Genio
Pharoahs Descendant - From Ameneti
- Joined
- Dec 15, 2025
- Posts
- 869
- Reputation
- 955
Will 12 IUs of Human Growth Hormone cause Acromegaly?
Multiple manlets on this Website will tell u that a Dosage like 10 to 15 IUs of HGH will cause Acromegaly, Few Examples pertain to;
acromegaly speedrun
Develop acromegaly
For tards that think HGH is a superpower
Now there are multiple Factors that come into play here when developing Acromegaly from Exogenous GH usage.
(If you do not wish to read all this, Then U can skip to reading only 3 Sections.)
1. Dosage of HGH
2. Elevated vs Pinning
3. Conclusion
#1. The Cycle's Duration
In multiple recorded Acromegaly cases, Acromegaly was caused through hightened GH Exposure for Years to Decades, And it mainly comes from Pituitary Adenoma's (Pituitary Gland Tumors). This is what we see in multiple Guinness World Record holder's for Height, They mainly have Pituitary Tumours causing Excessive Growth Hormone at an elevated rate, not in spikes (like what we see in Injections), And we particularly see in Patients with Acromegaly that this causes facial changes over the duration of Years to a Decade (and a Half in some cases). You would need to be pinning for years on end to even start having the facial aesthetics of Acromegaly.
Sources that I used to deduce this:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12428067
https://pmc.ncbi.nlm.nih.gov/articles/PMC2563724
https://link.springer.com/article/10.1186/1472-6823-14-97
https://pubmed.ncbi.nlm.nih.gov/19884662
#2. The Dosage of HGH
Now this is the factor that most of these people focus on, The amount of HGH being pinned during your cycle. Now if youre like the first dude that was mentioned above, youll basically be called a retard because your disregarding the Timing of the Injection, How long the Cycle will be, and at what age the Pinning is; and will just act like 12 IUs will make u True Ogre while disregarding Science because the person informing u has under 50 posts
lul
- What should be the Dosage taken at Tanner IV?
There are multiple arguments on what dosage fits Adolescents in Pubertal Stage Tanner IV, However, The People arguing for a lower dosage being Endogenous Production are conflating many thing's into one. Adolescents produce around 1.9 to 2.2 Milligrams of HGH per day, meaning 5.7 IUS to 6.6 IUs Daily. Now if we were to inject Human Growth Hormone, BIoavailability would be a big marker in deciding wether we grow or not. Assuming Injections will be Intra-Musculature, The Bio-Availability is really weak around that area (Measured around 63%), meaning if u were producing 6 IUs endogenously, youd need 9.6 IUs just to MATCH your Endogenous Production, and around 12 IUs to actually be having a benefit. Sub-Q has Better Bio-Availability, Ranging for 75 to 82%. Overall, you would need to be injecting over 9 IUs to actually make a difference in comparison to Endogenous (Natural) Production.
Studies I used to deduce this dosage:
https://pubmed.ncbi.nlm.nih.gov/14964431
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019640s104lbl.pdf
https://pubmed.ncbi.nlm.nih.gov/1730812
#3. Elevated Levels vs Pinning
Patients of Acromegaly and Cardiomegaly always have Elevated Levels of Human Growth Hormone and IGF1, Meaning no matter what, The HGH in their blood is always at a constant level, and higher than the Healthy Adult; This means that even IF their body wanted to lower the dosage, its efforts would be in vain. However, People who inject rHGH do not have continuously elevated GH levels in their bloodstream. After injection, The HGH will circulate around the blood, it peaks approximately 2–4 hours post-administration and is cleared from the blood within a few hours due to its short plasma half-life. The longer-lasting effects are mediated indirectly through IGF-1, which remains elevated well after circulating GH has declined; The only way u can get "acromegaly" via Exogenous HGH is by through Hightened IGF1 Levels which can cause mild acromegaloid features (not like the Ogre Features youre already informed about).
https://pubmed.ncbi.nlm.nih.gov/8949572
#4. Figures who are known to have injected large amounts of Growth Hormone
-Richi Piana 20 IUs ED of Serostim (Pharma) Human Growth Hormone.
Richi Piana has previously talked in multiple interviews about his previous cycles involving Growth Hormone, where he has started off with 8 IU's, and went up to 20 Ius daily, presumably for a few years. And he does not have a large jaw, he doesnt have a prominent nose, and he does not have Acromegaly.
-Ronnie Coleman; 9 IUs ED of Serostim.
Ronnie Coleman has talked about his experience with anabolics, while denying the use of Trenbolone, Synthol, and Insulin, admitted to using Testosterone and Human Growth Hormone under the supervision of a Doctor.
Conclusion:
No, Youre not gonna get Acromegaly if u pin HGH over 3 IUs, Your heart is not gonna buss when u decide to hop on a 3 week cycle of 6 IUs, and you aren't cutting your life span by 20 years if you go over 8 IU's. If you want to pin under 12 IUs then go for it, your money, not mine. But the entire propoganda behind "Over 10 IUs = Acromegaly, Heart attack, Cancer, and your family dying in a car crash" is frankly retarded.
Acromegaly is simply Elevated HGH Circulating in your blood for Years on end, Nobody here is going to be injecting 30 IUs of HGH for a decade. Hence Acromegaly isn't an issue to be concerned with when cycling/stacking Human Growth Hormone.
