FIX YOUR DISGUSTING UNDER-EYE AREA WITH PIOGLITAZONE + OLEIC ACID

[heighceldnrr]

Brutal

 

[LukaMiku]

How can I differentiate between thin skin and shit bones?

Send me a photo and I’ll tell u side profile of ur eyes and front profile

 

[sandro]

sooo has anyone tried tihs

 

[camondo88]

use tazarotene it will make ur skin thicker

i dont think its safe for eye area

 

[NotaChadyet]

i dont think its safe for eye area

I used to use a local brand of tazarotene 0.1% for acne didn't have any side effects apart from redness

 

[LukaMiku]

i dont think its safe for eye area

it’s not going to do anything if u use it moderately put it thin and dont put it straight into ur eyes

 

[pscel]

Saving this

 

[camondo88]

it’s not going to do anything if u use it moderately put it thin and dont put it straight into ur eyes

homie you're gonna go blind

 

[copemachine]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

 

[LukaMiku]

homie you're gonna go blind

well don’t put the fucking chemicals in ur eye wtf? if u use face cream and under eye creams I don’t think they are safe in the eye either

 

[LukaMiku]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

well do fucking research and make nano-emulsion then big boy

 

[LukaMiku]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

also the amount u put under the eyes couldn’t not possible bloat u since the dosage is miniscule

 

[Randolf]

• Pioglitazone powder – 1g (1000mg)

Where can you buy that shit?

 

[garfyld]

CBD Oil combined with Geranylgeraniol work wonders, both are easily to buy and also natural so no side effects. They have low molecular weight so easily penetrate the skin. You may add coconut oil or oleic acid as well for faster results
Pioglitazone was my old idea.

 

[nokku]

dnr any undereye softmaxx method is cope

 

[garfyld]

CBD Oil combined with Geranylgeraniol work wonders, both are easily to buy and also natural so no side effects. They have low molecular weight so easily penetrate the skin. You may add coconut oil or oleic acid as well for faster results
Pioglitazone was my old idea.

I was not aware of new research and it actually shows that CBD is enough to dramatically increase fat absorption

Just buy CBD Oil mix it with oleic acid or any other non omega-6 oil(omega 9 fats are the best though) and rub it into your skin everyday
Absolutely amazing

 

[jeoyw9192]

I was not aware of new research and it actually shows that CBD is enough to dramatically increase fat absorption

Just buy CBD Oil mix it with oleic acid or any other non omega-6 oil(omega 9 fats are the best though) and rub it into your skin everyday
Absolutely amazing

Is this like a non cope volufiline? Curious if you've tried this

 

[HighTierNormie]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

 

[LukaMiku]

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

gng it will increase subq fat everywhere in the body atp, just get fat u will get same result, the difference between good fat distribution is lean jaw and high amount of fat in eye area

 

[HighTierNormie]

gng it will increase subq fat everywhere in the body atp, just get fat u will get same result, the difference between good fat distribution is lean jaw and high amount of fat in eye area

but you could be the kind of person who has skinny arms and face with a huge belly from visceral fat, if your lean and try low dose maybe it could help go to undereye area but if your unlucky and get bloated face wouldnt work but tbh it seems there is not anyway for this drug to be selective from what i understand

 

[LukaMiku]

but you could be the kind of person who has skinny arms and face with a huge belly from visceral fat, if your lean and try low dose maybe it could help go to undereye area but if your unlucky and get bloated face wouldnt work but tbh it seems there is not anyway for this drug to be selective from what i understand

no it wouldn’t isolate fat gain to ur eye area in any circumstances, u will subq fat everywhere in ur body

 

[HighTierNormie]

No it wouldn’t isolate fat gain to ur eye area in any circumstances, u will subq fat everywhere in ur body

Yh your right i was looking into it more and as it is a PPAR agonist drug that apparently needs to circulate and reach nuclear receptors in liver and muscle for full effects it seems to prefer depositing fat into limbs as they are more sensitive to the fat accumulation effect of the drug but the head doesnt count as a limb since it doesnt seem to add any fat there as i saw in that HIV study and it seems to not add much subq fat to places you actually want if you just take it orally

 

[copemachine]

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

Just so you know some tranny forums use pioglitazone orally for "improving" feminized fat redistribution. I dont know whether they add hormones like estrogen or use it alone though. This could explain why it might be "feminizing" for them. Anyways, it would increase fat everywhere, which is something we want to avoid, and increasing feminizing fat distrubution doesnt seem great either.

The research and anecdotal evidence around locally increasing fat through serums, oils and peptides are really lacking. For example most of the "fat increasing" results on the lips are often explained by a increase in hydration, giving some illusion. If you want to see any results, you would have to experiment on yourself. @garfyld cbd theory does seem promising, though.

Pioglitazone, hexapeptide, sarsapogenin, etc, all increase fat, but they are hard to formulate since they would need to go past the dermis to have a good effect, and be local not systemic. Many of the ingredients that increase penetration are also terrible for the skin, and applying them around the eyes where the skin is thin and sensitive doesnt seem like the best idea. This penetration problem is the main flaw of volufiline, as it struggles to penetrate the dermis optimally, and the store bought ones have a low concentration of sarsapogenin as well.

