Wonders of this skin bleaching agent(Tri-Luma)[hydroquinone + tretinoin + Fluocinolone Acetonide]

[yordancel]

Just share the link instead of acting all mysterious, JFL

Nigga I got it from a local cosmeceutical online brand which isn't available anywhere else go do your own research. It is available on Indiamart tho

 

[htn007]

Would using 4% hydroquinone alone around the eyes for hyperpigmentation actually work? Im on day 3 of using it

 

[yordancel]

Would using 4% hydroquinone alone around the eyes for hyperpigmentation actually work? Im on day 3 of using it

It's not safe to do that boyo get cysteamine for eye area. I tried it's nd the skin around my eyes would burn whenever I started sweating

 

[T-BAG]

mirin

 

[TheWigger]

can you get the same benenefits with hydroquinone 1% over a prolonged use

 

[yordancel]

can you get the same benenefits with hydroquinone 1% over a prolonged use

It's better, this compound has hydroquinone 4%
But prolonged use isn't recommended obviously. It's more of a cycle

 

[htn007]

It's not safe to do that boyo get cysteamine for eye area. I tried it's nd the skin around my eyes would burn whenever I started sweating

What about lasers? Arent there lasers that can zap away the pigment around the eyes?

 

[yordancel]

What about lasers? Arent there lasers that can zap away the pigment around the eyes?

Nobodys talking about laser treatment here tard. Lasers destroy melanocytes and that makes you brighter

 

[Uehdbwidbfngj]

Greetings buddy boyos!
So I'll be talking about the skin bleaching cream/agent Tri-Luma Which is composed of
• hydroquinone(4%)
• tretinoin(0.05%)
• Fluocinolone Acetonide(0.01%)
I haven't seen anyone talking about this for some reason. Also there were a LOT of questions about skin bleaching/brightening I got from my Ascension documentary thread. Though I'm naturally lightskinned and only detanned in that thread, I suppose a lot of you guys might find this useful as hell.
this thread is about this specific combination product of hydroquinone, good ol' tretinoin and a corticosteroid Fluocinolone Acetonide.
View attachment 5145820​

The brand name for this is Tri-Luma but you might find this in other brand names if you're getting it locally in some other countries rather than in the west. What's to look for is it's composition not the name.

FUNCTION OF CONTENTS
Hydroquinone
So, hydroquinone is the main driver in this combination product. Hydroquinone acts as a topical tyrosinase inhibitor that arrests melanogenesis at its rate-limiting step. As a structural analogue to L-tyrosine, it competitively binds the binuclear copper site of the tyrosinase enzyme, blocking the oxidation of L-tyrosine into L-DOPA. Concurrently, its intracellular oxidation generates semiquinone free radicals, inducing localized oxidative stress and lipid peroxidation that selectively degrades hyperactive melanosome ultrastructures. In short, it'll fight your stupid melanogenesis. It's really simple.
View attachment 5145883
View attachment 5145896

Tbh, this portion is not really useful for impatient tards. But it's better to know how hydroquinone works, there's isn't any magical compound that is gonna make you white overnight. You're not going from an incel sludge monster to Scandinavian chad with random skincare products you see foids using online.

Tretinoin
Tretinoin (all-trans retinoic acid) acts as a nuclear RAR/RXR receptor agonist that optimizes the microenvironment for depigmentation. By modulating epidermal gene expression, it accelerates basal layer mitosis to rapidly expel existing melanosomes via forced desquamation. Crucially, this rapid turnover compacts the stratum corneum, significantly reducing barrier resistance to maximize the transepithelial penetration of hydroquinone.

And on top of that, cause of being a retinoid it's gonna give you all the benefits of retinoid while making it easier for hydroquinone penetration. It's common ball so y'all don't need this retinoid part tbh but it assists hydroquinone and that's why it's included in this combination product.

Fluocinolone Acetonide
Fluocinolone acetonide is a critical component of this formulation. This specialized, fluorinated corticosteroid is vital because it halts the inflammatory pathways that actively drive melasma. At the cellular level, it binds to internal glucocorticoid receptors, moving into the nucleus to rewrite how cells respond to stress. This action shuts down the production of key inflammatory signals, specifically interleukin-1 alpha (IL-1α) and tumor necrosis factor-alpha (TNF-α). By stopping these signals, it blocks the skin from triggering pigment production due to sun damage, while simultaneously preventing the redness and irritation caused by tretinoin. There are a lot of cons for corticosteroids but this one synergises well with the rest of the combination product so there's less risk but most y'all mfs dgaf about risk tbh.

