aromatose inhibators+ hgh

[Kevla]

what is the best aromatase inhibitors with hgh

 

[Zagro]

Also I want to add more onto this.

Exemestane is irreversible, it binds permanently to the Aromatase enzymes. So if he ever wanted to go back to normal estrogen production, it would be impossible. This is dangerous misinformation that could harm the quality of his sperm, since estradiol does help prevent sperm death.

https://academic.oup.com/jcem/article-abstract/85/5/2057/2660648

Nigga doesn't know that your body produces the enzymes back

 

[LTLightskin]

I already stated that the nuance was not implied, not that your implications were hard to infer; your implications did not exist.
Regardless, you can continue trying to argue with me all you like, but you're an idiot that I won't consider debating because you will shift the goal posts every time I prove you wrong.
Your initial comments were wrong, and I said that... later you can add all the nuance you want, I'll just continue to disregard it.

>Yeah I'm wrong so instead of admitting it, I'm going to claim my opponent is "shifting the goal posts" even though the same premises were kept.

Also still no counter source to my study that aromasin could potentially have a brief estrogen rebound due to the increased endogenous testosterone from aromasin being aromatized. And shame on you for being a sophist, knowing that 99% of the people here aren't autistic enough to know basic pharmacology to refute your BS. Taking advantage of the ignorance so many people here have.

 

[Zagro]

>Yeah I'm wrong so instead of admitting it, I'm going to claim my opponent is "shifting the goal posts" even though the same premises were kept.

Also still no counter source to my study that aromasin could potentially have a brief estrogen rebound due to the increased endogenous testosterone from aromasin being aromatized. And shame on you for being a sophist, knowing that 99% of the people here aren't autistic enough to know basic pharmacology to refute your BS. Taking advantage of the ignorance so many people here have.

The increase in testosterone is temporary is just your lh exceeding the normal work rate, and even if that wasn't the case a short estrogen rebound by your increased endogenous test will be negligible and wont cause any premature ossification to the epiphyses

 

[LTLightskin]

Nigga doesn't know that your body produces the enzymes back

Nigga doesn't know enzyme synthesis has feedback loops and can be downregulated after long durations of needing to compensate for the lack of said enzyme.

 

[LTLightskin]

The increase in testosterone is temporary is just your lh exceeding the normal work rate, and even if that wasn't the case a short estrogen rebound by your increased endogenous test will be negligible and wont cause any premature ossification to the epiphyses

I know, I fully agree with you and earlier I said the rebound only lasts for about a day. It's pretty insignificant since it's only about 10% E2 rebound.

But this fucking retard said aromasin has NO rebound which is bullshit.

 

[Zagro]

Nigga doesn't know enzyme synthesis has feedback loops and can be downregulated after long durations of needing to compensate for the lack of said enzyme.

Yeah ngl i do not know that

 

[LTLightskin]

Yeah ngl i do not know that

It's kinda like how gnrh agonists work.

At first glance, lurpon for example should be increasing GNRH and therefore increasing endogenous hormones and the gonadtropins. But ultimately it overexhuasts the pituitary due to the overly large amounts of GNRH so instead it just shuts down the receptors and downregulates. Stopping all endogenous hormone production.

The same would theoretically happen with the aromatase enzymes, but I didn't find any articles on the long term usage of aromasin in men. But it seems likely this is the case.

But this is protein synthesis, so it's far more complex. I might go ask my med student friend to help me find some studies to come to a more robust explanation and conclusion.

 

[Bitchwhipper2]

That's misinformation.

Exemestane only has a mean inhibition rate of 97.9%.

In vivo inhibition of aromatization by exemestane, a novel irreversible aromatase inhibitor, in postmenopausal breast cancer patients - PubMed

The effect of exemestane (6-methylenandrosta-1,4-diene-3,17-dione) 25 mg p.o. once daily on in vivo aromatization was studied in 10 postmenopausal women with advanced breast cancer. Aromatization was determined before treatment and after 6-8 weeks on therapy by administering a bolus injection of...

pubmed.ncbi.nlm.nih.gov

Like it even matters after 98%

 

[aids]

It's kinda like how gnrh agonists work.

At first glance, lurpon for example should be increasing GNRH and therefore increasing endogenous hormones and the gonadtropins. But ultimately it overexhuasts the pituitary due to the overly large amounts of GNRH so instead it just shuts down the receptors and downregulates. Stopping all endogenous hormone production.

The same would theoretically happen with the aromatase enzymes, but I didn't find any articles on the long term usage of aromasin in men. But it seems likely this is the case.

But this is protein synthesis, so it's far more complex. I might go ask my med student friend to help me find some studies to come to a more robust explanation and conclusion.

Wow, I'm caging.

You provide incorrect blanket statements, try to add nuance to justify as to why you are right in hindsight (disregarding the fact the issue I took was with your blanket statements, not what you might've meant but that is your own fault due to the inability to imply/explicitly state context), then you admit yourself that you are just theorising and there is nothing that actually supports your claims.

This is the type of people I have to argue with? JFL

 

[LTLightskin]

Wow, I'm caging.

You provide incorrect blanket statements, try to add nuance to justify as to why you are right in hindsight (disregarding the fact the issue I took was with your blanket statements, not what you might've meant but that is your own fault due to the inability to imply/explicitly state context), then you admit yourself that you are just theorising and there is nothing that actually supports your claims.

This is the type of people I have to argue with? JFL

Are you genuinely malding over not getting the full reasoning the first time I wrote my paragraph? Maybe you're more autistic than me but how discussions usually work is that there is back and forth. You typically won't get the entire information the first time, which is why you ask questions.

Now I already explained myself...

Then after I explained myself, I repeatedly asked you multiple times to send sources as to why I am or why I might be wrong. You entirely failed at this job. You also lied and said aromasin doesn't have rebound, when even your friend agreed it does.

@Zagro also admitted he didn't know enough about protein synthesis pathways to comment, I'm assuming you're the same. The difference is that you don't want to admit it.

This is genuinely impressive, I've found way more high degree autistics here than on my small Discord servers.

 

[Zagro]

Are you genuinely malding over not getting the full reasoning the first time I wrote my paragraph? Maybe you're more autistic than me but how discussions usually work is that there is back and forth. You typically won't get the entire information the first time, which is why you ask questions.

Now I already explained myself...

Then after I explained myself, I repeatedly asked you multiple times to send sources as to why I am or why I might be wrong. You entirely failed at this job. You also lied and said aromasin doesn't have rebound, when even your friend agreed it does.

@Zagro also admitted he didn't know enough about protein synthesis pathways to comment, I'm assuming you're the same. The difference is that you don't want to admit it.

This is genuinely impressive, I've found way more high degree autistics here than on my small Discord servers.

I barely even talk to him nor do i have enough knowledge regarding this topic or overall knowledge as much as he does. Don’t bring me up to make a point bro

its all indirect, temporary and caused by your endogenous testosterone, as you’ve said yourself aswell its barely anything, so it shouldn’t even be worth pointing out