Why Systemic GHK-CU is ass

[skigmamigma]

Dumb nigger you used the exact same study, fuck you kill yourself

Wow i used the same study on a very popular mice test regarding ghk cu while talking about ghk-cu..... HOW CAN THIS BE

 

[Eno]

Wow i used the same study on a very popular mice test regarding ghk cu while talking about ghk-cu..... HOW CAN THIS BE

Fuck off nigger give me credit or you are getting banned

 

[Diᴏgenes]

No.
HED (mg/kg) = Animal dose (mg/kg) × (Km_animal / Km_human)
Mouse Km = 3, Human Km = 37
0.5 × (3 / 37) = 0.0405 mg/kg
0.0405 × 90 kg = ≈3.6 mg/day

Even if you use the 0.75 allometric exponent method:
Dose₂ = 0.0125 × (90 / 0.025)^0.75 = ≈5.8 mg

View attachment 4299680

But that would only be effective localized? noone is injecting it directly into their face, they're injecting it subq in their abdomen

 

[nr1fraudmaxxer]

But that would only be effective localized? noone is injecting it directly into their face, they're injecting it subq in their abdomen

No localized injections doesnt matter, the point of systemic is just to activate the pathways to upregulate the collagen production etc. It doesn’t need to sit in the exact tissue to work.

 

[Diᴏgenes]

No localized injections doesnt matter, the point of systemic is just to activate the pathways to upregulate the collagen production etc. It doesn’t need to sit in the exact tissue to work.

isn't the half life too short

 

[nr1fraudmaxxer]

isn't the half life too short

Half life is short but can still trigger signaling even after its cleared

 

[Diᴏgenes]

Half life is short but can still trigger signaling even after its cleared

What's the point of injecting it for a possible effect that, at best, will be minuscule, when you could just apply it topically on the face?

 

[nr1fraudmaxxer]

What's the point of injecting it for a possible effect that, at best, will be minuscule, when you could just apply it topically on the face?

Topical oxidizes and has poor penetration unless you dermatsamp and alot of serums has poor stability and it doesnt get the same benefits like anti aging, hair, overall collagen synthesis you get from systemic

 

[Diᴏgenes]

Topical oxidizes and has poor penetration unless you dermatsamp and alot of serums has poor stability and it doesnt get the same benefits like anti aging, hair, overall collagen synthesis you get from systemic

Does that matter tho? Even if we assume it's all true, the studies we have where it was applied topically still showed great results

 

[nr1fraudmaxxer]

Does that matter tho? Even if we assume it's all true, the studies we have where it was applied topically still showed great results

Well if you only want localized effects sure topical works but there are only good results with deep penetration with stamping. But mechanistic or in vitro data doesn’t prove that topical use gives the same clinical benefits as systemic dosing