Hacking Your Hunger: The Science of Effortless Weight Loss

[Seth Walsh]

Sucks, and I did hear from them from @Seth Walsh, but I’ve found no studies indicating they systematically “destroy your hormones” so I’ll just take it as conjecture

Just not eating destroys hormones, not the drugs themselves. Too much of a caloric deficit will make you feel tired and wreck your hormonal balance. I'm on Tirzepatide again right now.

It's all about finding the right dose to not completely nuke your appetite but to help you stick to a long-term weight loss regime. I think I was being misquoted a bit.

 

[AlbinoMaxxer]

I tried both and amphetamines are much worse. dont touch that shit

Which one? Do u have adhd? I have adhd, so ig it effects me a lot differently still wide awake and it’s about 5 in the morning. I took the ir type too and it was like 6

 

[Seth Walsh]

It obviously works different for everyone, for some its good,for some horrible. But i dont think its a coincidence that my gut and stomach are fucked up after using semaglutide. I will do a colonscopy and endoscopy for stomach soon since 1 month ago right after i quit semaglutide i had to call the ambulance because i had horrible stomach pain, never happened before, i literally thought my stomach will explode. Even tho it doesnt affect directly the gut it cause constipation which can lead also to gut issues, hemoroihdes, anal fissures, etc

Sorry to hear that. I had worse GI sides on sema/tirz whenever I'd eat larger portions. I don't think anyone should really be taking GLP1s unless a definitive plan is build around it. For ex; making sure you're getting so much activity per day, eating no more than X times a day, no more than X calories per day.

I got off Tirz a few times when I just no longer needed to actively lose weight. Having a weight loss regimen built around taking the drugs weirdly makes the side effects more bareable for me, probably because you're actively making your body more conducive to the effects of the drug.

A large volume of foods, starchy carbs, breads, lack of physical activity, beer etc all seemed to bring out the worst sides. They make food sit in your stomach longer, so a poor diet or eating a lot of processed foods will also make it unbearable. But in most cases (mine too), 5mg Tirz or its Semaglutide equivalent is just excessive.

 

[NZb6Air]

Sorry to hear that. I had worse GI sides on sema/tirz whenever I'd eat larger portions. I don't think anyone should really be taking GLP1s unless a definitive plan is build around it. For ex; making sure you're getting so much activity per day, eating no more than X times a day, no more than X calories per day.

I got off Tirz a few times when I just no longer needed to actively lose weight. Having a weight loss regimen built around taking the drugs weirdly makes the side effects more bareable for me, probably because you're actively making your body more conducive to the effects of the drug.

A large volume of foods, starchy carbs, breads, lack of physical activity, beer etc all seemed to bring out the worst sides. They make food sit in your stomach longer, so a poor diet or eating a lot of processed foods will also make it unbearable. But in most cases (mine too), 5mg Tirz or its Semaglutide equivalent is just excessive.

you both prolly injected more than 0.25-0.5 per week

 

[TitusA]

Just use stimulants and have fun at the same time.

 

[$Abomination]

Good for you, but this thread is called effortless weight loss for a reason.

Why would people want to work hard to lose weight, when easier alternatives exist?

Very odd that you’d consider two weeks into a diet a success story, that’s very early.

Most people would’ve already tried dieting, multiple times, before considering this.

If people want to go the classic route about weight loss, more power to them, though.

I just don't believe in trying to cheat hunger. The brain is very resilient in enforcing hunger. Broccoli and Cauliflower is a much more effective bet than any drug for reducing hunger because it solves the actual underlying problem. It gives your intestines something to digest, it fills your stomach up with volume.

You just gotta drink water and eat it in conjunction with something more desirable. One bite from what you wanna eat, one bite from the vegetables.

I am not against using drugs to lose weight but the drug has to make sense. Something like steroids to build and retain muscle or a fat burner to help shed an extra 400 calories a day, sure. But appetite suppressants, from my personal experience, just aren't any good.

 

[Netrunner]

Seems like you forgot one of the big boys… amphetamines. I don’t have an appetite, it literally doesn’t exist. Great thread though, thank you for making this high effort, high iq thread, will be researching

rapes your sleep, irritates the shit out of you, impairs judgement. prolonged stimulant use seems like a viable idea only when you have never tried it or you are high on it..

I am on sema and i must say aside from slight slower bowel movement(taking a shit every 2-3 days, easily resolvable through a mild laxative) it is pretty much side effect free if you adjust your dosage well. Nausea related sides are caused by dosing too high.

 

[AlbinoMaxxer]

rapes your sleep, irritates the shit out of you, impairs judgement. prolonged stimulant use seems like a viable idea only when you have never tried it or you are high on it..

I am on sema and i must say aside from slight slower bowel movement(taking a shit every 2-3 days, easily resolvable through a mild laxative) it is pretty much side effect free if you adjust your dosage well. Nausea related sides are caused by dosing too high.

Gotcha man. I’m just biased because I have extreme adhd so it’s a miracle drug for me. I can’t lie I didn’t sleep at all last night and still dialed in asf

 

[AlexBrown84]

Sorry, but no. I mean, there's been weight loss medication around for years, but none, and I mean none are as unequivocally effective as these (with a safety profile as good). Hell, some of these will do even more than appetite reduction by accelerating the burning of fat itself.

If you haven't tried yet, you can just try to lose weight by exercising more or trying a more healthy diet, if you've already tried that (as I guess you have), then these are probably your best bet.

