MoggsWithBoness
Anti-vegan
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BTW to any low iq incel reading this, MF DONT TAKE THIS SRSLY
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do you have any sources for this? where to get it? i will honestly do it soonI haven't tried it
If you do don't go higher than 1%, we discussed it above
Good shii bhauPossibly a big mistake reveling this but here we go
As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye
View attachment 2876990View attachment 2876999View attachment 2877007
This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent
Eye color is determined by the following process
View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051
A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important
View attachment 2877061
Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions
A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate
Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo
View attachment 2877122
This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process
If anyone wants to dig further go ahead, here you might find something
Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance
Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...link.springer.com
Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo
And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146
Now I could go on with explaining a few more things but I already made my point
I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again
Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed
The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...pubmed.ncbi.nlm.nih.gov
Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl
H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously
Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.
If someone wants to expand and try something with the copper please be my guest.
YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY
View attachment 2877187View attachment 2877200
You can get hydrogen peroxide in supermarketsdo you have any sources for this? where to get it? i will honestly do it soon
Appreciate your help brother,No, not yet. The problem is that there is a lot of concentrated melanin in the iris (especially in mine T40), so first I want to give explosive doses of pure h2o2 to my right iris and wait to see a noticeable change between the 2. After finishing To confirm, added copper to see if it is more efficient. For now, with the 1% peroxide I have no redness, I apply it 9 times a day and I have only seen that I have yellowish spots on the lower part of my iris, but it is only noticeable with direct flash. The difference between my two eyes in ambient light is not yet evident. I am also using tobramycin to prevent inflammation.
I use 6% peroxide cream (20 vol) and mix it with 50% water and 50% peroxide. so I get 3%. I apply 2 drops when I wake up, 2 in the middle of the day, 2 in the afternoon and 3 at night. Then I store the mixture in generic droppers. When you apply it, try to aim at the iris and not the sclera (this is what gets irritated). The first 15 seconds of contact are responsible for irritating the blood vessels, keep this in mind as well. The best thing to control irritation and the health of your eye is to apply hydrogen peroxide every 6 hours. Tobramycin 0.10-0.5% is the key to getting relief from your eye. Apply it 1 hour after applying the peroxide. This irritation is only a temporary dilation, it is nothing serious, it is just that you will produce a lot of ocular mucous if you use +3%. Honestly, I do not recommend using 0.5%, since it is a very weak concentration, it would take a long time to see noticeable results. Start with 1.5% and if you feel confident you can increase to 2%. I am planning to increase to 6% since I am very impatient and want to reach T07 by next month. I don't recommend it, this is just my betAgradezco tu ayuda hermano,
¿Puedes decirme cómo hiciste estas gotas para los ojos y a qué hora las pusiste? ¿Y cómo debo lidiar con la irritación?
Are you seeing results already?I use 6% peroxide cream (20 vol) and mix it with 50% water and 50% peroxide. so I get 3%. I apply 2 drops when I wake up, 2 in the middle of the day, 2 in the afternoon and 3 at night. Then I store the mixture in generic droppers. When you apply it, try to aim at the iris and not the sclera (this is what gets irritated). The first 15 seconds of contact are responsible for irritating the blood vessels, keep this in mind as well. The best thing to control irritation and the health of your eye is to apply hydrogen peroxide every 6 hours. Tobramycin 0.10-0.5% is the key to getting relief from your eye. Apply it 1 hour after applying the peroxide. This irritation is only a temporary dilation, it is nothing serious, it is just that you will produce a lot of ocular mucous if you use +3%. Honestly, I do not recommend using 0.5%, since it is a very weak concentration, it would take a long time to see noticeable results. Start with 1.5% and if you feel confident you can increase to 2%. I am planning to increase to 6% since I am very impatient and want to reach T07 by next month. I don't recommend it, this is just my bet
yes, but minimal¿Ya estás viendo resultados?
