Exposing PTH analogs for bone mass (literally biogest cope ever)

[Amex.]

Rat pharmacokinetics show a much shorter residence time than humans, but measured half-lives in rats are on the order of ~0.2–1.0 hours (12–60 minutes) in preclinical reports (not “a few minutes”).

Human half-life is longer (clinical t½ reported ~1–2 hours), so the same absolute dose in µg produces much higher exposure in humans than in rats. Regulatory documents and PK reviews note rapid clearance in rodents and higher clearance per kg than in humans

 

[ihatemySOST]

Rat pharmacokinetics show a much shorter residence time than humans, but measured half-lives in rats are on the order of ~0.2–1.0 hours (12–60 minutes) in preclinical reports (not “a few minutes”).

Human half-life is longer (clinical t½ reported ~1–2 hours), so the same absolute dose in µg produces much higher exposure in humans than in rats. Regulatory documents and PK reviews note rapid clearance in rodents and higher clearance per kg than in humans

 

[Amex.]

You are a coper who doesn't know how to research

Every 1-2 months you change your opinion entirely

I have carefully looked through all your statements in the past 12 months, and every 1-2 month you change your old opinions, do you want proof, or I can create a full document showing this.