HDAC Inhibition during puberty -epigenetic enhancement of growth and development

[ajshabs]

hdac inhibitors could be used to boost natural growth + development during puberty

not like gh or steroids — this is epigenetic, not hormonal
basically you’re not forcing growth, you’re just taking the brakes off your dna during the time your body’s already trying to grow


what’s an hdac inhibitor?
hdacs = enzymes that keep certain genes “switched off” by tightening the dna

when you inhibit them, the dna loosens and more genes can activate — especially ones involved in bone growth, muscle development, and facial structure

so instead of adding more hormones, you just make your existing growth system work better

why puberty matters:

puberty is the only time where:

your growth plates are open (so bones can still lengthen)
testosterone is increasing naturally
face bones are shaping (jawline, cheekbones etc)
muscles respond better to training and diet
tissue remodels faster

hdac inhibitors during this window could (in theory) amplify all that

possible benefits of hdac inhibition during puberty (if done right):

denser bones (better cheekbones, jaw, orbital rims)
slightly taller height (growth plates stay active longer)
more lean muscle growth from same test levels
faster tissue recovery/remodeling
long-term changes that might stick (epigenetic memory)

what compounds do this?
these are drugs already used in medicine (like for epilepsy or cancer):

valporic acid (VPA) – known hdac inhibitor
vorinostat / trichostatin A – very potent, mostly research use
givinostat – newer, more selective version

most of these are not safe for casual use — they affect brain chemistry and other systems, so any actual use would have to be super controlled and spaced out (like once every few weeks in microdoses)

example theoretical use (vpa):

250–500mg per day for 5–7 days
then take 2–3 weeks off
only during early–mid puberty (13–17)
idea is to hit short windows without causing damage

why it’s interesting:
hdac inhibition isn’t about adding more fuel (like gear) it’s about removing the limiters your dna puts on certain growth genes
it could make your natural growth hit harder, without pushing it past your genetic limit

 

[ajshabs]

bump

 

[Iwillbehtn]

bump

Loox has vorinostat in his course, it's almost impossible to source however in adequate dosing, as the dosage for cancer treatment regularly described is pretty dangerous (cytotoxic meaning it kills your cells) in normal healthy individuals. I would be extremely hesitant.

 

[slaters]

And what happens if you combine this with hormones and pth analogs

 

[ajshabs]

And what happens if you combine this with hormones and pth analogs

combining hdac inhibitors with pth analogs and hormones during puberty could amplify bone growth

hdac inhibitors unlock growth genes, pth analogs directly stimulate bone formation

and hormones like test/gh fuel the whole process; it’d be a high-risk, high-reward stack if timed perfectly, but could easily cause permanent dysregulation if misused.

 

[slaters]

combining hdac inhibitors with pth analogs and hormones during puberty could amplify bone growth

hdac inhibitors unlock growth genes, pth analogs directly stimulate bone formation

and hormones like test/gh fuel the whole process; it’d be a high-risk, high-reward stack if timed perfectly, but could easily cause permanent dysregulation if misused.

Always wanted to try this for more frame and height but I value my face so idk if it’s worth it
I might be able to get my hands on tetraparatide and I can get my hands on VPA but Idk
My times running out for this so ig I better decide

 

[ajshabs]

Always wanted to try this for more frame and height but I value my face so idk if it’s worth it
I might be able to get my hands on tetraparatide and I can get my hands on VPA but Idk
My times running out for this so ig I better decide

tetraparatide + vpa will enhance skeletal and craniofacial development, but vpa especially comes with neurotoxicity concerns, and once you mess with your brain or hormone system, there’s no reset button.

if your face is already decent, risking it for a bit more frame or height might do more harm than good.

low, intermittent dosing under medical supervision is the only semi-safe route

which is almost impossible to get as i doubt any medical official will allow you to do dose vpa + teri for pure asthetic reasons aha otherwise it’s just gambling with your genetics

but idk ig lol it’s a big desicion

 

[slaters]

tetraparatide + vpa will enhance skeletal and craniofacial development, but vpa especially comes with neurotoxicity concerns, and once you mess with your brain or hormone system, there’s no reset button.

if your face is already decent, risking it for a bit more frame or height might do more harm than good.

