VeryFuglyNiyguhs
887 high t beast
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Here's the study:
pubmed.ncbi.nlm.nih.gov
"Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In this study, GSE was found to inhibit aromatase activity in a dose-dependent manner and reduce androgen-dependent tumor growth in an aromatase-transfected MCF-7 (MCF-7aro) breast cancer xenograft model, agreeing with our previous findings. We have also examined the effect of GSE on aromatase expression. Reverse transcription-PCR experiments showed that treatment with 60 mug/mL of GSE suppressed the levels of exon I.3-, exon PII-, and exon I.6-containing aromatase mRNAs in MCF-7 and SK-BR-3 cells. The levels of exon I.1-containing mRNA, however, did not change with GSE treatment. Transient transfection experiments with luciferase-aromatase promoter I.3/II or I.4 reporter vectors showed the suppression of the promoter activity in a dose-dependent manner. The GSE treatment also led to the down-regulation of two transcription factors, cyclic AMP-responsive element binding protein-1 (CREB-1) and glucocorticoid receptor (GR). CREB-1 and GR are known to up-regulate aromatase gene expression through promoters I.3/II and I.4, respectively."
What this means for non nerds is that, Grape Seed extract not only suppresses aromatase enzyme, but attacks the genes responsible for it to begin with.
However you need to megadose it as it has low bioavailability to begin with. High estrogen stunts everything in your body(your igf-1, androgenic traits, frame, literally everything, so keep it sub 15 pgs/mls for looksmaxxing purposes. Bonesmashing is heavily limited by your hormone profile(low estrogen), so keep it low if you want that to work.
Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression - PubMed
Aromatase is the enzyme that converts androgen to estrogen. It is expressed at higher levels in breast cancer tissues than normal breast tissues. Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In...
pubmed.ncbi.nlm.nih.gov
"Grape seed extract (GSE) contains high levels of procyanidin dimers that have been shown in our laboratory to be potent inhibitors of aromatase. In this study, GSE was found to inhibit aromatase activity in a dose-dependent manner and reduce androgen-dependent tumor growth in an aromatase-transfected MCF-7 (MCF-7aro) breast cancer xenograft model, agreeing with our previous findings. We have also examined the effect of GSE on aromatase expression. Reverse transcription-PCR experiments showed that treatment with 60 mug/mL of GSE suppressed the levels of exon I.3-, exon PII-, and exon I.6-containing aromatase mRNAs in MCF-7 and SK-BR-3 cells. The levels of exon I.1-containing mRNA, however, did not change with GSE treatment. Transient transfection experiments with luciferase-aromatase promoter I.3/II or I.4 reporter vectors showed the suppression of the promoter activity in a dose-dependent manner. The GSE treatment also led to the down-regulation of two transcription factors, cyclic AMP-responsive element binding protein-1 (CREB-1) and glucocorticoid receptor (GR). CREB-1 and GR are known to up-regulate aromatase gene expression through promoters I.3/II and I.4, respectively."
What this means for non nerds is that, Grape Seed extract not only suppresses aromatase enzyme, but attacks the genes responsible for it to begin with.
However you need to megadose it as it has low bioavailability to begin with. High estrogen stunts everything in your body(your igf-1, androgenic traits, frame, literally everything, so keep it sub 15 pgs/mls for looksmaxxing purposes. Bonesmashing is heavily limited by your hormone profile(low estrogen), so keep it low if you want that to work.