When are you going to publish the results? I think If it does(which it will) we it should be gatekeptyes, but minimal
You mentioned that see breaking of pigmentation, around the corners of your iris, is it notice able?yes, but minimal
(NO COPE): Both photos are taken with an iPhone in a totally dark environment with flash. I just applied the drops that's why my eye is red. As you can see, there is not such a noticeable change. These first weeks I was only experimenting with low doses and infrequently to see if it really depigmentedYou mentioned that see breaking of pigmentation, around the corners of your iris, is it notice able?
maybe its just lighting but the after does seem slightly lighter, such a considerable amount that I think its lighting(NO COPE): Both photos are taken with an iPhone in a totally dark environment with flash. I just applied the drops that's why my eye is red. As you can see, there is not such a noticeable change. These first weeks I was only experimenting with low doses and infrequently to see if it really depigmented
but if its not lighting its life fuel!!maybe its just lighting but the after does seem slightly lighter, such a considerable amount that I think its lighting
brother, I took the photo directly to the iris at the same angle with a distance of 30cm from the camera in my room with all the lights off. Just give me more time so there is more difference between the two eyesmaybe its just lighting but the after does seem slightly lighter, such a considerable amount that I think its lighting
By the way, the first is my left eye, the second is my right, it's not a before and after.maybe its just lighting but the after does seem slightly lighter, such a considerable amount that I think its lighting
Nice effort, not everyone would be willing to go head first on a new concept(NO COPE): Both photos are taken with an iPhone in a totally dark environment with flash. I just applied the drops that's why my eye is red. As you can see, there is not such a noticeable change. These first weeks I was only experimenting with low doses and infrequently to see if it really depigmented
https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1834-7819.2000.tb00261.xIn fact, studies in which hydrogen peroxide at concentrations of 3 per cent or less have been used daily for up to six years, have reported occasional and transitory irritant effects only in a small number of subjects with pre-existing ulceration, or when salt solutions were concurrently administered
Conclusion:Eye irritation - non human information
The EU Risk Assessment Report for hydrogen peroxide (European Commission 2003) mentions that solutions containing 1-3% hydrogen peroxide were used topically as an on-eye antibacterial agent historically without causing significant injury. In a series of reliable animal studies, no ocular irritation was noted after application of a 3% solution of hydrogen peroxide. Testing of eye irritation with a 5% solution indicated a slight irritation when the Draize method was used to assess effects (FMC 1987a). An 8% solution was moderately irritating (FMC 1987b) and a 10% solution was highly irritating to the rabbit eye (FMC 1985). A 35% hydrogen peroxide solution was corrosive to the rabbit eye (FMC 1983).
Eye irritation - human information
The following text on human information about eye irritation is copied from the EU risk assessment report for hydrogen peroxide (European Commission 2003, page 112-113):
“In the retrospective review of all exposures reported to the Utah Poison Control Center over a 36-month period, 8% of the reports involving hydrogen peroxide concerned eye as the route of exposure. The most frequently encountered ocular symptoms included burning (65%), redness (50%), and blurry vision (19%). The most common ocular exposure outcome was a minor, transient effect and there were no permanent sequelae (Dickson and Caravati 1994).
Historically 1 to 3% hydrogen peroxide (10,000-30,000 ppm) has been used topically as an on-eye antibacterial agent 3 to 5 times per day without causing significant injury (Grant 1993). The effect of hydrogen peroxide is dose related with 0.5% (5,000 ppm) being used previously for treatment whereas 5 and 10% (50,000 and 100,000 ppm) are definitely known to cause cloudiness in the cornea, severe pain, and intraocular inflammation (Chalmers 1989).
No ocular irritation was noted after application of 3% hydrogen peroxide. The 5% and 6% “hydrogen peroxide” solutions induced signs of eye irritation which support the classification as "Eye irritant category 2" (H319) according to Regulation (EC) No 1272/2008. The effects of 8% and 10% hydrogen peroxide to the rabbit eye were severe and justified current classification with "Eye damage category 1" (H318). The evocation of respiratory irritancy in the experiments with 50% solutions of hydrogen peroxide justify the classification with “Specific target organ toxicity, single exposure 3” (H335).
Are you ignoring the redness on your sclera?(NO COPE): Both photos are taken with an iPhone in a totally dark environment with flash. I just applied the drops that's why my eye is red. As you can see, there is not such a noticeable change. These first weeks I was only experimenting with low doses and infrequently to see if it really depigmented
MaybeAre you ignoring the redness on your sclera?