low, intermittent dosing under medical supervision is the only semi-safe route

which is almost impossible to get as i doubt any medical official will allow you to do dose vpa + teri for pure asthetic reasons aha otherwise it’s just gambling with your genetics

but idk ig lol it’s a big desicion

I wonder if ancillaries and maybe something like cerebrolysin could help
You’d def have to monitor calcium levels and megadose it on pth

 

[slaters]

Buiuujjjmp

 

[hapagenes2]

Always wanted to try this for more frame and height but I value my face so idk if it’s worth it
I might be able to get my hands on tetraparatide and I can get my hands on VPA but Idk
My times running out for this so ig I better decide

I ordered Teriparatide from this indiamart source, coming in 4 weeks and im excited

 

[hapagenes2]

hdac inhibitors could be used to boost natural growth + development during puberty

not like gh or steroids — this is epigenetic, not hormonal
basically you’re not forcing growth, you’re just taking the brakes off your dna during the time your body’s already trying to grow


what’s an hdac inhibitor?
hdacs = enzymes that keep certain genes “switched off” by tightening the dna

when you inhibit them, the dna loosens and more genes can activate — especially ones involved in bone growth, muscle development, and facial structure

so instead of adding more hormones, you just make your existing growth system work better

why puberty matters:

puberty is the only time where:

your growth plates are open (so bones can still lengthen)
testosterone is increasing naturally
face bones are shaping (jawline, cheekbones etc)
muscles respond better to training and diet
tissue remodels faster

hdac inhibitors during this window could (in theory) amplify all that

possible benefits of hdac inhibition during puberty (if done right):

denser bones (better cheekbones, jaw, orbital rims)
slightly taller height (growth plates stay active longer)
more lean muscle growth from same test levels
faster tissue recovery/remodeling
long-term changes that might stick (epigenetic memory)

what compounds do this?
these are drugs already used in medicine (like for epilepsy or cancer):

valporic acid (VPA) – known hdac inhibitor
vorinostat / trichostatin A – very potent, mostly research use
givinostat – newer, more selective version

most of these are not safe for casual use — they affect brain chemistry and other systems, so any actual use would have to be super controlled and spaced out (like once every few weeks in microdoses)

example theoretical use (vpa):

250–500mg per day for 5–7 days
then take 2–3 weeks off
only during early–mid puberty (13–17)
idea is to hit short windows without causing damage

why it’s interesting:
hdac inhibition isn’t about adding more fuel (like gear) it’s about removing the limiters your dna puts on certain growth genes
it could make your natural growth hit harder, without pushing it past your genetic limit

U think theres a way we can source a cnp analogue or fgfr3 inhibitor

 

[ajshabs]

I ordered Teriparatide from this indiamart source, coming in 4 weeks and im excited

how are you going to cycle it

 

[hapagenes2]

how are you going to cycle it

20 up to 40 mcg for 5 weeks, 3 weeks off

 

[ajshabs]

U think theres a way we can source a cnp analogue or fgfr3 inhibitor

if you’re not running a lab or locked into a clinical program then i highly doubt you could source them

 

[ajshabs]

20 up to 40 mcg for 5 weeks, 3 weeks off

you should make a thread about it and update with your results, would be very interesting to see

 

[hapagenes2]

you should make a thread about it and update with your results, would be very interesting to see

I have to see first if they scam me, i really hope not bc they seem legit with their amount of reviews and rating quality.

 

[slaters]

I ordered Teriparatide from this indiamart source, coming in 4 weeks and im excited

What’s the full cycle?
What does the teriparatide come in? Vials?
Someone here that claimed to use pth analogs said they had to make their own vials with rubberstoppers and all with the powder

Also you could get janoshik to verify it

 

[hapagenes2]

What’s the full cycle?
What does the teriparatide come in? Vials?
Someone here that claimed to use pth analogs said they had to make their own vials with rubberstoppers and all with the powder

Also you could get janoshik to verify it

Mine comes in a pen ,hopefully, iit's 1x2.4ml of 600mcg, and they make me buy in bulk(3+), I'm planning to cycle the full 40mcg/day for 5 weeks on 3 weeks off for a year or so. Also for the testing, not sure if they test teriparatide or the cost for it but yea i'll see.