Tesofensine is a pretty popular weight loss medication in capsule form, but of course not nearly as effective. I've used it, and then I used GLP-1s for the first time, and they've been untouched ever since.

how was taking tesofensine? i got terrible sides so stopped taking it. worst fat loss drug i’ve taken

 

[lesnar]

I dont recommend semaglutide atleast . I will hop on tirzepatide in the next month but semaglutide even tho it worked had horrible side effects

+1, not worth unless ur extremely overweight, plus for a small group of people it will not work so you'll just be experiencing the side effects

 

[LooksmaxxHopeful]

Introduction

This is the reality for too many of us. Endless cravings, failed diets, and a gnawing feeling that we're stuck in a body that doesn't reflect who we want to be.

View attachment 3150855

Let's be honest – we've all got excuses when it comes to weight loss. "I'm too busy," "My genetics are bad," "I just love food too much." But what if those excuses were no longer valid? What if there was a solution that could help you overcome those obstacles and finally achieve the body you deserve?

Been there. Done that. Tried every diet, every workout, every "miracle" pill under the sun. The scale just keeps going up, and the frustration is a constant companion. You're a victim of your own biology, right? Wrong.

This is the weight loss secret that's been quietly transforming bodies for years. Now, it's your turn.
View attachment 3151049View attachment 3151232

I'll be honest, this shit's so much of a cheat code, part of me didn't even feel like sharing it, even if it's only to you guys here. Still, as I found out about these drugs on this forum, I felt it was only fair to take on the mantle and spread the word. Now come along boyos, and I'll show you the promised land.
View attachment 3150579

The Big 3: Semaglutide, Tirzepatide, and Retatrutide

1. Semaglutide (Ozempic/Wegovy)
View attachment 3150747
Semaglutide mimics GLP-1, a hormone that tells your brain you're full even when you've eaten less. This translates to fewer cravings and a reduced appetite, making it easier to stick to your diet and create the calorie deficit needed for fat loss. Semaglutide also slows down digestion, keeping you satisfied for longer and preventing those energy crashes that often lead to unhealthy snacking. And it doesn't stop there – Semaglutide also helps your body use glucose more efficiently, leading to better blood sugar control and sustained energy levels throughout the day.

View attachment 3150769

2. Tirzepatide (Mounjaro)
View attachment 3150757
Tirzepatide takes fat loss a step further by activating both the GLP-1 and GIP receptors. This dual action leads to even more powerful appetite suppression and potentially enhanced fat burning, helping you torch those stubborn pounds more effectively. Tirzepatide could also offer a range of benefits beyond weight loss, including nausea reduction, improved brain health, and stronger bones.

View attachment 3150763View attachment 3150765

3. Retatrutide
View attachment 3150754
Retatrutide is the newest and most potent GLP-1 receptor agonist, setting itself apart by targeting three key receptors: GLP-1, GIP, and glucagon. This triple-action approach creates a potent synergy that will likely significantly accelerate your fat loss.

Retatrutide ramps up appetite control to the extreme, making it easier to stick to your diet without feeling deprived. But what truly sets it apart is its activation of the glucagon receptor. Glucagon is a hormone that helps your body release stored energy, particularly from fat. By stimulating glucagon, Retatrutide encourages your body to tap into its fat reserves for fuel, enhancing fat burning.

So, we're not simply talking about eating less here, it'll actively burn fat too. It also optimizes blood sugar control, further contributing to a leaner, healthier physique.

While Retatrutide is still in clinical trials, early results are incredibly promising, suggesting it could be the most effective fat-loss medication yet. So much so that there's already plenty of people purchasing and using it.
View attachment 3150575

View attachment 3150774

Dosage and Frequency
Each medication has its own recommended dosage and injection frequency. Here's a quick rundown:

• Semaglutide: Typically injected once a week, starting at a low dose (0.25 mg) and gradually increasing to a maximum of 2.4 mg.
• Tirzepatide: Also injected once a week, with starting doses ranging from 2.5 mg to 5 mg and potentially increasing to a maximum of 15 mg.
• Retatrutide: In clinical trials, it's being administered once a week, with dosages ranging from 1 mg to 12 mg.

Tip: Some users find that injecting every 5 days instead of every 7 helps maintain better appetite control throughout the week.

Okay, now that you know the players, let's break down how they work and why they're creating so much buzz.

How They Work​

So, how do these drugs actually work? Well, here's the gist.

They work by cleverly mimicking the actions of natural gut hormones that already play a key role in regulating your appetite, metabolism, and how your body processes food.

Think of it like this: your gut and your brain are in constant communication, sending signals back and forth about hunger, fullness, and energy levels. GLP-1 receptor agonists basically "hack" this communication system, amplifying the signals that tell your brain "I'm full" and "Slow down digestion."

Let's delve a bit more into detail.

Appetite Control. GLP-1 receptor agonists bind to specific receptors in your brain that are involved in regulating hunger and satiety. This directly reduces those nagging hunger pangs and cravings that usually make dieting such a struggle. You'll find yourself feeling satisfied with smaller portions and less tempted by those unhealthy snacks (it's genuinely crazy, I haven't eaten sweets in months).

Slower Digestion. These medications also delay gastric emptying, which is the process of food moving from your stomach to your intestines. This means food stays in your stomach for longer, further contributing to that feeling of fullness and preventing those rapid blood sugar spikes that can lead to cravings and energy crashes. This could affect (delay) the absorption of some oral medication or supplements you'd be consuming, however.

