FIX YOUR DISGUSTING UNDER-EYE AREA WITH PIOGLITAZONE + OLEIC ACID

[jeoyw9192]

It is worth noting that oral pioglitazone is known to inhibit bone formation and increase bone resorption by causing stem cells to preferentially differentiate into adipocytes rather than osteoblasts (tldr more fat, less bone).

I'm not sure if this effect will be seen in topical administration; it might only be relevant to high systemic levels.

The Effects of Pioglitazone on Bone Formation and Resorption Markers in Type 2 Diabetes Mellitus - PMC

The use of thiazolidinediones is reported to be associated with an increased frequency of fractures, especially in women; however, the underlying mechanism is not clear. In this prospective study, we compared the effects of pioglitazone and ...

pmc.ncbi.nlm.nih.gov

Frontiers | Clinical implications of fracture severity risk with pioglitazone: a systematic review and meta-analysis of clinical randomized trials

IntroductionPioglitazone, a thiazolidinedione, effectively reduces stroke and cardiovascular events in individuals with type 2 diabetes, insulin resistance, ...

www.frontiersin.org

Interesting hopefully those side effects are t systematic.

Btw what about something like sunflower oil @LukaMiku? This was mentioned a couple of times I believe (@RecessedPrettyboy, @AscendingHero might know more about it too).

 

[LukaMiku]

Interesting hopefully those side effects are t systematic.

Btw what about something like sunflower oil @LukaMiku? This was mentioned a couple of times I believe (@RecessedPrettyboy, @AscendingHero might know more about it too).

i would say if you apply small dosage on small area topically it wouldn’t cause systemic effects, and I believe sunflower oil is pretty weak compared to pioglitazone

 

[LukaMiku]

No worries; I was mainly referring that to @garfyld since he mentioned CBD a couple of times

I would say if you want to apply it daily multiple times a day it’s better to apply something stronger so you have higher chance of it working

 

[jeoyw9192]

I would say if you want to apply it daily multiple times a day it’s better to apply something stronger so you have higher chance of it working

Yeah makes sense - hopefully he responds nonetheless curious to what his experiences with it were.

Anyways do you have all the components of the formula yet to prepare it and everything?

 

[LukaMiku]

Yeah makes sense - hopefully he responds nonetheless curious to what his experiences with it were.

Anyways do you have all the components of the formula yet to prepare it and everything?

I have the formula but not the ingredients, I am missing some of them and saving up some money to purchase it

 

[jeoyw9192]

I have the formula but not the ingredients, I am missing some of them and saving up some money to purchase it

Got it do update me. Btw ur doing this to combat hollowness right, and to stimulate more fat in the under eye area?

 

[doctormeow2]

The Bootleg Biohacker Serum for People Who Look Like Sleep-Deprived Divorcees



WHAT ARE WE FIXING?

Your under-eyes looking like a niglet with no under-eye support

We’re going to obliterate:

• Puffy orbital fat that swells like you’re allergic to good choices
• Sagging, deflated skin from collagen collapse
• No under-eye support
• Fibrosis and inflammation that makes everything look worse
• Your self-loathing (hopefully)

Pioglitazone is our main active ingredient. Oleic acid is the penetrator

And you? You’re the desperate test subject who might finally look human again.



WHY PIOGLITAZONE WORKS



Yeah, it’s a diabetes drug — and now it’s coming for your face.
Pioglitazone is a PPAR-γ agonist. That means it literally walks into your cells and rewrites how they function.

• Reduces inflammation like a fire extinguisher for your face
• Stops rogue fat growth under the eyes
• Boosts collagen and tissue repair
• Promotes Adipogenesis (Fat growth)

WHAT OLEIC ACID DOES

You think your skin just lets anything in? No.
It’s a thick, waxy, smug little barrier. Oleic acid disrupts the stratum corneum, pushes the pioglitazone through the front lines, and pushes itself in like a priest into a child.


This is skin penetration on roids




HOW TO MAKE THE SERUM

Pick Your Path:


OPTION A: You Have Raw Pioglitazone Powder (Like a Good Little Nigger)


Ingredients:

• Pioglitazone powder – 1g (1000mg)
• Oleic Acid – 5ml
• Propylene Glycol (or PEG-400) – 85ml
• Aloe Vera Gel or Distilled Water – 10ml

Instructions:

1. Add 1g pioglitazone to beaker
2. Pour in 85ml propylene glycol
3. Add 5ml oleic acid
4. Stir that shit
5. Add 10ml aloe vera or water for softness
6. Bottle it in 100ml dark glass container
7. Store in fridge

OPTION B: You’re Crushing Pills Like a Crackhead


You’ll need:

• 10–15 pioglitazone tablets (15mg each)
• Ethanol (95%) or warm distilled water
• 2 jars
• Coffee filter
• Oleic Acid – 5ml
• Propylene Glycol – 85ml
• Aloe Vera – 10ml

Instructions:

1. Crush tablets into powder
2. Add warm ethanol or water to cover and stir
3. Cry about not getting any pussy
4. Let sit 30–60 mins, stir occasionally
5. Let garbage sink — pour off the good liquid through filter
6. Discard sludge
7. Evaporate or reduce volume to approx. 1g pioglitazone worth
8. Mix that with 85ml propylene glycol + 5ml oleic acid + 10ml aloe
9. Bottle it. Store it. Name it Copejuice.

HOW TO USE IT (WITHOUT BURNING YOUR FACE OFF)

• Apply 1 drop per eye at night
• Dab gently with your ring finger
• Use 5 nights a week. Rest on weekends
• Avoid sun exposure after application
• If it stings, dilute with more aloe or propylene glycol, if tolerated well increase the concentration up until it melts your face off

WHEN TO EXPECT RESULTS

• Week 1–2: Puffiness reduces. You look slightly less cooked.
• Week 3–5: Fat pads start growing. Skin is tightening. You remember hope.
• Week 6–8: People ask if you got filler. You lie and say, “just good sleep and hydration.”

THE SCIENCE


PPAR-γ AGONISM: THE GOD SWITCH


Pioglitazone binds to PPAR-γ receptors inside your cells — a type of nuclear receptor that controls genes related to inflammation, fat storage, and cell differentiation.

Here’s what it does to your trash under-eye support:

• Shuts off pro-inflammatory cytokines — less swelling, redness, puff
• Increases adiponectin — a protein that helps fat cells stay healthy and slim
• Prevents adipocyte hypertrophy — stops the eye bags from becoming chunky and bloated
• Promotes controlled adipogenesis — support growth of stable fat cells
• Inhibits fibrosis — so your under-eyes don’t turn into stiff, scarred wastelands

Pioglitazone encourages the creation of youthful, supportive subcutaneous fat, not that inflamed, droopy kind that makes you look like you lost a fistfight with insomnia.


The result?

• Better support under the skin
• Smoother texture
• More Under-Eye Support
• Reduced sagging and wrinkling
• The return of that tight, filled, rested look you had before life steamrolled your face

Awesome thread but where the fuck would I buy pioglitazone

 

[jeoyw9192]

Bumping any updates