Why you should switch from tretinoin to trifarotene!

[kisszael]

Both are topical retinoids, but they differ a lot in targeting, efficacy, side effects, and tolerability.

1. Selectivity & Precision
Tretinoin → A first-generation retinoid. It activates all three retinoic acid receptors (RAR-α, RAR-β, RAR-γ).
Trifarotene → A fourth-generation retinoid and the first RAR-γ selective retinoid.
Since RAR-γ is the most abundant receptor in facial skin, trifarotene works more precisely where it's needed.
This means better efficacy at lower concentrations and potentially fewer side effects.

2. Better for Body & Back Acne:
Tretinoin mainly focuses on facial acne, and its effectiveness on thicker body skin is limited.
Trifarotene was specifically designed and clinically tested for both face and trunk (chest, back, shoulders).
Studies show significant improvements in body acne within 12 weeks.

3. Faster, Smoother Results:
Because trifarotene targets RAR-γ directly, it promotes:
Faster skin turnover
More efficient clogged pore clearing
Better collagen stimulation
Users often report seeing initial improvements in 6–8 weeks vs 10–12 weeks for tretinoin.

4. Reduced Irritation & Dryness:
Tretinoin’s broad receptor activation often causes redness, peeling, stinging, especially in the first 4–6 weeks.
Trifarotene, being RAR-γ selective, tends to cause less dryness and irritation while still delivering strong results.
Ideal for sensitive skin users or those who struggled with tretinoin purging.

5. Photostability Advantage:
Tretinoin degrades quickly in sunlight, meaning it must be used at night and loses potency if exposed.
Trifarotene has better photostability → meaning it holds up better against light exposure.
Still recommended at night, but you get stronger, more consistent results.

6. Better for Pigmentation & Texture:
Trifarotene’s precise activity stimulates even collagen remodeling, making it better for:
1. Post-acne marks
2. Uneven texture
3. Mild scars
It also has a slightly stronger depigmenting effect compared to tretinoin.
Only con I've experienced so far is the pricing of this thing but it can be handled by using it carefully

QUICK NOTE:
PLS ASK YOUR DOCTOR/DERMATOLOGIST BEFORE USING ANY TOPICAL CREAMS AND RETINOIDS!
IK this thread isnchat gpt ahh but alright its not bs!!

Thank you for reading this thread!

 

[Orka]

→

Smells like AI....

 

[unon]

View attachment 4095026
Smells like AI....

He said ai jfl

 

[Orka]

He said ai jfl

i did not read an atom tbf

 

[kisszael]

i did not read an atom tbf

Very bad no skin gains for you then

 

[PRAG]

Very bad no skin gains for you then

I got my prescription but this bad boy 50 euro where tret was free

 

[PRAG]

I got my prescription but this bad boy 50 euro where tret was free

Oh i forgot i have tret at home so is it worth 50 bucka

 

[kisszael]

Oh i forgot i have tret at home so is it worth 50 bucka

Tret is good but isn't photostable it'll vanish the minute you step outside in the sun without sunscreen meanwhile Trifarotene has a very high photostability and also less irritation issues with better results.

 

[PRAG]

Tret is good but isn't photostable it'll vanish the minute you step outside in the sun without sunscreen meanwhile Trifarotene has a very high photostability and also less irritation issues with better results.

Whon tf uses tret in the morning tho ?????

 

[kisszael]

Whon tf uses tret in the morning tho ???

Basically your skin is going through the retinoic or whatever effect throughout the day so once sunlight it touches your skin while using tret and youre exposed to sun, it starts to degrades

 

[kief]

Both are topical retinoids, but they differ a lot in targeting, efficacy, side effects, and tolerability.

1. Selectivity & Precision
Tretinoin → A first-generation retinoid. It activates all three retinoic acid receptors (RAR-α, RAR-β, RAR-γ).
Trifarotene → A fourth-generation retinoid and the first RAR-γ selective retinoid.
Since RAR-γ is the most abundant receptor in facial skin, trifarotene works more precisely where it's needed.
This means better efficacy at lower concentrations and potentially fewer side effects.

2. Better for Body & Back Acne:
Tretinoin mainly focuses on facial acne, and its effectiveness on thicker body skin is limited.
Trifarotene was specifically designed and clinically tested for both face and trunk (chest, back, shoulders).
Studies show significant improvements in body acne within 12 weeks.

3. Faster, Smoother Results:
Because trifarotene targets RAR-γ directly, it promotes:
Faster skin turnover
More efficient clogged pore clearing
Better collagen stimulation
Users often report seeing initial improvements in 6–8 weeks vs 10–12 weeks for tretinoin.