Enhanced Insulin Response. GLP-1 receptor agonists also stimulate your pancreas to release more insulin, the hormone responsible for shuttling glucose (sugar) from your bloodstream into your cells for energy. This improves your body's ability to utilize glucose, leading to better blood sugar control and more stable energy levels.
View attachment 3151210

These medications are basically working with your body, not against it, to help you lose weight and even get healthier. Welcome to the future lads.

What you need to know before you start
While GLP-1s sound like a dream come true for any guy looking to level up his physique, they're not without their potential downsides.

Muscle Loss
While GLP-1s primarily target fat loss, some studies suggest they could affect muscle mass. (Likely due to quick, significant weight loss). To avoid this, prioritize protein intake (at least 1 gram per pound of body weight) and keep hitting the weights.

Nausea
Nausea is a common side effect, especially when you're first starting or increasing your dosage. It also depends on which exact GLP-1 you are using. It usually subsides, but out of caution, start low and go slow. Staying hydrated can also help.

The Cost Factor.
These medications are expensive, and insurance coverage varies. For now, it's a barrier to entry for most. (Thank God). But as demand increases, prices and accessibility might improve. You'd likely still need a prescription though.

Luckily for you, there are (far cheaper) prescription-free ways you can get your hands on this shit, which will be explored later on in this thread.

The "Ozempic Face" Myth
That more defined facial appearance is primarily due to overall weight loss, not a unique effect of the medication.

Long-Term Commitment
GLP-1s are typically used long-term (maybe for life). To maintain your results, you'll either need to stay on it or adopt a healthy lifestyle so you don't regain most of the weight.

View attachment 3151121

Moving on...

1. The Ideal Scenario: Talk to a Doctor
View attachment 3151222
Listen, guys, consulting with a doctor is (almost) always the safest and smartest move. They're the experts, and they can provide the personalized guidance you need for optimal results.

Alright, now that I've got my ass covered...

2. Going Solo?

Now I know most of you guys will be going this route. Hell, I went this route, and I get it – sometimes (most) times, a doctor's visit isn't feasible. Maybe you don't have insurance or diabetes, or your insurance won't cover it (because you don't have diabetes), or the medication is simply unavailable in your region.

In any case, if you wanna go at it alone, a quick word of caution.

Self-administering medications like GLP-1s comes with risks. You could get the dosage wrong, experience unexpected side effects, or have an interaction with other medications you're taking. Take some responsibility, do a bit of research (this thread isn't enough, sorry boyos), and then decide whether it'd be worth it.

(It almost certainly would be, but you know how these disclaimers go).

Right, so you've made up your mind? Done your research? No? But still, determined to go at it alone? Well, here's how.

3. Reconstituting Peptides
View attachment 3150721

Most GLP-1s you'll find online come in powder form and need to be mixed with bacteriostatic water ("bac water") before injecting. This is called reconstitution. It's not as complicated as it sounds.

Here's the process:

1. Calculate Your Dose: Use a peptide calculator (like this one: https://primepeptides.co/pages/peptide-calculator) to determine the exact amount of solution you need to draw up to get your desired dose.
2. Mix it Up: Always use high-quality bac water from a reputable source. Use an insulin syringe (e.g., 31G 1 ml/cc) for accuracy. Inject the water slowly into the peptide vial, letting it slide down the side. Swirl gently to mix (don't shake). The solution should be clear.

Injection Technique​

GLP-1s are injected subcutaneously (under the skin) into fatty tissue. Common sites include your abdomen (at least two inches away from your belly button), thigh (front or outer part), or upper arm.

Thigh injections are preferred because they have fewer side effects, according to a study. Use a needle length of 5/16" (8mm) or shorter.
View attachment 3150745

Here's how to inject:

1. Prepare: Wash your hands and gather your supplies (alcohol wipes, syringe, medication vial).
2. Clean: Clean the vial top and your injection site with alcohol wipes.
3. Draw: Attach a new, sterile needle to your syringe. Draw air into the syringe equal to your dose. Inject the air into the vial, turn it upside down, and withdraw the calculated amount of solution.
4. Inject: Pinch the skin at the injection site and insert the needle at a 45-degree angle (or 90-degree, if needle size is short). Slowly inject the medication, withdraw the needle, and dispose of it properly. Don't rub the injection site.
5. Rotate: Switch injection sites each time (or every few injections) to prevent irritation.

View attachment 3150911


It's basically like injecting insulin, which millions of people do daily. You really can't fuck this up, (well, maybe you can).

Sourcing
By now, you're probably wondering where to get your hands on all of this.

GLP-1 Forum
View attachment 3151206
There's a whole community dedicated to GLP-1s, with tons of vendor discussions: https://glp1forum.com/.
It's an independently run forum, so they are more open about discussing sources and vendors than Reddit.

Reputable Sources
The consensus is to stick with the top 2-3 most reputable vendors, even if they're not the cheapest. You'll find a lot of helpful information about vendors on that forum.

The user "dionysos", in particular, has some useful content. Including the following thread on the most actively used vendors on said forum, so you'd at least have a reference for where to start looking.

Which Vendors Have You Used ?

Which peptide vendors have you chosen to use? Choices shown are vendors who are often active here. Used other vendors? Please vote "Other" then post their details. Thanks!!!

glp1forum.com

View attachment 3150697
Along with some useful Google docs on which vendors might be safest to buy from, and have the best standing. These documents can (currently), all still be found in his signature.

