Exposing PTH analogs for bone mass (literally biogest cope ever)

[Amex.]

Rat pharmacokinetics show a much shorter residence time than humans, but measured half-lives in rats are on the order of ~0.2–1.0 hours (12–60 minutes) in preclinical reports (not “a few minutes”).

Human half-life is longer (clinical t½ reported ~1–2 hours), so the same absolute dose in µg produces much higher exposure in humans than in rats. Regulatory documents and PK reviews note rapid clearance in rodents and higher clearance per kg than in humans

 

[ihatemySOST]

Rat pharmacokinetics show a much shorter residence time than humans, but measured half-lives in rats are on the order of ~0.2–1.0 hours (12–60 minutes) in preclinical reports (not “a few minutes”).

Human half-life is longer (clinical t½ reported ~1–2 hours), so the same absolute dose in µg produces much higher exposure in humans than in rats. Regulatory documents and PK reviews note rapid clearance in rodents and higher clearance per kg than in humans

 

[Amex.]

You are a coper who doesn't know how to research

Every 1-2 months you change your opinion entirely

I have carefully looked through all your statements in the past 12 months, and every 1-2 month you change your old opinions, do you want proof, or I can create a full document showing this.

 

[JerichoTorrent]

Saif you are a fucking retard. Comparing absolute mcg exposure between species as if a human is equivalent to a 200 pound rat is so stupid. Here go read this if you actually want to learn the dumb mistakes you made in this thread: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/
Nice way to cherrypick endpoints btw. Completely left out mandibular body height and thickness. Share your ChatGPT chat export with us so we can see exactly what it told you to write

 

[ihatemySOST]

Saif you are a fucking retard. Comparing absolute mcg exposure between species as if a human is equivalent to a 200 pound rat is so stupid. Here go read this if you actually want to learn the dumb mistakes you made in this thread: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/
Nice way to cherrypick endpoints btw. Completely left out mandibular body height and thickness. Share your ChatGPT chat export with us so we can see exactly what it told you to write

Yeah i used this from this study “HED (mg / kg = Animal NOAEL mg/kg) × (Weightanimal [kg]/Weighthuman [kg])(1–0.67)      Eq. (1)”

 

[kise]

Saif you are a fucking retard. Comparing absolute mcg exposure between species as if a human is equivalent to a 200 pound rat is so stupid. Here go read this if you actually want to learn the dumb mistakes you made in this thread: https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/
Nice way to cherrypick endpoints btw. Completely left out mandibular body height and thickness. Share your ChatGPT chat export with us so we can see exactly what it told you to write

Thats not even why hes wrong. hes wrong because 1. abalo reacts differently to abalo than humans. 2. he thinks abalo doesn't effect chondrocytes when they are proven to. 3. hes a retard

 

[kise]

Thats not even why hes wrong. hes wrong because 1. abalo reacts differently to abalo than humans. 2. he thinks abalo doesn't effect chondrocytes when they are proven to. 3. hes a retard

i meant rats* lol rats react differently

 

[ihatemySOST]

Thats not even why hes wrong. hes wrong because 1. abalo reacts differently to abalo than humans. 2. he thinks abalo doesn't effect chondrocytes when they are proven to. 3. hes a retard

As always i will ignore u if u dont have any prove for what u have claimed

 

[Micrognathic]

Rat pharmacokinetics show a much shorter residence time than humans, but measured half-lives in rats are on the order of ~0.2–1.0 hours (12–60 minutes) in preclinical reports (not “a few minutes”).

Human half-life is longer (clinical t½ reported ~1–2 hours), so the same absolute dose in µg produces much higher exposure in humans than in rats. Regulatory documents and PK reviews note rapid clearance in rodents and higher clearance per kg than in humans

So by this u are saying that pth analogs do work?

Also why did u use chat gpt to make ur reply

Saif should I read ur thread?
As always I’m going to give my honest thoughts and try to debunk it
If I can ofc since last time u raped me

 

[Amex.]

So by this u are saying that pth analogs do work?

Also why did u use chat gpt to make ur reply

Saif should I read ur thread?
As always I’m going to give my honest thoughts and try to debunk it
If I can ofc since last time u raped me

"Do work."
-> Work for what purpose?

