LVZZO
̿̿ ̿̿ ̿̿ ̿'̿'\̵͇̿̿\з= ( ▀ ͜͞ʖ▀) =ε/̵͇̿̿/’̿’̿ ̿ ̿̿
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Possibly a big mistake reveling this but here we go
As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye
Eye color is determined by the following process
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important
Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions
A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate
Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo
This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process
link.springer.com
Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo
I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again
pubmed.ncbi.nlm.nih.gov
Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
Don't bleach your face with this jfl
H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously
Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.
If someone wants to expand and try something with the copper please be my guest.
YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY
As most of you know melanin turns everything into brown poopo shitskin, it's main function is to provide protection against solar radiation
The same happens in the eye
This makes the iris the most outer part of the eye that contains melanin, the cornea and anterior chamber are transparent
Eye color is determined by the following process
These melanossomes are within a structure called melanocytes, which migrate to other structures to provide protection
A number of genes are involved in regulating the amount of melanin produced, among which the ones that control the enzyme tyrosinase are the most important
Now, the goal is to apply something that breaks down melanin
Hydrogen peroxide is a natural bleach material, I say natural because it's involved in body functions
A melanin-Cu complex enhances the effect of hydrogen peroxide, but in vivo it might not be achievable or not be ideal
They used a copper nitrate
Copper has been shown to regulate melanin production, in a concentration dependent manner by regulating the enzyme tyrosinase
At lower concentrations it increases melanin biosynthesis but in higher concentrations it seemed to act as a tyrosinase inhibitor, big news if this can be applied in vivo
This might be explained by the fact that melanin binds to metals to protect the body although the authors refer to the concentration of melanin as melanin biosynthesis, so who knows about the underlying process
If anyone wants to dig further go ahead, here you might find something
Interaction of Melanin with Metal Ions Modulates Their Cytotoxic Potential - Applied Magnetic Resonance
Melanin is one the most common biological pigments. In humans, specialized cells called melanocytes synthesize the pigment from tyrosine and 3,4-dihydroxyphenylalanine via enzyme-catalyzed reactions and spontaneous processes. The formed melanin granule consists of nanoaggregates of oligomers...
link.springer.com
Now continuing with h2o2
With an alkaline environment the bleaching is highly effective but we have to work at a neutral ph in vivo
And here are the results both in dark and light conditions with h2o2 and it combined with the copper
Now I could go on with explaining a few more things but I already made my point
I must also mention that the study below says that h2o2 can up the tyrosinase activity by mirroring the quantities of it, not sure who was the nigger that wrote this, idk what that means, but the consequences might be signaling the increase of melanin production
So while h2o2 bleaches in the short term it may cause melanin production to bounce back again
Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells - PubMed
The effects of systems generating active oxygen species (superoxide anion, hydrogen peroxide, hydroxyl radical) on tyrosinase have been studied in cultured human melanoma cells. Tyrosinase activity was determined by measuring the quantity of 5-S-L-cysteinyl-L-dopa (5-S-CD) formed in the presence...
pubmed.ncbi.nlm.nih.gov
Now to show that this shit actually does something this is what happens when you pour 35% h2o2 on your hands
This is likely the result of chemical irritation not removing melanin immediate, I think, maybe it's because of that too
Don't bleach your face with this jfl
H2O2 is normally sold at 3% (v/v) for safety reasons but it causes oxidative damage, obviously
Now for potential eye drops you would want a fraction of that, never 3% or more, the study mentioned concentrations of less than 1mM, I'm not doing the conversions rn but it's likely 1/100 of 3% or less, start low to test if you get eye irritation or something, in vitro is completely different than in vivo, you must go slow and evaluate what's happening to reduce risks.
If someone wants to expand and try something with the copper please be my guest.
YOU SHOULD TRY THIS
THIS COULD BE YOU, ALL THE NEGRALINAS AND POJEETAS YOURS
JUST DROP HYDROGEN PEROXIDE ON YOUR EYEBALLS AND CALL IT A DAY
