collagen fiber density increases with age

[yue]

According to Ray Peat

"Plastic surgeons have promoted the idea of injecting collagen into tissues with the argument that they are "replacing collagen lost with aging," but in fact collagen accumulates with aging. It is the greater compactness and stiffness of collagen in old skin that produces noticeable changes such as wrinkling."

The Cancer Matrix

If someone tells a cancer patient or an oncologist that cancer is a systemic disease, the thought will be flatly rejected as untrue. They have been taught that cancer is a disease of bad, mutated, cells, which have to be completely eradicated, and that the patient's general health is a separate...

raypeat.com

 

[optimisticzoomer]

Thank you Gay Peat

 

[Youㅤ]

what u need to do it slow AGE accumulation in skin

 

[mvp2v1]

So the skin has a process of remodeling just like bones. collagen and elastin cells are taken away and new collagen and elastin cells are produced. Due to inflammation and other factors the creator of those 2 cells becomes inhibited (less of them). So you end up with collagen and elastin loss without replenishment which leads to the wrinkls and saggy skin etc. How does this process fit into his explanation?

 

[Youㅤ]

So the skin has a process of remodeling just like bones. collagen and elastin cells are taken away and new collagen and elastin cells are produced. Due to inflammation and other factors the creator of those 2 cells becomes inhibited (less of them). So you end up with collagen and elastin loss without replenishment which leads to the wrinkls and saggy skin etc. How does this process fit into his explanation?

collagen and elastin are proteins produced by fibroblasts . also , elastin production is usually negligible in adults .

fibroblasts can age due to mesenchymal stem cell ageing . this (pure speculation) ageing of the fibroblasts could lead to irregular and abnormal collagen production causes old skin

Glycation plays a major role in extracellular matrix ageing is my view

 

[yue]

So the skin has a process of remodeling just like bones. collagen and elastin cells are taken away and new collagen and elastin cells are produced. Due to inflammation and other factors the creator of those 2 cells becomes inhibited (less of them). So you end up with collagen and elastin loss without replenishment which leads to the wrinkls and saggy skin etc. How does this process fit into his explanation?

Collagen and elastin are protein fibers, not cells. Fibroblasts are the cells that make protein fibers in your connective tissue.

 

[Deleted member 29747]

what u need to do it slow AGE accumulation in skin

what

 

[Youㅤ]

what

Advanced Glycation End products (AGE) , these will stiffen ur extracellular matrix ageing ur skin . also stiffen blood vessels potentially decreaseing blood flow to skin , contributing to aged skin

"AGEs are formed through four pathways: (1) the Maillard reaction, (2) sugars auto-oxidation pathway, (3) lipid peroxidation pathway, and (4) polyols pathway. Glucose is converted into fructose via the polyol pathway (based on aldo-keto reductase enzymes), which accelerates the production of AGEs [7]. AGEs precursors can also be formed by metal-catalyzed auto-oxidation of glucose (Wolff pathway) and lipid peroxidation (acetyl alcohol pathway) [8]."

also , dont forget dietary AGEs . cooked foods conatin this , these will age ur entire body

btw , AGEs dont just age u by altering proteins but somehow cause oxidative stress (im not expert i dont understand all this but i read this , might be the RAGE , receptor of AGE , im not expert as i said)

 

[Youㅤ]

btw , AGEs dont just age u by altering proteins but somehow cause oxidative stress (im not expert i dont understand all this but i read this , might be the RAGE , receptor of AGE , im not expert as i said)

hmm , basically AGE -> bad , damage cascade . ur cells probably doesnt want AGEs in genral

seems to be inflammatory , the AGE protein immune cells not like so they hostile , fight , injuring more things

oxidative stress can result from glycated mitochondrial proteins . I DID NOT THINK ABOUT INTRACELLULAR PROTEINS , MITOCHONDRIA MAKE MORE REACTIVE OXYGEN SPECIES ITS OVER

 

