Here's all the scientific evidence of the damage Minoxidil does to your skin's collagen

[Htrtt]

In vivo study from 2018:

Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β1/Smad3 Signaling Pathway

Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of the lungs. Collagen is the primary protein component of the ECM. However, the exact mechanisms underlying the formation and ...

www.ncbi.nlm.nih.gov

In vitro study:

Effect of lysyl hydroxylase inhibitor, minoxidil, on ultrastructure and behavior of cultured rabbit subconjunctival fibroblasts - PubMed

The results indicated that minoxidil attenuated cellular activities of SCFs such as proliferation and migration in vitro. The exact mechanism of the inhibitory effects of minoxidil on these cellular activities is unknown. The findings suggest that the drug might help to prevent bleb scarring...

pubmed.ncbi.nlm.nih.gov

 

[Htrtt]

@Maesthetic @Oberyn

 

[HighClassMaxing]

did u even read the article lol

 

[Kokra]

Simply reactivate the collagen with microneedling and collagen, then moisturize the skin with a moisturizer containing hyaluronic acid

 

[Deleted member 20189]

did u even read the article lol

Does it say something different? I ain’t taking my time to read any of this shit

 

[BucketCrab]

Minoxidil is supposed to inhibit collagen production in the scalp in order to prevent cicatrization of the hair follicle and scalp fibrosis. You people read "collagen" and think inhibiting it will turn into an old man within a month - it's targeted to the area of application, and it's beneficial for what minoxidil is intended to do.

 

[Deleted member 21340]

I'd rather have hair and mediocre skin (minoxidil won't make you a wrinkly 60 year old man with a severe case of acne)
Than no hair and good skin

 

[Htrtt]

Minoxidil is supposed to inhibit collagen production in the scalp in order to prevent cicatrization of the hair follicle and scalp fibrosis. You people read "collagen" and think inhibiting it will turn into an old man within a month - it's targeted to the area of application, and it's beneficial for what minoxidil is intended to do.

Minoxidil is systemic, so it affects your whole body, proof of this is that I only applied it to the scalp and saw my face aging drastically in addition to hair growing on my face and hands

I use collagen supplements, I do a skin care routine with Tretinoin and I eat very well

 

[Gandy]

Does it say something different? I ain’t taking my time to read any of this shit

It says excess minox usage can cause death throuh excess collagen production in the lungs. It says nothing about skin degradation.

 

[bara]

Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen

Previous studies showed that lysyl hydroxylase (LH) plays a crucial role in the formation of collagen.

Minoxidil is an FDA-approved anti-hypertensive agent that inhibits LH that reduces fibrosis.

The results of this study suggest that LH represents a target to prevent or treat pulmonary fibrosis, and minoxidil may provide an effective agent to inhibit LHs.

 

[SubhumanCurrycel]

You clearly didn’t even read the first paragraphs of the studies you posted

 

[Htrtt]

You clearly didn’t even read the first paragraphs of the studies you posted

“The PLOD mRNA levels were significantly higher in the IPF patients than in the healthy control subjects. Minoxidil suppressed the BLM-induced pulmonary fibrosis in vivo. These effects were associated with blocking TGF-β1/Smad3 signal transduction and attenuating the expression and activity of LHs, resulting in decreased collagen formation, thus reducing the pulmonary fibrosis.”

Conclusions​

The results of this study suggest that LH represents a target to prevent or treat pulmonary fibrosis, and minoxidil may provide an effective agent to inhibit LHs.

 

[Deleted member 18361]

jfl at minoxidil still being discussed here

its almost like this forum is attracted to what harms you

 

[BucketCrab]

Minoxidil is systemic, so it affects your whole body, proof of this is that I only applied it to the scalp and saw my face aging drastically in addition to hair growing on my face and hands

I use collagen supplements, I do a skin care routine with Tretinoin and I eat very well

Systemic absorption of topical minoxidil is less than 99% of the amount applied on the scalp. Minoxidil does not bind to plasma proteins or crosses the blood–brain barrier. Approximately 95% of the systemically absorbed drug and its metabolites are excreted via the kidney within 4 days.

