Why Systemic GHK-CU is ass

[skigmamigma]

Dumb nigger you used the exact same study, fuck you kill yourself

Wow i used the same study on a very popular mice test regarding ghk cu while talking about ghk-cu..... HOW CAN THIS BE

 

[Deleted member 230985]

Wow i used the same study on a very popular mice test regarding ghk cu while talking about ghk-cu..... HOW CAN THIS BE

Fuck off nigger give me credit or you are getting banned

 

[Diᴏgenes]

No.
HED (mg/kg) = Animal dose (mg/kg) × (Km_animal / Km_human)
Mouse Km = 3, Human Km = 37
0.5 × (3 / 37) = 0.0405 mg/kg
0.0405 × 90 kg = ≈3.6 mg/day

Even if you use the 0.75 allometric exponent method:
Dose₂ = 0.0125 × (90 / 0.025)^0.75 = ≈5.8 mg

View attachment 4299680

But that would only be effective localized? noone is injecting it directly into their face, they're injecting it subq in their abdomen

 

[nr1fraudmaxxer]

But that would only be effective localized? noone is injecting it directly into their face, they're injecting it subq in their abdomen

No localized injections doesnt matter, the point of systemic is just to activate the pathways to upregulate the collagen production etc. It doesn’t need to sit in the exact tissue to work.

 

[Diᴏgenes]

No localized injections doesnt matter, the point of systemic is just to activate the pathways to upregulate the collagen production etc. It doesn’t need to sit in the exact tissue to work.

isn't the half life too short

 

[nr1fraudmaxxer]

isn't the half life too short

Half life is short but can still trigger signaling even after its cleared

 

[Diᴏgenes]

Half life is short but can still trigger signaling even after its cleared

What's the point of injecting it for a possible effect that, at best, will be minuscule, when you could just apply it topically on the face?

 

[nr1fraudmaxxer]

What's the point of injecting it for a possible effect that, at best, will be minuscule, when you could just apply it topically on the face?

Topical oxidizes and has poor penetration unless you dermatsamp and alot of serums has poor stability and it doesnt get the same benefits like anti aging, hair, overall collagen synthesis you get from systemic

 

[Diᴏgenes]

Topical oxidizes and has poor penetration unless you dermatsamp and alot of serums has poor stability and it doesnt get the same benefits like anti aging, hair, overall collagen synthesis you get from systemic

Does that matter tho? Even if we assume it's all true, the studies we have where it was applied topically still showed great results

 

[nr1fraudmaxxer]

Does that matter tho? Even if we assume it's all true, the studies we have where it was applied topically still showed great results

Well if you only want localized effects sure topical works but there are only good results with deep penetration with stamping. But mechanistic or in vitro data doesn’t prove that topical use gives the same clinical benefits as systemic dosing

 

[Mrinfinityx]

So currently, the copper peptide GHK-CU has gained alot of fame for it's supposed collagen benefits. But can this peptide actually live up to its hype?

Spoiler: Systemic GHK-CU benefits

So recently a lot of people have been throwing around the supposed "benefits" of Systemic GHK-CU dosed daily from 2-5mg.
(Anti-aging, Improved skin & hair, Skin & collagen improvement)
But when you look into the literature the dose and the benefits simply do not correlate.

Spoiler: Explanation

So you may be wondering why I say this - well, let me explain.
View attachment 4299178
Here for example, we see a study of GHK-Cu being used on mice (like nearly all other GHK-Cu tests), and if you look where I drew the red circle, the study explains that they dosed the mice with 10 µg/g. doesn't sound like much, but that is actually 10mg/kg

And every single GHK-CU study you find out there, every single one dosed the subjects at over 0.5mg/kg for it to be "significant" as for example shown in this study by The Journal Of Clinical Investigation
View attachment 4299209

Spoiler: Half-Life of GHK-CU

And unfortunately GHK-CU has one more major problem about it, that being the half life.
Now we don't actually know a lot about GHK-CU's half-life but it's estimated to be somewhere from 5 minutes to an hour.

Spoiler: My Conclusion On Systemic Usage of GHK-CU

So with that being said, when we actually look at the data instead of the marketing, it becomes clear that systemic GHK-Cu simply doesn’t live up to the hype. But hypothetically let's say we use the copious dose that they used on mice in the studies. The average weight of a man in USA is 199 Pounds / 90 KG.
So as I said earlier the dose at which GHK-CU became significantly effective was 0.5mg / kg.
And if we apply that to the average weight of an American man, You would have to dose 45mg GHK-CU everyday


Just to put that into perspective, it would be more expensive to effectively dose GHK-CU monthly than HGH

Spoiler: Sources

In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds - PubMed

The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) was first described as a growth factor for differentiated cells. Recent in vitro data showed that it possesses several properties of a potential activator of wound repair. We investigated the effects of GHK-Cu in vivo, using...

pubmed.ncbi.nlm.nih.gov

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice | Oncotarget

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data - PubMed

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports...

pubmed.ncbi.nlm.nih.gov

Spoiler: Final Note

Thank you for reading, I apologize if the formatting is not ideal as this is my first thread.

Finally I can be a poor pussy in peace

 

[theübermenschboy]

So currently, the copper peptide GHK-CU has gained alot of fame for it's supposed collagen benefits. But can this peptide actually live up to its hype?

Spoiler: Systemic GHK-CU benefits

So recently a lot of people have been throwing around the supposed "benefits" of Systemic GHK-CU dosed daily from 2-5mg.
(Anti-aging, Improved skin & hair, Skin & collagen improvement)
But when you look into the literature the dose and the benefits simply do not correlate.

Spoiler: Explanation

So you may be wondering why I say this - well, let me explain.
View attachment 4299178
Here for example, we see a study of GHK-Cu being used on mice (like nearly all other GHK-Cu tests), and if you look where I drew the red circle, the study explains that they dosed the mice with 10 µg/g. doesn't sound like much, but that is actually 10mg/kg

And every single GHK-CU study you find out there, every single one dosed the subjects at over 0.5mg/kg for it to be "significant" as for example shown in this study by The Journal Of Clinical Investigation
View attachment 4299209

Spoiler: Half-Life of GHK-CU

And unfortunately GHK-CU has one more major problem about it, that being the half life.
Now we don't actually know a lot about GHK-CU's half-life but it's estimated to be somewhere from 5 minutes to an hour.

Spoiler: My Conclusion On Systemic Usage of GHK-CU

So with that being said, when we actually look at the data instead of the marketing, it becomes clear that systemic GHK-Cu simply doesn’t live up to the hype. But hypothetically let's say we use the copious dose that they used on mice in the studies. The average weight of a man in USA is 199 Pounds / 90 KG.
So as I said earlier the dose at which GHK-CU became significantly effective was 0.5mg / kg.
And if we apply that to the average weight of an American man, You would have to dose 45mg GHK-CU everyday


Just to put that into perspective, it would be more expensive to effectively dose GHK-CU monthly than HGH

Spoiler: Sources

In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds - PubMed

The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) was first described as a growth factor for differentiated cells. Recent in vitro data showed that it possesses several properties of a potential activator of wound repair. We investigated the effects of GHK-Cu in vivo, using...

pubmed.ncbi.nlm.nih.gov

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice | Oncotarget

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data - PubMed

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports...

pubmed.ncbi.nlm.nih.gov

Spoiler: Final Note

Thank you for reading, I apologize if the formatting is not ideal as this is my first thread.

This needs to get stickied @SlayerJonas @TechnoBoss