[Youㅤ]

hmm , basically AGE -> bad , damage cascade . ur cells probably doesnt want AGEs in genral

seems to be inflammatory , the AGE protein immune cells not like so they hostile , fight , injuring more things

oxidative stress can result from glycated mitochondrial proteins . I DID NOT THINK ABOUT INTRACELLULAR PROTEINS , MITOCHONDRIA MAKE MORE REACTIVE OXYGEN SPECIES ITS OVER

hmm , also the AGEs distract and deplete the anti oxidants . well not the AGEs on extracellular matrix but the schiff bases and amadoris maybe ?

this could be BIG , i mean even IF schiff base not survive to AGE , and even IF absorbed dietary AGEs are excreted urinary , these crooks use up detox capacity . then maybe u age more from other things , not to mention health consequences

intracellular AGEs underrated , i guess u cant just use extracellular matrix AGE breaking enzymes

 

[yue]

also , dont forget dietary AGEs . cooked foods conatin this , these will age ur entire body

Examples?

And why does glycation occur? I'm guessing it isn't correlated the amount of glucose you are consuming

 

[Allornothing]

Ray Peat

Stopped reading here.

 

[Youㅤ]

Examples?

And why does glycation occur? I'm guessing it isn't correlated the amount of glucose you are consuming

examples of what ?

AGEs form in multiple ways . glucose can create schiff bases but so can lipid peroxidation , and fructose is more likely than glucose to make schiff base

u will have more glycation if u have bad anti-oxidative capacity , more PUFAs , or bad blood glucose control . eating more glucose would increase glycation relative to eating nothing , but benefits of glucose containing natural foods outweigh this

 

[yue]

examples of what ?

AGEs form in multiple ways . glucose can create schiff bases but so can lipid peroxidation , and fructose is more likely than glucose to make schiff base

u will have more glycation if u have bad anti-oxidative capacity , more PUFAs , or bad blood glucose control . eating more glucose would increase glycation relative to eating nothing , but benefits of glucose containing natural foods outweigh this

define natural food

 

[Roge]

what u need to do it slow AGE accumulation in skin

Elab how

 

[Youㅤ]

define natural food

Whole foods I mean , like fruit and starch

 

[Youㅤ]

Elab how

Too complex too lazy to write an essay

 

[Luh?nn?]

Stopped reading here.

Ong twin

 

[Luh?nn?]

Raypeat doesn’t have rizz or swag not listening to him

 

[Youㅤ]

Elab how

Just do what I recommended , AGEs are result of oxidative stress lipid peroxidation and inflammation

 

[Roge]

Just do what I recommended , AGEs are result of oxidative stress lipid peroxidation and inflammation

Too complex to comprehend

 

[Youㅤ]

Too complex to comprehend

Read my above messages on this thread I’ll let u know if I learn more stuff on glycation

 

[Roge]

Read my above messages on this thread I’ll let u know if I learn more stuff on glycation

I've bookmarked but now its rocket science for me. Probably anti aging is the only topic I dont understand now. With the surgery results that I showed you in PMs I'm not worrying too much

 

[Youㅤ]

I've bookmarked but now it’s rocket science for me. Probably anti aging is the only topic I dont understand now. With the surgery results that I showed you in PMs I'm not worrying too much

Just remember that real anti ageing is far superior to hideing signs of ageing, even if u can hide them very effectively

I will research glycation right now

 

[yue]

@RealSurgerymax I noticed you didn't rep my post but repped optimisticzoomer, saying, "Gay Peat." I'm disappointed, but not surprised, that a member of the medical establishment continues to uphold the profitable lies of the industry.

 

[greycel]

Just remember that real anti ageing is far superior to hideing signs of ageing, even if u can hide them very effectively

I will research glycation right now

Can real anti aging even be done, without use of certain artificial supplements like NAD+/NMN etc. Surely, just eating a normal balanced diet is not included in Anti Aging.

 

[Youㅤ]

Can real anti aging even be done, without use of certain artificial supplements like NAD+/NMN etc. Surely, just eating a normal balanced diet is not included in Anti Aging.

natural diet is anti ageing relative to standard diets

u can go further to optimize natural diet for ageing less