BIOCHEMICAL SYNERGY
This fixed-dose combination operates as an optimized, multi-layered loop. Tretinoin acts first by compacting the stratum corneum, radically lowering barrier resistance to accelerate the deeper penetration of hydroquinone. While hydroquinone shuts down tyrosinase activity to halt pigment synthesis, fluocinolone acetonide continuously suppresses the cellular inflammation triggered by both UV rays and retinoid irritation. But you still gotta be on SPF for optimal results, no escaping no SPF boyo.

Timeline and pathological risks
Due to corticosteroid potency, usage is strictly capped at a definitive 8-week cycle, applied once daily at night. Exceeding this 60-day window introduces severe dermatological dangers. Prolonged use causes permanent epidermal atrophy (skin thinning), visible telangiectasia (broken blood vessels), and a compromised skin barrier. Most paradoxically, long-term hydroquinone can trigger exogenous ochronosis—an irreversible blue-black hyperpigmentation caused by pigment deposition in the deep dermis. And yes same thing is meant by epidermal atrophy as hydrocortisone y'all use for smaller nose which isn't quite optimal tbh. If you're a darker skinned person using this to get lighter and overuse it beyond the timecap you'll probably get ochronosis and have to LDAR or rope. Never play smart like a tard and do shit without knowing(speaking from experience)

I hope you guys didn't DNR the useful parts jfl. Tri-Luma can be paired with your other skin brightening treatments for more optimal results(just do it separately). It's mainly gonna destroy your hyperpigmentation then move on to brighten you. So yes, acnecels with acne scarring with hyperpigmentation can use it to ascend

Either way I thought I was gonna gatekeep ts and enjoy the benefits alone but my. Undying sense of mortal empathy(which I don't have
btw) took over and made this thread
Goodbye buddy boyos-
Ascend!​

How much less shitskinned can this get one?

 

[yordancel]

How much less shitskinned can this get one?

Approximately 2-3 tones. It's mostly gonna affect your tone on your first cycle. If you have brown under tone then you can possibly get olive under tone and if luck sides with you, even reddish undertone. That alone can be enough for a currycel to Larp Latino easily.

 

[ltnfoidraperer]

all that while you can do glutathione injections

 

[yordancel]

all that while you can do glutathione injections

Gluta is expensive, this is a cheaper topical alternative. Don't make dumb statements without thinking, a lot of mfs can't access gluta but can access triluma.

 

[yordancel]

Bump too why not jfl

 

[ltnfoidraperer]

Gluta is expensive, this is a cheaper topical alternative. Don't make dumb statements without thinking, a lot of mfs can't access gluta but can access triluma.

Look bro triluma is not gonna do shit i had been on hydroquinone 4% and tretinoin 0.05% and azelaic acid 20% i barely see much difference and i barely see the sunlight both inside and outside i started from March, hydroquinone isn't the goat of skin whitening it only whitens by 1.5 shade at best
glutathione makes a difference though

 

[yordancel]

Look bro triluma is not gonna do shit i had been on hydroquinone 4% and tretinoin 0.05% and azelaic acid 20% i barely see much difference and i barely see the sunlight both inside and outside i started from March, hydroquinone isn't the goat of skin whitening it only whitens by 1.5 shade at best
glutathione makes a difference though

It works the same as tret, your skin is more resistant to it. Try higher frequency. Gluta is superior but obviously it's not widely accessible

 

[ltnfoidraperer]

It works the same as tret, your skin is more resistant to it. Try higher frequency. Gluta is superior but obviously it's not widely accessible

Nigga i applied hydroquinone everyday 2 times and tret Every other day once

 

[ltnfoidraperer]

It works the same as tret, your skin is more resistant to it. Try higher frequency. Gluta is superior but obviously it's not widely accessible

i agree it's not widely accessible but its the only one that actually gives ur skintone a difference unlike topical treatments

 

[Satxrn]

Wont the steroid cause skin thinning regardless of whether someone cycles it or not? using it for 60 days, then not doing 60 days, then doing 60 days again, i feel like this sort of exposure to the steroid will still cause some harmful sort of skin atrophy! What do you think?

 

[yordancel]

i agree it's not widely accessible but its the only one that actually gives ur skintone a difference unlike topical treatments

Logically, the ideal thing is to laser blast melanocytes away and pair with gluta for optimal results

 

[yordancel]

Wont the steroid cause skin thinning regardless of whether someone cycles it or not? using it for 60 days, then not doing 60 days, then doing 60 days again, i feel like this sort of exposure to the steroid will still cause some harmful sort of skin atrophy! What do you think?