For height growth? An 80mcg daily dosage is unlikely to contribute to height growth.
For bone growth, the answer is definitely yes, especially when combined with other practices.

"Also why did u use chat gpt to make ur reply"

Didn't use ChatGPT at all; just because you see some semi-professional wording doesn't mean it's AI slop:

Warning to anyone who reads threads from this user (Saif):

I am working to compile a full document (still working on it though)

Showing that saif has made over 45 contradicting statements within only the past 3 months. He's made over 200 in the past 1 year.

I reviewed 10-12 key Discord servers where he is active, analyzing over 40,000 messages to identify and highlight the contradicting information he shares. On looksmax.org, you can check for contradicting statements as well. He is simply a jester who can't make up his mind, decides to actively spill misinformation or just doesn't understand the misinformation he spreads. Regardless, if you want to have a real discussion, I can easily debunk any of this nonsense that isn't rooted in science.

 

[smaxx01]

Ppl will do anything but raise the GH dose bro istg

 

[Micrognathic]

"Do work."
-> Work for what purpose?

For height growth? An 80mcg daily dosage is unlikely to contribute to height growth.
For bone growth, the answer is definitely yes, especially when combined with other practices.

"Also why did u use chat gpt to make ur reply"

Didn't use ChatGPT at all; just because you see some semi-professional wording doesn't mean it's AI slop:
View attachment 4468882

Warning to anyone who reads threads from this user (Saif):

I am working to compile a full document (still working on it though)

Showing that saif has made over 45 contradicting statements within only the past 3 months. He's made over 200 in the past 1 year.
View attachment 4468883

I reviewed 10-12 key Discord servers where he is active, analyzing over 40,000 messages to identify and highlight the contradicting information he shares. On looksmax.org, you can check for contradicting statements as well. He is simply a jester who can't make up his mind, decides to actively spill misinformation or just doesn't understand the misinformation he spreads. Regardless, if you want to have a real discussion, I can easily debunk any of this nonsense that isn't rooted in science.

idk why the fuck u felt the need to lie about using GPT
Anyway, it doesn't matter much to me, but assuming u needed to use GPT to make this reply, are u even capable of debunking his threads???

I don't agree with most of his threads either, but u have to admit that Saif is pretty dang smart and knows what he's doing.
Also, he's very chill, idk why u guys hate him so much
Best of luck with whatever u have planned here

this shit is so fucking funny
@ihatemySOST

 

[narrator_313]

PTH analogs, like abaloparatide and
teriparatide, are being heavily promoted lately for increasing facial bone mass and lower jaw growth, marketed as the "magic solution" to make you a CHAD. But the real question is: does it actually work? The answer is no or to be more precise, yes, but only at doses roughly 2,000 times higher than what people are currently using. I'm going to prove this in this post

https://academic.oup.com/ejo/article/45/2/224/6964454

In this study, the scientists used the most well-known PTH analogs, Abaloparatide and Teriparatide, on young mice (four weeks old) for a treatment duration of four weeks, with the aim of stimulating jaw growth. This is comparable to treating a child from the age of 8 continuously until they reach 16 years old, essentially from childhood through puberty. They divided the groups into different doses: low dose 80 mcg/kg, medium dose 800 mcg/kg, and high dose 8 mg/kg. But what about the results?
View attachment 4159744View attachment 4159746View attachment 4159747

The jaw did not show significant growth in the groups that received low and medium doses, even though the treatment period was very long (from early childhood to the end of sexual maturation, roughly). Significant jaw growth was observed only in the groups that received very high doses for very long periods.

You can see this in the image above there is no noticeable difference in jaw size or length between the control group and those that received low or medium doses

View attachment 4159750View attachment 4159751

So, what's the problem with that? You might say yourself: "Just use higher doses, and it will work, right?" The answer is no. If we use the official FDA equation to convert doses from mice to


humans, which is HED (mg/kg) = Animal


dose (mg/kg) × (Animal Km / Human Km), and knowing that the mouse Km is 6 and human Km is 37 (so the conversion


factor is 6/37 = 0.162), the human-


equivalent dose becomes extremely high. Let's calculate it using a mouse dose of 8 mg/kg and assuming a human weight of 70 kg: HED = 8 × (6/37) ≥ 1.3 mg/kg, and for a 70 kg person that is 1.3


× 70 ≥ 91 mg, which is roughly 2,000 times higher than the dose people actually use to increase facial bone mass, usually around 40 mcg.


