Guide To "Glass" Skin

[Shishani]

I'm going to preface by saying, I don't condone the use of pharmaceutical compounds without medical assistance.
This guide is purely for educational purposes.
all of this is pretty water, but alot of yous complicate it.

the base for your journey is going to be:

Isotretinoin:

• reduces pore size
• reduces oil production
• removes all acne lesions permanently (in most cases)
• 120-150mg/kg cumulative dose

risks: liver damage, dry lips, dry skin, dry eyes, etc...

AFTER Isotretinoin:

1. Tazarotene 0.1% (fixes skin texture, and anti-aging)
2. Glutathione (fixes hyperpigmentation)
3. GHK-Cu (collagen, hair)
4. Estriol 1mg Cream (collagen)
5. Beta Carotene, Lycopene & Astaxanthin (for warm complexion/glow).

low effort post but there isn't much to say. Isotretinoin over topical tretinoin because of systemic effects, targets all acne lesions on the body (back, chest, shoulders, arms, etc...), low relapse risk if you reach your cumulative dosage (120-150mg/kg). Isotretinoin is fat-soluble, which means the effectiveness is higher when taken with a high fat meal, as opposed to just taking it on an empty stomach which reduces its effectiveness to 60-65%. I personally take 20mg during or after 5 eggs (25g of fat).

I'm doing 290mg/kg in the future though.
pmid 22909370

 

[avgsub5human]

 

[aids]

I'm doing 290mg/kg in the future though.

"just take twenty grams of isotretinoin per day bro, you will not experience liver failure"

It's much more nuanced than this which is why people do "complicate it".

 

[Shishani]

"just take twenty grams of isotretinoin per day bro, you will not experience liver failure"

It's much more nuanced than this which is why people do "complicate it".

1. Never said anyone in here should do whatever exaggerated dose you had in mind, you hump.
2. go read the fucking study I cited. if you read it, you'd know 120mg per day isn't dangerous at all.
3. When I said people complicated it, I mean they add in all these cope cleansers and every other product that doesn't work.
4. go fuck yourself

 

[LANCEPRETTYBOY]

I'm going to preface by saying, I don't condone the use of pharmaceutical compounds without medical assistance.
This guide is purely for educational purposes.
all of this is pretty water, but alot of yous complicate it.

the base for your journey is going to be:

Isotretinoin:

• reduces pore size
• reduces oil production
• removes all acne lesions permanently (in most cases)
• 120-150mg/kg cumulative dose

risks: liver damage, dry lips, dry skin, dry eyes, etc...

AFTER Isotretinoin:

1. Tazarotene 0.1% (fixes skin texture, and anti-aging)
2. Glutathione (fixes hyperpigmentation)
3. GHK-Cu (collagen, hair)
4. Estriol 1mg Cream (collagen)
5. Beta Carotene, Lycopene & Astaxanthin (for warm complexion/glow).

low effort post but there isn't much to say. Isotretinoin over topical tretinoin because of systemic effects, targets all acne lesions on the body (back, chest, shoulders, arms, etc...), low relapse risk if you reach your cumulative dosage (120-150mg/kg). Isotretinoin is fat-soluble, which means the effectiveness is higher when taken with a high fat meal, as opposed to just taking it on an empty stomach which reduces its effectiveness to 60-65%. I personally take 20mg during or after 5 eggs (25g of fat).

I'm doing 290mg/kg in the future though.
pmid 22909370

brah

 

[aids]

1. Never said anyone in here should do whatever exaggareted dose you had in mind, you hump.

You said this, as I quoted:

I'm doing 290mg/kg in the future though.

Irrespective of the absence of the phrase "i recommend you do this", such a dose is suicidal.

2. go read the fucking study I cited. if you read it, you'd know 120mg per day isn't dangerous at all.

Yes, it can be. I just read the study briefly. You must understand that these people are using isotretinoin in isolation, and (though I don't care to validate my speculation) likely are using hepatoprotective compounds concurrent to the isotretinoin.

The mention of 290mg/kg is in respect to the highest cumulative dose for isotretinoin over the course of ~178 days (average).

So if your implication of "doing 290mg/kg" was in respect to cumulative dose, then sure, but you are only now providing nuance which I didn't have during my initial reply yet you respond like I did.

Either way, this one piece of literature doesn't mean using 120mg/day is smart nor reasonable.

3. When I said people complicated it, I mean they add in all these cope cleansers and every other product that doesn't work.