Fluo isn't as strong as your other corticosteroids like hydrocortisone. If you continuously keep applying it in a non uniform frequency then yes you might get skin atrophy. But it'll take prolonged use so it's not really a risk if you let your skin heal up after the cycle, this would be a different case if it was hydrocortisone instead

 

[yordancel]

Nigga i applied hydroquinone everyday 2 times and tret Every other day once

Lol why bro got nerfed 2 times is a lot nga you could've gotten bad effects. But obv if anyone has access to laser or gluta then it's superior to triluma, topical appliances aren't optimal and everyone knows about it.

 

[ltnfoidraperer]

Lol why bro got nerfed 2 times is a lot nga you could've gotten bad effects. But obv if anyone has access to laser or gluta then it's superior to triluma, topical appliances aren't optimal and everyone knows about it.

2 times is recommended for hydroquinone only side effects i got was rashing all over my body but i didnt experience any redness or irritation on face it only itched my nose a bit and like its just best to use tretinoin with azelaic acid and nothing else and triluma pretty much sucks it also contains a steroid which is like class 5 mid potency tho stronger than hydrocortisone

 

[yordancel]

2 times is recommended for hydroquinone only side effects i got was rashing all over my body but i didnt experience any redness or irritation on face it only itched my nose a bit and like its just best to use tretinoin with azelaic acid and nothing else and triluma pretty much sucks it also contains a steroid which is like class 5 mid potency tho stronger than hydrocortisone

Skin atrophy effects from fluo is different than that of hydroco. Tho it is stronger it's made to assist hydroquinone. Tri-Luma mainly works best on people with hyperpigmentation which I talked about in the thread, the results are all over the internet. Tret and azelaic is a stable combo but triluma is more potent for dealing with directly layered melanogenesis. Also Tri-Luma is only supposed to be applied before sleep at night, maybe the double appliance you were talking about is for hydroquinone only. Triluma is a very harsh skin bleaching agent but it does the work. Tret and aze works as well if you wanna hit it for the long term game

 

[yordancel]

Bump

 

[cold_nano]

Normal Hydroquinone + Taz mogs

Normal Hydroquinone + Taz mogs

Taz after how many months of tretnion lmk

 

[yordancel]

Bump

 

[ivanvelchev]

i know retinoids u can use how much u want but what abt hydroq and FA

 

[Xazzy]

Greetings buddy boyos!
So I'll be talking about the skin bleaching cream/agent Tri-Luma Which is composed of
• hydroquinone(4%)
• tretinoin(0.05%)
• Fluocinolone Acetonide(0.01%)
I haven't seen anyone talking about this for some reason. Also there were a LOT of questions about skin bleaching/brightening I got from my Ascension documentary thread. Though I'm naturally lightskinned and only detanned in that thread, I suppose a lot of you guys might find this useful as hell.
this thread is about this specific combination product of hydroquinone, good ol' tretinoin and a corticosteroid Fluocinolone Acetonide.
View attachment 5145820​

The brand name for this is Tri-Luma but you might find this in other brand names if you're getting it locally in some other countries rather than in the west. What's to look for is it's composition not the name.

FUNCTION OF CONTENTS
Hydroquinone
So, hydroquinone is the main driver in this combination product. Hydroquinone acts as a topical tyrosinase inhibitor that arrests melanogenesis at its rate-limiting step. As a structural analogue to L-tyrosine, it competitively binds the binuclear copper site of the tyrosinase enzyme, blocking the oxidation of L-tyrosine into L-DOPA. Concurrently, its intracellular oxidation generates semiquinone free radicals, inducing localized oxidative stress and lipid peroxidation that selectively degrades hyperactive melanosome ultrastructures. In short, it'll fight your stupid melanogenesis. It's really simple.
View attachment 5145883
View attachment 5145896

Tbh, this portion is not really useful for impatient tards. But it's better to know how hydroquinone works, there's isn't any magical compound that is gonna make you white overnight. You're not going from an incel sludge monster to Scandinavian chad with random skincare products you see foids using online.

Tretinoin
Tretinoin (all-trans retinoic acid) acts as a nuclear RAR/RXR receptor agonist that optimizes the microenvironment for depigmentation. By modulating epidermal gene expression, it accelerates basal layer mitosis to rapidly expel existing melanosomes via forced desquamation. Crucially, this rapid turnover compacts the stratum corneum, significantly reducing barrier resistance to maximize the transepithelial penetration of hydroquinone.