Is this redness permanent or it fades away after an hour or two? And how long do you think it will take for someone to reach T07 eyes, with 3% concentration and 8 time application per day?Maybe
The irritation disappears by 80% within 30 minutes, then disappears entirely within 36 hours later without any use of peroxide. As for how long it will take, I really don't know, note that with 3-2% applying 9 times it takes 2 weeks to start seeing changes. Most likely it will take 2,5 months or a little longer if you go slowlyIs this redness permanent or it fades away after an hour or two? And how long do you think it will take for someone to reach T07 eyes, with 3% concentration and 8 time application per day?
The irritation disappears by 80% within 30 minutes, then disappears entirely within 36 hours later without any use of peroxide. As for how long it will take, I really don't know, note that with 3-2% applying 9 times it takes 2 weeks to start seeing changes. Most likely it will take 2,5 months or a little longer if you go slowly
I don't know, I haven't tried it. I guess it can be more efficientHear me out what if you took higher dosages but with a 36 hour gap?
Like using 12% after 36 hours. Theoretically it should work just as well.
Hear me out what if you took higher dosages but with a 36 hour gap?
Like using 12% after 36 hours. Theoretically it should work just as well.
No you shouldn't I just read op's reply on your previous replies he attached a study in which they experimented with different dosages of hydrogen peroxide, 3% didnt cause any irritation, 6 and 8% had irritations categorised as eye irritation level 2, and 35% did corrosive damage.I don't know, I haven't tried it. I guess it can be more efficient
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again
The production of prostaglandin E2 (PGE2), but not prostaglandin I2, from coronary arterioles was significantly increased by H2O2
We investigated the effect of one reactive oxygen product, hydrogen peroxide, on in vitro activity of uterine segments from the 18-day-pregnant rat. H2O2 (0.3 mmol/L) was found to elicit rhythmic contractions and increase prostaglandins F2 alpha and E2 release by uterine tissue. Indomethacin blocked both of these effects. We conclude that H2O2 stimulates uterine contractions through a prostaglandin release mechanism. A speculative hypothesis of peripartum regulation of prostaglandin production by reactive oxygen is discussed
Prostaglandins are formed by sequential oxygenation of arachidonic acid. Cyclooxygenase has two isoforms COX-1 and COX-2
Prostaglandin E2 and Inflammation
It is one of the most abundant prostaglandins in the body. It has diverse functions but in inflammation, it mediates the emergence of all classical signs of inflammation such as redness, swelling, and pain. The importance of PGE2 in the inflammation process mainly comes from mPGES-1. mPGES-1 is a member of the MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism) superfamily that needs glutathione as a cofactor for PGE2 production.
Preliminary results suggest that prostaglandins may increase melanin production in cultured RPE cell lines
Do you mean that I should expose my iris to ultraviolet light when I apply h2o2? By the way, my eye have cleared up more, and I have been producing a lot of mucous. Do you think I should continue?Update
In the initial thread I said the following
After writing the previous comment I thought in a mechanism this could happen
H2O2 has been shown to increase prostaglandin
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels - PubMed
Hydrogen peroxide, a relatively stable reactive oxygen species, is known to elicit vasodilation, but its underlying mechanism remains elusive. Here, we examined the role of endothelial nitric oxide (NO), prostaglandin, cytochrome P-450-derived metabolites, and smooth muscle potassium channels in...pubmed.ncbi.nlm.nih.gov
If anything evident by redness and inflammation present in the eyeEffect of hydrogen peroxide on prostaglandin production and contractions of the pregnant rat uterus - PubMed
Although evidence for a role for prostaglandins in parturition is abundant, less is known about how prostaglandin levels are regulated at term. Conditions occurring peripartum in the uteroplacental unit can result in reactive oxygen production. We investigated the effect of one reactive oxygen...pubmed.ncbi.nlm.nih.gov
Prostaglandins as the Agents That Modulate the Course of Brain Disorde | DNND
Prostaglandins as the Agents That Modulate the Course of Brain Disorderswww.dovepress.com
And prostaglandin has been shown to increase melanin synthesis
So @lzrl if you get results might be a from the "bleaching" effect from h2o2 balanced with the increase in melanin from prostaglandin release
So reducing inflammation might be necessary to enhance the effect from h2o2
Also h2o2 have been shown to "bleach" melanin
And it's enhanced if the ph of h2o2 is alkalineMechanistic insights into the bleaching of melanin by alkaline hydrogen peroxide - PubMed
This work aims to determine the roles of reactive oxygen species HO∙ and HO<sub>2</sub><sup>-</sup> in the bleaching of melanins by alkaline hydrogen peroxide. Experiments using melanosomes isolated from human hair indicated that the HO∙ radical generated in the outside solution does not...pubmed.ncbi.nlm.nih.gov
And also by light exposure, as I mentioned in the original post
Still I remind that I presented other options other than h2o2, that likely work better and are safer
They are harder to get tho
how do you take your photos?Do you mean that I should expose my iris to ultraviolet light when I apply h2o2? By the way, my eye have cleared up more, and I have been producing a lot of mucous. Do you think I should continue?