Ok, what is the problem here? Like before, I inferred incorrectly given your omission of context. It's not simple regardless.

4. go fuck yourself

Don't care for your personal insults. I'm turning a new leaf and won't entertain such menial attacks. You should do the same.

Also, cumulative dose is some random bullshit hypothetical and I have no idea who popularised such a concept.

 

[Shishani]

Don't care for your personal insults. I'm turning a new leaf and won't entertain such menial attacks. You should do the same.

Coming from the guy who opened with "just take twenty grams of isotretinoin per day bro" while completely misreading what I wrote is hilarious, you spineless hypocrite.

You accused me of advocating a "suicidal dose" because you didn't understand the paper. pmid 22909370 is discussing 290mg/kg cumulative dose over a treatment course, not 290mg/kg/day. That's literally the study I cited.

Now you're admitting that if I meant cumulative dose, then your criticism doesn't apply. Exactly. That was the point from the start.

Also, the hepatoprotective compound thing is pure speculation on your part, as you said yourself jfl. The paper doesn't say that, you're just making things up to win the argument lmao.

As for 120mg/day, whether that's high depends on bodyweight. But that's a completely different discussion from your original claim that 290mg/kg was "suicidal."

You misread the study, misread the dosage, then spent two paragraphs arguing against something I never said.

 

[aids]

Coming from the guy who opened with "just take twenty grams of isotretinoin per day bro" while completely misreading what I wrote is hilarious, you spineless hypocrite.

You accused me of advocating a "suicidal dose" because you didn't understand the paper. pmid 22909370 is discussing 290mg/kg cumulative dose over a treatment course, not 290mg/kg/day. That's literally the study I cited.

Now you're admitting that if I meant cumulative dose, then your criticism doesn't apply. Exactly. That was the point from the start.

Also, the hepatoprotective compound thing is pure speculation on your part, as you said yourself jfl. The paper doesn't say that, you're just making things up to win the argument lmao.

As for 120mg/day, whether that's high depends on bodyweight. But that's a completely different discussion from your original claim that 290mg/kg was "suicidal."

You misread the study, misread the dosage, then spent two paragraphs arguing against something I never said.

Yahdah yahdah yahdah don't care.

 

[Shishani]

Yahdah yahdah yahdah don't care.

"I have no more arguments left, and I was packed into a lunch by Shishani, but I can't admit it because of my ego."

 

[GODFATHER_0]

I'm going to preface by saying, I don't condone the use of pharmaceutical compounds without medical assistance.
This guide is purely for educational purposes.
all of this is pretty water, but alot of yous complicate it.

the base for your journey is going to be:

Isotretinoin:

• reduces pore size
• reduces oil production
• removes all acne lesions permanently (in most cases)
• 120-150mg/kg cumulative dose

risks: liver damage, dry lips, dry skin, dry eyes, etc...

AFTER Isotretinoin:

1. Tazarotene 0.1% (fixes skin texture, and anti-aging)
2. Glutathione (fixes hyperpigmentation)
3. GHK-Cu (collagen, hair)
4. Estriol 1mg Cream (collagen)
5. Beta Carotene, Lycopene & Astaxanthin (for warm complexion/glow).

low effort post but there isn't much to say. Isotretinoin over topical tretinoin because of systemic effects, targets all acne lesions on the body (back, chest, shoulders, arms, etc...), low relapse risk if you reach your cumulative dosage (120-150mg/kg). Isotretinoin is fat-soluble, which means the effectiveness is higher when taken with a high fat meal, as opposed to just taking it on an empty stomach which reduces its effectiveness to 60-65%. I personally take 20mg during or after 5 eggs (25g of fat).

I'm doing 290mg/kg in the future though.
pmid 22909370

mirin bookmarked

 

[peter1287]

Starching the surface of clear skin btw

 

[aids]

"I have no more arguments left, and I was packed into a lunch by Shishani, but I can't admit it because of my ego."

No, I just can't be bothered arguing semantics with you.
You omitted detail that I mis-inferred because you expect people to look at a study with no explicit reference as to why before replying to your thread. No reasonable person will do that.


Cumulative dosing is, as aforementioned, some bullshit hypothetical because it is in reality far more nuanced than take x dose for y time.

You can't just permanently downregulate sebaceous gland activity from isotretinoin use. God forbid you do something to upregulate sebaceous gland activity e.g., take steroids (increased DHT levels assuming no 5ARi is being taken will upregulate sebaceous gland activity). Do you expect to not get acne then? Isotretinoin and/or other retinoids are for life so as to continuously inhibit sebaceous glands rather than expect them to be permanently inhibited irrespective of other things you do once you come off.