Even if you managed to find the "perfect" formulation, you would have to source these ingredients, create the solution at home, and then use it consistently, possibly in combination with dermarolling to increase penetration. Dermarolling is also problematic around the eyes. If you still manage to successfully formulate such a solution and use it consistently, you might also just see a couple of mm of change over a long period of time.

If you lack fat around the eyes just get a fat graft tbh. It has immediate results and is not that expensive compared to other surgeries.

 

[HighTierNormie]

Just so you know some tranny forums use pioglitazone orally for "improving" feminized fat redistribution. I dont know whether they add hormones like estrogen or use it alone though. This could explain why it might be "feminizing" for them. Anyways, it would increase fat everywhere, which is something we want to avoid, and increasing feminizing fat distrubution doesnt seem great either.

Does pioglitazone have some kind of hormonal effect? I was thinking the subcutaneous fat would make you look like a happy Buddha statue, or just spread evenly around your skin. Is PPARy a gene that is more expressed in females but not related to hormones? The Peter Attia podcast had an insulin video, and the section on pio made it seem like it was favourable

 

[jeoyw9192]

Bumping for more visibility

 

[high_ltn]

dnr but looks high iq, ill take a look later cause my undereye area is horrific

lmk if you try it bhai

 

[Orka]

The Bootleg Biohacker Serum for People Who Look Like Sleep-Deprived Divorcees



WHAT ARE WE FIXING?

Your under-eyes looking like a niglet with no under-eye support

We’re going to obliterate:

• Puffy orbital fat that swells like you’re allergic to good choices
• Sagging, deflated skin from collagen collapse
• No under-eye support
• Fibrosis and inflammation that makes everything look worse
• Your self-loathing (hopefully)

Pioglitazone is our main active ingredient. Oleic acid is the penetrator

And you? You’re the desperate test subject who might finally look human again.



WHY PIOGLITAZONE WORKS



Yeah, it’s a diabetes drug — and now it’s coming for your face.
Pioglitazone is a PPAR-γ agonist. That means it literally walks into your cells and rewrites how they function.

• Reduces inflammation like a fire extinguisher for your face
• Stops rogue fat growth under the eyes
• Boosts collagen and tissue repair
• Promotes Adipogenesis (Fat growth)

WHAT OLEIC ACID DOES

You think your skin just lets anything in? No.
It’s a thick, waxy, smug little barrier. Oleic acid disrupts the stratum corneum, pushes the pioglitazone through the front lines, and pushes itself in like a priest into a child.


This is skin penetration on roids




HOW TO MAKE THE SERUM

Pick Your Path:


OPTION A: You Have Raw Pioglitazone Powder (Like a Good Little Nigger)


Ingredients:

• Pioglitazone powder – 1g (1000mg)
• Oleic Acid – 5ml
• Propylene Glycol (or PEG-400) – 85ml
• Aloe Vera Gel or Distilled Water – 10ml

Instructions:

1. Add 1g pioglitazone to beaker
2. Pour in 85ml propylene glycol
3. Add 5ml oleic acid
4. Stir that shit
5. Add 10ml aloe vera or water for softness
6. Bottle it in 100ml dark glass container
7. Store in fridge

OPTION B: You’re Crushing Pills Like a Crackhead


You’ll need:

• 10–15 pioglitazone tablets (15mg each)
• Ethanol (95%) or warm distilled water
• 2 jars
• Coffee filter
• Oleic Acid – 5ml
• Propylene Glycol – 85ml
• Aloe Vera – 10ml

Instructions:

1. Crush tablets into powder
2. Add warm ethanol or water to cover and stir
3. Cry about not getting any pussy
4. Let sit 30–60 mins, stir occasionally
5. Let garbage sink — pour off the good liquid through filter
6. Discard sludge
7. Evaporate or reduce volume to approx. 1g pioglitazone worth
8. Mix that with 85ml propylene glycol + 5ml oleic acid + 10ml aloe
9. Bottle it. Store it. Name it Copejuice.

HOW TO USE IT (WITHOUT BURNING YOUR FACE OFF)

• Apply 1 drop per eye at night
• Dab gently with your ring finger
• Use 5 nights a week. Rest on weekends
• Avoid sun exposure after application
• If it stings, dilute with more aloe or propylene glycol, if tolerated well increase the concentration up until it melts your face off

WHEN TO EXPECT RESULTS

• Week 1–2: Puffiness reduces. You look slightly less cooked.
• Week 3–5: Fat pads start growing. Skin is tightening. You remember hope.
• Week 6–8: People ask if you got filler. You lie and say, “just good sleep and hydration.”

THE SCIENCE


PPAR-γ AGONISM: THE GOD SWITCH


Pioglitazone binds to PPAR-γ receptors inside your cells — a type of nuclear receptor that controls genes related to inflammation, fat storage, and cell differentiation.

