Thatsall101
Iron
- Joined
- Apr 11, 2026
- Posts
- 15
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I see too many guys getting on erda but never considering CNP, which not only reduces FGFR3 but also promotes longitudinal bone growth,
while both inhibiting fgfr3 and promoting bone growth
Simplified pathway of CNP's effects on FGFR3
**[ FGF18 → FGFR3 → RAF → MEK → ERK
↓
Growth inhibition
CNP → NPR2 → cGMP → PKG II ─┤ RAF/MEK/ERK
↓
Less growth inhibition]**
and unlike FGFR3 inhibitors such as erdafitinib, CNP doesn't directly block the receptor. It counteracts FGFR3 signaling and helps maintain normal IHH-PTHrP growth plate signaling, which supports the pool of proliferating chondrocytes and may slow growth plate exhaustion, again simplified pathway
[
IHH ↔ PTHrP
↑
Supports growth plate expansion
FGFR3 ─┤ Chondrocyte proliferation
FGFR3 ─┤ IHH-related growth programs
CNP/NPR2 ─┤ FGFR3-MAPK signaling
↓
Allows normal IHH-PTHrP activity]
which in turn lets you grow for a longer time frame.
'also CNP is used in children with dwarfism (achondroplasia) to the people who think you can only grow to your genetic limit'
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
The other half of this post will be dedicated on ways of sourcing CNP
The main issue in sourcing CNP, aka (vosorotide, TransCon CNP, Navepegritide), `if cnp is mentioned it may mean any of these 3`
in my opinion TransCon CNP being the best with the longest half life, (~7 days between injections)
Best prices being in china however you cannot just ask for cnp youll get over priced sources,
[
]
However the beauty of this is that you can go straight to the source and ask for a custom peptide synthesis, and for which CNP
the cost ranges from 12$-30$ per mg!
which is insane, ill link those sources below
(https://www.glbiochem.com/en/index.html/
www.conscientia-industrial.com
www.novoprolabs.com
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
my foot notes
honestly i think its worth it if youre really willing to get taller and will do anything for it but obviously id pair this with HGH
and can someone tell me how to highlight my messages pls
while both inhibiting fgfr3 and promoting bone growth
Simplified pathway of CNP's effects on FGFR3
**[ FGF18 → FGFR3 → RAF → MEK → ERK
↓
Growth inhibition
CNP → NPR2 → cGMP → PKG II ─┤ RAF/MEK/ERK
↓
Less growth inhibition]**
and unlike FGFR3 inhibitors such as erdafitinib, CNP doesn't directly block the receptor. It counteracts FGFR3 signaling and helps maintain normal IHH-PTHrP growth plate signaling, which supports the pool of proliferating chondrocytes and may slow growth plate exhaustion, again simplified pathway
[
IHH ↔ PTHrP
↑
Supports growth plate expansion
FGFR3 ─┤ Chondrocyte proliferation
FGFR3 ─┤ IHH-related growth programs
CNP/NPR2 ─┤ FGFR3-MAPK signaling
↓
Allows normal IHH-PTHrP activity]
which in turn lets you grow for a longer time frame.
'also CNP is used in children with dwarfism (achondroplasia) to the people who think you can only grow to your genetic limit'
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
The other half of this post will be dedicated on ways of sourcing CNP
The main issue in sourcing CNP, aka (vosorotide, TransCon CNP, Navepegritide), `if cnp is mentioned it may mean any of these 3`
in my opinion TransCon CNP being the best with the longest half life, (~7 days between injections)
Best prices being in china however you cannot just ask for cnp youll get over priced sources,
[
However the beauty of this is that you can go straight to the source and ask for a custom peptide synthesis, and for which CNP
the cost ranges from 12$-30$ per mg!
which is insane, ill link those sources below
(https://www.glbiochem.com/en/index.html/
Conscientia Industrial Co Ltd | API Manufacturer Supplier | China
Conscientia Industrial is a core manufacturer of Active Pharmaceutical Ingredients (APIs), peptides, nutritional & cosmetic ingredients in China, providing comprehensive chemical solutions for the global market.
www.conscientia-industrial.com
NovoPro Bioscience Inc.
my foot notes
honestly i think its worth it if youre really willing to get taller and will do anything for it but obviously id pair this with HGH
and can someone tell me how to highlight my messages pls