Spoiler

Here's one specifically for the U.S.

Spoiler

Handy Tool
For planning your GLP-1 dosage schedule, check out GLP-1 Plotter: https://glp1plotter.com/
It's a free online tool that helps you visualize different combinations and track your progress.

View attachment 3150632

Nutrition and Exercise
After all this, I know some of you'll be asking yourself, "With these drugs, do I even need to eat healthy and exercise?"

Well, here's the truth: GLP-1s are not a "get out of jail free card" when it comes to diet and exercise. They still work best when combined with a healthy lifestyle.

Could you get away with eating less-than-ideal food and skipping the gym? Short answer: Yes. You'd still lose weight, but you'd be missing out on the full potential of these medications.

But here's the thing: if you can't eat healthy now with the help of GLP-1s, you're probably never going to be able to stick to a healthy diet later either. So, use this opportunity to improve your nutrition, and learn how to eat & cook healthy food.

A Look Towards The Future
View attachment 3150806

Looking ahead, the weight loss landscape is changing, pretty rapidly. The current GLP-1 revolution is just the beginning, as researchers delve even deeper into gut hormone science, exploring new medications that promise even greater control over weight loss.

View attachment 3151213
Combination therapies are one promising development. Imagine targeting multiple hunger hormones simultaneously for a synergistic effect. That's exactly what's happening with Cagrilintide, a potent amylin analog that's showing impressive results in trials, even surpassing some existing GLP-1s. Combining Cagrilintide with Semaglutide has created Cagrisema, a dual-action medication that shows promise in early trials too.
View attachment 3151214
Scientists are also exploring Peptide YY (PYY) analogs, which could revolutionize appetite control (again). PYY signals fullness and reduces food intake, and long-acting versions are currently being tested, both alone and with GLP-1s.

In short: The weight loss industry is about to become a gold mine, and companies are scrambling to cash in on the next big thing.

Will everyone soon be walking around with 10-12% body fat? I doubt it, but the fact that it's even a plausible question is pretty fuckin' crazy to me.

Guess we'll end with a quote.

Spoiler: TLDR

GO READ THE THREAD LAZY ASS NIGGA

Bros would rather do drugs than just exercise some self-control lol

 

[nigbob2000]

Introduction

This is the reality for too many of us. Endless cravings, failed diets, and a gnawing feeling that we're stuck in a body that doesn't reflect who we want to be.

View attachment 3150855

Let's be honest – we've all got excuses when it comes to weight loss. "I'm too busy," "My genetics are bad," "I just love food too much." But what if those excuses were no longer valid? What if there was a solution that could help you overcome those obstacles and finally achieve the body you deserve?

Been there. Done that. Tried every diet, every workout, every "miracle" pill under the sun. The scale just keeps going up, and the frustration is a constant companion. You're a victim of your own biology, right? Wrong.

This is the weight loss secret that's been quietly transforming bodies for years. Now, it's your turn.
View attachment 3151049View attachment 3151232

I'll be honest, this shit's so much of a cheat code, part of me didn't even feel like sharing it, even if it's only to you guys here. Still, as I found out about these drugs on this forum, I felt it was only fair to take on the mantle and spread the word. Now come along boyos, and I'll show you the promised land.
View attachment 3150579

The Big 3: Semaglutide, Tirzepatide, and Retatrutide

1. Semaglutide (Ozempic/Wegovy)
View attachment 3150747
Semaglutide mimics GLP-1, a hormone that tells your brain you're full even when you've eaten less. This translates to fewer cravings and a reduced appetite, making it easier to stick to your diet and create the calorie deficit needed for fat loss. Semaglutide also slows down digestion, keeping you satisfied for longer and preventing those energy crashes that often lead to unhealthy snacking. And it doesn't stop there – Semaglutide also helps your body use glucose more efficiently, leading to better blood sugar control and sustained energy levels throughout the day.

View attachment 3150769

2. Tirzepatide (Mounjaro)
View attachment 3150757
Tirzepatide takes fat loss a step further by activating both the GLP-1 and GIP receptors. This dual action leads to even more powerful appetite suppression and potentially enhanced fat burning, helping you torch those stubborn pounds more effectively. Tirzepatide could also offer a range of benefits beyond weight loss, including nausea reduction, improved brain health, and stronger bones.

View attachment 3150763View attachment 3150765

3. Retatrutide
View attachment 3150754
Retatrutide is the newest and most potent GLP-1 receptor agonist, setting itself apart by targeting three key receptors: GLP-1, GIP, and glucagon. This triple-action approach creates a potent synergy that will likely significantly accelerate your fat loss.

Retatrutide ramps up appetite control to the extreme, making it easier to stick to your diet without feeling deprived. But what truly sets it apart is its activation of the glucagon receptor. Glucagon is a hormone that helps your body release stored energy, particularly from fat. By stimulating glucagon, Retatrutide encourages your body to tap into its fat reserves for fuel, enhancing fat burning.

So, we're not simply talking about eating less here, it'll actively burn fat too. It also optimizes blood sugar control, further contributing to a leaner, healthier physique.

While Retatrutide is still in clinical trials, early results are incredibly promising, suggesting it could be the most effective fat-loss medication yet. So much so that there's already plenty of people purchasing and using it.
View attachment 3150575

View attachment 3150774

Dosage and Frequency
Each medication has its own recommended dosage and injection frequency. Here's a quick rundown:

• Semaglutide: Typically injected once a week, starting at a low dose (0.25 mg) and gradually increasing to a maximum of 2.4 mg.
• Tirzepatide: Also injected once a week, with starting doses ranging from 2.5 mg to 5 mg and potentially increasing to a maximum of 15 mg.
• Retatrutide: In clinical trials, it's being administered once a week, with dosages ranging from 1 mg to 12 mg.

