FIX YOUR DISGUSTING UNDER-EYE AREA WITH PIOGLITAZONE + OLEIC ACID

[heighceldnrr]

Brutal

 

[LukaMiku]

How can I differentiate between thin skin and shit bones?

Send me a photo and I’ll tell u side profile of ur eyes and front profile

 

[sandro]

sooo has anyone tried tihs

 

[camondo88]

use tazarotene it will make ur skin thicker

i dont think its safe for eye area

 

[NotaChadyet]

i dont think its safe for eye area

I used to use a local brand of tazarotene 0.1% for acne didn't have any side effects apart from redness

 

[LukaMiku]

i dont think its safe for eye area

it’s not going to do anything if u use it moderately put it thin and dont put it straight into ur eyes

 

[pscel]

Saving this

 

[camondo88]

it’s not going to do anything if u use it moderately put it thin and dont put it straight into ur eyes

homie you're gonna go blind

 

[copemachine]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

 

[LukaMiku]

homie you're gonna go blind

well don’t put the fucking chemicals in ur eye wtf? if u use face cream and under eye creams I don’t think they are safe in the eye either

 

[LukaMiku]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

well do fucking research and make nano-emulsion then big boy

 

[LukaMiku]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

also the amount u put under the eyes couldn’t not possible bloat u since the dosage is miniscule

 

[Randolf]

• Pioglitazone powder – 1g (1000mg)

Where can you buy that shit?

 

[garfyld]

CBD Oil combined with Geranylgeraniol work wonders, both are easily to buy and also natural so no side effects. They have low molecular weight so easily penetrate the skin. You may add coconut oil or oleic acid as well for faster results
Pioglitazone was my old idea.

 

[nokku]

dnr any undereye softmaxx method is cope

 

[garfyld]

CBD Oil combined with Geranylgeraniol work wonders, both are easily to buy and also natural so no side effects. They have low molecular weight so easily penetrate the skin. You may add coconut oil or oleic acid as well for faster results
Pioglitazone was my old idea.

I was not aware of new research and it actually shows that CBD is enough to dramatically increase fat absorption

Just buy CBD Oil mix it with oleic acid or any other non omega-6 oil(omega 9 fats are the best though) and rub it into your skin everyday
Absolutely amazing

 

[jeoyw9192]

I was not aware of new research and it actually shows that CBD is enough to dramatically increase fat absorption

Just buy CBD Oil mix it with oleic acid or any other non omega-6 oil(omega 9 fats are the best though) and rub it into your skin everyday
Absolutely amazing

Is this like a non cope volufiline? Curious if you've tried this

 

[HighTierNormie]

Pioglitazone and rosiglitazone is cope. Your formulation is too simple, it wont stay local. It goes past the epidermis, into your bloodstream, and you end up bloatmaxxing since it goes systemic. The alcohol needed for adequate penetration would also rape your collagen. There is a reason topokines project was canceled after they were bought out by allergan. https://patents.google.com/patent/US8883834B2/en

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

 

[LukaMiku]

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

gng it will increase subq fat everywhere in the body atp, just get fat u will get same result, the difference between good fat distribution is lean jaw and high amount of fat in eye area

 

[HighTierNormie]

gng it will increase subq fat everywhere in the body atp, just get fat u will get same result, the difference between good fat distribution is lean jaw and high amount of fat in eye area

but you could be the kind of person who has skinny arms and face with a huge belly from visceral fat, if your lean and try low dose maybe it could help go to undereye area but if your unlucky and get bloated face wouldnt work but tbh it seems there is not anyway for this drug to be selective from what i understand

 

[LukaMiku]

but you could be the kind of person who has skinny arms and face with a huge belly from visceral fat, if your lean and try low dose maybe it could help go to undereye area but if your unlucky and get bloated face wouldnt work but tbh it seems there is not anyway for this drug to be selective from what i understand

no it wouldn’t isolate fat gain to ur eye area in any circumstances, u will subq fat everywhere in ur body

 

[HighTierNormie]

No it wouldn’t isolate fat gain to ur eye area in any circumstances, u will subq fat everywhere in ur body

Yh your right i was looking into it more and as it is a PPAR agonist drug that apparently needs to circulate and reach nuclear receptors in liver and muscle for full effects it seems to prefer depositing fat into limbs as they are more sensitive to the fat accumulation effect of the drug but the head doesnt count as a limb since it doesnt seem to add any fat there as i saw in that HIV study and it seems to not add much subq fat to places you actually want if you just take it orally

 

[copemachine]

why not just dose pioglitazone orally like intended? from what I understand it doesnt have a huge direct affect on healthy peoples blood sugar and even causes fat gain overall and is a diabetic drug because it shrinks visceral fat and grows subcutaneous fat which is metabolically healthier but I was thinking wouldnt everyone benefit from this change and any eye area improvements would be a boost to shrinking visceral fat?

Just so you know some tranny forums use pioglitazone orally for "improving" feminized fat redistribution. I dont know whether they add hormones like estrogen or use it alone though. This could explain why it might be "feminizing" for them. Anyways, it would increase fat everywhere, which is something we want to avoid, and increasing feminizing fat distrubution doesnt seem great either.

The research and anecdotal evidence around locally increasing fat through serums, oils and peptides are really lacking. For example most of the "fat increasing" results on the lips are often explained by a increase in hydration, giving some illusion. If you want to see any results, you would have to experiment on yourself. @garfyld cbd theory does seem promising, though.

Pioglitazone, hexapeptide, sarsapogenin, etc, all increase fat, but they are hard to formulate since they would need to go past the dermis to have a good effect, and be local not systemic. Many of the ingredients that increase penetration are also terrible for the skin, and applying them around the eyes where the skin is thin and sensitive doesnt seem like the best idea. This penetration problem is the main flaw of volufiline, as it struggles to penetrate the dermis optimally, and the store bought ones have a low concentration of sarsapogenin as well.

Even if you managed to find the "perfect" formulation, you would have to source these ingredients, create the solution at home, and then use it consistently, possibly in combination with dermarolling to increase penetration. Dermarolling is also problematic around the eyes. If you still manage to successfully formulate such a solution and use it consistently, you might also just see a couple of mm of change over a long period of time.

If you lack fat around the eyes just get a fat graft tbh. It has immediate results and is not that expensive compared to other surgeries.

 

[HighTierNormie]

Just so you know some tranny forums use pioglitazone orally for "improving" feminized fat redistribution. I dont know whether they add hormones like estrogen or use it alone though. This could explain why it might be "feminizing" for them. Anyways, it would increase fat everywhere, which is something we want to avoid, and increasing feminizing fat distrubution doesnt seem great either.

Does pioglitazone have some kind of hormonal effect? I was thinking the subcutaneous fat would make you look like a happy Buddha statue, or just spread evenly around your skin. Is PPARy a gene that is more expressed in females but not related to hormones? The Peter Attia podcast had an insulin video, and the section on pio made it seem like it was favourable