Even the mice weighed only about 100 g, so a dose of 8 mg/kg literally means the scientists were giving the mice 800 mcg daily from childhood through the end of adolescence just to see noticeable jaw growth. Do you really think a 40 mcg dose taken at the very end of skeletal maturation would cause any significant lower jaw growth in humans? JFL




Tldr: Parathyroid hormone analogues are suitable because the dose required to stimulate jaw growth, according to studies on rats, is thousands of times higher than the doses used to treat osteoporosis in humans.

High iq post

 

[Amex.]

View attachment 4469415
idk why the fuck u felt the need to lie about using GPT
Anyway, it doesn't matter much to me, but assuming u needed to use GPT to make this reply, are u even capable of debunking his threads???

I don't agree with most of his threads either, but u have to admit that Saif is pretty dang smart and knows what he's doing.
Also, he's very chill, idk why u guys hate him so much
Best of luck with whatever u have planned here

View attachment 4469430
this shit is so fucking funny
@ihatemySOST

It's not GPT. I remember typing it myself; the only issue that might make it seem AI is my QuillBot extension, which was used to fix spelling and add the exact markings. I vividly remember typing it myself and never use AI.

Additionally, in the statement, nothing is wrong; everything is correct. I know what I'm talking about.

"but u have to admit that Saif is pretty dang smart and knows what he's doing."

I'm warning you, don't get his help; he will only lead you down a retarded path.
Not at all; he doesn't have the slightest idea. The thread was already debunked and his reply didn't change anything.

You can add me on discord and i can show you hes literally insane, hes retarded, hes made so many false statements and contradicting statements, and changes his mind on EVERY SINGLE THING you can think of

-> height growth methods. 1 month hes saying certain things work, 1 month he's saying they dont work
-> compounds, 1 month he doesnt even know what they are, the next week he says they dont work, the week after he says they work at X dose, the week after he says they are entirely cope

This is not a result of evolving research; this is a result of pure ignorance and stupidity.

Please refrain from listening to this individual. PTH analogs are not the only issue. It's about everything he says. His ego especially, he thinks he's even smart, let alone the smartest on this forum. He's probably dumber than the greys that enter this forum from TikTok. I mean, he has the capacity to "research," but he can't do it properly. He has dedication but lots of bias. Bias, especially because he lives in a shit 3rd world country, is extremely broke, and can't get access to many drugs he wishes he could.

 

[Micrognathic]

It's not GPT. I remember typing it myself; the only issue that might make it seem AI is my QuillBot extension, which was used to fix spelling and add the exact markings. I vividly remember typing it myself and never use AI.

Additionally, in the statement, nothing is wrong; everything is correct. I know what I'm talking about.

"but u have to admit that Saif is pretty dang smart and knows what he's doing."

I'm warning you, don't get his help; he will only lead you down a retarded path.
Not at all; he doesn't have the slightest idea. The thread was already debunked and his reply didn't change anything.

You can add me on discord and i can show you hes literally insane, hes retarded, hes made so many false statements and contradicting statements, and changes his mind on EVERY SINGLE THING you can think of

-> height growth methods. 1 month hes saying certain things work, 1 month he's saying they dont work
-> compounds, 1 month he doesnt even know what they are, the next week he says they dont work, the week after he says they work at X dose, the week after he says they are entirely cope

This is not a result of evolving research; this is a result of pure ignorance and stupidity.

Please refrain from listening to this individual. PTH analogs are not the only issue. It's about everything he says. His ego especially, he thinks he's even smart, let alone the smartest on this forum. He's probably dumber than the greys that enter this forum from TikTok. I mean, he has the capacity to "research," but he can't do it properly. He has dedication but lots of bias. Bias, especially because he lives in a shit 3rd world country, is extremely broke, and can't get access to many drugs he wishes he could.

Thank you for responding
I'll add u on Discord, if u can show me the proof, that would be amazing

 

[ihatemySOST]

So by this u are saying that pth analogs do work?

Also why did u use chat gpt to make ur reply

Saif should I read ur thread?
As always I’m going to give my honest thoughts and try to debunk it
If I can ofc since last time u raped me

So by this u are saying that pth analogs do work?