Tip: Some users find that injecting every 5 days instead of every 7 helps maintain better appetite control throughout the week.

Okay, now that you know the players, let's break down how they work and why they're creating so much buzz.

How They Work​

So, how do these drugs actually work? Well, here's the gist.

They work by cleverly mimicking the actions of natural gut hormones that already play a key role in regulating your appetite, metabolism, and how your body processes food.

Think of it like this: your gut and your brain are in constant communication, sending signals back and forth about hunger, fullness, and energy levels. GLP-1 receptor agonists basically "hack" this communication system, amplifying the signals that tell your brain "I'm full" and "Slow down digestion."

Let's delve a bit more into detail.

Appetite Control. GLP-1 receptor agonists bind to specific receptors in your brain that are involved in regulating hunger and satiety. This directly reduces those nagging hunger pangs and cravings that usually make dieting such a struggle. You'll find yourself feeling satisfied with smaller portions and less tempted by those unhealthy snacks (it's genuinely crazy, I haven't eaten sweets in months).

Slower Digestion. These medications also delay gastric emptying, which is the process of food moving from your stomach to your intestines. This means food stays in your stomach for longer, further contributing to that feeling of fullness and preventing those rapid blood sugar spikes that can lead to cravings and energy crashes. This could affect (delay) the absorption of some oral medication or supplements you'd be consuming, however.

Enhanced Insulin Response. GLP-1 receptor agonists also stimulate your pancreas to release more insulin, the hormone responsible for shuttling glucose (sugar) from your bloodstream into your cells for energy. This improves your body's ability to utilize glucose, leading to better blood sugar control and more stable energy levels.
View attachment 3151210

These medications are basically working with your body, not against it, to help you lose weight and even get healthier. Welcome to the future lads.

What you need to know before you start
While GLP-1s sound like a dream come true for any guy looking to level up his physique, they're not without their potential downsides.

Muscle Loss
While GLP-1s primarily target fat loss, some studies suggest they could affect muscle mass. (Likely due to quick, significant weight loss). To avoid this, prioritize protein intake (at least 1 gram per pound of body weight) and keep hitting the weights.

Nausea
Nausea is a common side effect, especially when you're first starting or increasing your dosage. It also depends on which exact GLP-1 you are using. It usually subsides, but out of caution, start low and go slow. Staying hydrated can also help.

The Cost Factor.
These medications are expensive, and insurance coverage varies. For now, it's a barrier to entry for most. (Thank God). But as demand increases, prices and accessibility might improve. You'd likely still need a prescription though.

Luckily for you, there are (far cheaper) prescription-free ways you can get your hands on this shit, which will be explored later on in this thread.

The "Ozempic Face" Myth
That more defined facial appearance is primarily due to overall weight loss, not a unique effect of the medication.

Long-Term Commitment
GLP-1s are typically used long-term (maybe for life). To maintain your results, you'll either need to stay on it or adopt a healthy lifestyle so you don't regain most of the weight.

View attachment 3151121

Moving on...

1. The Ideal Scenario: Talk to a Doctor
View attachment 3151222
Listen, guys, consulting with a doctor is (almost) always the safest and smartest move. They're the experts, and they can provide the personalized guidance you need for optimal results.

Alright, now that I've got my ass covered...

2. Going Solo?

Now I know most of you guys will be going this route. Hell, I went this route, and I get it – sometimes (most) times, a doctor's visit isn't feasible. Maybe you don't have insurance or diabetes, or your insurance won't cover it (because you don't have diabetes), or the medication is simply unavailable in your region.

In any case, if you wanna go at it alone, a quick word of caution.

Self-administering medications like GLP-1s comes with risks. You could get the dosage wrong, experience unexpected side effects, or have an interaction with other medications you're taking. Take some responsibility, do a bit of research (this thread isn't enough, sorry boyos), and then decide whether it'd be worth it.

(It almost certainly would be, but you know how these disclaimers go).

Right, so you've made up your mind? Done your research? No? But still, determined to go at it alone? Well, here's how.

3. Reconstituting Peptides
View attachment 3150721

Most GLP-1s you'll find online come in powder form and need to be mixed with bacteriostatic water ("bac water") before injecting. This is called reconstitution. It's not as complicated as it sounds.

Here's the process:

1. Calculate Your Dose: Use a peptide calculator (like this one: https://primepeptides.co/pages/peptide-calculator) to determine the exact amount of solution you need to draw up to get your desired dose.
2. Mix it Up: Always use high-quality bac water from a reputable source. Use an insulin syringe (e.g., 31G 1 ml/cc) for accuracy. Inject the water slowly into the peptide vial, letting it slide down the side. Swirl gently to mix (don't shake). The solution should be clear.

Injection Technique​

GLP-1s are injected subcutaneously (under the skin) into fatty tissue. Common sites include your abdomen (at least two inches away from your belly button), thigh (front or outer part), or upper arm.