I turn off all the lights and look for the darkest environment possible. I pull my lower eyelid to show my iris completely and raise my eyebrows. The distance between the camera and my eye is 30-28cm. so I can see the pigmentation of my iris with no-fraud. I'm already starting to notice a slight heterochromia when direct sun shines on me, I'm thinking about increasing my dose to 6.5% to start seeing green tones. It all depends on what you think @LVZZOhow do you take your photos?
Honestly, I wouldn't think about stopping it since it has worked very well for me, and I haven't had a problem with my eye so far.I turn off all the lights and look for the darkest environment possible. I pull my lower eyelid to show my iris completely and raise my eyebrows. The distance between the camera and my eye is 30-28cm. so I can see the pigmentation of my iris fraud. I'm already starting to notice a slight heterochromia when direct sun shines on me, I'm thinking about increasing my dose to 6.5% to start seeing green tones. It all depends on what you think @LVZZO
You should use lighter photos, so the details of your iris are not very noticeableI turn off all the lights and look for the darkest environment possible. I pull my lower eyelid to show my iris completely and raise my eyebrows. The distance between the camera and my eye is 30-28cm. so I can see the pigmentation of my iris with no-fraud. I'm already starting to notice a slight heterochromia when direct sun shines on me, I'm thinking about increasing my dose to 6.5% to start seeing green tones. It all depends on what you think @LVZZO
Apago todas las luces y busco el ambiente más oscuro posible. Tiro de mi párpado inferior para mostrar mi iris por completo y levanto las cejas. La distancia entre la cámara y mi ojo es de 30 a 28 cm. para que pueda ver la pigmentación de mi iris sin fraude. Ya estoy empezando a notar una ligera heterocromía cuando me da el sol directo, estoy pensando en aumentar mi dosis al 6,5% para empezar a ver tonos verdes. Todo depende de lo que pienses @LVZZO
if you use brighter lighting you can take a photo that comes out with other details and flashes so it is better to use only flashYou should use lighter photos, so the details of your iris are not very noticeable
Do you mean that I should expose my iris to ultraviolet light when I apply h2o2? By the way, my eye have cleared up more, and I have been producing a lot of mucous. Do you think I should continue?
You can take some days of rest to give your body some time to recover from potential damageI'm already starting to notice a slight heterochromia when direct sun shines on me, I'm thinking about increasing my dose to 6.5% to start seeing green tones. It all depends on what you think @@LVZZO
If you end up trying it I would take at least 2 days off before, as it might cause more damage than usualBleaching of melanin in the dark was compared with light-induced processes. Under the conditions studied, visible and near-UV light enhanced the initial rate of melanin bleaching in 0.15 M H202 by a factor of 10.
Vision problems can be reduced or healed by taking vitamin A, you can buy a bottle of 25 000 IUProbably going blind with this, but I am already blind
If you are asking that you didn't read enoughI just read the thread, where do I acquire hydrogen peroxide below 3%?