Also why did u use chat gpt to make ur reply

Saif should I read ur thread?
As always I’m going to give my honest thoughts and try to debunk it
If I can ofc since last time u raped me

It's not GPT. I remember typing it myself; the only issue that might make it seem AI is my QuillBot extension, which was used to fix spelling and add the exact markings. I vividly remember typing it myself and never use AI.

Additionally, in the statement, nothing is wrong; everything is correct. I know what I'm talking about.

"but u have to admit that Saif is pretty dang smart and knows what he's doing."

I'm warning you, don't get his help; he will only lead you down a retarded path.
Not at all; he doesn't have the slightest idea. The thread was already debunked and his reply didn't change anything.

You can add me on discord and i can show you hes literally insane, hes retarded, hes made so many false statements and contradicting statements, and changes his mind on EVERY SINGLE THING you can think of

-> height growth methods. 1 month hes saying certain things work, 1 month he's saying they dont work
-> compounds, 1 month he doesnt even know what they are, the next week he says they dont work, the week after he says they work at X dose, the week after he says they are entirely cope

This is not a result of evolving research; this is a result of pure ignorance and stupidity.

Please refrain from listening to this individual. PTH analogs are not the only issue. It's about everything he says. His ego especially, he thinks he's even smart, let alone the smartest on this forum. He's probably dumber than the greys that enter this forum from TikTok. I mean, he has the capacity to "research," but he can't do it properly. He has dedication but lots of bias. Bias, especially because he lives in a shit 3rd world country, is extremely broke, and can't get access to many drugs he wishes he could.

Whats thats bull shit bro

 

[ihatemySOST]

> height growth methods. 1 month hes saying certain things work, 1 month he's saying they dont work
-> compounds, 1 month he doesnt even know what they are, the next week he says they dont work, the week after he says they work at X dose, the week after he says they are entirely cope

Prove please?

 

[birthdefect]

"Do work."
-> Work for what purpose?

For height growth? An 80mcg daily dosage is unlikely to contribute to height growth.
For bone growth, the answer is definitely yes, especially when combined with other practices.

"Also why did u use chat gpt to make ur reply"

Didn't use ChatGPT at all; just because you see some semi-professional wording doesn't mean it's AI slop:
View attachment 4468882

Warning to anyone who reads threads from this user (Saif):

I am working to compile a full document (still working on it though)

Showing that saif has made over 45 contradicting statements within only the past 3 months. He's made over 200 in the past 1 year.
View attachment 4468883

I reviewed 10-12 key Discord servers where he is active, analyzing over 40,000 messages to identify and highlight the contradicting information he shares. On looksmax.org, you can check for contradicting statements as well. He is simply a jester who can't make up his mind, decides to actively spill misinformation or just doesn't understand the misinformation he spreads. Regardless, if you want to have a real discussion, I can easily debunk any of this nonsense that isn't rooted in science.

could be wrong on this but why would it be unlikely for abaloparatide to be unlikely to contribute to height growth?
should it not keep chondrocytes younger through the ihh - pthrp feedback loop? and since it keeps proliferating chondrocytes young, they should have more time to divide and increase longitudinal growth. or maybe you're referring to an 80mcg dose specifically being too low, not entirely sure

 

[ihatemySOST]

"Do work."
-> Work for what purpose?

For height growth? An 80mcg daily dosage is unlikely to contribute to height growth.
For bone growth, the answer is definitely yes, especially when combined with other practices.

"Also why did u use chat gpt to make ur reply"

Didn't use ChatGPT at all; just because you see some semi-professional wording doesn't mean it's AI slop:
View attachment 4468882

Warning to anyone who reads threads from this user (Saif):

I am working to compile a full document (still working on it though)

Showing that saif has made over 45 contradicting statements within only the past 3 months. He's made over 200 in the past 1 year.
View attachment 4468883

I reviewed 10-12 key Discord servers where he is active, analyzing over 40,000 messages to identify and highlight the contradicting information he shares. On looksmax.org, you can check for contradicting statements as well. He is simply a jester who can't make up his mind, decides to actively spill misinformation or just doesn't understand the misinformation he spreads. Regardless, if you want to have a real discussion, I can easily debunk any of this nonsense that isn't rooted in science.

Ah thats funny asf