Minoxidil and its use in hair disorders: a review | DDDT

Minoxidil and its use in hair disorders: a review Poonkiat Suchonwanit, Sasima Thammarucha, Kanchana LeerunyakulDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandAbstract: Minoxidil was first introduced as an...

www.dovepress.com

 

[Htrtt]

Systemic absorption of topical minoxidil is less than 99% of the amount applied on the scalp. Minoxidil does not bind to plasma proteins or crosses the blood–brain barrier. Approximately 95% of the systemically absorbed drug and its metabolites are excreted via the kidney within 4 days.

Minoxidil and its use in hair disorders: a review | DDDT

Minoxidil and its use in hair disorders: a review Poonkiat Suchonwanit, Sasima Thammarucha, Kanchana LeerunyakulDivision of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandAbstract: Minoxidil was first introduced as an...

www.dovepress.com

not systematic, right. So I only applied it to my scalp, it didn't runned or splatted, and hair grew on my hands because God put it there.

 

[BucketCrab]

not systematic, right. So I only applied it to my scalp, it didn't runned or splatted, and hair grew on my hands because God put it there.

You're not giving me a whole lot to work with here.
How much are you applying? How often? How old are you? Where are you applying it?

 

[Htrtt]

You're not giving me a whole lot to work with here.
How much are you applying? How often? How old are you? Where are you applying it?

Just a few drops at night 3 hours before bad, I use the non-alcohol version. Once a day. I’m 23. Just scalp

 

[BucketCrab]

Just a few drops at night 3 hours before bad, I use the non-alcohol version. Once a day. I’m 23. Just scalp

How long did it take for these side effects to appear, exactly?
And can you describe the increase in body hair, as well as facial aging?

 

[Deleted member 18361]

all these studies but not one mention about its target in pge2 which transfers to estrogen to cortisol and i dont even need to discuss what happens then..

 

[Htrtt]

How long did it take for these side effects to appear, exactly?
And can you describe the increase in body hair, as well as facial aging?

Almost 2 years, it just started to thicken body hair with time of use, facial aging and swelling on the face was progressively noticed as well

 

[Deleted member 20189]

all these studies but not one mention about its target in pge2 which transfers to estrogen to cortisol and i dont even need to discuss what happens then..

Explain

 

[Htrtt]

Explain

Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts​

Collagen type I production decreases with aging, leading to wrinkles and impaired skin function. Prostaglandin E2 (PGE2), a lipid-derived signaling molecule produced from arachidonic acid by cyclo-oxygenase, inhibits collagen production, and induces matrix metallopeptidase 1 (MMP1) expression by fibroblasts in vitro. PGE2-induced collagen expression inhibition and MMP1 promotion are aging mechanisms.

Prostaglandin E2 Induces Skin Aging via E-Prostanoid 1 in Normal Human Dermal Fibroblasts - PubMed

Collagen type I production decreases with aging, leading to wrinkles and impaired skin function. Prostaglandin E2 (PGE2), a lipid-derived signaling molecule produced from arachidonic acid by cyclo-oxygenase, inhibits collagen production, and induces matrix metallopeptidase 1 (MMP1) expression by...

pubmed.ncbi.nlm.nih.gov

 

[BucketCrab]

Almost 2 years, it just started to thicken body hair with time of use, facial aging and swelling on the face was progressively noticed as well

I'm not trying to say it's all in your head, because I don't think it's a valid way of discussing this type of issue.
But don't you think that getting thicker body hair is quite normal for a male in his early 20s? We don't fully stop developing secondary sexual characteristics until we're in our mid 20s.
For what concerns facial aging and swelling, there are dozens of possible causes; immediately attributing them to minoxidil sounds a bit forced, especially if you've been using it for 2 entire years without any adverse effect.

I personally know people who have been using minoxidil for 4+ years and they have experienced none of the issues you're talking about. Now, is it possible that you were just plain unlucky and are naturally more sensitive to whatever is inside Minoxidil? Sure, it is a possibility, I am not denying that. But I wouldn't rush to such a hasty generalization.

all these studies but not one mention about its target in pge2 which transfers to estrogen to cortisol and i dont even need to discuss what happens then..

