1 concentrations, limiting further cellular proliferation.
• Physiologic ceiling effect.
  In GH-sufficient children, endogenous GH already saturates IGF-1 production and downstream growth plate signaling. Exogenous GH cannot enhance this process; the system is operating at maximal physiological capacity. Clinical evidence and studies supports these claims: children with normal GH levels do not achieve increased adult height despite high-dose GH administration

EVIDENCE AND STUDIES ON NORMAL KIDS:

Final height after growth hormone therapy in non-growth-hormone-deficient children with short stature - PubMed

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PMC

https://www.sciencedirect.com/science/article/abs/pii/S002234769470192X

No Improvement of Adult Height in Non-growth Hormone (GH) Deficient Short Children with GH Treatment - PubMed



Analogy (for conceptual clarity): Imagine a plant with genetically fixed maximum height. Adequate water and nutrients allow it to reach its potential. Adding more water beyond what it can physiologically use does not make it grow taller; it may even disrupt normal growth processes.

Summary: GH in healthy, non-deficient children simply optimizes a process that is already at capacity. There is no latent or “hidden” height to unlock the endocrine system and growth plates are already functioning at their maximum biological limits.

4. Why people think it works!!!!!!

Spoiler: Why most people think it works!!!!!!

This is where most people get fooled and start to think it’s working.

HGH can TEMPORARILY increase growth rate (as seen in the studies). You grow faster for a period, but it does NOT increase final adult height. Your genetic height ceiling remains THE SAME. In the end you will grow the same without HGH.

5. What you actually get and are paying for: Side Effects

Spoiler: What you actually get and are paying for: Side Effects

Injecting ratpiss HGH from Chinese labs is retarded and will NOT work all you are paying for are potential risks including:

• Insulin resistance
• Increased risk of type 2 diabetes
• Fluid retention and edema
• Joint pain
• Carpal tunnel syndrome
• Hip growth plate injury
• Benign intracranial hypertension (severe headaches and vision changes)
• Abnormal IGF‑1 elevations
• Theoretical increased cancer risk due to chronic IGF‑1 stimulation

​

6. Summary

Spoiler: Summary

HGH only works in:

• Documented GH deficiency
• Select ISS cases

HGH does NOT:

• Make normal kids taller than their genetics allow
• Extend growth plates
• Increase final adult height
• Create height out of nowhere

If you do not have a diagnosed condition, you will not gain any adult height you will only get side effects.

The truth?: There is no hack around genetics. Injecting Chinese ratpiss HGH is expensive, unnecessary, and retarded.



Biology does not care about your retarded cope.

W was highkey considering it a few weeks ago since im 5'11

 

[wintercrow]

No, ive explained this multiple times in this thread, e2 is needed for growth

Estradiol (E2) significantly enhances Growth Hormone (GH) secretion by amplifying the size of GH pulses (not frequency) while simultaneously lowering circulating IGF-1 levels.
This is backed by the research paper linked below:

· URL: https://pubmed.ncbi.nlm.nih.gov/8964860/
· Key Findings: The 1996 study found that E2 treatment increased 24-hour integrated GH concentrations from 494 to 860 (oral) and 832 (transdermal). It increased GH pulse height and area without changing pulse frequency. Concurrently, IGF-1 concentrations decreased from 165 to 109 (oral) and 122 (transdermal).

More GH and less IGF 1 is inherently worse because igf 1 is the builder and gh is the signal. You can signal all you want but if you do not have the building blocks, you will not grow. If you block e2, you’re decreasing the gh signals, which you can maintain by exogenous hgh