Frecklesmaxxing via SIK inhibitors

[buccalfatremoval]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

 

[bonesmasher245]

good thread mirin

 

[uglyretardednigga]

 

[Blasian-K]

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

Gotcha, thanks for this I didn't know.

On a real note nice thread will read all the way through.

 

[buccalfatremoval]

Might be interested
@Sayori @chang cypionate @Emolifta @ICL

 

[idontmogYET]

kind of unrelated but, in theory could SIK inhibitors be used for sunless tanning? since they increase melanin production leading to skin pigmentation, which of course is what a tan actually is at the end of the day

might be a promising method for palecels such as myself

 

[buccalfatremoval]

kind of unrelated but, in theory could SIK inhibitors be used for sunless tanning? since they increase melanin production leading to skin pigmentation, which of course is what a tan actually is at the end of the day

might be a promising method for palecels such as myself

Yeah but mt1/2 is much better

 

[idontmogYET]

Yeah but mt1/2 is much better

absolutely, it's just a thought I had whilst reading

also I can't pin anything rn so tbh any method might be worth looking into

 

[XIX]

BUMP

 

[Mumbai_HTN]

does it only work if you already have frecles or does it activate clusters of melanin replicating the look of freckles.

 

[buccalfatremoval]

does it only work if you already have frecles or does it activate clusters of melanin replicating the look of freckles.

If you already have freckles

 

[Sayori]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

This is cool but Dnrd the fuck out of this since I purchased freckles make up last night

Bump bump bump ( I don’t want perma freckles if this is what the thread is talking about )

 

[buccalfatremoval]

This is cool but Dnrd the fuck out of this since I purchased freckles make up last night

Bump bump bump ( I don’t want perma freckles if this is what the thread is talking about )

Not perma it’s just a selective tan, fades away if you stop using the cream

 

[chang cypionate]

Might be interested
@Sayori @chang cypionate @Emolifta @ICL

Niggas after reading this thread

 

[ICL]

I'd like these near my nose they're tough around that area

Mirin thread

 

[cargo70]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

Freckles mog if you're a pretty boy.

I never understood why people try to get rid of them.

 

[1966Ford]

Lifefuel as a black man...

 

[Nerogen]

Ok but freckles look so badddd

 

[buccalfatremoval]

Ok but freckles look so badddd

How?

Great halo for pale pretty boys

 

[Nerogen]

How?

Great halo for pale pretty boys

Well its just not for me but ill say that freckles can be so hit or miss

 

[jnxy]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

Would this work on the limbal ring?

 

[buccalfatremoval]

Would this work on the limbal ring?

Is this a joke?

 

[buccalfatremoval]

@Askinov

 

[Askinov]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

skim through it looks sexy and short

 

[Niebvll]

What if I dont have freckles

 

[buccalfatremoval]

What if I dont have freckles

Henna

 

[Askinov]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

good thread tbh

 

[buccalfatremoval]

good thread tbh

Thanks mate

 

[Askinov]

Thanks mate

both of our guides are not getting any engagement bhai sad reality

 

[buccalfatremoval]

both of our guides are not getting any engagement bhai sad reality

State of the forum or some shit

 

[jnxy]

Is this a joke?

Yes nigga what did you think. I’m curious tho and looking for a solution to thicken the limbal ring.

 

[anabolic68]

freckles look like shit if you have an abundance you are cooked.

 

[buccalfatremoval]

freckles look like shit if you have an abundance you are cooked.

Grey ramblings

If you have the pheno and coloring for it it’s a great halo

 

[anabolic68]

Grey ramblings

If you have the pheno and coloring for it it’s a great halo

yeah youre honestly right for the most part. i will accept my defeat there haha

 

[voks]

Great thread, unc

 

[buccalfatremoval]

Great thread, unc

Mirin ptr

 

[zennn]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

Dnr+mirin

 

[Shirobon]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

i hate you yo been working on a thread for this for a bit

 

[𝕯𝖓𝖆𝖌`]

Okay today’s guide is a new and promising idea, it’s about using topical SIK inhibitors to darken freckles without losing contrast like you would on MT1/2 or sun tanning.

I’ll keep it simple and straightforward!

WHAT ARE TOPICAL SIK INHIBITORS​

Spoiler

It’s pretty much just a topical version of SIK inhibitors (Salt-inducible kinases), it’s not systematic and much more selective to your topical application.

In research it shows that inhibiting SIKs in melanocytes (pigment-producing cells) activates the MITF (microphthalmia-associated transcription factor) pathway.

To put it in short, when there’s SIK in melanocytes they suppress MITF activity, so by inhibiting SIK it mimics MITF activity hence causing a sunless tan.

It also giga improves skin after UV exposure by reducing cyclobutane pyrimidine dimers, or CPDs, reducing MMP-1 and Decreasing UV-induced erythema.

Okay now that we understand that, I’ll explain what freckles are.

WHAT ARE FRECKLES?​

Spoiler

alright fuck you if actually wanna know

TLDR clusters of melanin on your skin, very small in size and most common in people with a genetic alteration in the MC1R gene

HOW THEY FUNCTION WHEN APPLIED​

Spoiler

TLDR They phosphorylate and inhibit CRTC proteins, which in turn limits the activity of CREB and upregulates MITF

Okay so first the inhibitor penetrates the skin and blocks SIK activity in melanocytes.

This allows CRTCs to activate CREB/MITF signaling even without UV exposure.

Result: Increased transcription of pigment-related genes → more melanin production (primarily eumelanin) and better transfer of melanosomes to keratinocytes

Fyi CREB is cAMP Response Element-Binding protein.
CRTC is CREB-Regulated Transcription Coactivators

So see what I’m getting at? It’s simply just selective tanning, apply it to pre existent freckles and they’ll get darker.


CONSIDERATIONS​

Spoiler

Results might not be perfectly even, everyone responds differently.
Over stimulation might lead to uneven pigmentation, hyperpigmentation in non freckled areas, or other skin reactions.
Long term safety for this specific use isn't fully established, as most work is still research oriented or cosmetic stage.
Sooo keep that in mind.

Alright that’s all I have to say I think, if you have any insights I didn’t mention please do.

Spoiler

Tags: @XIX @voks

Freckles are ugly

 

[buccalfatremoval]

Freckles are ugly

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definetlynotagray​

Rep me, 3rd account don’t ban me again · 92
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@pony @Gengar’s Ghost @DildoFaggins isnt this just blatant alting?

 

[𝕯𝖓𝖆𝖌`]

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definetlynotagray​

Rep me, 3rd account don’t ban me again · 92
Joined Oct 19, 2025
Last seen A moment ago ·Viewing thread Hgh + orals
Posts364Reputation163

@pony @Gengar’s Ghost @DildoFaggins isnt this just blatant alting?

No

 

[𝕯𝖓𝖆𝖌`]

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definetlynotagray​

Rep me, 3rd account don’t ban me again · 92
Joined Oct 19, 2025
Last seen A moment ago ·Viewing thread Hgh + orals
Posts364Reputation163

@pony @Gengar’s Ghost @DildoFaggins isnt this just blatant alting?

I’m gonna get banned again why