I've taken accutane despite people online saying it's a literal poison, that it would make me impotent/bald/depressed/aging faster/dead...
Guess what? It fully cured my acne with 0 side effects.

It's so cringe to read people on forums like these spreading fear about medications that could help people.
Post studies that confirm your stance or stop fear-mongering.
As of today, there is no scientific evidence that minoxidil causes accelerated facial aging or that it may have any significant adverse side effects (except for people with history of heart disease).

 

[Htrtt]

I'm not trying to say it's all in your head, because I don't think it's a valid way of discussing this type of issue.
But don't you think that getting thicker body hair is quite normal for a male in his early 20s? We don't fully stop developing secondary sexual characteristics until we're in our mid 20s.
For what concerns facial aging and swelling, there are dozens of possible causes; immediately attributing them to minoxidil sounds a bit forced, especially if you've been using it for 2 entire years without any adverse effect.

I personally know people who have been using minoxidil for 4+ years and they have experienced none of the issues you're talking about. Now, is it possible that you were just plain unlucky and are naturally more sensitive to whatever is inside Minoxidil? Sure, it is a possibility, I am not denying that. But I wouldn't rush to such a hasty generalization.


I've taken accutane despite people online saying it's a literal poison, that it would make me impotent/bald/depressed/aging faster/dead...
Guess what? It fully cured my acne with 0 side effects.

It's so cringe to read people on forums like these spreading fear about medications that could help people.
Post studies that confirm your stance or stop fear-mongering.
As of today, there is no scientific evidence that minoxidil causes accelerated facial aging or that it may have any significant adverse side effects (except for people with history of heart disease).

I understand your point, but no. Clearly things happened because of Minoxidil, but I understand your stance. Now that it's been 1 month since I stopped, ABSOLUTELY EVERYTHING GONE

 

[Deleted member 18361]

I've taken accutane despite people online saying it's a literal poison, that it would make me impotent/bald/depressed/aging faster/dead...
Guess what? It fully cured my acne with 0 side effects.

It's so cringe to read people on forums like these spreading fear about medications that could help people.
Post studies that confirm your stance or stop fear-mongering.
As of today, there is no scientific evidence that minoxidil causes accelerated facial aging or that it may have any significant adverse side effects (except for people with history of heart disease).

Sexual complications in people treated with Accutane | RxISK

Editorial: Bill G. Sex and skin There are an ever-increasing and disturbing number of young people claiming their sex lives have been permanently ruined from taking the acne drug, isotretinoin, commonly referred to by its former brand-name, Accutane. Often these affected young men and women...

rxisk.org

Furthermore, minoxidil treatment increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity, which may influence testosterone metabolism [41]. Recently, the prostaglandin D2 receptor G protein-coupled receptor 44 pathway was shown to play an important role in AGA pathogenesis [17]. Minoxidil treatment increases prostaglandin E2 levels

Minoxidil may suppress androgen receptor-related functions

Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence ...

www.ncbi.nlm.nih.gov

Prostaglandin E2 (PGE2) induces aromatase expression in adipose tissue leading to increased estrogen production that may promote the development and progression of breast cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336521/

when you take drugs, you should know you’re dealing with hormones

 

[BucketCrab]

I understand your point, but no. Clearly things happened because of Minoxidil, but I understand your stance. Now that it's been 1 month since I stopped, ABSOLUTELY EVERYTHING GONE

If side effects vanished within 1 month of discontinuing minoxidil then yeah, I guess minoxidil was the culprit.
Did your body hair return to normal too?

Sexual complications in people treated with Accutane | RxISK

Editorial: Bill G. Sex and skin There are an ever-increasing and disturbing number of young people claiming their sex lives have been permanently ruined from taking the acne drug, isotretinoin, commonly referred to by its former brand-name, Accutane. Often these affected young men and women...

rxisk.org

Sure, isotretinoin has a chance to cause nasty side effects.
But my options were still risking side effects, or just accepting life as an acne-ghoul.
I am glad I took the risk, as have 99.99% of the people who took isotretinoin and can now live their lives without any acne.