 

[hapagenes2]

can u send the thread of that guy with the pth analogs? I'm wondering if he just ordered the powder, i'm looking at a VPA source rn and it's just powder but insanely cheap(₹ 1650 / Kg), i'd be fine with making it I don't think it'd be hard for the other supplies.

What’s the full cycle?
What does the teriparatide come in? Vials?
Someone here that claimed to use pth analogs said they had to make their own vials with rubberstoppers and all with the powder

Also you could get janoshik to verify it

 

[slaters]

Mine comes in a pen ,hopefully, iit's 1x2.4ml of 600mcg, and they make me buy in bulk(3+), I'm planning to cycle the full 40mcg/day for 5 weeks on 3 weeks off for a year or so. Also for the testing, not sure if they test teriparatide or the cost for it but yea i'll see.

Ok pen injections make me believe it’s actually legit
And by full cycle I mean u running test or hgh or anything else with it? Or just straight up
teriparatide

And how fast is the shipping? Or is the shipping packed in a cooler or smthn
teriparatide Needs to be refrigerated but it can be transported at room temp for 36 hours apparently

Thread 'AMA Im on teriparatide (pth analogs) for 4 months AMA'
https://looksmax.org/threads/ama-im-on-teriparatide-pth-analogs-for-4-months-ama.1423859/

 

[slaters]

can u send the thread of that guy with the pth analogs? I'm wondering if he just ordered the powder, i'm looking at a VPA source rn and it's just powder but insanely cheap(₹ 1650 / Kg), i'd be fine with making it I don't think it'd be hard for the other supplies.

VPA can be used orally. Pretty sure most use of VPA is through pills for hypomania or seizures and shit

I wish you could dm the guy but he’s banned …

 

[hapagenes2]

Ok pen injections make me believe it’s actually legit
And by full cycle I mean u running test or hgh or anything else with it? Or just straight up
teriparatide

And how fast is the shipping? Or is the shipping packed in a cooler or smthn
teriparatide Needs to be refrigerated but it can be transported at room temp for 36 hours apparently

Thread 'AMA Im on teriparatide (pth analogs) for 4 months AMA'
https://looksmax.org/threads/ama-im-on-teriparatide-pth-analogs-for-4-months-ama.1423859/

I'm hopping back on HGH at 8 iu, running test e rn at 100mg/w and letrozole. Also the guy's source apparently constricts "patients" , wonder how a 16.5 y/o bypassed this?

 

[hapagenes2]

Ok pen injections make me believe it’s actually legit
And by full cycle I mean u running test or hgh or anything else with it? Or just straight up
teriparatide

And how fast is the shipping? Or is the shipping packed in a cooler or smthn
teriparatide Needs to be refrigerated but it can be transported at room temp for 36 hours apparently

Thread 'AMA Im on teriparatide (pth analogs) for 4 months AMA'
https://looksmax.org/threads/ama-im-on-teriparatide-pth-analogs-for-4-months-ama.1423859/

It's insulated + gel ice packs ( bit more expensive, but needed) and i think they take 4 weeks or so to get to the states at least for me.

 

[slaters]

Also the guy's source apparently constricts "patients" , wonder how a 16.5 y/o bypassed this?

Could’ve 100% been a larp but my friend use to get xans through his dads lab so not impossible

It's insulated + gel ice packs ( bit more expensive, but needed) and i think they take 4 weeks or so to get to the states at least for me.

I wouldn’t worry about validity then if reviews are good, comes in a pen, and comes with stuff to cool the packaging

 

[hapagenes2]

Could’ve 100% been a larp but my friend use to get xans through his dads lab so not impossible

I wouldn’t worry about validity then if reviews are good, comes in a pen, and comes with stuff to cool the packaging

Only part that concerned me was I paid through bank transfer and apparently they dont accept paypal. I've heard most ppl say that indiamart scammers dont accept paypal but Ig it's a risk worth taking.

 

[slaters]

Only part that concerned me was I paid through bank transfer and apparently they dont accept paypal. I've heard most ppl say that indiamart scammers dont accept paypal but Ig it's a risk worth taking.

I saw someone else said they didn’t buy teriparatide cus their source didn’t accept PayPal
Better than the regret of not trying though

 

[hapagenes2]

I saw someone else said they didn’t buy teriparatide cus their source didn’t accept PayPal
Better than the regret of not trying though

Look at this vstat source,unfortunately the thing with indiaamrt is they make u buy in bulk so it's possible you waste great amounts of money.