And on top of that, cause of being a retinoid it's gonna give you all the benefits of retinoid while making it easier for hydroquinone penetration. It's common ball so y'all don't need this retinoid part tbh but it assists hydroquinone and that's why it's included in this combination product.

Fluocinolone Acetonide
Fluocinolone acetonide is a critical component of this formulation. This specialized, fluorinated corticosteroid is vital because it halts the inflammatory pathways that actively drive melasma. At the cellular level, it binds to internal glucocorticoid receptors, moving into the nucleus to rewrite how cells respond to stress. This action shuts down the production of key inflammatory signals, specifically interleukin-1 alpha (IL-1α) and tumor necrosis factor-alpha (TNF-α). By stopping these signals, it blocks the skin from triggering pigment production due to sun damage, while simultaneously preventing the redness and irritation caused by tretinoin. There are a lot of cons for corticosteroids but this one synergises well with the rest of the combination product so there's less risk but most y'all mfs dgaf about risk tbh.

BIOCHEMICAL SYNERGY
This fixed-dose combination operates as an optimized, multi-layered loop. Tretinoin acts first by compacting the stratum corneum, radically lowering barrier resistance to accelerate the deeper penetration of hydroquinone. While hydroquinone shuts down tyrosinase activity to halt pigment synthesis, fluocinolone acetonide continuously suppresses the cellular inflammation triggered by both UV rays and retinoid irritation. But you still gotta be on SPF for optimal results, no escaping no SPF boyo.

Timeline and pathological risks
Due to corticosteroid potency, usage is strictly capped at a definitive 8-week cycle, applied once daily at night. Exceeding this 60-day window introduces severe dermatological dangers. Prolonged use causes permanent epidermal atrophy (skin thinning), visible telangiectasia (broken blood vessels), and a compromised skin barrier. Most paradoxically, long-term hydroquinone can trigger exogenous ochronosis—an irreversible blue-black hyperpigmentation caused by pigment deposition in the deep dermis. And yes same thing is meant by epidermal atrophy as hydrocortisone y'all use for smaller nose which isn't quite optimal tbh. If you're a darker skinned person using this to get lighter and overuse it beyond the timecap you'll probably get ochronosis and have to LDAR or rope. Never play smart like a tard and do shit without knowing(speaking from experience)

I hope you guys didn't DNR the useful parts jfl. Tri-Luma can be paired with your other skin brightening treatments for more optimal results(just do it separately). It's mainly gonna destroy your hyperpigmentation then move on to brighten you. So yes, acnecels with acne scarring with hyperpigmentation can use it to ascend

Either way I thought I was gonna gatekeep ts and enjoy the benefits alone but my. Undying sense of mortal empathy(which I don't have
btw) took over and made this thread
Goodbye buddy boyos-
Ascend!​

are the results after 2-3 cycles gonna be permanent if I drop everything except tret dont like using too much stuff

 

[joja]

Greetings buddy boyos!
So I'll be talking about the skin bleaching cream/agent Tri-Luma Which is composed of
• hydroquinone(4%)
• tretinoin(0.05%)
• Fluocinolone Acetonide(0.01%)
I haven't seen anyone talking about this for some reason. Also there were a LOT of questions about skin bleaching/brightening I got from my Ascension documentary thread. Though I'm naturally lightskinned and only detanned in that thread, I suppose a lot of you guys might find this useful as hell.
this thread is about this specific combination product of hydroquinone, good ol' tretinoin and a corticosteroid Fluocinolone Acetonide.
View attachment 5145820​

The brand name for this is Tri-Luma but you might find this in other brand names if you're getting it locally in some other countries rather than in the west. What's to look for is it's composition not the name.

FUNCTION OF CONTENTS
Hydroquinone
So, hydroquinone is the main driver in this combination product. Hydroquinone acts as a topical tyrosinase inhibitor that arrests melanogenesis at its rate-limiting step. As a structural analogue to L-tyrosine, it competitively binds the binuclear copper site of the tyrosinase enzyme, blocking the oxidation of L-tyrosine into L-DOPA. Concurrently, its intracellular oxidation generates semiquinone free radicals, inducing localized oxidative stress and lipid peroxidation that selectively degrades hyperactive melanosome ultrastructures. In short, it'll fight your stupid melanogenesis. It's really simple.
View attachment 5145883
View attachment 5145896

Tbh, this portion is not really useful for impatient tards. But it's better to know how hydroquinone works, there's isn't any magical compound that is gonna make you white overnight. You're not going from an incel sludge monster to Scandinavian chad with random skincare products you see foids using online.