Here’s what it does to your trash under-eye support:

• Shuts off pro-inflammatory cytokines — less swelling, redness, puff
• Increases adiponectin — a protein that helps fat cells stay healthy and slim
• Prevents adipocyte hypertrophy — stops the eye bags from becoming chunky and bloated
• Promotes controlled adipogenesis — support growth of stable fat cells
• Inhibits fibrosis — so your under-eyes don’t turn into stiff, scarred wastelands

Pioglitazone encourages the creation of youthful, supportive subcutaneous fat, not that inflamed, droopy kind that makes you look like you lost a fistfight with insomnia.


The result?

• Better support under the skin
• Smoother texture
• More Under-Eye Support
• Reduced sagging and wrinkling
• The return of that tight, filled, rested look you had before life steamrolled your face

@BigBallsLarry @vincentzygo @Bryce @ybuyhgui my dear high iq users, what do you think?

I'm considering trying option A although I'm quite oblivious to most of the stuff mentioned in this thread, it doesn't look amazing or promising but also doesn't look like COMPLETE dogshit.

The hatred for my infras might be blinding my logic though

 

[BigBallsLarry]

@BigBallsLarry @vincentzygo @Bryce @ybuyhgui my dear high iq users, what do you think?

I'm considering trying option A although I'm quite oblivious to most of the stuff mentioned in this thread, it doesn't look amazing or promising but also doesn't look like COMPLETE dogshit.

The hatred for my infras might be blinding my logic though

if it bothers you, 0 reason to not try it.

 

[vincentzygo]

@BigBallsLarry @vincentzygo @Bryce @ybuyhgui my dear high iq users, what do you think?

I'm considering trying option A although I'm quite oblivious to most of the stuff mentioned in this thread, it doesn't look amazing or promising but also doesn't look like COMPLETE dogshit.

The hatred for my infras might be blinding my logic though

yeah i linked this thread recently

realisitcally its useless, noones gonna do all that

 

[Orka]

if it bothers you, 0 reason to not try it.

sounds good

yeah i linked this thread recently

realisitcally its useless, noones gonna do all that

useless as in it won't do anything? or as in too much effort to be worth it?

 

[ybuyhgui]

@BigBallsLarry @vincentzygo @Bryce @ybuyhgui my dear high iq users, what do you think?

I'm considering trying option A although I'm quite oblivious to most of the stuff mentioned in this thread, it doesn't look amazing or promising but also doesn't look like COMPLETE dogshit.

The hatred for my infras might be blinding my logic though

realistically the effect would be minimal and low roi for the amount of effort put in. Get your fat grafting bud

if it bothers you, 0 reason to not try it.

price and effort, surgery will always be law

 

[vincentzygo]

too much effort

i think no one will bother to get all ingridients and go through with the whole process

 

[JizzFarmer]

have you tried this shit OP? I'm interested

 

[jeoyw9192]

Bumping again

 

[LukaMiku]

have you tried this shit OP? I'm interested

I currently have 1g of pioglitazone and need some more money for all the ingredients the initial formula was low effort formula just to put it out there so more people may try it, now what I think might work alot better is nano carrier formula, but I am missing a lot of ingredients which I need 200more dollars to get

initial patent formula by the information I found was very simple like mine, “



The base likely used penetration enhancers such as oleic acid (3%), propylene glycol, and ethanol, ingredients noted in broader Topokine formulations targeting subcutaneous fat delivery
“ which is why the product failed and had many side effects despite the promising phase II trial

and they didn’t use nanocarriers, I will try to get the missing money and when I get it I’ll start working on it

 

[LukaMiku]

realistically the effect would be minimal and low roi for the amount of effort put in. Get your fat grafting bud

price and effort, surgery will always be law

• Topokine Therapeutics, based in Boston, developed a lead topical agent called XAF5 aimed at reducing subcutaneous fat—specifically for the condition steatoblepharon (undereye bags) .
• They ran:
  • A Phase II randomized, placebo-controlled trial (XOPH5‑OINT‑2) where XAF5 achieved statistically significant and clinically meaningful reduction in undereye bags .
  • A pivotal Phase IIb/III study (XOPH5‑OINT‑3) started in January 2016 to further test XAF5’s cosmetic fat-reduction effects

the effects were pretty significant in the study but the problem was the active ingredient was leaking too much in the bloodstream causing side effects

 

[jeoyw9192]

I currently have 1g of pioglitazone and need some more money for all the ingredients the initial formula was low effort formula just to put it out there so more people may try it, now what I think might work alot better is nano carrier formula, but I am missing a lot of ingredients which I need 200more dollars to get

initial patent formula by the information I found was very simple like mine, “



The base likely used penetration enhancers such as oleic acid (3%), propylene glycol, and ethanol, ingredients noted in broader Topokine formulations targeting subcutaneous fat delivery
“ which is why the product failed and had many side effects despite the promising phase II trial

and they didn’t use nanocarriers, I will try to get the missing money and when I get it I’ll start working on it

This would in theory address hollow under eyes right (give more of a aegyo sal type appearance)?

 

[LukaMiku]

This would in theory address hollow under eyes right (give more of a aegyo sal type appearance)?

in theory It would help with under eye hollowing

 

[jeoyw9192]

in theory It would help with under eye hollowing

Makes sense; btw have u seen the subreddit r/estrogel? There were a few related threads on this matter, in terms of locally increasing fat