 

[slaters]

Look at this vstat source,unfortunately the thing with indiaamrt is they make u buy in bulk so it's possible you waste great amounts of money. View attachment 3748372

What woukd the benefit in choosing Vorinostat over VPA or vice versa ?

 

[hapagenes2]

What woukd the benefit in choosing Vorinostat over VPA or vice versa ?

VPA has longer safety record. Vstat is also a bit more expensive despite being more potent and selective. So it's really a choice at the end. I think longer term use u should use VPA, and vstat is more for cycled and shorter usage <6months.

 

[flambria]

I'm not experienced in hdac inhibitors
My current plan is cruise on 300 test for an entire year with 3IU HGH
then blast 200mg tren with 20IU of HGH for 8 weeks

I'm 17.5 y/o currently, and stopped growing vertically last 8 months
Will the gear help with height (never checked for growth plate closure), or mainly facial bones growth?
Heard some guy on reddit blasting at 17ish got 3-4cm in height after growth plate fused
in legs, (not sure if it's true, maybe spine growth)

Also pairing a 8 week Tren blast & 20IU HGH with HDAC Inhibitor, would allow me to grow bigger facial bones in theory?

@hapagenes2 @slaters @ajshabs @Iwillbehtn

 

[ajshabs]

I'm not experienced in hdac inhibitors
My current plan is cruise on 300 test for an entire year with 3IU HGH
then blast 200mg tren with 20IU of HGH for 8 weeks

I'm 17.5 y/o currently, and stopped growing vertically last 8 months
Will the gear help with height (never checked for growth plate closure), or mainly facial bones growth?
Heard some guy on reddit blasting at 17ish got 3-4cm in height after growth plate fused
in legs, (not sure if it's true, maybe spine growth)

Also pairing a 8 week Tren blast & 20IU HGH with HDAC Inhibitor, would allow me to grow bigger facial bones in theory?

@hapagenes2 @slaters @ajshabs @Iwillbehtn

blasting 20ius of hgh daily for 8 weeks is extremely aggressive and is very risky

while it’s true that high hgh paired with androgens like tren and an hdac inhibitor could theoretically enhance facial bone remodeling — especially in areas like the mandible, brow ridge, and cheekbones

the problem is that such high doses of hgh can lead to insulin resistance, water retention, carpal tunnel, organ growth, and long-term metabolic issues.

3–6ius daily is already effective for cosmetic benefits over time, especially if paired with something like test and tren.

if your goal is aesthetic facial changes, you might see some enhancement with a more moderate and safer approach over time, rather than nuking your system with 20ius and hoping for a miracle in 8 weeks.

it’s about managing risk vs reward, and imo the reward at that dose isn’t worth the potential damage.

if your growth plates are already fused, you likely won’t see true long bone growth (like femur or tibia lengthening), but it’s still possible to gain 1–3 cm in height through spinal disc thickening and cartilage expansion — especially with high doses of hgh, which increases igf-1 and promotes soft tissue and cartilage growth.

however don’t take my word for it and definitely don’t trust reddit anecdotes without biomarkers or scans — always verify with real feedback + imaging

 

[flambria]

blasting 20ius of hgh daily for 8 weeks is extremely aggressive and is very risky

while it’s true that high hgh paired with androgens like tren and an hdac inhibitor could theoretically enhance facial bone remodeling — especially in areas like the mandible, brow ridge, and cheekbones

the problem is that such high doses of hgh can lead to insulin resistance, water retention, carpal tunnel, organ growth, and long-term metabolic issues.

3–6ius daily is already effective for cosmetic benefits over time, especially if paired with something like test and tren.

if your goal is aesthetic facial changes, you might see some enhancement with a more moderate and safer approach over time, rather than nuking your system with 20ius and hoping for a miracle in 8 weeks.

it’s about managing risk vs reward, and imo the reward at that dose isn’t worth the potential damage.

if your growth plates are already fused, you likely won’t see true long bone growth (like femur or tibia lengthening), but it’s still possible to gain 1–3 cm in height through spinal disc thickening and cartilage expansion — especially with high doses of hgh, which increases igf-1 and promotes soft tissue and cartilage growth.

however don’t take my word for it and definitely don’t trust reddit anecdotes without biomarkers or scans — always verify with real feedback + imaging

I was stupid, when I said, that
Real cycle plan is 300 test with 3IU as cruise
then a blasting 200mg tren 8 weeks with 8IU HGH (synergistic for bone growth)
Maybe some HDAC inhibitors like tetraparatide or vorinostat, along with this all.