Thigh injections are preferred because they have fewer side effects, according to a study. Use a needle length of 5/16" (8mm) or shorter.
View attachment 3150745

Here's how to inject:

1. Prepare: Wash your hands and gather your supplies (alcohol wipes, syringe, medication vial).
2. Clean: Clean the vial top and your injection site with alcohol wipes.
3. Draw: Attach a new, sterile needle to your syringe. Draw air into the syringe equal to your dose. Inject the air into the vial, turn it upside down, and withdraw the calculated amount of solution.
4. Inject: Pinch the skin at the injection site and insert the needle at a 45-degree angle (or 90-degree, if needle size is short). Slowly inject the medication, withdraw the needle, and dispose of it properly. Don't rub the injection site.
5. Rotate: Switch injection sites each time (or every few injections) to prevent irritation.

View attachment 3150911


It's basically like injecting insulin, which millions of people do daily. You really can't fuck this up, (well, maybe you can).

Sourcing
By now, you're probably wondering where to get your hands on all of this.

GLP-1 Forum
View attachment 3151206
There's a whole community dedicated to GLP-1s, with tons of vendor discussions: https://glp1forum.com/.
It's an independently run forum, so they are more open about discussing sources and vendors than Reddit.

Reputable Sources
The consensus is to stick with the top 2-3 most reputable vendors, even if they're not the cheapest. You'll find a lot of helpful information about vendors on that forum.

The user "dionysos", in particular, has some useful content. Including the following thread on the most actively used vendors on said forum, so you'd at least have a reference for where to start looking.

Which Vendors Have You Used ?

Which peptide vendors have you chosen to use? Choices shown are vendors who are often active here. Used other vendors? Please vote "Other" then post their details. Thanks!!!

glp1forum.com

View attachment 3150697
Along with some useful Google docs on which vendors might be safest to buy from, and have the best standing. These documents can (currently), all still be found in his signature.

Spoiler

Here's one specifically for the U.S.

Spoiler

Handy Tool
For planning your GLP-1 dosage schedule, check out GLP-1 Plotter: https://glp1plotter.com/
It's a free online tool that helps you visualize different combinations and track your progress.

View attachment 3150632

Nutrition and Exercise
After all this, I know some of you'll be asking yourself, "With these drugs, do I even need to eat healthy and exercise?"

Well, here's the truth: GLP-1s are not a "get out of jail free card" when it comes to diet and exercise. They still work best when combined with a healthy lifestyle.

Could you get away with eating less-than-ideal food and skipping the gym? Short answer: Yes. You'd still lose weight, but you'd be missing out on the full potential of these medications.

But here's the thing: if you can't eat healthy now with the help of GLP-1s, you're probably never going to be able to stick to a healthy diet later either. So, use this opportunity to improve your nutrition, and learn how to eat & cook healthy food.

A Look Towards The Future
View attachment 3150806

Looking ahead, the weight loss landscape is changing, pretty rapidly. The current GLP-1 revolution is just the beginning, as researchers delve even deeper into gut hormone science, exploring new medications that promise even greater control over weight loss.

View attachment 3151213
Combination therapies are one promising development. Imagine targeting multiple hunger hormones simultaneously for a synergistic effect. That's exactly what's happening with Cagrilintide, a potent amylin analog that's showing impressive results in trials, even surpassing some existing GLP-1s. Combining Cagrilintide with Semaglutide has created Cagrisema, a dual-action medication that shows promise in early trials too.
View attachment 3151214
Scientists are also exploring Peptide YY (PYY) analogs, which could revolutionize appetite control (again). PYY signals fullness and reduces food intake, and long-acting versions are currently being tested, both alone and with GLP-1s.

In short: The weight loss industry is about to become a gold mine, and companies are scrambling to cash in on the next big thing.

Will everyone soon be walking around with 10-12% body fat? I doubt it, but the fact that it's even a plausible question is pretty fuckin' crazy to me.

Guess we'll end with a quote.

Spoiler: TLDR

GO READ THE THREAD LAZY ASS NIGGA

very good thread, deffo botb worthy

Introduction

This is the reality for too many of us. Endless cravings, failed diets, and a gnawing feeling that we're stuck in a body that doesn't reflect who we want to be.

View attachment 3150855

Let's be honest – we've all got excuses when it comes to weight loss. "I'm too busy," "My genetics are bad," "I just love food too much." But what if those excuses were no longer valid? What if there was a solution that could help you overcome those obstacles and finally achieve the body you deserve?

Been there. Done that. Tried every diet, every workout, every "miracle" pill under the sun. The scale just keeps going up, and the frustration is a constant companion. You're a victim of your own biology, right? Wrong.

This is the weight loss secret that's been quietly transforming bodies for years. Now, it's your turn.
View attachment 3151049View attachment 3151232

I'll be honest, this shit's so much of a cheat code, part of me didn't even feel like sharing it, even if it's only to you guys here. Still, as I found out about these drugs on this forum, I felt it was only fair to take on the mantle and spread the word. Now come along boyos, and I'll show you the promised land.
View attachment 3150579

The Big 3: Semaglutide, Tirzepatide, and Retatrutide

1. Semaglutide (Ozempic/Wegovy)
View attachment 3150747
Semaglutide mimics GLP-1, a hormone that tells your brain you're full even when you've eaten less. This translates to fewer cravings and a reduced appetite, making it easier to stick to your diet and create the calorie deficit needed for fat loss. Semaglutide also slows down digestion, keeping you satisfied for longer and preventing those energy crashes that often lead to unhealthy snacking. And it doesn't stop there – Semaglutide also helps your body use glucose more efficiently, leading to better blood sugar control and sustained energy levels throughout the day.