4. Reduced Irritation & Dryness:
Tretinoin’s broad receptor activation often causes redness, peeling, stinging, especially in the first 4–6 weeks.
Trifarotene, being RAR-γ selective, tends to cause less dryness and irritation while still delivering strong results.
Ideal for sensitive skin users or those who struggled with tretinoin purging.

5. Photostability Advantage:
Tretinoin degrades quickly in sunlight, meaning it must be used at night and loses potency if exposed.
Trifarotene has better photostability → meaning it holds up better against light exposure.
Still recommended at night, but you get stronger, more consistent results.

6. Better for Pigmentation & Texture:
Trifarotene’s precise activity stimulates even collagen remodeling, making it better for:
1. Post-acne marks
2. Uneven texture
3. Mild scars
It also has a slightly stronger depigmenting effect compared to tretinoin.
Only con I've experienced so far is the pricing of this thing but it can be handled by using it carefully

QUICK NOTE:
PLS ASK YOUR DOCTOR/DERMATOLOGIST BEFORE USING ANY TOPICAL CREAMS AND RETINOIDS!
IK this thread isnchat gpt ahh but alright its not bs!!

Thank you for reading this thread!

is it better than taz

 

[LosPollosTV]

thanks this is high iq

 

[kisszael]

is it better than taz

As per my dermat, YES. This is better than taz and tret yes its the 4th gen retinoid with less irritation and a lil faster result

 

[theübermenschboy]

As per my dermat, YES. This is better than taz and tret yes its the 4th gen retinoid with less irritation and a lil faster result

What do you think is better :
Adapalene or Trifarotene?
As Adapalene is also selective in RAR,s and does not target all three

 

[Deleted member 93082]

Both are topical retinoids, but they differ a lot in targeting, efficacy, side effects, and tolerability.

1. Selectivity & Precision
Tretinoin → A first-generation retinoid. It activates all three retinoic acid receptors (RAR-α, RAR-β, RAR-γ).
Trifarotene → A fourth-generation retinoid and the first RAR-γ selective retinoid.
Since RAR-γ is the most abundant receptor in facial skin, trifarotene works more precisely where it's needed.
This means better efficacy at lower concentrations and potentially fewer side effects.

2. Better for Body & Back Acne:
Tretinoin mainly focuses on facial acne, and its effectiveness on thicker body skin is limited.
Trifarotene was specifically designed and clinically tested for both face and trunk (chest, back, shoulders).
Studies show significant improvements in body acne within 12 weeks.

3. Faster, Smoother Results:
Because trifarotene targets RAR-γ directly, it promotes:
Faster skin turnover
More efficient clogged pore clearing
Better collagen stimulation
Users often report seeing initial improvements in 6–8 weeks vs 10–12 weeks for tretinoin.

4. Reduced Irritation & Dryness:
Tretinoin’s broad receptor activation often causes redness, peeling, stinging, especially in the first 4–6 weeks.
Trifarotene, being RAR-γ selective, tends to cause less dryness and irritation while still delivering strong results.
Ideal for sensitive skin users or those who struggled with tretinoin purging.

5. Photostability Advantage:
Tretinoin degrades quickly in sunlight, meaning it must be used at night and loses potency if exposed.
Trifarotene has better photostability → meaning it holds up better against light exposure.
Still recommended at night, but you get stronger, more consistent results.

6. Better for Pigmentation & Texture:
Trifarotene’s precise activity stimulates even collagen remodeling, making it better for:
1. Post-acne marks
2. Uneven texture
3. Mild scars
It also has a slightly stronger depigmenting effect compared to tretinoin.
Only con I've experienced so far is the pricing of this thing but it can be handled by using it carefully

QUICK NOTE:
PLS ASK YOUR DOCTOR/DERMATOLOGIST BEFORE USING ANY TOPICAL CREAMS AND RETINOIDS!
IK this thread isnchat gpt ahh but alright its not bs!!

Thank you for reading this thread!

Is it better than taz?

 

[kisszael]

What do you think is better :
Adapalene or Trifarotene?
As Adapalene is also selective in RAR,s and does not target all three

Can't really say much it really depends on your skin type. But its a good cheaper alternative plus adap is also well tolerated by the skin as it causes less irritation but works slower than trifarotene and can be used long term. I compared Trifarotene with Tretinoin cuz tret in the long term causes pigmentation issues.

 

[theübermenschboy]

Can't really say much it really depends on your skin type. But its a good cheaper alternative plus adap is also well tolerated by the skin as it causes less irritation but works slower than trifarotene and can be used long term. I compared Trifarotene with Tretinoin cuz tret in the long term causes pigmentation issues.

I see ,mirin thread

 

[kisszael]

Is it better than taz?

Yes but its costlier than taz,tret and adapalene.