Yeah this stack is not for height growth, it's for maximum aesthetic facial bone growth

 

[ajshabs]

I was stupid, when I said, that
Real cycle plan is 300 test with 3IU as cruise
then a blasting 200mg tren 8 weeks with 8IU HGH (synergistic for bone growth)
Maybe some HDAC inhibitors like tetraparatide or vorinostat, along with this all.

Yeah this stack is not for height growth, it's for maximum aesthetic facial bone growth

just make sure you’re not neglecting bloodwork

tren + high hgh isn’t something you wanna run blind, especially for glucose, prolactin, and igf-1 levels.

how u affording this tho out of curiosity aha

 

[flambria]

just make sure you’re not neglecting bloodwork

tren + high hgh isn’t something you wanna run blind, especially for glucose, prolactin, and igf-1 levels.

how u affording this though out of curiosity aha

I have a job in the trades, so I can afford it, just a bit hard but definitely doable, plus Australia has highest minimum wages in the world, so that helps, plus living with parents helps even further

 

[flambria]

just make sure you’re not neglecting bloodwork

tren + high hgh isn’t something you wanna run blind, especially for glucose, prolactin, and igf-1 levels.

how u affording this tho out of curiosity aha

should, I use Teriparatide, Varinostat or valporic acid (VPA)? (maybe a combination of them) Sourcing from India Mart?
Would this help with bone growth in face for aesthetics?

 

[flambria]

@hapagenes2 @slaters @ajshabs @Iwillbehtn

Using GPT, I found estimated facial bone growth % in a 1 year time period

For my use case scenario, which is not using it during puberty, but only for facial bone growth, it seems Teriparatide, will be the most advantageous option. It is clinically proven to work, has a somewhat moderate safety profile, and strong effects on bone. Out of Teriparatide, Varinostat, trichostatin A, givinostat, valporic acid (VPA), Teriparatide is one of the easiest to source, only falling behind Valproic Acid (VPA) for ease of finding.

 

[flambria]

Is this legit? ₹350 for 750mcg of Teriparatide? Seems ridiculously cheap, pricing more than 10x cheaper, sometimes.
Competitors are selling for ₹4,000 - ₹2,500, but the cheap seller has a crazy 4.9/5 rating, with 202 reviews.
Seller link: Teriparatide 750 Mcg Injection India Mart

@hapagenes2 @slaters @ajshabs @Iwillbehtn (your insights would be helpful)

 

[Iwillbehtn]

@hapagenes2 @slaters @ajshabs @Iwillbehtn

Using GPT, I found estimated facial bone growth % in a 1 year time period

For my use case scenario, which is not using it during puberty, but only for facial bone growth, it seems Teriparatide, will be the most advantageous option. It is clinically proven to work, has a somewhat moderate safety profile, and strong effects on bone. Out of Teriparatide, Varinostat, trichostatin A, givinostat, valporic acid (VPA), Teriparatide is one of the easiest to source, only falling behind Valproic Acid (VPA) for ease of finding.

Good effort bro.
Firstly we have to understand that the compounds Loox promotes, and some alternatives of the same caliber that you listed, work by very different mechanisms of action, for example, Vorinostat, the cancer medication works by offsetting HDAC which would otherwise inhibit osteoblast activity among other things from a certain points, even if you blasted everything else, 20 IUs HGH, abaloparatide, teriparatide, IGF-1 localized BMP-s it would never be able to reach a kind of limit that your body sets in order to not grow bone that is not biologically called for. Of course we aren't looking at functionality but aesthetics, Vorinostat is, to much knowledge the most potent HDACi to date. But it is also really fucking dangerous and hard to source. Teriparatide seems good yes, although it has a few caveats as well, you shouldn't trust chatgpt so much, as it mostly looks at wikipedia and a couple random medical journals usually. Often taking things out of context.