so which is it? h2o2 reduce or increase melanin if you use it low dose consistently?Update
In the initial thread I said the following
After writing the previous comment I thought in a mechanism this could happen
H2O2 has been shown to increase prostaglandin
Hydrogen peroxide induces endothelium-dependent and -independent coronary arteriolar dilation: role of cyclooxygenase and potassium channels - PubMed
Hydrogen peroxide, a relatively stable reactive oxygen species, is known to elicit vasodilation, but its underlying mechanism remains elusive. Here, we examined the role of endothelial nitric oxide (NO), prostaglandin, cytochrome P-450-derived metabolites, and smooth muscle potassium channels in...pubmed.ncbi.nlm.nih.gov
If anything evident by redness and inflammation present in the eyeEffect of hydrogen peroxide on prostaglandin production and contractions of the pregnant rat uterus - PubMed
Although evidence for a role for prostaglandins in parturition is abundant, less is known about how prostaglandin levels are regulated at term. Conditions occurring peripartum in the uteroplacental unit can result in reactive oxygen production. We investigated the effect of one reactive oxygen...pubmed.ncbi.nlm.nih.gov
Prostaglandins as the Agents That Modulate the Course of Brain Disorde | DNND
Prostaglandins as the Agents That Modulate the Course of Brain Disorderswww.dovepress.com
And prostaglandin has been shown to increase melanin synthesis
So @lzrl if you get results might be a from the "bleaching" effect from h2o2 balanced with the increase in melanin from prostaglandin release
So reducing inflammation might be necessary to enhance the effect from h2o2
Also h2o2 have been shown to "bleach" melanin
And it's enhanced if the ph of h2o2 is alkalineMechanistic insights into the bleaching of melanin by alkaline hydrogen peroxide - PubMed
This work aims to determine the roles of reactive oxygen species HO∙ and HO<sub>2</sub><sup>-</sup> in the bleaching of melanins by alkaline hydrogen peroxide. Experiments using melanosomes isolated from human hair indicated that the HO∙ radical generated in the outside solution does not...pubmed.ncbi.nlm.nih.gov
And also by light exposure, as I mentioned in the original post
Still I remind that I presented other options other than h2o2, that likely work better and are safer
They are harder to get tho
I still think that the bleaching effect is greater, so an overall melanin reduction should happenso which is it? h2o2 reduce or increase melanin if you use it low dose consistently?
also heard prostaglandin makes fat around the eye disappear. huge failo if happens.
Yes you can do that and adjust if you feel necessaryCorrect me if I am wrong, @LVZZO
I am planning to try this out.
I can easily get my hands on 3% hydrogen peroxide
I should use it 8 times everyday for 5 days
I should expose my eyes to the sun after using H2O2
I Should use Tobramycin after 1 hour
No idea, but at least two months I would sayAlso I have T17 eyes, so If I use this will I get result soomer?
I am also aiming for T07 eyes and if use the above stack how long do you think I have to use this to achieve results?
As the mechanism of action of alpha-arbutin is for the most part based on the release of hydroquinone, which inhibits the tyrosinase activity in the skin, it is important to get reliable exposure data which takes the in vivo formation of hydroquinone on the skin and its further fate into consideration. During the commenting period, a new tape-strip study on human volunteers was submitted by the applicant in which the release of hydroquinone from alpha-arbutin (with mass balance) was measured when the compound was in contact with the skin microbiome. The amounts of hydroquinone thus released were taken into consideration in the safety evaluation of alphaarbutin when present as 2% and 0.5% in face cream and body lotion, respectively.
Toxicological Evaluation Irritation and corrosivity: the conclusions of 2015 Opinion are taken over, namely Alphaarbutin is non-irritant to rabbit skin and a 10% aqueous solution of beta-arbutin is slightly irritating to the skin.
Skin sensitisation: conclusions of 2015 Opinion are taken over, namely alpha-arbutin is a weak skin sensitiser in animal studies; human data are not available.
In the eye I would test 0.1-1% concentration, low to highAlpha-arbutin: only minimally irritant to rabbit eye (OECD 405).
3.3.1.2 Mucous membrane irritation / eye irritation From SCCP/1182/08
A single dose of 0.05 mL of 3% aqueous solution of Kojic acid was applied to the eye of rabbits (mean bw of 2.8 kg) and scored without washing. Kojic acid caused no eye disturbances in the preliminary test, but mild transient hyperemia was observed in the second experiment in 2 out of 4 animals. The overall eye irritability was reported to be very weak. In a supplementary test no specific response was observed for up to 72 hours.
In the eye 0.5-3% concentration should be fineSCCS comment No new data was submitted or identified from the open literature. SCCS overall comment on skin and mucous membrane irritation The SCCS agrees with the former Opinion that Kojic acid is not irritant to rabbit skin or mucous membranes.
Did they notice any eye color change in the rabbits?Here is the safety information if anyone wants to try a tyrosinase inhibitor
Alpha-Arbutin
In the eye I would test 0.1-1% concentration, low to high
Higher concentrations can be tolerable but you would need to test
Kojic Acid
In the eye 0.5-3% concentration should be fine
For higher concentrations you would need to test