buccalfatremoval
Fuchsia
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Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.
I’ll keep it simple and straightforward!
Okay now that we understand that, I’ll explain what freckles are.
WHAT ARE FRECKLES?
So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.
CONSIDERATIONS
Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.
I’ll keep it simple and straightforward!
WHAT ARE TOPICAL SIK INHIBITORS
It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.
In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.
To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.
It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.
In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.
To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.
It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.
Okay now that we understand that, I’ll explain what freckles are.
WHAT ARE FRECKLES?
alright fuck you if actually wanna know 
TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene
TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene
HOW THEY FUNCTION WHEN APPLIED
TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF
Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.
This allows CRTCs to activate CREB/MITF signaling even without UV exposure.
Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes
Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators
Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.
This allows CRTCs to activate CREB/MITF signaling even without UV exposure.
Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes
Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators
So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.
CONSIDERATIONS
Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.
Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.
Tags: @XIX @voks