Tretinoin
Tretinoin (all-trans retinoic acid) acts as a nuclear RAR/RXR receptor agonist that optimizes the microenvironment for depigmentation. By modulating epidermal gene expression, it accelerates basal layer mitosis to rapidly expel existing melanosomes via forced desquamation. Crucially, this rapid turnover compacts the stratum corneum, significantly reducing barrier resistance to maximize the transepithelial penetration of hydroquinone.

And on top of that, cause of being a retinoid it's gonna give you all the benefits of retinoid while making it easier for hydroquinone penetration. It's common ball so y'all don't need this retinoid part tbh but it assists hydroquinone and that's why it's included in this combination product.

Fluocinolone Acetonide
Fluocinolone acetonide is a critical component of this formulation. This specialized, fluorinated corticosteroid is vital because it halts the inflammatory pathways that actively drive melasma. At the cellular level, it binds to internal glucocorticoid receptors, moving into the nucleus to rewrite how cells respond to stress. This action shuts down the production of key inflammatory signals, specifically interleukin-1 alpha (IL-1α) and tumor necrosis factor-alpha (TNF-α). By stopping these signals, it blocks the skin from triggering pigment production due to sun damage, while simultaneously preventing the redness and irritation caused by tretinoin. There are a lot of cons for corticosteroids but this one synergises well with the rest of the combination product so there's less risk but most y'all mfs dgaf about risk tbh.

BIOCHEMICAL SYNERGY
This fixed-dose combination operates as an optimized, multi-layered loop. Tretinoin acts first by compacting the stratum corneum, radically lowering barrier resistance to accelerate the deeper penetration of hydroquinone. While hydroquinone shuts down tyrosinase activity to halt pigment synthesis, fluocinolone acetonide continuously suppresses the cellular inflammation triggered by both UV rays and retinoid irritation. But you still gotta be on SPF for optimal results, no escaping no SPF boyo.

Timeline and pathological risks
Due to corticosteroid potency, usage is strictly capped at a definitive 8-week cycle, applied once daily at night. Exceeding this 60-day window introduces severe dermatological dangers. Prolonged use causes permanent epidermal atrophy (skin thinning), visible telangiectasia (broken blood vessels), and a compromised skin barrier. Most paradoxically, long-term hydroquinone can trigger exogenous ochronosis—an irreversible blue-black hyperpigmentation caused by pigment deposition in the deep dermis. And yes same thing is meant by epidermal atrophy as hydrocortisone y'all use for smaller nose which isn't quite optimal tbh. If you're a darker skinned person using this to get lighter and overuse it beyond the timecap you'll probably get ochronosis and have to LDAR or rope. Never play smart like a tard and do shit without knowing(speaking from experience)

I hope you guys didn't DNR the useful parts jfl. Tri-Luma can be paired with your other skin brightening treatments for more optimal results(just do it separately). It's mainly gonna destroy your hyperpigmentation then move on to brighten you. So yes, acnecels with acne scarring with hyperpigmentation can use it to ascend

Either way I thought I was gonna gatekeep ts and enjoy the benefits alone but my. Undying sense of mortal empathy(which I don't have
btw) took over and made this thread
Goodbye buddy boyos-
Ascend!​

Can a death ethic use this im around Fitzpatrick 5 or 6 minimum

 

[yordancel]

Can a death ethic use this im around Fitzpatrick 5 or 6 minimum

Only this isn't gonna save you from deathnic hell, you'll need more compounds. I'm experimenting skin bleaching creams on myself. I'll make a skin bleaching thread soon

 

[yordancel]

are the results after 2-3 cycles gonna be permanent if I drop everything except tret dont like using too much stuff

Depends on how good you abstain yourself from sun damage and things that accelerate melanogenesis. This compound stops melanogenesis and fixes hyperpigmentation, if you stop the stoppage of melanogenesis obviously you'll start getting pigmentation. But for the long run, most of your discoloration will be permanently gone if the cycle turns out to be a success

 

[wintercrow]

Brahhh @yordancel i was gonna send the the link of this thread to you then i saw that you yourself have posted ts

 

[yordancel]

Brahhh @yordancel i was gonna send the the link of this thread to you then i saw that you yourself have posted ts

I'm deep into ts lmao

 

[wintercrow]

I'm deep into ts lmao