View attachment 3150769

2. Tirzepatide (Mounjaro)
View attachment 3150757
Tirzepatide takes fat loss a step further by activating both the GLP-1 and GIP receptors. This dual action leads to even more powerful appetite suppression and potentially enhanced fat burning, helping you torch those stubborn pounds more effectively. Tirzepatide could also offer a range of benefits beyond weight loss, including nausea reduction, improved brain health, and stronger bones.

View attachment 3150763View attachment 3150765

3. Retatrutide
View attachment 3150754
Retatrutide is the newest and most potent GLP-1 receptor agonist, setting itself apart by targeting three key receptors: GLP-1, GIP, and glucagon. This triple-action approach creates a potent synergy that will likely significantly accelerate your fat loss.

Retatrutide ramps up appetite control to the extreme, making it easier to stick to your diet without feeling deprived. But what truly sets it apart is its activation of the glucagon receptor. Glucagon is a hormone that helps your body release stored energy, particularly from fat. By stimulating glucagon, Retatrutide encourages your body to tap into its fat reserves for fuel, enhancing fat burning.

So, we're not simply talking about eating less here, it'll actively burn fat too. It also optimizes blood sugar control, further contributing to a leaner, healthier physique.

While Retatrutide is still in clinical trials, early results are incredibly promising, suggesting it could be the most effective fat-loss medication yet. So much so that there's already plenty of people purchasing and using it.
View attachment 3150575

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Dosage and Frequency
Each medication has its own recommended dosage and injection frequency. Here's a quick rundown:

• Semaglutide: Typically injected once a week, starting at a low dose (0.25 mg) and gradually increasing to a maximum of 2.4 mg.
• Tirzepatide: Also injected once a week, with starting doses ranging from 2.5 mg to 5 mg and potentially increasing to a maximum of 15 mg.
• Retatrutide: In clinical trials, it's being administered once a week, with dosages ranging from 1 mg to 12 mg.

Tip: Some users find that injecting every 5 days instead of every 7 helps maintain better appetite control throughout the week.

Okay, now that you know the players, let's break down how they work and why they're creating so much buzz.

How They Work​

So, how do these drugs actually work? Well, here's the gist.

They work by cleverly mimicking the actions of natural gut hormones that already play a key role in regulating your appetite, metabolism, and how your body processes food.

Think of it like this: your gut and your brain are in constant communication, sending signals back and forth about hunger, fullness, and energy levels. GLP-1 receptor agonists basically "hack" this communication system, amplifying the signals that tell your brain "I'm full" and "Slow down digestion."

Let's delve a bit more into detail.

Appetite Control. GLP-1 receptor agonists bind to specific receptors in your brain that are involved in regulating hunger and satiety. This directly reduces those nagging hunger pangs and cravings that usually make dieting such a struggle. You'll find yourself feeling satisfied with smaller portions and less tempted by those unhealthy snacks (it's genuinely crazy, I haven't eaten sweets in months).

Slower Digestion. These medications also delay gastric emptying, which is the process of food moving from your stomach to your intestines. This means food stays in your stomach for longer, further contributing to that feeling of fullness and preventing those rapid blood sugar spikes that can lead to cravings and energy crashes. This could affect (delay) the absorption of some oral medication or supplements you'd be consuming, however.

Enhanced Insulin Response. GLP-1 receptor agonists also stimulate your pancreas to release more insulin, the hormone responsible for shuttling glucose (sugar) from your bloodstream into your cells for energy. This improves your body's ability to utilize glucose, leading to better blood sugar control and more stable energy levels.
View attachment 3151210

These medications are basically working with your body, not against it, to help you lose weight and even get healthier. Welcome to the future lads.

What you need to know before you start
While GLP-1s sound like a dream come true for any guy looking to level up his physique, they're not without their potential downsides.

Muscle Loss
While GLP-1s primarily target fat loss, some studies suggest they could affect muscle mass. (Likely due to quick, significant weight loss). To avoid this, prioritize protein intake (at least 1 gram per pound of body weight) and keep hitting the weights.

Nausea
Nausea is a common side effect, especially when you're first starting or increasing your dosage. It also depends on which exact GLP-1 you are using. It usually subsides, but out of caution, start low and go slow. Staying hydrated can also help.

The Cost Factor.
These medications are expensive, and insurance coverage varies. For now, it's a barrier to entry for most. (Thank God). But as demand increases, prices and accessibility might improve. You'd likely still need a prescription though.

Luckily for you, there are (far cheaper) prescription-free ways you can get your hands on this shit, which will be explored later on in this thread.

The "Ozempic Face" Myth
That more defined facial appearance is primarily due to overall weight loss, not a unique effect of the medication.

Long-Term Commitment
GLP-1s are typically used long-term (maybe for life). To maintain your results, you'll either need to stay on it or adopt a healthy lifestyle so you don't regain most of the weight.

View attachment 3151121

Moving on...

1. The Ideal Scenario: Talk to a Doctor
View attachment 3151222
Listen, guys, consulting with a doctor is (almost) always the safest and smartest move. They're the experts, and they can provide the personalized guidance you need for optimal results.

Alright, now that I've got my ass covered...

2. Going Solo?

Now I know most of you guys will be going this route. Hell, I went this route, and I get it – sometimes (most) times, a doctor's visit isn't feasible. Maybe you don't have insurance or diabetes, or your insurance won't cover it (because you don't have diabetes), or the medication is simply unavailable in your region.

