Extra Chromosome
- Joined
- Nov 20, 2018
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Disclaimer:
This is a very experimental thread and before you go ahead and try anything, research intensively. I am also not responsible if anything goes wrong.
Without saying, obviously nothing comes side-effect free, so take that in mind before trying anything.
I had this idea for a while now.
Supplements are usually ingested orally in the form of gelatin capsules. And then absorbed into the blood stream from the digestive system.
As we know, there are multiple ways to administer chemicals to the human body.
Administration routes include:
-Oral (taken by mouth), could be by ingestion(capsules) or sublingual (like mk677)
-Subcutaneos (injected into the fat layer, like peptides)
-Intramuscular (Injected into the muscle like roids)
-Intraperitoneal (Injected into the body cavity, like chemotherapy)
-Intracardiac (Injected into the heart)
-Intraarticular (Injected into joints)
-Intracavernous (Injection at the base of a penis)
-Intranasal (could be using sprays or timed inhalation)
-Intradermal (Injected at the skin like vaccines)
-percutaneous (Absorption by intact skin)
-Intraosseous (Injection into the bone marrow)
What is the use of this list? you may ask.
Well, here comes the good part.
Let us take for example melatonin.
Melatonin is taken by caps orally and you have to wait till the digestive system sends it to the blood stream to take effect.
What if we could manipulate the way it is administered to get a quicker and more efficient results?
For example, by nasal gels.
Here is a study done on rats:
www.ncbi.nlm.nih.gov
Another example is the delivery of insulin using a nose gel.
www.ncbi.nlm.nih.gov
And behold, Intranasal hexarelin. @Wincel @Madness @CupOfCoffee
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
This is huge.
Although I never seen hexarelin nasal sprays sold, it can be easily manufactured at home.
Retarded 4x a day injections can be replaced with 4x a day sprays.
L-theanine, the anti-anxiety, mood enhancing, GABAergic chemical in green can be administered subliminally for a shorter time of onset and a greater power.
Reddit link
Ceretropic that used to sell it has shutdown, it was one of my favourite sources. They had a special extract of cerebrolysin which I don't seem to find anywhere.
Amazon looks like it sells sublingual L-theanine, but had no experience with it.
Intranasal testosterone gel. @jefferson
www.ncbi.nlm.nih.gov
This study surely overlooks a lot of aspects, even lacks placebo. But shows the possibility of nasal testosterone.
www.ncbi.nlm.nih.gov
^another study. Intranasal testosterone crosses the BBB, I won't go into implications here.
@ZUZZCEL Posted a video of a kid that died due to snorting caffeine.
Caffeine is possible to be intranasaly administrated although dangerous and not recommended.
Subcutaneous duasteride.
Castrationcels gtfh @fobos @Vanillestorms
www.researchgate.net
^Done on rats btw.
Vitamin B injections.
Good for people who can't absorb vitamin B in oral form.
Also good for huge doses which the liver can't handle.
These are only a tiny amount of examples from the realm of possibilities. Just wanted to point out new things to this community.
Take great care when stepping into this realm of experimentation.
Try to research your favorite chemical/supplement and see what methods of administration is possible with it.
Good luck.
Requested tags:
@Bluepill @kobecel @dogtown @Wool @Coping @The Dude Abides @Facial AESTHETICS @Blitz @dodt @Madness @mido the slayer (mido, you kept asking for now shit on the psl community, here u go. same for @KrissKross) @Legitcel
Tell me if you want to be tagged/untagged in the future threads.
This is a very experimental thread and before you go ahead and try anything, research intensively. I am also not responsible if anything goes wrong.
Without saying, obviously nothing comes side-effect free, so take that in mind before trying anything.
I had this idea for a while now.
Supplements are usually ingested orally in the form of gelatin capsules. And then absorbed into the blood stream from the digestive system.
As we know, there are multiple ways to administer chemicals to the human body.
Administration routes include:
-Oral (taken by mouth), could be by ingestion(capsules) or sublingual (like mk677)
-Subcutaneos (injected into the fat layer, like peptides)
-Intramuscular (Injected into the muscle like roids)
-Intraperitoneal (Injected into the body cavity, like chemotherapy)
-Intracardiac (Injected into the heart)
-Intraarticular (Injected into joints)
-Intracavernous (Injection at the base of a penis)
-Intranasal (could be using sprays or timed inhalation)
-Intradermal (Injected at the skin like vaccines)
-percutaneous (Absorption by intact skin)
-Intraosseous (Injection into the bone marrow)
What is the use of this list? you may ask.
Well, here comes the good part.
Let us take for example melatonin.
Melatonin is taken by caps orally and you have to wait till the digestive system sends it to the blood stream to take effect.
What if we could manipulate the way it is administered to get a quicker and more efficient results?
For example, by nasal gels.