Multiple manlets on this Website will tell u that a Dosage like 10 to 15 IUs of HGH will cause Acromegaly, Few Examples pertain to;
acromegaly speedrun
Develop acromegaly
For tards that think HGH is a superpower
Now there are multiple Factors that come into play here when developing Acromegaly from Exogenous GH usage.
(If you do not wish to read all this, Then U can skip to reading only 3 Sections.)
1. Dosage of HGH
2. Elevated vs Pinning
3. Conclusion
#1. The Cycle's Duration
In multiple recorded Acromegaly cases, Acromegaly was caused through hightened GH Exposure for Years to Decades, And it mainly comes from Pituitary Adenoma's (Pituitary Gland Tumors). This is what we see in multiple Guinness World Record holder's for Height, They mainly have Pituitary Tumours causing Excessive Growth Hormone at an elevated rate, not in spikes (like what we see in Injections), And we particularly see in Patients with Acromegaly that this causes facial changes over the duration of Years to a Decade (and a Half in some cases). You would need to be pinning for years on end to even start having the facial aesthetics of Acromegaly.
Sources that I used to deduce this:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12428067
https://pmc.ncbi.nlm.nih.gov/articles/PMC2563724
https://link.springer.com/article/10.1186/1472-6823-14-97
https://pubmed.ncbi.nlm.nih.gov/19884662
#2. The Dosage of HGH
Now this is the factor that most of these people focus on, The amount of HGH being pinned during your cycle. Now if youre like the first dude that was mentioned above, youll basically be called a retard because your disregarding the Timing of the Injection, How long the Cycle will be, and at what age the Pinning is; and will just act like 12 IUs will make u True Ogre while disregarding Science because the person informing u has under 50 posts
lul- What should be the Dosage taken at Tanner IV?
There are multiple arguments on what dosage fits Adolescents in Pubertal Stage Tanner IV, However, The People arguing for a lower dosage being Endogenous Production are conflating many thing's into one. Adolescents produce around 1.9 to 2.2 Milligrams of HGH per day, meaning 5.7 IUS to 6.6 IUs Daily. Now if we were to inject Human Growth Hormone, BIoavailability would be a big marker in deciding wether we grow or not. Assuming Injections will be Intra-Musculature, The Bio-Availability is really weak around that area (Measured around 63%), meaning if u were producing 6 IUs endogenously, youd need 9.6 IUs just to MATCH your Endogenous Production, and around 12 IUs to actually be having a benefit
. Sub-Q has Better Bio-Availability, Ranging for 75 to 82%. Overall, you would need to be injecting over 9 IUs to actually make a difference in comparison to Endogenous (Natural) Production.Studies I used to deduce this dosage:
https://pubmed.ncbi.nlm.nih.gov/14964431
https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019640s104lbl.pdf
https://pubmed.ncbi.nlm.nih.gov/1730812
#3. Elevated Levels vs Pinning
Patients of Acromegaly and Cardiomegaly always have Elevated Levels of Human Growth Hormone and IGF1, Meaning no matter what, The HGH in their blood is always at a constant level, and higher than the Healthy Adult; This means that even IF their body wanted to lower the dosage, its efforts would be in vain. However, People who inject rHGH do not have continuously elevated GH levels in their bloodstream. After injection, The HGH will circulate around the blood, it peaks approximately 2–4 hours post-administration and is cleared from the blood within a few hours due to its short plasma half-life. The longer-lasting effects are mediated indirectly through IGF-1, which remains elevated well after circulating GH has declined; The only way u can get "acromegaly" via Exogenous HGH is by through Hightened IGF1 Levels which can cause mild acromegaloid features (not like the Ogre Features youre already informed about).
https://pubmed.ncbi.nlm.nih.gov/8949572
#4. Figures who are known to have injected large amounts of Growth Hormone
-Richi Piana 20 IUs ED of Serostim (Pharma) Human Growth Hormone.
Richi Piana has previously talked in multiple interviews about his previous cycles involving Growth Hormone, where he has started off with 8 IU's, and went up to 20 Ius daily, presumably for a few years. And he does not have a large jaw, he doesnt have a prominent nose, and he does not have Acromegaly.
-Ronnie Coleman; 9 IUs ED of Serostim.
Ronnie Coleman has talked about his experience with anabolics, while denying the use of Trenbolone, Synthol, and Insulin, admitted to using Testosterone and Human Growth Hormone under the supervision of a Doctor.
Conclusion:
No, Youre not gonna get Acromegaly if u pin HGH over 3 IUs, Your heart is not gonna buss when u decide to hop on a 3 week cycle of 6 IUs, and you aren't cutting your life span by 20 years if you go over 8 IU's. If you want to pin under 12 IUs then go for it, your money, not mine. But the entire propoganda behind "Over 10 IUs = Acromegaly, Heart attack, Cancer, and your family dying in a car crash" is frankly retarded.
Acromegaly is simply Elevated HGH Circulating in your blood for Years on end, Nobody here is going to be injecting 30 IUs of HGH for a decade. Hence Acromegaly isn't an issue to be concerned with when cycling/stacking Human Growth Hormone.
Last edited:
