EYE BRIGHTENING METHOD THAT ACTUALLY WORKS

[LVZZO]

Did they notice any eye color change in the rabbits?

I wasn't reported, they only mention their function as a melanin inhibitor

 

[yoshisand]

Legit, you NEED tyrosinase.
You don’t want less melanin OP, you want less conversion of brown melanin (brown eyes) as opposed to yellow melanin (blue eyes).

Where can i buy this

 

[rickysalomano]

@LVZZO

im ordering a formula from a compounding pharmacy for me to use (so I can order any ingredient lol)
do you think it is safe? hydrogen peroxide and dmso could perhaps harm me? have any unwanted interactions? any other ingredients to add or remove?

1. Glutathione: 1%
2. NAC: 1%
3. Glycine: 1%
4. MSM: 1%
5. Vit C: 3%
6. DMSO: 1,5%
7. Licorice Root Extract: 1%
8. Sodium Chloride: 0,9%
9. Hydrogen Peroxide: 0,01%
10. EDTA: 0,1%
11. Rest of Water

 

[LVZZO]

@LVZZO

im ordering a formula from a compounding pharmacy for me to use (so I can order any ingredient lol)
do you think it is safe? hydrogen peroxide and dmso could perhaps harm me? have any unwanted interactions? any other ingredients to add or remove?

1. Glutathione: 1%
2. NAC: 1%
3. Glycine: 1%
4. MSM: 1%
5. Vit C: 3%
6. DMSO: 1,5%
7. Licorice Root Extract: 1%
8. Sodium Chloride: 0,9%
9. Hydrogen Peroxide: 0,01%
10. EDTA: 0,1%
11. Rest of Water

DMSO and H2O2 causes an exothermic reaction (heat) to form msm

EYE BRIGHTENING METHOD THAT ACTUALLY WORKS

Possibly a big mistake reveling this but here we go As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation The same happens in the eye In the eye, melanin-containing cells are localized in the uveal tract...

looksmax.org

I mean it may be safe since you mix it before applying it but all the H2O2 will be converted, so it's useless to add h2o2 with dmso and msm. If you want H2O2 in the formula you can't add DMSO

Also EDTA will likely react with NaCl and possibly others
Tbh I would add one or two of these in a formula and see if it works, adding more doesn't mean it's better

Diosodium edta at this concentration has been used in eyes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770724/

Also NAC on itself might give some results since it interacts with copper

NAC pretreatment significantly reduces intracellular copper uptake triggered by the ionophores

 

[rickysalomano]

DMSO and H2O2 causes an exothermic reaction (heat) to form msm

EYE BRIGHTENING METHOD THAT ACTUALLY WORKS

Possibly a big mistake reveling this but here we go As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation The same happens in the eye In the eye, melanin-containing cells are localized in the uveal tract...

looksmax.org

I mean it may be safe since you mix it before applying it but all the H2O2 will be converted, so it's useless to add h2o2 with dmso and msm. If you want H2O2 in the formula you can't add DMSO

Also EDTA will likely react with NaCl and possibly others
Tbh I would add one or two of these in a formula and see if it works, adding more doesn't mean it's better

Diosodium edta at this concentration has been used in eyes

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770724/

View attachment 2998770

Also NAC on itself might give some results since it interacts with copper

thx
so maybe I could replace h2o2 with something else? maybe kojic acid?

since NAC is similar to EDTA, I will remove EDTA

about NaCl, it is to make the eye drop composition similar to tears and not cause irritation

 

[rickysalomano]

i was researching and yeah, h2o2 fucks up all the other ingredients

 

[LVZZO]

since NAC is similar to EDTA, I will remove EDTA

EDTA is completely different from NAC
EDTA on it's own might do more than all the rest maybe apart from a tyrosinase inhibitor like kojic acid

so maybe I could replace h2o2 with something else? maybe kojic acid?

Yes, from your stack it's the most likely thing to do lighten the eyes, as I have been explaining on previous posts in the thread

 

[ferfdd]

show Ur resultd

 

[AscendableReal]

I will maybe try hydrogen peroxide.

I hope you don’t go blind bro

Cant go blind or get a severe injury from 3%, let alone 1.

 

[AscendableReal]

(NO COPE): Both photos are taken with an iPhone in a totally dark environment with flash. I just applied the drops that's why my eye is red. As you can see, there is not such a noticeable change. These first weeks I was only experimenting with low doses and infrequently to see if it really depigmented

Eye looked darker ngl

 

[potatoenjoyer05]

buddy got noticaeble heterochromia, theres hope for my dookie shit colored eyes

 

[AscendableReal]

Vision problems can be reduced or healed by taking vitamin A, you can buy a bottle of 25 000 IU
And astaxanthin, high doses up to 12mg or even 24mg will provide faster, better results
Some ophthalmological drops contain an antioxidant are probably available online, they also work to reverse damage and vision loss
Anyone of these or them combined will give you results in like 3 months

Vit A wouldnt do much since very little amount goes to the eyes.

 

[underaveragemaxxer]

I wasn't reported, they only mention their function as a melanin inhibitor

I’ve been using 10% msm and alpha arbutin eye drops for 2 months now and they do lighten but the problem is my eyes are sensitive to light, I start tearing up in a room with a light and fan on which is making me consider if I should stop. I wanted to ask you if El Bastardos method would give me progress aswell because I just bought all the ingredients.

 

[mlbmogger252]

I’ve been using 10% msm and alpha arbutin eye drops for 2 months now and they do lighten but the problem is my eyes are sensitive to light, I start tearing up in a room with a light and fan on which is making me consider if I should stop. I wanted to ask you if El Bastardos method would give me progress aswell because I just bought all the ingredients.

Self made formula that will blind me or something I can source online?

 

[Akatlyn]

LASER

Drops DO NOT work. Maybe I'll need to repeat it during my entire life BUT these drops DO NOT penetrate your iris

 

[LVZZO]

I’ve been using 10% msm and alpha arbutin eye drops for 2 months now and they do lighten but the problem is my eyes are sensitive to light, I start tearing up in a room with a light and fan on which is making me consider if I should stop. I wanted to ask you if El Bastardos method would give me progress aswell because I just bought all the ingredients.

What concentration are you using for alpha arbutin, you can try to lower it
Or maybe it's the msm or other thing in the formula
Take some days off if you are sensitive to light, also normal eye drops can help mitigate sides

 

[underaveragemaxxer]

What concentration are you using for alpha arbutin, you can try to lower it
Or maybe it's the msm or other thing in the formula
Take some days off if you are sensitive to light, also normal eye drops can help mitigate sides

It’s a 10% msm eyedrop solution in distilled water and then I wait 5 minutes for it to penetrate then use a 10% alpha arbutin solution in distilled water. I do this because msm and alpha arbutin don’t mix. They really do lighten quickly but it’s just my eyes are becoming a little more sensitive. I can see better in the dark though which is weird. Just wanted to ask you if El Bastardos formula would cause sensitivity also?

 

[underaveragemaxxer]

LASER

Drops DO NOT work. Maybe I'll need to repeat it during my entire life BUT these drops DO NOT penetrate your iris

I went from t50 to t25 in 2 months lmao. They do work. You need MSM to soften your eyes then you use a lightener.

 

[underaveragemaxxer]

Self made formula that will blind me or something I can source online?

It’s a formula people have been using since 2012. Somebody in a gym thread did this formula and got insane results.

 

[mlbmogger252]

I went from t50 to t25 in 2 months lmao. They do work. You need MSM to soften your eyes then you use a lightener.

Guide?

 

[Newday*V3]

It’s a 10% msm eyedrop solution in distilled water and then I wait 5 minutes for it to penetrate then use a 10% alpha arbutin solution in distilled water.

How would this even work, alpha arbutin only inhibits melanin production, it doesn’t bleach pre-existing melanin already present in the iris (which is quite stable and doesn’t turnover as easy as the skin)

 

[hasba1feuj]

It’s a 10% msm eyedrop solution in distilled water and then I wait 5 minutes for it to penetrate then use a 10% alpha arbutin solution in distilled water. I do this because msm and alpha arbutin don’t mix. They really do lighten quickly but it’s just my eyes are becoming a little more sensitive. I can see better in the dark though which is weird. Just wanted to ask you if El Bastardos formula would cause sensitivity also?

I went from t50 to t25 in 2 months lmao. They do work. You need MSM to soften your eyes then you use a lightener.

can we chat in dm ? ive been searching a forumula that work since a long time , if your formula really work i will use it and stick with it with no problem, i wanna know exactly how you use it and how you make it , im T50 jfl

 

[underaveragemaxxer]

How would this even work, alpha arbutin only inhibits melanin production, it doesn’t bleach pre-existing melanin already present in the iris (which is quite stable and doesn’t turnover as easy as the skin)

Brother I don’t know the science behind arbutin lightening the eyes. All I know is that it works, I SWEAR TO GOD it works bro.

 

[underaveragemaxxer]

can we chat in dm ? ive been searching a forumula that work since a long time , if your formula really work i will use it and stick with it with no problem, i wanna know exactly how you use it and how you make it , im T50 jfl

i don’t have the pm feature cuz I just started using this site. It does work but it could cause sensitivity in your eyes and I don’t want anybody to get hurt since arbutin is a powerful tyrosinase inhibitor and I know people wont know when to stop using it and they would just get hurt.

 

[100potential]

i don’t have the pm feature cuz I just started using this site. It does work but it could cause sensitivity in your eyes and I don’t want anybody to get hurt since arbutin is a powerful tyrosinase inhibitor and I know people wont know when to stop using it and they would just get hurt.

bro drop before and after and would be helpful if u mentioned how many times a day did u do your protocol

 

[protomogger9873]

Possibly a big mistake reveling this but here we go

As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye

View attachment 2876990View attachment 2876999View attachment 2877007


This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent


Eye color is determined by the following process

View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051

A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important


View attachment 2877061

Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions

https://www.jbc.org/article/S0021-9258(19)38362-0/pdf

A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate

Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo

https://www.researchgate.net/publication/5600184_Melanin_biosynthesis_by_Frankia_strain_CeI5

View attachment 2877122

This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process

If anyone wants to dig further go ahead, here you might find something

Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance

Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...

link.springer.com

Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo

And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146


Now I could go on with explaining a few more things but I already made my point

I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again

Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed

The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...

pubmed.ncbi.nlm.nih.gov

Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl

Please visit wikiHow directly

H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously

Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.

If someone wants to expand and try something with the copper please be my guest.

YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY

View attachment 2877187View attachment 2877200

dnr poured hydrogen peroxide in my eyes

 

[lor]

Legit, you NEED tyrosinase.
You don’t want less melanin OP, you want less conversion of brown melanin (brown eyes) as opposed to yellow melanin (blue eyes).

what do u think abt Thiamidol? I couldn’t find any good tyrosinase source to buy

 

[hasba1feuj]

i don’t have the pm feature cuz I just started using this site. It does work but it could cause sensitivity in your eyes and I don’t want anybody to get hurt since arbutin is a powerful tyrosinase inhibitor and I know people wont know when to stop using it and they would just get hurt.

when will you be able to pm ppl?

 

[superyassenhamed]

Possibly a big mistake reveling this but here we go

As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye

View attachment 2876990View attachment 2876999View attachment 2877007


This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent


Eye color is determined by the following process

View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051

A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important


View attachment 2877061

Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions

https://www.jbc.org/article/S0021-9258(19)38362-0/pdf

A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate

Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo

https://www.researchgate.net/publication/5600184_Melanin_biosynthesis_by_Frankia_strain_CeI5

View attachment 2877122

This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process

If anyone wants to dig further go ahead, here you might find something

Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance

Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...

link.springer.com

Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo

And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146


Now I could go on with explaining a few more things but I already made my point

I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again

Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed

The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...

pubmed.ncbi.nlm.nih.gov

Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl

Please visit wikiHow directly

H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously

Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.

If someone wants to expand and try something with the copper please be my guest.

YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY

View attachment 2877187View attachment 2877200

Ok but have you yourself tried it and did it work or do you know anyone who tried it and it work with them and how do I even get my hands on this stuff and also will this make me blind and is this permanent

 

[superyassenhamed]

Brother I don’t know the science behind arbutin lightening the eyes. All I know is that it works, I SWEAR TO GOD it works bro.

can you tell me where to buy it or how to make it

 

[ripikke]

Thoughts Megadosing on aspirin?

 

[Newday*V3]

Has any1 tried 1% yet?

 

[LVZZO]

Ok but have you yourself tried it and did it work or do you know anyone who tried it and it work with them and how do I even get my hands on this stuff and also will this make me blind and is this permanent

You will go blind but have blue eyes so it's worth it

 

[superyassenhamed]

You will go blind but have blue eyes so it's worth it

how do you know this makes you blind

 

[iamthenight]

It’s a 10% msm eyedrop solution in distilled water and then I wait 5 minutes for it to penetrate then use a 10% alpha arbutin solution in distilled water. I do this because msm and alpha arbutin don’t mix. They really do lighten quickly but it’s just my eyes are becoming a little more sensitive. I can see better in the dark though which is weird. Just wanted to ask you if El Bastardos formula would cause sensitivity also?