 

[Iwillbehtn]

Is this legit? ₹350 for 750mcg of Teriparatide? Seems ridiculously cheap, pricing more than 10x cheaper, sometimes.
Competitors are selling for ₹4,000 - ₹2,500, but the cheap seller has a crazy 4.9/5 rating, with 202 reviews.
Seller link: Teriparatide 750 Mcg Injection India Mart

@hapagenes2 @slaters @ajshabs @Iwillbehtn (your insights would be helpful)

No one can truly say until 2 things happen:
1. Someone actually has the balls to order it
2. The compound is lab tested via high-performance liquid chromatography, the most trustworthy metric, which is used by anyone who want's to know what is inside any solution. Janoshik mostly tests steroids but he has also branched out to medications, like Accutane, RU58841, Finasteride and so on as things you would find deployed in a steroid user context, I think he would have test this Indian mystery liquid as well. With HGH for example there's a huge risk of degraded HGH proteins and dimer which can be dangerous, I have no idea what the risks would be with Teriparatide

 

[hapagenes2]

Is this legit? ₹350 for 750mcg of Teriparatide? Seems ridiculously cheap, pricing more than 10x cheaper, sometimes.
Competitors are selling for ₹4,000 - ₹2,500, but the cheap seller has a crazy 4.9/5 rating, with 202 reviews.
Seller link: Teriparatide 750 Mcg Injection India Mart

@hapagenes2 @slaters @ajshabs @Iwillbehtn (your insights would be helpful)

yea 4.9/5 is good with 150+ reviews, look for something higher like 4.95+/5, also try to ask for Paypal bc I Didnt' JFL and I think I got scammed as they're hesistant to drop me a tracking link literally a week after purchase. And they'll probably make u buy in bulk if it's that cheap.

 

[Iwillbehtn]

yea 4.9/5 is good with 150+ reviews, look for something higher like 4.95+/5, also try to ask for Paypal bc I Didnt' JFL and I think I got scammed as they're hesistant to drop me a tracking link literally a week after purchase. And they'll probably make u buy in bulk if it's that cheap.

keep us updated bro

 

[hapagenes2]

Good effort bro.
Firstly we have to understand that the compounds Loox promotes, and some alternatives of the same caliber that you listed, work by very different mechanisms of action, for example, Vorinostat, the cancer medication works by offsetting HDAC which would otherwise inhibit osteoblast activity among other things from a certain points, even if you blasted everything else, 20 IUs HGH, abaloparatide, teriparatide, IGF-1 localized BMP-s it would never be able to reach a kind of limit that your body sets in order to not grow bone that is not biologically called for. Of course we aren't looking at functionality but aesthetics, Vorinostat is, to much knowledge the most potent HDACi to date. But it is also really fucking dangerous and hard to source. Teriparatide seems good yes, although it has a few caveats as well, you shouldn't trust chatgpt so much, as it mostly looks at wikipedia and a couple random medical journals usually. Often taking things out of context.

There is VPA and Vstat on indiamart, i know VPA is gigacheap especially in the powder fom where you would just need to put it in vials and order stoppers and all that gear. I dont knwo if it's trustable though.

 

[flambria]

yea 4.9/5 is good with 150+ reviews, look for something higher like 4.95+/5, also try to ask for Paypal bc I Didnt' JFL and I think I got scammed as they're hesistant to drop me a tracking link literally a week after purchase. And they'll probably make u buy in bulk if it's that cheap.

I found a person, who can get it delivered (parents would freak out, if it delivered to my house), but my priority is getting the steroids cycle, this is more of a secondary thing, to be honest. Since it so ridiculously cheap, I might bulk order it.

 

[slaters]

I found a person, who can get it delivered (parents would freak out, if it delivered to my house), but my priority is getting the steroids cycle, this is more of a secondary thing, to be honest. Since it so ridiculously cheap, I might bulk order it.

Good luck bru

 

[19nor]

bump, interesting thread

 

[hapagenes2]

keep us updated bro

got seized, do not order from fucking india mart jfl

 

[mogandpillage]

got seized, do not order from fucking india mart jfl

What country you in?

 

[slaters]

Dm I have a source mag d

got seized, do not order from fucking india mart jfl