In any case, if you wanna go at it alone, a quick word of caution.

Self-administering medications like GLP-1s comes with risks. You could get the dosage wrong, experience unexpected side effects, or have an interaction with other medications you're taking. Take some responsibility, do a bit of research (this thread isn't enough, sorry boyos), and then decide whether it'd be worth it.

(It almost certainly would be, but you know how these disclaimers go).

Right, so you've made up your mind? Done your research? No? But still, determined to go at it alone? Well, here's how.

3. Reconstituting Peptides
View attachment 3150721

Most GLP-1s you'll find online come in powder form and need to be mixed with bacteriostatic water ("bac water") before injecting. This is called reconstitution. It's not as complicated as it sounds.

Here's the process:

1. Calculate Your Dose: Use a peptide calculator (like this one: https://primepeptides.co/pages/peptide-calculator) to determine the exact amount of solution you need to draw up to get your desired dose.
2. Mix it Up: Always use high-quality bac water from a reputable source. Use an insulin syringe (e.g., 31G 1 ml/cc) for accuracy. Inject the water slowly into the peptide vial, letting it slide down the side. Swirl gently to mix (don't shake). The solution should be clear.

Injection Technique​

GLP-1s are injected subcutaneously (under the skin) into fatty tissue. Common sites include your abdomen (at least two inches away from your belly button), thigh (front or outer part), or upper arm.

Thigh injections are preferred because they have fewer side effects, according to a study. Use a needle length of 5/16" (8mm) or shorter.
View attachment 3150745

Here's how to inject:

1. Prepare: Wash your hands and gather your supplies (alcohol wipes, syringe, medication vial).
2. Clean: Clean the vial top and your injection site with alcohol wipes.
3. Draw: Attach a new, sterile needle to your syringe. Draw air into the syringe equal to your dose. Inject the air into the vial, turn it upside down, and withdraw the calculated amount of solution.
4. Inject: Pinch the skin at the injection site and insert the needle at a 45-degree angle (or 90-degree, if needle size is short). Slowly inject the medication, withdraw the needle, and dispose of it properly. Don't rub the injection site.
5. Rotate: Switch injection sites each time (or every few injections) to prevent irritation.

View attachment 3150911


It's basically like injecting insulin, which millions of people do daily. You really can't fuck this up, (well, maybe you can).

Sourcing
By now, you're probably wondering where to get your hands on all of this.

GLP-1 Forum
View attachment 3151206
There's a whole community dedicated to GLP-1s, with tons of vendor discussions: https://glp1forum.com/.
It's an independently run forum, so they are more open about discussing sources and vendors than Reddit.

Reputable Sources
The consensus is to stick with the top 2-3 most reputable vendors, even if they're not the cheapest. You'll find a lot of helpful information about vendors on that forum.

The user "dionysos", in particular, has some useful content. Including the following thread on the most actively used vendors on said forum, so you'd at least have a reference for where to start looking.

Which Vendors Have You Used ?

Which peptide vendors have you chosen to use? Choices shown are vendors who are often active here. Used other vendors? Please vote "Other" then post their details. Thanks!!!

glp1forum.com

View attachment 3150697
Along with some useful Google docs on which vendors might be safest to buy from, and have the best standing. These documents can (currently), all still be found in his signature.

Spoiler

Here's one specifically for the U.S.

Spoiler

Handy Tool
For planning your GLP-1 dosage schedule, check out GLP-1 Plotter: https://glp1plotter.com/
It's a free online tool that helps you visualize different combinations and track your progress.

View attachment 3150632

Nutrition and Exercise
After all this, I know some of you'll be asking yourself, "With these drugs, do I even need to eat healthy and exercise?"

Well, here's the truth: GLP-1s are not a "get out of jail free card" when it comes to diet and exercise. They still work best when combined with a healthy lifestyle.

Could you get away with eating less-than-ideal food and skipping the gym? Short answer: Yes. You'd still lose weight, but you'd be missing out on the full potential of these medications.

But here's the thing: if you can't eat healthy now with the help of GLP-1s, you're probably never going to be able to stick to a healthy diet later either. So, use this opportunity to improve your nutrition, and learn how to eat & cook healthy food.

A Look Towards The Future
View attachment 3150806

Looking ahead, the weight loss landscape is changing, pretty rapidly. The current GLP-1 revolution is just the beginning, as researchers delve even deeper into gut hormone science, exploring new medications that promise even greater control over weight loss.

View attachment 3151213
Combination therapies are one promising development. Imagine targeting multiple hunger hormones simultaneously for a synergistic effect. That's exactly what's happening with Cagrilintide, a potent amylin analog that's showing impressive results in trials, even surpassing some existing GLP-1s. Combining Cagrilintide with Semaglutide has created Cagrisema, a dual-action medication that shows promise in early trials too.
View attachment 3151214
Scientists are also exploring Peptide YY (PYY) analogs, which could revolutionize appetite control (again). PYY signals fullness and reduces food intake, and long-acting versions are currently being tested, both alone and with GLP-1s.

In short: The weight loss industry is about to become a gold mine, and companies are scrambling to cash in on the next big thing.

Will everyone soon be walking around with 10-12% body fat? I doubt it, but the fact that it's even a plausible question is pretty fuckin' crazy to me.

Guess we'll end with a quote.

Spoiler: TLDR

GO READ THE THREAD LAZY ASS NIGGA

very good thread, deffo botb worthy

 

[evannes]

wow, everyone loves a well-informed greycel. good thread.