For what concerns Minoxidil; I have many personal friends who have been using minoxidil for years with zero adverse side effects. The studies you posted offer some insight to the mechanism that allow minoxidil to do its work - but do not raise any real health concerns for people who use it. They merely describe the researcher's assumptions as to how it may help inhibiting baldness.

• minoxidil treatment increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity, which may influence testosterone metabolism.

Not to mention you specifically avoided to post the entire sentence from the study; it's weird, you cut it right before the researchers admitted they don't really know whether minoxidil plays a role in prostaglandin D2. I'm sure it was just a coincidence, huh?

• Recently, the prostaglandin D2 receptor G protein-coupled receptor 44 pathway was shown to play an important role in AGA pathogenesis. Minoxidil treatment increases prostaglandin E2 levels, but whether it influences prostaglandin D2-related pathways is unknown.

For what concerns prostaglandin e2, the study does not even mention the extent to which it is increased, but judging by how no other study raises any concern about breast cancer from minoxidil usage, I wouldn't worry about it. What the study DOES say is that minoxidil may also be useful in preventing other types of cancer:

• The current findings provide evidence that minoxidil could be used to treat both cancer and age-related disease.

But again, I'm sure it was a coincidence that you forgot to post this inbetween all the breast cancer fearmongering.

 

[bara]

Minoxidil may suppress androgen receptor-related functions

Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence ...

www.ncbi.nlm.nih.gov

Prostaglandin E2 (PGE2) induces aromatase expression in adipose tissue leading to increased estrogen production that may promote the development and progression of breast cancer.

when you take drugs, you should know you’re dealing with hormones

I didn't bother to read the other studies you linked, but regarding your prostaglandin quote, the 2 studies cited for that quote are done on mice, and one is suffering from a conflict of interest :

We show that PGD(2) inhibits hair growth in explanted human hair follicles and when applied topically to mice.

Orchiectomized male BALB/c mice were treated with placebo- or testosterone-containing hormone pellets for 14 days.

Competing interests: A.G. is an inventor of a patent owned by the Gillette Corporation to use PGD2 to inhibit hair growth. L.A.G. and G.C. are co-inventors of a patent owned by the University of Pennsylvania describing the PGD2 pathway as a target for inhibiting hair loss, among other claims

Just seems a bit disingenuous to make claims without at least mentioning or knowing that it was done on mice, and being cautious of conflicts of interest.

 

[Deleted member 18361]

If side effects vanished within 1 month of discontinuing minoxidil then yeah, I guess minoxidil was the culprit.
Did your body hair return to normal too?


Sure, isotretinoin has a chance to cause nasty side effects.
But my options were still risking side effects, or just accepting life as an acne-ghoul.
I am glad I took the risk, as have 99.99% of the people who took isotretinoin and can now live their lives without any acne.

For what concerns Minoxidil; I have many personal friends who have been using minoxidil for years with zero adverse side effects. The studies you posted offer some insight to the mechanism that allow minoxidil to do its work - but do not raise any real health concerns for people who use it. They merely describe the researcher's assumptions as to how it may help inhibiting baldness.

• minoxidil treatment increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity, which may influence testosterone metabolism.

Not to mention you specifically avoided to post the entire sentence from the study; it's weird, you cut it right before the researchers admitted they don't really know whether minoxidil plays a role in prostaglandin D2. I'm sure it was just a coincidence, huh?

• Recently, the prostaglandin D2 receptor G protein-coupled receptor 44 pathway was shown to play an important role in AGA pathogenesis. Minoxidil treatment increases prostaglandin E2 levels, but whether it influences prostaglandin D2-related pathways is unknown.

For what concerns prostaglandin e2, the study does not even mention the extent to which it is increased, but judging by how no other study raises any concern about breast cancer from minoxidil usage, I wouldn't worry about it. What the study DOES say is that minoxidil may also be useful in preventing other types of cancer:

• The current findings provide evidence that minoxidil could be used to treat both cancer and age-related disease.

