CalebIQ
Iron
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NAAAS (Non-Aromatizing Androgenic Anabolic Steroids) are the second most important part of heightmaxxing.
Growth plates SOLELY close because of estrogen. People think androgens close growth plates, when they simply make them multiply more. But this only advances cells towards the hayflick limit. However, if someone reached the hayflick limit of chondrocytes without estrogen, they would be over 12 feet tall. Effectively, androgens do not close growth plates. The biggest piece of evidence in support of this is aromatase deficient men, growing into 20s and 30s despite higher testosterone.
The reason WHY estrogen closes growth plates is through 2 things:
1. Upregulating VEGF (Vascular Endothelial Growth Factor) which makes blood vessels invade the growth plate, causing it to turn into bone
2. Rapidly cycling chondrocytes through the hayflick limit WITHOUT letting them proliferate.. AND it inhibits the final hypertrophied size.
Androgens do neither of these.
Androgens enhance proliferation rate, effectively giving a permanent growth spurt in the absence of estrogen. Normally, androgens aromatize into estrogen, which is why steroids have the reputation of stunting growth.
This is where NAAAS come in. NAAAS (Such as Masteron, Trenbolone, Anavar, Primobolan, Halotestin, etc) are incapable of being converted into estrogen. This means they solely give the growth boost. On TOP of that, external steroid use shuts down your HPTA (Hypothalamic-Pituitary-Testicular Axis), which is what we want in this situation. Shutting off your own hormones with NAAAS guarantees zero estrogen (except for small amounts from adrenal glands, so an aromatase inhibitor can be helpful)
Anavar at an extremely low dose (2.5mg) was used in children with growth delay and it DOUBLED rate of height growth. Even at such a low dose it helped.
Overall, NAAAS are better than AIs at inhibiting estrogen and give a strong growth signal. Proliferation AND the final size of hypertrophied chondrocytes is increased. Hypertrophied chondrocytes are what actually add to your height. Many content creators say that androgens advance bone age, which is partially true, but only up to a certain point. If they really wanted to avoid estrogen and androgens, they would take puberty blockers. Yet in EVERY study, blocking androgens with puberty blockers vastly decreased growth rates.
Not all NAAAS are created equal, though. Anavar is mild and very hepatotoxic, Halotestin is extremely hepatotoxic, Tren can replicate progesterone and cause breast growth, and Primo is more anabolic than androgenic. You want androgenic signalling for facial and height growth. This is why Masteron is the best NAAAS available. Very androgenic, injectable, no major caveats. Something to note is that bone density is very impaired with low e2. Tamoxifen (a unique medicine that displays either estrogenic or anti estrogenic properties based on the type of tissue) can be used to improve bone density and lipid profiles because it is uniquely estrogenic in trabecular and cortical bone, and the liver, while being anti estrogenic in breast and growth plates. This improves bone density, lipid profiles, growth plates, and may help manage tren tits if you take tren.
Androgens are also synergistic with growth hormone, enhancing the receptors as well as modulating IGFBPs (IGF Binding Proteins) to make igf1 more effective. They cause paracrine (local) release of igf1 in chondrocytes. Androgens and gh will result in much higher proliferation and final hypertrophied size of chondrocytes, as well as expanding the resting zone. NAAAS are even stronger due to not being locally inhibited by estrogen within cells.
In conclusion, using NAAAS to suppress natural hormones and e2 would lead to growth plates that dont close for many, many years. With proper methods to increase growth velocity, you could basically choose any height you want with no e2.
Growth plates SOLELY close because of estrogen. People think androgens close growth plates, when they simply make them multiply more. But this only advances cells towards the hayflick limit. However, if someone reached the hayflick limit of chondrocytes without estrogen, they would be over 12 feet tall. Effectively, androgens do not close growth plates. The biggest piece of evidence in support of this is aromatase deficient men, growing into 20s and 30s despite higher testosterone.
The reason WHY estrogen closes growth plates is through 2 things:
1. Upregulating VEGF (Vascular Endothelial Growth Factor) which makes blood vessels invade the growth plate, causing it to turn into bone
2. Rapidly cycling chondrocytes through the hayflick limit WITHOUT letting them proliferate.. AND it inhibits the final hypertrophied size.
Androgens do neither of these.
Androgens enhance proliferation rate, effectively giving a permanent growth spurt in the absence of estrogen. Normally, androgens aromatize into estrogen, which is why steroids have the reputation of stunting growth.
This is where NAAAS come in. NAAAS (Such as Masteron, Trenbolone, Anavar, Primobolan, Halotestin, etc) are incapable of being converted into estrogen. This means they solely give the growth boost. On TOP of that, external steroid use shuts down your HPTA (Hypothalamic-Pituitary-Testicular Axis), which is what we want in this situation. Shutting off your own hormones with NAAAS guarantees zero estrogen (except for small amounts from adrenal glands, so an aromatase inhibitor can be helpful)
Anavar at an extremely low dose (2.5mg) was used in children with growth delay and it DOUBLED rate of height growth. Even at such a low dose it helped.
Overall, NAAAS are better than AIs at inhibiting estrogen and give a strong growth signal. Proliferation AND the final size of hypertrophied chondrocytes is increased. Hypertrophied chondrocytes are what actually add to your height. Many content creators say that androgens advance bone age, which is partially true, but only up to a certain point. If they really wanted to avoid estrogen and androgens, they would take puberty blockers. Yet in EVERY study, blocking androgens with puberty blockers vastly decreased growth rates.
Not all NAAAS are created equal, though. Anavar is mild and very hepatotoxic, Halotestin is extremely hepatotoxic, Tren can replicate progesterone and cause breast growth, and Primo is more anabolic than androgenic. You want androgenic signalling for facial and height growth. This is why Masteron is the best NAAAS available. Very androgenic, injectable, no major caveats. Something to note is that bone density is very impaired with low e2. Tamoxifen (a unique medicine that displays either estrogenic or anti estrogenic properties based on the type of tissue) can be used to improve bone density and lipid profiles because it is uniquely estrogenic in trabecular and cortical bone, and the liver, while being anti estrogenic in breast and growth plates. This improves bone density, lipid profiles, growth plates, and may help manage tren tits if you take tren.
Androgens are also synergistic with growth hormone, enhancing the receptors as well as modulating IGFBPs (IGF Binding Proteins) to make igf1 more effective. They cause paracrine (local) release of igf1 in chondrocytes. Androgens and gh will result in much higher proliferation and final hypertrophied size of chondrocytes, as well as expanding the resting zone. NAAAS are even stronger due to not being locally inhibited by estrogen within cells.
In conclusion, using NAAAS to suppress natural hormones and e2 would lead to growth plates that dont close for many, many years. With proper methods to increase growth velocity, you could basically choose any height you want with no e2.