Why do you think it did not work for her

Latisse Turned my Eyes from Green/brown to Darker Brown - Virginia, VA

I used latisse for 3 months and it made my eyes darker. My eyes were sort of hazel/brown with a brown ring around the pupil and green around the outer rim...

www.realself.com

 

[Outerz14]

What tf is that profile

 

[thegiganigga]

dnrd but profile picture source?

 

[Washa_bhai]

View attachment 2882036View attachment 2882036View attachment 2882036
View attachment 2882036View attachment 2882036View attachment 2882036
View attachment 2882036View attachment 2882036View attachment 2882036


FUCKING MASSIVE UPDATE
YOU BETTER READ EVERY SINGLE MOLECULE


The following chart show the effects of each compound on melanin production
View attachment 2881929

Improved natural melanin production by Aspergillus nidulans after optimization of factors involved in the pigment biosynthesis pathway - Microbial Cell Factories

Background Melanin is a natural pigment that can be applied in different fields such as medicine, environment, pharmaceutical, and nanotechnology. Studies carried out previously showed that the melanin produced by the mel1 mutant from Aspergillus nidulans exhibits antioxidant, anti-inflammatory...

microbialcellfactories.biomedcentral.com

I don't think you can mess much with L-dopa, just don't supplement if your goal is decreasing melanin or supplement if you want to get tanned easily and have more dopamine

Glucose is implicated here but is due to being an energy source of the fungus in the study, doesn't translate to humans


Tyrosine is the amino acid that serves as a substrate, so more of it means more melanin production, don't supplement with it

Glutamic acid also seems to up tyrosinase activity, so reducing it may be beneficial


Now I previously touched on the copper mechanism but this new piece of data just corroborated its importance

To recap low concentrations increase melanin production a lot and over a threashold it massively reduces it
View attachment 2877122

It's probably not safe to over apply concentrated copper solution on your eyes

So the solution might be the exact opposite
Try to remove as much copper from the site

Here is a schematic representation showing copper as a cofactor in melanin production
View attachment 2881928
And a study showing that a drug that chelates copper inhibits tyrosinase

https://www.sciencedirect.com/science/article/abs/pii/S0006291X18327542

This is the exact mechanism of kojitic acid
It lights skin by chelating copper


Just to show the function of tyrosinase
View attachment 2881978

KOJITIC ACID IS THE MAIN INGREDIENT OF THESE EYE DROPS

Change eye color to Green. Kojic Mushroom Eye colour Changer

Premium Kojic Mushroom Color changing Eye Drop. An innovative eye drop that permanently lightens the color of your eyes. All natural, organic and preservative free, Eye Color changer.

www.lighteyez.com

View attachment 2882027

Alpha-arbutin is also a potent copper chelator even more so than kojitic acid according to this study

https://www.researchgate.net/publication/342527281_Screening_of_an_Epigenetic_Drug_Library_Identifies_4-hydroxyaminocarbonyl-N-2-hydroxyethyl-N-Phenyl-Benzeneacetamide_that_Reduces_Melanin_Synthesis_by_Inhibiting_Tyrosinase_Activity_Independently_of_E

View attachment 2882031

In this patent the authors specify a formulation

DE102019128188A1 - Eye drops for aesthetic optimization of the eye - Google Patents

Eye drops for the medical, healing and / or aesthetic effect on the eye and / or the area around the eye are described, with the eye drops changing the pigment density and / or amount of pigment in the iris of the eye and / or thereby causing a Smoothing of skin folds is achieved and / or...

patents.google.com

The main ingredients are kojitic acid and alpha arbutin, and apart from adding an antioxidant the rest is a waste of money

Also note that "x% proportion on the eye drops" is not indicative of the concentration used

Concentration is probably pretty low, likely less than 1%

You can buy the powder and add it to some cheap eye drops solution
OR...
Find some skin serum with safe ingredients and dilute it with an eye drop solution

W research
Thanks for the info

 

[FutureChadronelite]

Possibly a big mistake reveling this but here we go

As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye

View attachment 2876990View attachment 2876999View attachment 2877007


This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent


Eye color is determined by the following process

View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051

A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important


View attachment 2877061

Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions

https://www.jbc.org/article/S0021-9258(19)38362-0/pdf

A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate

Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo

https://www.researchgate.net/publication/5600184_Melanin_biosynthesis_by_Frankia_strain_CeI5

View attachment 2877122

This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process

If anyone wants to dig further go ahead, here you might find something

Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance

Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...

link.springer.com

Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo

And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146


Now I could go on with explaining a few more things but I already made my point

I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again

Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed

The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...

pubmed.ncbi.nlm.nih.gov

Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl

Please visit wikiHow directly

H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously

Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.

If someone wants to expand and try something with the copper please be my guest.

YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY

View attachment 2877187View attachment 2877200

so a fraction of that mixed with what exactly ?

 

[aboriginalmaxxing]

Thoughts Megadosing on aspirin?

I retardmaxxed once and did this (10 375mg ASA/day), I got some serious tinnitus so I looked it up if taking aspirin has something to do with it, the results said it causes hearing damage so I stopped taking them. My ears stopped ringing the next day and thru it I didn't notice any significant changes to the pigmentation of my eyes.

 

[LVZZO]

so a fraction of that mixed with what exactly ?

99.9% sulfuric acid

 

[aboriginalmaxxing]

99.9% sulfuric acid

acktually when you concentrate sulphiric acid over 98% it just turns into water and sulphur trioxide

 

[rickysalomano]

I’ve been using 10% msm and alpha arbutin eye drops for 2 months now and they do lighten but the problem is my eyes are sensitive to light, I start tearing up in a room with a light and fan on which is making me consider if I should stop. I wanted to ask you if El Bastardos method would give me progress aswell because I just bought all the ingredients.

how much shades did they lightened?

 

[PsychoH]

Possibly a big mistake reveling this but here we go

As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye

View attachment 2876990View attachment 2876999View attachment 2877007


This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent


Eye color is determined by the following process

View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051

A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important


View attachment 2877061

Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions

https://www.jbc.org/article/S0021-9258(19)38362-0/pdf

A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate

Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo

https://www.researchgate.net/publication/5600184_Melanin_biosynthesis_by_Frankia_strain_CeI5

View attachment 2877122

This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process

If anyone wants to dig further go ahead, here you might find something

Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance

Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...

link.springer.com

Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo

And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146


Now I could go on with explaining a few more things but I already made my point

I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again

Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed

The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...

pubmed.ncbi.nlm.nih.gov

Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl

Please visit wikiHow directly

H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously

Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.

If someone wants to expand and try something with the copper please be my guest.

YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY

View attachment 2877187View attachment 2877200

Just put 3% drops in. How long will it take to see even a slight result you think? If done once daily?

 

[LVZZO]

Just put 3% drops in. How long will it take to see even a slight result you think? If done once daily?

@lzrl tested it, if it works at all probably a month or so, I wouldn't do it more than 2 months with no results
I think other things might work better, as I already mentioned after the original post

 

[PsychoH]

@lzrl tested it, if it works at all probably a month or so, I wouldn't do it more than 2 months with no results
I think other things might work better, as I already mentioned after the original post

bros last seen fucking august jfl.
But alright thanks, ill pm you if it works

 

[vrt]

Possibly a big mistake reveling this but here we go

As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye

View attachment 2876990View attachment 2876999View attachment 2877007


This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent


Eye color is determined by the following process

View attachment 2877046
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
View attachment 2877055View attachment 2877051

A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important


View attachment 2877061

Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions

https://www.jbc.org/article/S0021-9258(19)38362-0/pdf

A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate

Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo

https://www.researchgate.net/publication/5600184_Melanin_biosynthesis_by_Frankia_strain_CeI5

View attachment 2877122

This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process

If anyone wants to dig further go ahead, here you might find something

Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance

Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...

link.springer.com

Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo

And here are the results both in dark and light conditions with h2o2 and it combined with the copper
View attachment 2877144View attachment 2877146


Now I could go on with explaining a few more things but I already made my point

I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again

Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed

The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...

pubmed.ncbi.nlm.nih.gov

Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
View attachment 2877165
Don't bleach your face with this jfl

Please visit wikiHow directly

H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously

Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.

If someone wants to expand and try something with the copper please be my guest.

YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY

View attachment 2877187View attachment 2877200

lets go blind together jfl

 

[LVZZO]

bros last seen fucking august jfl.
But alright thanks, ill pm you if it works

Yeah he might have killed himself

 

[PsychoH]

Yeah he might have killed himself
View attachment 3193563

Hope he's in heaven atleast.
Fuck man, hope he's doing alright and is just getting professional help or smt

 

[LVZZO]

Hope he's in heaven atleast.
Fuck man, hope he's doing alright and is just getting professional help or smt

This site makes people way more insecure, it's harder if you have good reasons to
On the positive side you can make changes and become better