But again, I'm sure it was a coincidence that you forgot to post this inbetween all the breast cancer fearmongering.

lol breast cancer? isnt estrogen production enough for you? i know for a fact that minoxidil fucks up your hormones from a first hand experience

if you look at my older posts, ive recommended minoxidil. im not gonna go through studies to help online weirdos and im already fighting my urge of selfishness to explain this to you

I didn't bother to read the other studies you linked, but regarding your prostaglandin quote, the 2 studies cited for that quote are done on mice, and one is suffering from a conflict of interest :



Just seems a bit disingenuous to make claims without at least mentioning or knowing that it was done on mice, and being cautious of conflicts of interest.

do you think studies done on mice are just done to test drugs on them? or do you think there might be a reason? iqmaxxing hard tbh

 

[Htrtt]

If side effects vanished within 1 month of discontinuing minoxidil then yeah, I guess minoxidil was the culprit.
Did your body hair return to normal too?


Sure, isotretinoin has a chance to cause nasty side effects.
But my options were still risking side effects, or just accepting life as an acne-ghoul.
I am glad I took the risk, as have 99.99% of the people who took isotretinoin and can now live their lives without any acne.

For what concerns Minoxidil; I have many personal friends who have been using minoxidil for years with zero adverse side effects. The studies you posted offer some insight to the mechanism that allow minoxidil to do its work - but do not raise any real health concerns for people who use it. They merely describe the researcher's assumptions as to how it may help inhibiting baldness.

• minoxidil treatment increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity, which may influence testosterone metabolism.

Not to mention you specifically avoided to post the entire sentence from the study; it's weird, you cut it right before the researchers admitted they don't really know whether minoxidil plays a role in prostaglandin D2. I'm sure it was just a coincidence, huh?

• Recently, the prostaglandin D2 receptor G protein-coupled receptor 44 pathway was shown to play an important role in AGA pathogenesis. Minoxidil treatment increases prostaglandin E2 levels, but whether it influences prostaglandin D2-related pathways is unknown.

For what concerns prostaglandin e2, the study does not even mention the extent to which it is increased, but judging by how no other study raises any concern about breast cancer from minoxidil usage, I wouldn't worry about it. What the study DOES say is that minoxidil may also be useful in preventing other types of cancer:

• The current findings provide evidence that minoxidil could be used to treat both cancer and age-related disease.

But again, I'm sure it was a coincidence that you forgot to post this inbetween all the breast cancer fearmongering.

Yes, I shaved the hair 1 week before I stopped and after stopping the use it didn't grow anymore, in 2 weeks when I was using Minoxidil there was hair everywhere. I understand your concern about because you also use the drug

 

[bara]

do you think studies done on mice are just done to test drugs on them? or do you think there might be a reason? iqmaxxing hard tbh

I am well aware why they are done, you were clearly not aware however that they were done on mice and quickly resorted to stating the findings as fact applicable to humans, and if you were aware you chose not to disclose that.

If you are going to cite, read, instead of cherrypicking lines that support your arguments or just reading the abstract.

 

[Baldingman1998]

I agree it gave my forehead a weird texture

 

[Deleted member 18361]

I am well aware why they are done, you were clearly not aware however that they were done on mice and quickly resorted to stating the findings as fact applicable to humans, and if you were aware you chose not to disclose that.

If you are going to cite, read, instead of cherrypicking lines that support your arguments or just reading the abstract.

they are applicable to humans, because its applicable to me jfl tbh

 

[Deleted member 17244]

Minoxidil is supposed to inhibit collagen production in the scalp in order to prevent cicatrization of the hair follicle and scalp fibrosis. You people read "collagen" and think inhibiting it will turn into an old man within a month - it's targeted to the area of application, and it's beneficial for what minoxidil is intended to do.

what about applying minox on cheeks for beard growth

 

[BucketCrab]

what about applying minox on cheeks for beard growth

That may cause some issue, first because minoxidil is usually sold in an alcoholic solution which dries out the face and highlights wrinkles, and secondly because yeah... I'm not sure inhibiting collagen on the face is beneficial