Here is a study done on rats:
Nose-to-brain transport of melatonin from polymer gel suspensions: a microdialysis study in rats
Exogenous melatonin (MT) has significant neuroprotective roles in Alzheimer’s and Parkinson’s diseases. This study investigates the delivery MT to brain via nasal route as a polymeric gel suspension using central brain microdialysis in ...
www.ncbi.nlm.nih.gov
Another example is the delivery of insulin using a nose gel.
Enhancement of the intranasal delivery of insulin via a novel mucoadhesive Carbopol gel - PubMed
The homogenized Carbopol intranasal gel could be an efficient noninvasive way for insulin delivery but selection of gel components and method of preparation are critical for achieving the most desired effect.
www.ncbi.nlm.nih.gov
And behold, Intranasal hexarelin. @Wincel @Madness @CupOfCoffee
Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging - PubMed
The function of the growth hormone-insulin-like growth factor I (GH-IGF-I) axis is reduced in aging, although the secretory capacity of somatotrope cells is preserved. Previous studies have suggested that continuous administration of GH-releasing peptides (GHRPs) results in homologous...
www.ncbi.nlm.nih.gov
Intranasal administration of the GHRP hexarelin accelerates growth in short children - PubMed
The long-term GH/IGF-I stimulating, anabolic and growth promoting effects achieved by intranasal administration of this hexapeptide, seemingly without undesirable side-effects, suggests clinical potential for this new class of drugs.
www.ncbi.nlm.nih.gov
Desensitization from long-term intranasal treatment with hexarelin does not interfere with the biological effects of this growth hormone-releasing peptide in short children - PubMed
A clinical, prospective experiment was carried out to determine whether long-term intranasal administration of the growth hormone-releasing peptide hexarelin (His-D-2-methyl-Trp-Ala-Trp-D-Phe -Lys-NH2) affects pituitary growth hormone secretion. Hexarelin (60 micrograms/kg t.i.d.) was...
www.ncbi.nlm.nih.gov
Although I never seen hexarelin nasal sprays sold, it can be easily manufactured at home.
Retarded 4x a day injections can be replaced with 4x a day sprays.
L-theanine, the anti-anxiety, mood enhancing, GABAergic chemical in green can be administered subliminally for a shorter time of onset and a greater power.
Reddit link
He also talks about why redosing caused him problems and that you should only dose once a day. He also notes that it lasts shorter than the supplement/tea form.
Ceretropic that used to sell it has shutdown, it was one of my favourite sources. They had a special extract of cerebrolysin which I don't seem to find anywhere.
Amazon looks like it sells sublingual L-theanine, but had no experience with it.
Intranasal testosterone gel. @jefferson
Natesto™ , a novel testosterone nasal gel, normalizes androgen levels in hypogonadal men - PubMed
Advantages of testosterone nasal gel include ease of administration, low dose, and no risk of secondary transference. The efficacy and safety of testosterone nasal gel was evaluated in hypogonadal males. The ninety-day, randomized, open-label, dose-ranging study, included potential dose...
www.ncbi.nlm.nih.gov
Delivery of testosterone to the brain by intranasal administration: comparison to intravenous testosterone - PubMed
Intranasal (i.n.) administration has emerged as a strategy to deliver therapeutics to the brain. Here, we compared i.n. and intravenous (i.v.) administration for testosterone. About 75% of the i.n. administered testosterone entered the blood. However, whole brain levels of testosterone were...
www.ncbi.nlm.nih.gov
@ZUZZCEL Posted a video of a kid that died due to snorting caffeine.
Caffeine is possible to be intranasaly administrated although dangerous and not recommended.
Subcutaneous duasteride.
Castrationcels gtfh @fobos @Vanillestorms
(PDF) Controlled Release of Dutasteride from Biodegradable Microspheres: In Vitro and In Vivo Studies
PDF | The aim of the present work was to study the in vitro/in vivo characteristics of dutasteride loaded biodegradable microspheres designed for sustained release of dutasteride over four weeks. An O/W emulsion-solvent evaporation method was used to incorporate dutasteride, which...
www.researchgate.net
Vitamin B injections.
Good for people who can't absorb vitamin B in oral form.
Also good for huge doses which the liver can't handle.
These are only a tiny amount of examples from the realm of possibilities. Just wanted to point out new things to this community.
Take great care when stepping into this realm of experimentation.
Try to research your favorite chemical/supplement and see what methods of administration is possible with it.
Good luck.
Requested tags:
@Bluepill @kobecel @dogtown @Wool @Coping @The Dude Abides @Facial AESTHETICS @Blitz @dodt @Madness @mido the slayer (mido, you kept asking for now shit on the psl community, here u go. same for @KrissKross) @Legitcel
Tell me if you want to be tagged/untagged in the future threads.
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