*And that is assuming that permanent downregulation of sebaceous gland activity is actually a thing. The only MoA I could reasonably estimate would cause such a thing is thru the atrophy of the gland so significantly that they are incapable of producing more sebum again, and that is completely baseless hypothetical.


I'm not replying further because it's futile.

 

[chrisisthenewclav]

 

[Shishani]

No, I just can't be bothered arguing semantics with you.
You omitted detail that I mis-inferred because you expect people to look at a study with no explicit reference as to why before replying to your thread. No reasonable person will do that.


Cumulative dosing is, as aforementioned, some bullshit hypothetical because it is in reality far more nuanced than take x dose for y time.

You went from "290mg/kg is suicidal" to "cumulative dosing is cope" because the first claim didn't survive contact with the paper.

You originally mocked me as if I was advocating some absurd acute dose. Now you've acknowledged the study is discussing cumulative exposure over a treatment course and have shifted to arguing about acne relapse instead

Whether cumulative dose is the entire story is irrelevant to your original reply. The study I cited is literally about high cumulative dosing, and that's what the 290mg/kg figure refers to.

Also, "cumulative dose is some bullshit hypothetical" is a strange take when cumulative dose has been one of the most studied variables in isotretinoin treatment for decades. It might not be the only variable affecting relapse, but pretending it doesn't exist because the biology is more complex isn't an argument.

And regarding sebaceous gland activity, NOBODY claimed isotretinoin makes you permanently acne-proof regardless of what you do afterwards. Obviously blasting roids can increase acne risk. That doesn't change the fact that higher cumulative isotretinoin exposure has repeatedly been associated with lower relapse rates.

So we've gone from "suicidal dose" to "I don't like cumulative dosing as a concept." lmao.

Strawman
Moving the goalposts
Red herring
Unsupported speculation

nice arguments bro!

 

[stnr74]

I'm going to preface by saying, I don't condone the use of pharmaceutical compounds without medical assistance.
This guide is purely for educational purposes.
all of this is pretty water, but alot of yous complicate it.

the base for your journey is going to be:

Isotretinoin:

• reduces pore size
• reduces oil production
• removes all acne lesions permanently (in most cases)
• 120-150mg/kg cumulative dose

risks: liver damage, dry lips, dry skin, dry eyes, etc...

AFTER Isotretinoin:

1. Tazarotene 0.1% (fixes skin texture, and anti-aging)
2. Glutathione (fixes hyperpigmentation)
3. GHK-Cu (collagen, hair)
4. Estriol 1mg Cream (collagen)
5. Beta Carotene, Lycopene & Astaxanthin (for warm complexion/glow).

low effort post but there isn't much to say. Isotretinoin over topical tretinoin because of systemic effects, targets all acne lesions on the body (back, chest, shoulders, arms, etc...), low relapse risk if you reach your cumulative dosage (120-150mg/kg). Isotretinoin is fat-soluble, which means the effectiveness is higher when taken with a high fat meal, as opposed to just taking it on an empty stomach which reduces its effectiveness to 60-65%. I personally take 20mg during or after 5 eggs (25g of fat).

I'm doing 290mg/kg in the future though.
pmid 22909370

Kinda water

 

[Shishani]

Starching the surface of clear skin btw

Elaborate.

 

[Bipolar2Cel]

Suppressing DHT with both finasteride but especially dutasteride can be extremely effective for acne, or treatment-resistant acne.. most guys here seem to sleep on this??! I had stubborn adult acne and suppressing DHT cleared almost all of it up, a bit of retinol supplementation fixed the rest. I clean my skin a bit with alcohol and all three together = clear fucking glass skin most of the times. Mogs.

Also just like isotretinoin/retinoids suppressing DHT seems to be capabale of shrinking sebaceous glands over time iirc. They seem capable of having a synergistic effect in this regard too. Also I got zero blackheads, the couple I get you only see if standing very next to the mirror ie not any worse than other "good/clear skin" older adult people.

Edit: Also gently squeezing my pores with a blackhead extractor keeps those pores clean for days lol.. literally turning them into "red holes", that is how clean they get with my current levels of sebum production. Suppressing DHT obviously is great for your hair and skin and anti-aging generally too otherwise anyway. Just worth considering at least, I suppress DHT nearly as much for my skin now as maintaining my hair.